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  1. Article ; Online: Opioids in advanced cancer: use, storage and disposal in the home.

    Mercadante, Sebastiano / Adamoli, Lucia / Bellavia, Giuseppe / Castellana, Luisa / Favara, Tommaso / Insalaco, Lavinia / Mauceri, Marco / Scibilia, Carla / Lo Mauro, Mario / Lo Cascio, Alessio / Casuccio, Alessandra

    BMJ supportive & palliative care

    2024  Volume 13, Issue e3, Page(s) e855–e858

    Abstract: Objectives: To determine the patterns of storing, using and disposing of opioids among patients with advanced cancer followed at home.: Methods: Patients who were prescribed opioids were selected. Prescribed opioids and their doses used for ... ...

    Abstract Objectives: To determine the patterns of storing, using and disposing of opioids among patients with advanced cancer followed at home.
    Methods: Patients who were prescribed opioids were selected. Prescribed opioids and their doses used for background pain and breakthrough pain were collected, as well as CAGE (cut down, annoyed, guilty and eye opener) for alcohol and drugs, smoking and history of illicit substance use. Questions regarding the opioid use, storage and disposal were posed.
    Results: 100 patients were surveyed. Fifty-one patients had unused opioids at home, 25 patients did not throw away the drugs, 40 patients saved opioids for future use and 35 patients were unaware of proper opioid disposal methods. A total of 28 patients reported unsafe use by sharing or losing their opioids; 12 patients were unaware that their opioid could be fatal when taken by others. Most patients acknowledged that pain medications could be dangerous when taken by others. Patients with a partner and who were married were more likely to keep their opioids locked (p=0.028 and p=0.025, respectively).
    Conclusion: A large number of patients with advanced cancer followed at home do not store, use and dispose of opioids safely. Patient education programmes should be incorporated to decrease the availability of opioids at home for abuse, diversion, and accidental poisoning.
    MeSH term(s) Humans ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Outpatients ; Neoplasms/complications ; Neoplasms/drug therapy ; Breakthrough Pain/drug therapy
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2022-003964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: International survey of human herpes virus 8 screening and management in solid organ transplantation.

    Mularoni, Alessandra / Mikulska, Malgorzata / Giannella, Maddalena / Adamoli, Lucia / Slavin, Monica / Van Delden, Christian / Garcia, Jose Maria Aguado / Cervera, Carlos / Grossi, Paolo Antonio

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 23, Issue 5, Page(s) e13698

    Abstract: Background: HHV-8/Kaposi Sarcoma herpesvirus has been associated with a broad spectrum of diseases in solid organ transplant (SOT) recipients. Primary donor-derived infection can be associated with severe and rapidly fatal non-neoplastic disease, and ... ...

    Abstract Background: HHV-8/Kaposi Sarcoma herpesvirus has been associated with a broad spectrum of diseases in solid organ transplant (SOT) recipients. Primary donor-derived infection can be associated with severe and rapidly fatal non-neoplastic disease, and diagnosis is made with high HHV-8 DNAemia.
    Methods: We carried out an international survey to investigate the current approach to HHV-8 screening, and management in SOT since a protocol has not been established by international guidelines.
    Results: A total of 51 transplant centers from 15 countries filled out the survey. HHV-8-associated diseases in SOT have been diagnosed during the previous 5 years in 67% of centers. Pretransplant serological screening is performed in 17 centers (33%), and posttransplant HHV-8 nucleic acid testing (NAT) monitoring is performed in 21 centers (41%). Performing HHV-8 NAT monitoring and serological screening were found associated with having diagnosed in the previous 5 years a non-malignant HHV-8-associated disease.
    Conclusions: Serological pretransplant screening of donors and recipients and post-transplant HHV-8 NAT monitoring recommendations should be standardized. Even though serological assays are not optimal, they could contribute to increasing knowledge on epidemiology and management of HHV-8-associated diseases after SOT.
    MeSH term(s) Herpesviridae Infections/diagnosis ; Herpesviridae Infections/epidemiology ; Herpesvirus 8, Human ; Humans ; Organ Transplantation/adverse effects ; Sarcoma, Kaposi/epidemiology ; Transplant Recipients
    Language English
    Publishing date 2021-08-21
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnostic and vaccine strategies to prevent infections in patients with inflammatory bowel disease.

    Mazzola, Giovanni / Macaluso, Fabio Salvatore / Adamoli, Lucia / Renna, Sara / Cascio, Antonio / Orlando, Ambrogio

    The Journal of infection

    2017  Volume 74, Issue 5, Page(s) 433–441

    Abstract: Objectives: The treatment of inflammatory bowel disease (IBD) has been revolutionized by the use of immunomodulatory agents. Although these potent drugs are effective in controlling disease activity, they also cause an increased risk of new infections ... ...

    Abstract Objectives: The treatment of inflammatory bowel disease (IBD) has been revolutionized by the use of immunomodulatory agents. Although these potent drugs are effective in controlling disease activity, they also cause an increased risk of new infections or reactivation of latent infections. On these premises, we aimed to provide guidance on the definitions of immunocompromised patients, opportunistic infections and the risk factors associated with their occurrence in an IBD context, and to suggest the proper screening tests for infectious diseases and the vaccination schedules to perform before and/or during therapy with immunomodulators.
    Methods: All the most recent evidences - filtered by the combined work of gastroenterologists and infectious disease experts - were summarized with the aim to provide a practical standpoint for the physician.
    Results: A systematic screening of all infections which may arise during therapy with immunomodulator drugs is necessary in all patients with IBD.
    Conclusions: The ideal timing to perform screening tests and vaccinations is at the diagnosis of the disease, regardless of its severity at onset, because the course of IBD and its treatment may vary over time, and an immunocompromised status may hamper efficacy and/or possibility to perform all necessary vaccines.
    MeSH term(s) Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Opportunistic Infections/diagnosis ; Opportunistic Infections/epidemiology ; Opportunistic Infections/etiology ; Opportunistic Infections/prevention & control ; Vaccines/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Vaccines
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2017.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How can we optimise antifungal use in a solid organ transplant centre? Local epidemiology and antifungal stewardship implementation: A single-centre study.

    Mularoni, Alessandra / Adamoli, Lucia / Polidori, Piera / Ragonese, Barbara / Gioè, Santi Mauro / Pietrosi, Astrid / Tuzzolino, Fabio / Guadagnino, Giuliana / Monaco, Francesco / Grossi, Paolo Antonio / Conaldi, Pier Giulio / Luca, Angelo / Mikulska, Malgorzata

    Mycoses

    2020  Volume 63, Issue 7, Page(s) 746–754

    Abstract: Purpose: We aimed to implement and to assess the impact of the antifungal stewardship programme (AFSp) on prescription appropriateness of antifungals, management and outcomes of candidaemia patients, and antifungal consumption and costs at our solid ... ...

    Abstract Purpose: We aimed to implement and to assess the impact of the antifungal stewardship programme (AFSp) on prescription appropriateness of antifungals, management and outcomes of candidaemia patients, and antifungal consumption and costs at our solid organ transplant (SOT) institute.
    Methods: Local epidemiology of invasive fungal infections (IFIs) from 2009 to 2017 was analysed in order to prepare an effective AFSp, implemented in January 2018. It included suspension of empirical antifungal prescriptions after 72 hours (antifungal time-out), automated alert and infectious disease (ID) consult for empirical prescriptions and for every patient with IFI, and indication for step-down to oral fluconazole when possible. We used process measures and results measures to assess the effects of the implemented programme.
    Results: The ASFp led to significant improvements in selection of the appropriate antifungal (40.5% in pre-AFS vs 78.6% in post-AFS), correct dosing (51.2% vs 79.8%), correct length of treatment (55.9% vs 75%) and better management of patients with candidaemia. Analysis of prescribed empirical antifungal revealed that defined daily doses (DDDs) per 100 patient days decreased by 36.7% in 2018 compared to the average of pre-AFSp period, with important savings in costs.
    Conclusion: This AFSp led to a better use of antifungal drugs in terms of appropriateness and consumption, with stable clinical and microbiological outcomes in patients with IFI.
    MeSH term(s) Antifungal Agents/therapeutic use ; Antimicrobial Stewardship ; Candidemia/drug therapy ; Candidemia/epidemiology ; Health Plan Implementation/economics ; Health Plan Implementation/methods ; Humans ; Invasive Fungal Infections/drug therapy ; Invasive Fungal Infections/epidemiology ; Italy/epidemiology ; Organ Transplantation ; Outcome and Process Assessment, Health Care ; Program Evaluation ; Prospective Studies ; Tertiary Care Centers
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2020-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Behavioral and clinical characteristics of people receiving medical care for HIV infection in an outpatient facility in Sicily, Italy

    Di Carlo P / Guadagnino G / Immordino P / Mazzola G / Colletti P / Alongi I / Adamoli L / Vitale F / Casuccio A

    Patient Preference and Adherence, Vol 2016, Iss Issue 1, Pp 919-

    2016  Volume 927

    Abstract: Paola Di Carlo,1 Giuliana Guadagnino,1 Palmira Immordino,1 Giovanni Mazzola,2 Pietro Colletti,2 Ilenia Alongi,1 Lucia Adamoli,1 Francesco Vitale,1 Alessandra Casuccio1 1Department of Sciences for Health Promotion and Mother-Child Care “G D’Alessandro”, ... ...

    Abstract Paola Di Carlo,1 Giuliana Guadagnino,1 Palmira Immordino,1 Giovanni Mazzola,2 Pietro Colletti,2 Ilenia Alongi,1 Lucia Adamoli,1 Francesco Vitale,1 Alessandra Casuccio1 1Department of Sciences for Health Promotion and Mother-Child Care “G D’Alessandro”, University of Palermo, 2Department of Medicinal Clinics and Emerging Diseases, “Paolo Giaccone” Polyclinic University Hospital, Palermo, Italy Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.Methods: Two hundred and twenty-four HIV-infected subjects were enrolled in the study. Demographic and HIV disease characteristics were recorded and assessed with the number of days accessed to our outpatients unit in univariate and multivariate analyses. The potential relationship with immunological status was also analyzed stratifying the patients into groups according to their CD4+ T-cell counts (≥500 vs <500/mm3, and ≥200 vs <200/mm3).Results: Both univariate and multivariate analyses showed that duration of antiretroviral therapy <5years and hypertension were significantly associated with a CD4+ T-cell count of <500/mm3, whereas geographic origin (Africa) was associated with a CD4+ T-cell count of <200/mm3. Mean number of days the patients sought access to day-care services for laboratory tests was negatively associated with CD4+ T-cell count.Conclusion: Patients with low CD4+ T-cell counts showed higher use of health care services, demonstrating how early HIV diagnosis can help to reduce health care costs. The CD4+ T-cell cut-off of 200 cells emphasizes the importance of identifying and managing HIV infection among hard-to-reach groups like vulnerable migrants. In our sample, the illegal status of immigrants does not influence the management of their HIV/AIDS condition, but the lack of European health card that documents the current antiretroviral status, could interfere ...
    Keywords HIV infection ; CD4+ T-cell count ; access to care ; HIV Outpatient Service ; hard-to-reach groups ; resource use ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2016-05-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Physicians' Knowledge and Application of Immunization Strategies in Patients with Inflammatory Bowel Disease: A Survey of the Italian Group for the Study of Inflammatory Bowel Disease.

    Macaluso, Fabio Salvatore / Mazzola, Giovanni / Ventimiglia, Marco / Alvisi, Patrizia / Renna, Sara / Adamoli, Lucia / Galli, Massimo / Armuzzi, Alessandro / Ardizzone, Sandro / Cascio, Antonio / Cottone, Mario / Orlando, Ambrogio

    Digestion

    2019  Volume 101, Issue 4, Page(s) 433–440

    Abstract: Background: No data on European countries about knowledge and application of immunization strategies in patients with inflammatory bowel disease (IBD) are available.: Objectives: We designed a questionnaire aimed at exploring these issues among ... ...

    Abstract Background: No data on European countries about knowledge and application of immunization strategies in patients with inflammatory bowel disease (IBD) are available.
    Objectives: We designed a questionnaire aimed at exploring these issues among Italian gastroenterologists dealing with adult and paediatric IBD.
    Methods: An anonymous, 24-item, questionnaire was sent via e-mail to all members of the Italian Group for the study of Inflammatory Bowel Disease. Three sets of questions were formulated: (1) Characteristics of respondents; (2) General opinions on the role of vaccines in IBD patients; (3) Immunizations of IBD patients in clinical practice.
    Results: Of the 455 total surveys sent, there were 198 respondents (response rate: 43.5%). The great majority of respondents (82.9%) reputed as "very important" to perform the vaccinations recommended by the guidelines in patients with IBD. The indication to immunization is given at the diagnosis of the disease by 55.6% of the respondents. The most frequently recommended vaccine in IBD patients is the annual flu vaccine, while the recommendation rate for the other vaccines is variable depending on the different pathogens.
    Conclusions: Efforts carried out by the scientific societies are required to increase the awareness of this relevant topic among physicians.
    MeSH term(s) Adult ; Attitude of Health Personnel ; Child ; Female ; Gastroenterologists/psychology ; Health Knowledge, Attitudes, Practice ; Humans ; Immunization/psychology ; Inflammatory Bowel Diseases/immunology ; Italy ; Male ; Middle Aged ; Practice Patterns, Physicians'/statistics & numerical data ; Surveys and Questionnaires
    Language English
    Publishing date 2019-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000500798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Behavioral and clinical characteristics of people receiving medical care for HIV infection in an outpatient facility in Sicily, Italy.

    Di Carlo, Paola / Guadagnino, Giuliana / Immordino, Palmira / Mazzola, Giovanni / Colletti, Pietro / Alongi, Ilenia / Adamoli, Lucia / Vitale, Francesco / Casuccio, Alessandra

    Patient preference and adherence

    2016  Volume 10, Page(s) 919–927

    Abstract: Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.: Methods: Two ... ...

    Abstract Aim: The authors examined a cohort of HIV-positive outpatients at the AIDS Center of Palermo University in Italy in order to identify factors related to the frequency of their visits to the outpatient facility for health care services.
    Methods: Two hundred and twenty-four HIV-infected subjects were enrolled in the study. Demographic and HIV disease characteristics were recorded and assessed with the number of days accessed to our outpatients unit in univariate and multivariate analyses. The potential relationship with immunological status was also analyzed stratifying the patients into groups according to their CD4(+) T-cell counts (≥500 vs <500/mm(3), and ≥200 vs <200/mm(3)).
    Results: Both univariate and multivariate analyses showed that duration of antiretroviral therapy <5 years and hypertension were significantly associated with a CD4(+) T-cell count of <500/mm(3), whereas geographic origin (Africa) was associated with a CD4(+) T-cell count of <200/mm(3). Mean number of days the patients sought access to day-care services for laboratory tests was negatively associated with CD4(+) T-cell count.
    Conclusion: Patients with low CD4(+) T-cell counts showed higher use of health care services, demonstrating how early HIV diagnosis can help to reduce health care costs. The CD4(+) T-cell cut-off of 200 cells emphasizes the importance of identifying and managing HIV infection among hard-to-reach groups like vulnerable migrants. In our sample, the illegal status of immigrants does not influence the management of their HIV/AIDS condition, but the lack of European health card that documents the current antiretroviral status, could interfere with the efforts to eradicate AIDS. A better understanding of the major determinants of HIV treatment costs has led to appropriate large-scale actions, which in turn has increased resources and expanded intervention programs. Further guidance should be offered to hard-to-reach groups in order to improve early AIDS diagnosis, and procedures for identifying and managing these vulnerable subjects should be made available to care commissioners and service providers.
    Language English
    Publishing date 2016-05-25
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S90456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The choice of whether to participate in a phase I clinical trial: increasing the awareness of patients with cancer. An exploratory study.

    Catania, C / Radice, D / Spitaleri, G / Adamoli, L / Noberasco, C / Delmonte, A / Vecchio, F / de Braud, F / Toffalorio, F / Goldhirsch, A / De Pas, T

    Psycho-oncology

    2014  Volume 23, Issue 3, Page(s) 322–329

    Abstract: Objective: In a previous study, we found that patients who were offered the possibility of participation in a clinical trial had unexpressed concerns and fears that prevented them from making free or fully knowledgeable choices about their trial ... ...

    Abstract Objective: In a previous study, we found that patients who were offered the possibility of participation in a clinical trial had unexpressed concerns and fears that prevented them from making free or fully knowledgeable choices about their trial participation. In a selected population of patients who were offered participation in a phase I trial, we prospectively investigated whether a face-to-face discussion about their unexpressed fears might lead to a more conscious decision about whether to accept/refuse participation in the trial.
    Methods: After the presentation of the trial, a questionnaire was administered to assess the presence of specific fears. Before the patients decided whether to participate in the trial, they discussed any fears that they had; finally, the impact of the discussion on the patients' choice to participate was evaluated.
    Results: The majority (86%) of the patients thought that physicians conduct clinical trials for scientific interest, 13% felt exploited as 'guinea pigs' and 20% believed they were offered participation because they had no further hope for improvement. These existing fears were not elicited during the trial interview because the patients were themselves unaware of having them (28%) and because of fear of the doctors (3%). The possibility of discussing these fears was felt as an opportunity and made patients feel more conscious (92%) and freer (97%) when making their choice.
    Conclusions: Recognising and discussing misconceptions and fears, often unexpressed, make patients freer and more aware when facing the choice of whether or not \to participate in a phase I clinical trial.
    MeSH term(s) Adult ; Aged ; Choice Behavior ; Clinical Trials, Phase I as Topic/psychology ; Communication ; Decision Making ; Fear ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Neoplasms/drug therapy ; Neoplasms/psychology ; Patient Participation ; Surveys and Questionnaires
    Language English
    Publishing date 2014-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.3424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Suboptimal performance of APRI and FIB-4 in ruling out significant fibrosis and confirming cirrhosis in HIV/HCV co-infected and HCV mono-infected patients.

    Mazzola, Giovanni / Adamoli, Lucia / Calvaruso, Vincenza / Macaluso, Fabio Salvatore / Colletti, Pietro / Mazzola, Sergio / Cervo, Adriana / Trizzino, Marcello / Di Lorenzo, Francesco / Iaria, Chiara / Prestileo, Tullio / Orlando, Ambrogio / Di Marco, Vito / Cascio, Antonio

    Infection

    2018  Volume 47, Issue 3, Page(s) 409–415

    Abstract: Purpose: We aimed to assess the diagnostic reliability of two indirect biomarkers, APRI and FIB-4, for the staging of liver fibrosis using transient elastography (TE) as reference standard, among HIV/HCV co-infected and HCV mono-infected patients.: ... ...

    Abstract Purpose: We aimed to assess the diagnostic reliability of two indirect biomarkers, APRI and FIB-4, for the staging of liver fibrosis using transient elastography (TE) as reference standard, among HIV/HCV co-infected and HCV mono-infected patients.
    Methods: This is an observational, retrospective study on subjects who had access to the RESIST HCV from October 2013 to December 2016, a regional network encompassing 22 hospitals and academic centers throughout Sicily. Sensitivity, specificity and diagnostic accuracy of indirect biomarkers for liver stiffness measurement (LSM) < 9.5 kPa (significant fibrosis) and LSM ≥ 12.5 kPa (cirrhosis) were determined by receiver operator characteristics (ROC) curves.
    Results: 238 HIV/HCV co-infected and 1937 HCV mono-infected patients were included. Performances of FIB-4 and APRI for the detection of significant fibrosis and cirrhosis proved to be unsatisfactory, with very high false negative and false positive rates among both cohorts. No significant differences were found after stratification of HIV/HCV co-infected patients for BMI < or ≥ 25, ALT < or ≥ 40 IU/L, ALT < or ≥ 80 IU/L, and presence/absence of a bright liver echo pattern on ultrasonography.
    Conclusions: Differently from other studies, we detected the unreliability of APRI and FIB-4 for the assessment of liver fibrosis in both HCV mono-infected and HIV/HCV co-infected patients.
    MeSH term(s) Adult ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Coinfection/complications ; Elasticity Imaging Techniques/methods ; Female ; HIV/physiology ; HIV Infections/complications ; Hepacivirus/physiology ; Hepatitis C/complications ; Humans ; Liver Cirrhosis/classification ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Function Tests ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Sicily
    Chemical Substances Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
    Language English
    Publishing date 2018-12-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-018-1258-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A case of visceral leishmaniasis and pulmonary tuberculosis in a post-partum woman.

    Colomba, Claudia / Adamoli, Lucia / Trizzino, Marcello / Siracusa, Lucia / Bonura, Silvia / Tolomeo, Manlio / Cajozzo, Massimo / Giammanco, Giovanni Maurizio

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2015  Volume 33, Page(s) 5–6

    Abstract: Visceral leishmaniasis due to Leishmania infantum is a vector-borne zoonotic disease transmitted by sand fly bites endemic in rural or periurban areas of the Mediterranean basin. Pregnancy is accompanied by changes in immune response, mainly a decrease ... ...

    Abstract Visceral leishmaniasis due to Leishmania infantum is a vector-borne zoonotic disease transmitted by sand fly bites endemic in rural or periurban areas of the Mediterranean basin. Pregnancy is accompanied by changes in immune response, mainly a decrease in cellular immunity and a proportional increase in humoral immunity. These physiological events result in increased risk of infection by pathogens whose immunity is based on a T-helper 1 predominant response. We describe a case of visceral leishmaniasis and pulmonary tuberculosis diagnosed in a post-partum woman four days after delivery. The diagnosis of leishmaniasis should be considered in pregnant women with fever and haematologic abnormalities in endemic regions or if a history of exposure in endemic areas is reported.
    MeSH term(s) Adult ; Coinfection/diagnosis ; Female ; Humans ; Leishmania infantum ; Leishmaniasis, Visceral/complications ; Leishmaniasis, Visceral/diagnosis ; Postpartum Period ; Pregnancy ; Pregnancy Complications/diagnosis ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/diagnosis ; Young Adult
    Language English
    Publishing date 2015-04
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2014.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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