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Mesh-Begriff(e)	Aged ; Antineoplastic Agents, Hormonal/administration & dosage ; Antineoplastic Agents, Hormonal/adverse effects ; Humans ; Leuprolide/administration & dosage ; Leuprolide/adverse effects ; Male ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/therapy ; Psychotic Disorders/complications ; Schizophrenia/complications ; Subcutaneous Absorption
Chemische Substanzen	Antineoplastic Agents, Hormonal ; Leuprolide (EFY6W0M8TG)
Sprache	Englisch
Erscheinungsdatum	2017-04-06
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Letter
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7772
ISSN (online)	2155-7780
ISSN	2155-7772
DOI	10.4088/PCC.16l02038
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Sprache	Englisch
Erscheinungsdatum	2020-10-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxaa332
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Abstract	The endogenous cannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) play vital roles during nervous system development. The degradation of 2-AG and AEA is mediated by monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. These enzymes are inhibited following developmental chlorpyrifos (CPF) exposure. To investigate whether this inhibition is persistent or whether accumulation of endocannabinoids in the brain occurs, 10-day-old rat pups were orally exposed daily for 7 days to either corn oil or increasing dosages of CPF (1, 2.5, or 5mg/kg), and forebrains were collected at 4, 12, 24, and 48h following the last administration. All dosages inhibited cholinesterase (ChE), FAAH, and MAGL, and elevated AEA and 2-AG levels with the greatest effect occurring at 12h with ChE, FAAH, AEA, and 2-AG and at 4h with MAGL. With the high dosage, return to control levels occurred with 2-AG (48h) only. With the medium dosage, return to control levels occurred with MAGL, 2-AG, and AEA (48h) but not with ChE or FAAH. With the low dosage, return to control levels occurred with MAGL (12h), ChE and 2-AG (24h), and AEA (48h) but not with FAAH. With the lowest dosage, peak inhibition of FAAH (52%) is greater than that of ChE (24%) and that level of FAAH inhibition is sufficient to induce a persistent pattern of elevated AEA. It is possible that this pattern of elevation could alter the appropriate development of neuronal brain circuits.
Mesh-Begriff(e)	Aging ; Amidohydrolases/antagonists & inhibitors ; Amidohydrolases/metabolism ; Animals ; Arachidonic Acids/analysis ; Brain/drug effects ; Brain/metabolism ; Chlorpyrifos/toxicity ; Cholinesterase Inhibitors/toxicity ; Endocannabinoids/analysis ; Female ; Glycerides/analysis ; Insecticides/toxicity ; Male ; Monoacylglycerol Lipases/antagonists & inhibitors ; Monoacylglycerol Lipases/metabolism ; Polyunsaturated Alkamides/analysis ; Rats ; Rats, Sprague-Dawley
Chemische Substanzen	Arachidonic Acids ; Cholinesterase Inhibitors ; Endocannabinoids ; Glycerides ; Insecticides ; Polyunsaturated Alkamides ; glyceryl 2-arachidonate (8D239QDW64) ; Monoacylglycerol Lipases (EC 3.1.1.23) ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-) ; Chlorpyrifos (JCS58I644W) ; anandamide (UR5G69TJKH)
Sprache	Englisch
Erscheinungsdatum	2013-06-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kft126
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Artikel ; Online: Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

Leung, Wilson / Shaffer, Christopher D / Reed, Laura K / Smith, Sheryl T / Barshop, William / Dirkes, William / Dothager, Matthew / Lee, Paul / Wong, Jeannette / Xiong, David / Yuan, Han / Bedard, James E J / Machone, Joshua F / Patterson, Seantay D / Price, Amber L / Turner, Bryce A / Robic, Srebrenka / Luippold, Erin K / McCartha, Shannon R /

Walji, Tezin A / Walker, Chelsea A / Saville, Kenneth / Abrams, Marita K / Armstrong, Andrew R / Armstrong, William / Bailey, Robert J / Barberi, Chelsea R / Beck, Lauren R / Blaker, Amanda L / Blunden, Christopher E / Brand, Jordan P / Brock, Ethan J / Brooks, Dana W / Brown, Marie / Butzler, Sarah C / Clark, Eric M / Clark, Nicole B / Collins, Ashley A / Cotteleer, Rebecca J / Cullimore, Peterson R / Dawson, Seth G / Docking, Carter T / Dorsett, Sasha L / Dougherty, Grace A / Downey, Kaitlyn A / Drake, Andrew P / Earl, Erica K / Floyd, Trevor G / Forsyth, Joshua D / Foust, Jonathan D / Franchi, Spencer L / Geary, James F / Hanson, Cynthia K / Harding, Taylor S / Harris, Cameron B / Heckman, Jonathan M / Holderness, Heather L / Howey, Nicole A / Jacobs, Dontae A / Jewell, Elizabeth S / Kaisler, Maria / Karaska, Elizabeth A / Kehoe, James L / Koaches, Hannah C / Koehler, Jessica / Koenig, Dana / Kujawski, Alexander J / Kus, Jordan E / Lammers, Jennifer A / Leads, Rachel R / Leatherman, Emily C / Lippert, Rachel N / Messenger, Gregory S / Morrow, Adam T / Newcomb, Victoria / Plasman, Haley J / Potocny, Stephanie J / Powers, Michelle K / Reem, Rachel M / Rennhack, Jonathan P / Reynolds, Katherine R / Reynolds, Lyndsey A / Rhee, Dong K / Rivard, Allyson B / Ronk, Adam J / Rooney, Meghan B / Rubin, Lainey S / Salbert, Luke R / Saluja, Rasleen K / Schauder, Taylor / Schneiter, Allison R / Schulz, Robert W / Smith, Karl E / Spencer, Sarah / Swanson, Bryant R / Tache, Melissa A / Tewilliager, Ashley A / Tilot, Amanda K / VanEck, Eve / Villerot, Matthew M / Vylonis, Megan B / Watson, David T / Wurzler, Juliana A / Wysocki, Lauren M / Yalamanchili, Monica / Zaborowicz, Matthew A / Emerson, Julia A / Ortiz, Carlos / Deuschle, Frederic J / DiLorenzo, Lauren A / Goeller, Katie L / Macchi, Christopher R / Muller, Sarah E / Pasierb, Brittany D / Sable, Joseph E / Tucci, Jessica M / Tynon, Marykathryn / Dunbar, David A / Beken, Levent H / Conturso, Alaina C / Danner, Benjamin L / DeMichele, Gabriella A / Gonzales, Justin A / Hammond, Maureen S / Kelley, Colleen V / Kelly, Elisabeth A / Kulich, Danielle / Mageeney, Catherine M / McCabe, Nikie L / Newman, Alyssa M / Spaeder, Lindsay A / Tumminello, Richard A / Revie, Dennis / Benson, Jonathon M / Cristostomo, Michael C / DaSilva, Paolo A / Harker, Katherine S / Jarrell, Jenifer N / Jimenez, Luis A / Katz, Brandon M / Kennedy, William R / Kolibas, Kimberly S / LeBlanc, Mark T / Nguyen, Trung T / Nicolas, Daniel S / Patao, Melissa D / Patao, Shane M / Rupley, Bryan J / Sessions, Bridget J / Weaver, Jennifer A / Goodman, Anya L / Alvendia, Erica L / Baldassari, Shana M / Brown, Ashley S / Chase, Ian O / Chen, Maida / Chiang, Scott / Cromwell, Avery B / Custer, Ashley F / DiTommaso, Tia M / El-Adaimi, Jad / Goscinski, Nora C / Grove, Ryan A / Gutierrez, Nestor / Harnoto, Raechel S / Hedeen, Heather / Hong, Emily L / Hopkins, Barbara L / Huerta, Vilma F / Khoshabian, Colin / LaForge, Kristin M / Lee, Cassidy T / Lewis, Benjamin M / Lydon, Anniken M / Maniaci, Brian J / Mitchell, Ryan D / Morlock, Elaine V / Morris, William M / Naik, Priyanka / Olson, Nicole C / Osterloh, Jeannette M / Perez, Marcos A / Presley, Jonathan D / Randazzo, Matt J / Regan, Melanie K / Rossi, Franca G / Smith, Melanie A / Soliterman, Eugenia A / Sparks, Ciani J / Tran, Danny L / Wan, Tiffany / Welker, Anne A / Wong, Jeremy N / Sreenivasan, Aparna / Youngblom, Jim / Adams, Andrew / Alldredge, Justin / Bryant, Ashley / Carranza, David / Cifelli, Alyssa / Coulson, Kevin / Debow, Calise / Delacruz, Noelle / Emerson, Charlene / Farrar, Cassandra / Foret, Don / Garibay, Edgar / Gooch, John / Heslop, Michelle / Kaur, Sukhjit / Khan, Ambreen / Kim, Van / Lamb, Travis / Lindbeck, Peter / Lucas, Gabi / Macias, Elizabeth / Martiniuc, Daniela / Mayorga, Lissett / Medina, Joseph / Membreno, Nelson / Messiah, Shady / Neufeld, Lacey / Nguyen, San Francisco / Nichols, Zachary / Odisho, George / Peterson, Daymon / Rodela, Laura / Rodriguez, Priscilla / Rodriguez, Vanessa / Ruiz, Jorge / Sherrill, Will / Silva, Valeria / Sparks, Jeri / Statton, Geeta / Townsend, Ashley / Valdez, Isabel / Waters, Mary / Westphal, Kyle / Winkler, Stacey / Zumkehr, Joannee / DeJong, Randall J / Hoogewerf, Arlene J / Ackerman, Cheri M / Armistead, Isaac O / Baatenburg, Lara / Borr, Matthew J / Brouwer, Lindsay K / Burkhart, Brandon J / Bushhouse, Kelsey T / Cesko, Lejla / Choi, Tiffany Y Y / Cohen, Heather / Damsteegt, Amanda M / Darusz, Jess M / Dauphin, Cory M / Davis, Yelena P / Diekema, Emily J / Drewry, Melissa / Eisen, Michelle E M / Faber, Hayley M / Faber, Katherine J / Feenstra, Elizabeth / Felzer-Kim, Isabella T / Hammond, Brandy L / Hendriksma, Jesse / Herrold, Milton R / Hilbrands, Julia A / Howell, Emily J / Jelgerhuis, Sarah A / Jelsema, Timothy R / Johnson, Benjamin K / Jones, Kelly K / Kim, Anna / Kooienga, Ross D / Menyes, Erika E / Nollet, Eric A / Plescher, Brittany E / Rios, Lindsay / Rose, Jenny L / Schepers, Allison J / Scott, Geoff / Smith, Joshua R / Sterling, Allison M / Tenney, Jenna C / Uitvlugt, Chris / VanDyken, Rachel E / VanderVennen, Marielle / Vue, Samantha / Kokan, Nighat P / Agbley, Kwabea / Boham, Sampson K / Broomfield, Daniel / Chapman, Kayla / Dobbe, Ali / Dobbe, Ian / Harrington, William / Ibrahem, Marwan / Kennedy, Andre / Koplinsky, Chad A / Kubricky, Cassandra / Ladzekpo, Danielle / Pattison, Claire / Ramirez, Roman E / Wande, Lucia / Woehlke, Sarah / Wawersik, Matthew / Kiernan, Elizabeth / Thompson, Jeffrey S / Banker, Roxanne / Bartling, Justina R / Bhatiya, Chinmoy I / Boudoures, Anna L / Christiansen, Lena / Fosselman, Daniel S / French, Kristin M / Gill, Ishwar S / Havill, Jessen T / Johnson, Jaelyn L / Keny, Lauren J / Kerber, John M / Klett, Bethany M / Kufel, Christina N / May, Francis J / Mecoli, Jonathan P / Merry, Callie R / Meyer, Lauren R / Miller, Emily G / Mullen, Gregory J / Palozola, Katherine C / Pfeil, Jacob J / Thomas, Jessica G / Verbofsky, Evan M / Spana, Eric P / Agarwalla, Anant / Chapman, Julia / Chlebina, Ben / Chong, Insun / Falk, I N / Fitzgibbons, John D / Friedman, Harrison / Ighile, Osagie / Kim, Andrew J / Knouse, Kristin A / Kung, Faith / Mammo, Danny / Ng, Chun Leung / Nikam, Vinayak S / Norton, Diana / Pham, Philip / Polk, Jessica W / Prasad, Shreya / Rankin, Helen / Ratliff, Camille D / Scala, Victoria / Schwartz, Nicholas U / Shuen, Jessica A / Xu, Amy / Xu, Thomas Q / Zhang, Yi / Rosenwald, Anne G / Burg, Martin G / Adams, Stephanie J / Baker, Morgan / Botsford, Bobbi / Brinkley, Briana / Brown, Carter / Emiah, Shadie / Enoch, Erica / Gier, Chad / Greenwell, Alyson / Hoogenboom, Lindsay / Matthews, Jordan E / McDonald, Mitchell / Mercer, Amanda / Monsma, Nicholaus / Ostby, Kristine / Ramic, Alen / Shallman, Devon / Simon, Matthew / Spencer, Eric / Tomkins, Trisha / Wendland, Pete / Wylie, Anna / Wolyniak, Michael J / Robertson, Gregory M / Smith, Samuel I / DiAngelo, Justin R / Sassu, Eric D / Bhalla, Satish C / Sharif, Karim A / Choeying, Tenzin / Macias, Jason S / Sanusi, Fareed / Torchon, Karvyn / Bednarski, April E / Alvarez, Consuelo J / Davis, Kristen C / Dunham, Carrie A / Grantham, Alaina J / Hare, Amber N / Schottler, Jennifer / Scott, Zackary W / Kuleck, Gary A / Yu, Nicole S / Kaehler, Marian M / Jipp, Jacob / Overvoorde, Paul J / Shoop, Elizabeth / Cyrankowski, Olivia / Hoover, Betsy / Kusner, Matt / Lin, Devry / Martinov, Tijana / Misch, Jonathan / Salzman, Garrett / Schiedermayer, Holly / Snavely, Michael / Zarrasola, Stephanie / Parrish, Susan / Baker, Atlee / Beckett, Alissa / Belella, Carissa / Bryant, Julie / Conrad, Turner / Fearnow, Adam / Gomez, Carolina / Herbstsomer, Robert A / Hirsch, Sarah / Johnson, Christen / Jones, Melissa / Kabaso, Rita / Lemmon, Eric / Vieira, Carolina Marques Dos Santos / McFarland, Darryl / McLaughlin, Christopher / Morgan, Abbie / Musokotwane, Sepo / Neutzling, William / Nietmann, Jana / Paluskievicz, Christina / Penn, Jessica / Peoples, Emily / Pozmanter, Caitlin / Reed, Emily / Rigby, Nichole / Schmidt, Lasse / Shelton, Micah / Shuford, Rebecca / Tirasawasdichai, Tiara / Undem, Blair / Urick, Damian / Vondy, Kayla / Yarrington, Bryan / Eckdahl, Todd T / Poet, Jeffrey L / Allen, Alica B / Anderson, John E / Barnett, Jason M / Baumgardner, Jordan S / Brown, Adam D / Carney, Jordan E / Chavez, Ramiro A / Christgen, Shelbi L / Christie, Jordan S / Clary, Andrea N / Conn, Michel A / Cooper, Kristen M / Crowley, Matt J / Crowley, Samuel T / Doty, Jennifer S / Dow, Brian A / Edwards, Curtis R / Elder, Darcie D / Fanning, John P / Janssen, Bridget M / Lambright, Anthony K / Lane, Curtiss E / Limle, Austin B / Mazur, Tammy / McCracken, Marly R / McDonough, Alexa M / Melton, Amy D / Minnick, Phillip J / Musick, Adam E / Newhart, William H / Noynaert, Joseph W / Ogden, Bradley J / Sandusky, Michael W / Schmuecker, Samantha M / Shipman, Anna L / Smith, Anna L / Thomsen, Kristen M / Unzicker, Matthew R / Vernon, William B / Winn, Wesley W / Woyski, Dustin S / Zhu, Xiao / Du, Chunguang / Ament, Caitlin / Aso, Soham / Bisogno, Laura Simone / Caronna, Jason / Fefelova, Nadezhda / Lopez, Lenin / Malkowitz, Lorraine / Marra, Jonathan / Menillo, Daniella / Obiorah, Ifeanyi / Onsarigo, Eric Nyabeta / Primus, Shekerah / Soos, Mahdi / Tare, Archana / Zidan, Ameer / Jones, Christopher J / Aronhalt, Todd / Bellush, James M / Burke, Christa / DeFazio, Steve / Does, Benjamin R / Johnson, Todd D / Keysock, Nicholas / Knudsen, Nelson H / Messler, James / Myirski, Kevin / Rekai, Jade Lea / Rempe, Ryan Michael / Salgado, Michael S / Stagaard, Erica / Starcher, Justin R / Waggoner, Andrew W / Yemelyanova, Anastasia K / Hark, Amy T / Bertolet, Anne / Kuschner, Cyrus E / Parry, Kesley / Quach, Michael / Shantzer, Lindsey / Shaw, Mary E / Smith, Mary A / Glenn, Omolara / Mason, Portia / Williams, Charlotte / Key, S Catherine Silver / Henry, Tyneshia C P / Johnson, Ashlee G / White, Jackie X / Haberman, Adam / Asinof, Sam / Drumm, Kelly / Freeburg, Trip / Safa, Nadia / Schultz, Darrin / Shevin, Yakov / Svoronos, Petros / Vuong, Tam / Wellinghoff, Jules / Hoopes, Laura L M / Chau, Kim M / Ward, Alyssa / Regisford, E Gloria C / Augustine, LaJerald / Davis-Reyes, Brionna / Echendu, Vivienne / Hales, Jasmine / Ibarra, Sharon / Johnson, Lauriaun / Ovu, Steven / Braverman, John M / Bahr, Thomas J / Caesar, Nicole M / Campana, Christopher / Cassidy, Daniel W / Cognetti, Peter A / English, Johnathan D / Fadus, Matthew C / Fick, Cameron N / Freda, Philip J / Hennessy, Bryan M / Hockenberger, Kelsey / Jones, Jennifer K / King, Jessica E / Knob, Christopher R / Kraftmann, Karen J / Li, Linghui / Lupey, Lena N / Minniti, Carl J / Minton, Thomas F / Moran, Joseph V / Mudumbi, Krishna / Nordman, Elizabeth C / Puetz, William J / Robinson, Lauren M / Rose, Thomas J / Sweeney, Edward P / Timko, Ashley S / Paetkau, Don W / Eisler, Heather L / Aldrup, Megan E / Bodenberg, Jessica M / Cole, Mara G / Deranek, Kelly M / DeShetler, Megan / Dowd, Rose M / Eckardt, Alexandra K / Ehret, Sharon C / Fese, Jessica / Garrett, Amanda D / Kammrath, Anna / Kappes, Michelle L / Light, Morgan R / Meier, Anne C / O'Rouke, Allison / Perella, Mallory / Ramsey, Kimberley / Ramthun, Jennifer R / Reilly, Mary T / Robinett, Deirdre / Rossi, Nadine L / Schueler, Mary Grace / Shoemaker, Emma / Starkey, Kristin M / Vetor, Ashley / Vrable, Abby / Chandrasekaran, Vidya / Beck, Christopher / Hatfield, Kristen R / Herrick, Douglas A / Khoury, Christopher B / Lea, Charlotte / Louie, Christopher A / Lowell, Shannon M / Reynolds, Thomas J / Schibler, Jeanine / Scoma, Alexandra H / Smith-Gee, Maxwell T / Tuberty, Sarah / Smith, Christopher D / Lopilato, Jane E / Hauke, Jeanette / Roecklein-Canfield, Jennifer A / Corrielus, Maureen / Gilman, Hannah / Intriago, Stephanie / Maffa, Amanda / Rauf, Sabya A / Thistle, Katrina / Trieu, Melissa / Winters, Jenifer / Yang, Bib / Hauser, Charles R / Abusheikh, Tariq / Ashrawi, Yara / Benitez, Pedro / Boudreaux, Lauren R / Bourland, Megan / Chavez, Miranda / Cruz, Samantha / Elliott, GiNell / Farek, Jesse R / Flohr, Sarah / Flores, Amanda H / Friedrichs, Chelsey / Fusco, Zach / Goodwin, Zane / Helmreich, Eric / Kiley, John / Knepper, John Mark / Langner, Christine / Martinez, Megan / Mendoza, Carlos / Naik, Monal / Ochoa, Andrea / Ragland, Nicolas / Raimey, England / Rathore, Sunil / Reza, Evangelina / Sadovsky, Griffin / Seydoux, Marie-Isabelle B / Smith, Jonathan E / Unruh, Anna K / Velasquez, Vicente / Wolski, Matthew W / Gosser, Yuying / Govind, Shubha / Clarke-Medley, Nicole / Guadron, Leslie / Lau, Dawn / Lu, Alvin / Mazzeo, Cheryl / Meghdari, Mariam / Ng, Simon / Pamnani, Brad / Plante, Olivia / Shum, Yuki Kwan Wa / Song, Roy / Johnson, Diana E / Abdelnabi, Mai / Archambault, Alexi / Chamma, Norma / Gaur, Shailly / Hammett, Deborah / Kandahari, Adrese / Khayrullina, Guzal / Kumar, Sonali / Lawrence, Samantha / Madden, Nigel / Mandelbaum, Max / Milnthorp, Heather / Mohini, Shiv / Patel, Roshni / Peacock, Sarah J / Perling, Emily / Quintana, Amber / Rahimi, Michael / Ramirez, Kristen / Singhal, Rishi / Weeks, Corinne / Wong, Tiffany / Gillis, Aubree T / Moore, Zachary D / Savell, Christopher D / Watson, Reece / Mel, Stephanie F / Anilkumar, Arjun A / Bilinski, Paul / Castillo, Rostislav / Closser, Michael / Cruz, Nathalia M / Dai, Tiffany / Garbagnati, Giancarlo F / Horton, Lanor S / Kim, Dongyeon / Lau, Joyce H / Liu, James Z / Mach, Sandy D / Phan, Thu A / Ren, Yi / Stapleton, Kenneth E / Strelitz, Jean M / Sunjed, Ray / Stamm, Joyce / Anderson, Morgan C / Bonifield, Bethany Grace / Coomes, Daniel / Dillman, Adam / Durchholz, Elaine J / Fafara-Thompson, Antoinette E / Gross, Meleah J / Gygi, Amber M / Jackson, Lesley E / Johnson, Amy / Kocsisova, Zuzana / Manghelli, Joshua L / McNeil, Kylie / Murillo, Michael / Naylor, Kierstin L / Neely, Jessica / Ogawa, Emmy E / Rich, Ashley / Rogers, Anna / Spencer, J Devin / Stemler, Kristina M / Throm, Allison A / Van Camp, Matt / Weihbrecht, Katie / Wiles, T Aaron / Williams, Mallory A / Williams, Matthew / Zoll, Kyle / Bailey, Cheryl / Zhou, Leming / Balthaser, Darla M / Bashiri, Azita / Bower, Mindy E / Florian, Kayla A / Ghavam, Nazanin / Greiner-Sosanko, Elizabeth S / Karim, Helmet / Mullen, Victor W / Pelchen, Carly E / Yenerall, Paul M / Zhang, Jiayu / Rubin, Michael R / Arias-Mejias, Suzette M / Bermudez-Capo, Armando G / Bernal-Vega, Gabriela V / Colon-Vazquez, Mariela / Flores-Vazquez, Arelys / Gines-Rosario, Mariela / Llavona-Cartagena, Ivan G / Martinez-Rodriguez, Javier O / Ortiz-Fuentes, Lionel / Perez-Colomba, Eliezer O / Perez-Otero, Joseph / Rivera, Elisandra / Rodriguez-Giron, Luke J / Santiago-Sanabria, Arnaldo J / Senquiz-Gonzalez, Andrea M / delValle, Frank R Soto / Vargas-Franco, Dorianmarie / Velázquez-Soto, Karla I / Zambrana-Burgos, Joan D / Martinez-Cruzado, Juan Carlos / Asencio-Zayas, Lillyann / Babilonia-Figueroa, Kevin / Beauchamp-Pérez, Francis D / Belén-Rodríguez, Juliana / Bracero-Quiñones, Luciann / Burgos-Bula, Andrea P / Collado-Méndez, Xavier A / Colón-Cruz, Luis R / Correa-Muller, Ana I / Crooke-Rosado, Jonathan L / Cruz-García, José M / Defendini-Ávila, Marianna / Delgado-Peraza, Francheska M / Feliciano-Cancela, Alex J / Gónzalez-Pérez, Valerie M / Guiblet, Wilfried / Heredia-Negrón, Aldo / Hernández-Muñiz, Jennifer / Irizarry-González, Lourdes N / Laboy-Corales, Ángel L / Llaurador-Caraballo, Gabriela A / Marín-Maldonado, Frances / Marrero-Llerena, Ulises / Martell-Martínez, Héctor A / Martínez-Traverso, Idaliz M / Medina-Ortega, Kiara N / Méndez-Castellanos, Sonya G / Menéndez-Serrano, Krizia C / Morales-Caraballo, Carol I / Ortiz-DeChoudens, Saryleine / Ortiz-Ortiz, Patricia / Pagán-Torres, Hendrick / Pérez-Afanador, Diana / Quintana-Torres, Enid M / Ramírez-Aponte, Edwin G / Riascos-Cuero, Carolina / Rivera-Llovet, Michelle S / Rivera-Pagán, Ingrid T / Rivera-Vicéns, Ramón E / Robles-Juarbe, Fabiola / Rodríguez-Bonilla, Lorraine / Rodríguez-Echevarría, Brian O / Rodríguez-García, Priscila M / Rodríguez-Laboy, Abneris E / Rodríguez-Santiago, Susana / Rojas-Vargas, Michael L / Rubio-Marrero, Eva N / Santiago-Colón, Albeliz / Santiago-Ortiz, Jorge L / Santos-Ramos, Carlos E / Serrano-González, Joseline / Tamayo-Figueroa, Alina M / Tascón-Peñaranda, Edna P / Torres-Castillo, José L / Valentín-Feliciano, Nelson A / Valentín-Feliciano, Yashira M / Vargas-Barreto, Nadyan M / Vélez-Vázquez, Miguel / Vilanova-Vélez, Luis R / Zambrana-Echevarría, Cristina / MacKinnon, Christy / Chung, Hui-Min / Kay, Chris / Pinto, Anthony / Kopp, Olga R / Burkhardt, Joshua / Harward, Chris / Allen, Robert / Bhat, Pavan / Chang, Jimmy Hsiang-Chun / Chen, York / Chesley, Christopher / Cohn, Dara / DuPuis, David / Fasano, Michael / Fazzio, Nicholas / Gavinski, Katherine / Gebreyesus, Heran / Giarla, Thomas / Gostelow, Marcus / Greenstein, Rachel / Gunasinghe, Hashini / Hanson, Casey / Hay, Amanda / He, Tao Jian / Homa, Katie / Howe, Ruth / Howenstein, Jeff / Huang, Henry / Khatri, Aaditya / Kim, Young Lu / Knowles, Olivia / Kong, Sarah / Krock, Rebecca / Kroll, Matt / Kuhn, Julia / Kwong, Matthew / Lee, Brandon / Lee, Ryan / Levine, Kevin / Li, Yedda / Liu, Bo / Liu, Lucy / Liu, Max / Lousararian, Adam / Ma, Jimmy / Mallya, Allyson / Manchee, Charlie / Marcus, Joseph / McDaniel, Stephen / Miller, Michelle L / Molleston, Jerome M / Diez, Cristina Montero / Ng, Patrick / Ngai, Natalie / Nguyen, Hien / Nylander, Andrew / Pollack, Jason / Rastogi, Suchita / Reddy, Himabindu / Regenold, Nathaniel / Sarezky, Jon / Schultz, Michael / Shim, Jien / Skorupa, Tara / Smith, Kenneth / Spencer, Sarah J / Srikanth, Priya / Stancu, Gabriel / Stein, Andrew P / Strother, Marshall / Sudmeier, Lisa / Sun, Mengyang / Sundaram, Varun / Tazudeen, Noor / Tseng, Alan / Tzeng, Albert / Venkat, Rohit / Venkataram, Sandeep / Waldman, Leah / Wang, Tracy / Yang, Hao / Yu, Jack Y / Zheng, Yin / Preuss, Mary L / Garcia, Angelica / Juergens, Matt / Morris, Robert W / Nagengast, Alexis A / Azarewicz, Julie / Carr, Thomas J / Chichearo, Nicole / Colgan, Mike / Donegan, Megan / Gardner, Bob / Kolba, Nik / Krumm, Janice L / Lytle, Stacey / MacMillian, Laurell / Miller, Mary / Montgomery, Andrew / Moretti, Alysha / Offenbacker, Brittney / Polen, Mike / Toth, John / Woytanowski, John / Kadlec, Lisa / Crawford, Justin / Spratt, Mary L / Adams, Ashley L / Barnard, Brianna K / Cheramie, Martin N / Eime, Anne M / Golden, Kathryn L / Hawkins, Allyson P / Hill, Jessica E / Kampmeier, Jessica A / Kern, Cody D / Magnuson, Emily E / Miller, Ashley R / Morrow, Cody M / Peairs, Julia C / Pickett, Gentry L / Popelka, Sarah A / Scott, Alexis J / Teepe, Emily J / TerMeer, Katie A / Watchinski, Carmen A / Watson, Lucas A / Weber, Rachel E / Woodard, Kate A / Barnard, Daron C / Appiah, Isaac / Giddens, Michelle M / McNeil, Gerard P / Adebayo, Adeola / Bagaeva, Kate / Chinwong, Justina / Dol, Chrystel / George, Eunice / Haltaufderhyde, Kirk / Haye, Joanna / Kaur, Manpreet / Semon, Max / Serjanov, Dmitri / Toorie, Anika / Wilson, Christopher / Riddle, Nicole C / Buhler, Jeremy / Mardis, Elaine R / Elgin, Sarah C R

G3 (Bethesda, Md.)

2015 Band 5, Heft 5, Seite(n) 719–740

Abstract: The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we ... ...

Abstract	The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11-27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4-3.6 vs. 8.4-8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu.
Mesh-Begriff(e)	Animals ; Codon ; Computational Biology ; DNA Transposable Elements ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Evolution, Molecular ; Exons ; Gene Rearrangement ; Genome ; Genomics ; Heterochromatin ; Introns ; Molecular Sequence Annotation ; Polytene Chromosomes ; Repetitive Sequences, Nucleic Acid ; Selection, Genetic ; Species Specificity
Chemische Substanzen	Codon ; DNA Transposable Elements ; Drosophila Proteins ; Heterochromatin
Sprache	Englisch
Erscheinungsdatum	2015-03-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1534/g3.114.015966
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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