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  1. Article ; Online: Right Ventricular Outflow Tract Stenting is a Safe and Effective Bridge to Definitive Repair in Symptomatic Infants With Tetralogy of Fallot

    Luxford, Jack C / Adams, Paul E / Roberts, Philip A / Mervis, Jonathan

    Heart, lung & circulation

    2023  Volume 32, Issue 5, Page(s) 638–644

    Abstract: Introduction: Right ventricular outflow tract (RVOT) stent angioplasty is a palliative procedure for neonates and infants with symptomatic tetralogy of Fallot prior to surgical repair. We review our institutional outcomes of RVOT stenting.: Methods: ... ...

    Abstract Introduction: Right ventricular outflow tract (RVOT) stent angioplasty is a palliative procedure for neonates and infants with symptomatic tetralogy of Fallot prior to surgical repair. We review our institutional outcomes of RVOT stenting.
    Methods: Retrospective review of all infants with tetralogy of Fallot under 3 months of age who underwent primary native RVOT stent angioplasty at The Children's Hospital at Westmead, Sydney, Australia between January 2010 and December 2020. Demographics and echocardiographic pulmonary artery dimensions were collected pre-stent angioplasty and prior to surgical repair.
    Results: Twenty (20) infants underwent primary RVOT stenting. Median age at stent was 14 days (interquartile range [IQR] 7-32) and median weight 2.7 kg (IQR 2.1-3.4). Three patients underwent hybrid per-ventricular procedures. Indication for RVOT stenting was recurrent hyper-cyanotic spells in 12 (60%) and duct-dependent pulmonary blood flow in 8 (40%). Saturations increased from a median of 80% (IQR 75-85) to 91% (IQR 90-95) post procedure (P<0.001). A single major complication occurred: transient complete atrioventricular dissociation requiring isoprenaline infusion for <24 hours. Twelve (12, 60%) required catheter re-intervention prior to definitive repair for further augmentation of pulmonary blood flow. There were two non-cardiac deaths distant from the stent procedure, but prior to surgical repair. Median right and left pulmonary artery Z-scores increased respectively from -2.06 (IQR -2.99 to -0.17) and -1.2 (IQR -2.59 to -0.14) prior to RVOT stent, to -0.74 (IQR [-1.21 to 0.26], P=0.01) and 0.06 (IQR [-1.87 to 1.15], P=0.006) by the time of definitive repair. Eighteen (18) patients achieved definitive repair at a median age of 6.1 months (IQR 4.7-7.3). Palliation with more than one RVOT stent was associated with an increased duration of cardiac bypass (P=0.035) and cross-clamp (P=0.044) time at definitive repair.
    Conclusions: In symptomatic neonates and infants with tetralogy of Fallot at high-risk of peri-operative complications, RVOT stent angioplasty can safely and effectively augment pulmonary blood flow prior to definitive repair.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; Infant ; Tetralogy of Fallot/diagnosis ; Tetralogy of Fallot/surgery ; Treatment Outcome ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery ; Stents ; Retrospective Studies
    Language English
    Publishing date 2023-03-22
    Publishing country Australia
    Document type Review ; Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4988: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Review of children with Takayasu's arteritis at a Southern African tertiary care centre.

    Cilliers, Antoinette M / Adams, Paul E / Ntsinjana, Hopewell / Kala, Udai

    Cardiology in the young

    2018  Volume 28, Issue 9, Page(s) 1129–1135

    Abstract: IntroductionTakayasu's arteritis is a rare idiopathic arteritis causing stenosis or aneurysms of the aorta, pulmonary arteries, and their branches. It usually occurs in women, but has been described in children.: Objective: The objective of this study ...

    Abstract IntroductionTakayasu's arteritis is a rare idiopathic arteritis causing stenosis or aneurysms of the aorta, pulmonary arteries, and their branches. It usually occurs in women, but has been described in children.
    Objective: The objective of this study was to determine the clinical presentation, demographic profile, vascular involvement, origins, management, and outcome of children diagnosed with Takayasu's arteritis at a Southern African tertiary care centre between 1993 and 2015.
    Methods: This is a retrospective analysis of all children with Takayasu's arteritis captured on a computerised electronic database during the study period.
    Results: A total of 55 children were identified. The female:male ratio was 3.2:1, and the mean age was 9.7±3.04 years. Most originated outside the provincial borders of the study centre. The majority presented with hypertension and heart failure. In all, 37 (67%) patients had a cardiomyopathy with a mean fractional shortening of 15±5%. A positive purified protein derivative test was documented in 73%. Abdominal aorta and renal artery stenosis were the predominant angiographic lesions. A total of 23 patients underwent 30 percutaneous interventions of the aorta, pulmonary, and renal arteries: eight stents, 22 balloon angioplasties, and seven had nephrectomies. All patients received empiric tuberculosis treatment, immunosuppressive therapy, and anti-hypertensive agents as required. Overall, there was a significant reduction in systolic blood pressure and improvement in fractional shortening (p<0.05) with all treatments.
    Conclusion: Takayasu's arteritis is more common in girls and frequently manifests with hypertension and heart failure. The abdominal aorta and renal arteries are mostly affected. Immunosuppressive, anti-hypertensive, and vascular intervention therapies improve blood pressure control and cardiac function.
    MeSH term(s) Africa, Southern/epidemiology ; Angiography ; Child ; Female ; Humans ; Incidence ; Male ; Retrospective Studies ; Survival Rate/trends ; Takayasu Arteritis/diagnosis ; Takayasu Arteritis/epidemiology ; Takayasu Arteritis/surgery ; Tertiary Care Centers ; Treatment Outcome ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2018-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951118000938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Early presentation of endomyocardial fibrosis in a 22-month-old child: a case report.

    Cilliers, Antoinette M / Adams, Paul E / Mocumbi, Ana O

    Cardiology in the young

    2011  Volume 21, Issue 1, Page(s) 101–103

    Abstract: We present an unusual, biopsy-proven case of endomyocardial fibrosis in a 22-month-old male child, which progressed rapidly resulting in death. The patient was born to a father originating from Mozambique, where the disease is endemic but who had not ... ...

    Abstract We present an unusual, biopsy-proven case of endomyocardial fibrosis in a 22-month-old male child, which progressed rapidly resulting in death. The patient was born to a father originating from Mozambique, where the disease is endemic but who had not himself travelled there, suggesting a genetic link. Other remarkable features were the presence of a right ventricular diverticulum, and a positive Mycoplasma pneumoniae immunoglobulin M enzyme-linked immunosorbent assay test.
    MeSH term(s) Angiography/methods ; Biopsy ; Diagnosis, Differential ; Early Diagnosis ; Echocardiography/methods ; Endomyocardial Fibrosis/diagnosis ; Fatal Outcome ; Humans ; Infant ; Male ; Myocardium/pathology
    Language English
    Publishing date 2011-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951110001460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Development and validation of a novel laboratory model of sound-induced fear and anxiety in Beagle dogs

    Araujo, Joseph A / de Rivera, Christina / Landsberg, Gary M / Adams, Paul E / Milgram, Norton W

    Journal of veterinary behavior. 2013 , v. 8, no. 4

    2013  

    Abstract: Disorders of fear and anxiety are significant behavioral and physiological concerns in veterinary medicine. Thus, the present studies sought to develop and validate novel preclinical laboratory models for the development of anxiolytics for the veterinary ...

    Abstract Disorders of fear and anxiety are significant behavioral and physiological concerns in veterinary medicine. Thus, the present studies sought to develop and validate novel preclinical laboratory models for the development of anxiolytics for the veterinary market. Specifically, noise-induced sensitivity and aversion using thunderstorm recordings on an open-field task in Beagle dogs was used to establish this model. This thunderstorm task was based on the open-field tests previously described for the dog, except that a thunderstorm recording, compiled from desensitization compact discs, played during the middle of the test was used to elicit anxious or fearful responses in laboratory dogs. Initially, we compared the behavioral response on this test with that on an open-field test, in which no sound stimulus was provided. When compared with the open field, the thunderstorm recording increased inactivity duration and frequency, which was related to freezing behaviors and near-door duration. This suggests that we can objectively characterize a fear and anxious response to noise. We then attempted to pharmacologically validate this model by testing 0.5, 1, or 2 mg/kg doses of diazepam on this behavioral outcome. In test-naïve subjects, diazepam reduced the increase in inactivity seen at washout compared with that seen at baseline, suggesting that this paradigm may be useful for establishing the effect of drugs that reduce or prevent sensitization to fear-invoking events. In test-experienced subjects, diazepam reduced inactivity compared with both baseline and washout, indicating that this model may be useful for screening drugs counteracting fear and phobia, as well as anticipatory anxiety responses. Interestingly, diazepam stimulated behavioral activity as measured with the Actiwatch method. The test described here provides a laboratory method for testing therapeutics targeted at reducing either anxiety or fear related to noise sensitivity and aversion in pet dogs.
    Keywords Beagle ; anxiety ; compact discs ; diazepam ; dogs ; fearfulness ; freezing ; laboratory techniques ; markets ; models ; screening ; therapeutics ; tranquilizers ; veterinary medicine
    Language English
    Dates of publication 2013-07
    Size p. 204-212.
    Publishing place Elsevier Inc.
    Document type Article
    ISSN 1558-7878
    DOI 10.1016/j.jveb.2012.10.008
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review.

    Chersich, Matthew F / Takkinen, Johanna / Charlier, Caroline / Leclercq, Alexandre / Adams, Paul E / Godbole, Gauri / Altmeyer, Ursula / Friesema, Ingrid H M / Labbé Sandelin, Lisa / Jenkin, Lorna / Fontana, Luigi / Aldigeri, Raffaella / Venter, Francois / Luchters, Stanley M F / Lecuit, Marc / Cimino, Luca

    Ocular immunology and inflammation

    2017  Volume 26, Issue 4, Page(s) 508–517

    Abstract: Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis.: Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline ( ... ...

    Abstract Purpose: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis.
    Methods: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded.
    Results: Most cases occurred in 2000-2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5-17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes.
    Conclusions: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition's rarity and variation in treatment makes it difficult to identify optimum therapy.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Endophthalmitis/diagnosis ; Endophthalmitis/microbiology ; Endophthalmitis/therapy ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/microbiology ; Eye Infections, Bacterial/therapy ; Humans ; Listeria monocytogenes/isolation & purification ; Listeriosis/diagnosis ; Listeriosis/microbiology ; Listeriosis/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2017-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2016.1276788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Development and validation of a novel laboratory model of sound-induced fear and anxiety in Beagle dogs

    Araujo, Joseph A. / de Rivera, Christina / Landsberg, Gary M. / Adams, Paul E. / Milgram, Norton W.

    Journal of veterinary behavior

    Volume v. 8,, Issue no. 4

    Abstract: Disorders of fear and anxiety are significant behavioral and physiological concerns in veterinary medicine. Thus, the present studies sought to develop and validate novel preclinical laboratory models for the development of anxiolytics for the veterinary ...

    Abstract Disorders of fear and anxiety are significant behavioral and physiological concerns in veterinary medicine. Thus, the present studies sought to develop and validate novel preclinical laboratory models for the development of anxiolytics for the veterinary market. Specifically, noise-induced sensitivity and aversion using thunderstorm recordings on an open-field task in Beagle dogs was used to establish this model. This thunderstorm task was based on the open-field tests previously described for the dog, except that a thunderstorm recording, compiled from desensitization compact discs, played during the middle of the test was used to elicit anxious or fearful responses in laboratory dogs. Initially, we compared the behavioral response on this test with that on an open-field test, in which no sound stimulus was provided. When compared with the open field, the thunderstorm recording increased inactivity duration and frequency, which was related to freezing behaviors and near-door duration. This suggests that we can objectively characterize a fear and anxious response to noise. We then attempted to pharmacologically validate this model by testing 0.5, 1, or 2 mg/kg doses of diazepam on this behavioral outcome. In test-naïve subjects, diazepam reduced the increase in inactivity seen at washout compared with that seen at baseline, suggesting that this paradigm may be useful for establishing the effect of drugs that reduce or prevent sensitization to fear-invoking events. In test-experienced subjects, diazepam reduced inactivity compared with both baseline and washout, indicating that this model may be useful for screening drugs counteracting fear and phobia, as well as anticipatory anxiety responses. Interestingly, diazepam stimulated behavioral activity as measured with the Actiwatch method. The test described here provides a laboratory method for testing therapeutics targeted at reducing either anxiety or fear related to noise sensitivity and aversion in pet dogs.
    Keywords therapeutics ; veterinary medicine ; dogs ; markets ; anxiety ; freezing ; laboratory techniques ; models ; diazepam ; screening ; fearfulness ; Beagle ; tranquilizers ; compact discs
    Language English
    Document type Article
    ISSN 1558-7878
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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