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Book: Wrist arthritis

Adams, Brian D.

(Hand clinics ; 21,4)

2005

Author's details	guest ed. Brian D. Adams
Series title	Hand clinics ; 21,4
Collection
Language	English
Size	XI S., S. 507 - 654 : zahlr. Ill.
Publisher	Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT014644791
ISBN	1-4160-2663-0 ; 978-1-4160-2663-1
Database	Catalogue ZB MED Medicine, Health

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Se 989 -21,4-	verfügbar in Königswinter	Königswinter

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Book: Operative techniques in hand, wrist, and elbow surgery

Hunt, Thomas R. / Adams, Brian D. / Wiesel, Sam W.

2016

Author's details	Thomas R. Hunt III, MD, DSc editor; Brian D. Adams, MD associate editor; Sam W. Wiesel, MD editor-in-chief
Keywords	Hand / surgery ; Upper Extremity / surgery ; Hand Injuries / surgery ; Arm Injuries / surgery
Language	English
Size	xxvii, 1386, 14, I-35 Seiten, Illustrationen
Edition	Second edition
Publisher	Wolters Kluwer
Publishing place	Philadelphia
Publishing country	United States
Document type	Book
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HBZ-ID	HT018903571
ISBN	978-1-4511-9305-3 ; 1-4511-9305-X
Database	Catalogue ZB MED Medicine, Health

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2016 A 579	available for loan (reading room)	Lesesaal EG
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Article ; Online: BRAF and RET polymorphism association with thyroid cancer risk, a preliminary study from Khyber Pakhtunkhwa population.

Batool, Maryam / Khan, Najeeb Ullah / Khan, Hamza / Almutairi, Mikhlid H / Ali, Ijaz / Adams, Brian D

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 502

Abstract: Background: Thyroid cancer, originating in the neck's thyroid gland, encompasses various types. Genetic mutations, particularly in BRAF and RET genes are crucial in its development. This study investigates the association between BRAF (rs113488022) and ... ...

Abstract	Background: Thyroid cancer, originating in the neck's thyroid gland, encompasses various types. Genetic mutations, particularly in BRAF and RET genes are crucial in its development. This study investigates the association between BRAF (rs113488022) and RET (rs77709286) polymorphisms and thyroid cancer risk in the Khyber Pakhtunkhwa (KP) population. Methods: Blood samples from 100 thyroid cancer patients and 100 healthy controls were genotyped using ARMS-PCR followed by gel electrophoresis and statistical analysis. Results: Analysis revealed a significant association between the minor allele T of BRAF (rs113488022) and thyroid cancer risk (P = 0.0001). Both genotypes of BRAF (rs113488022) showed significant associations with thyroid cancer risk (AT; P = 0.0012 and TT; P = 0.045). Conversely, the minor allele G of RET (rs77709286) exhibited a non-significant association with thyroid cancer risk (P = 0.2614), and neither genotype showed significant associations (CG; P = 0.317, GG; P = 0.651). Demographic and clinical parameters analysis using SPSS showed a non-significant association between BRAF and RET variants and age group (P = 0.878 and P = 0.536), gender (P = 0.587 and P = 0.21), tumor size (P = 0.796 and P = 0.765), or tumor localization (P = 0.689 and P = 0.727). Conclusion: In conclusion, this study emphasizes the significant association between BRAF polymorphism and thyroid cancer risk, while RET polymorphism showed a less pronounced impact. Further validation using larger and specific datasets is essential to establish conclusive results.
MeSH term(s)	Humans ; Proto-Oncogene Proteins B-raf/genetics ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/genetics ; Alleles ; Proto-Oncogene Proteins c-ret/genetics ; Sulfones ; Uridine/analogs & derivatives
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; P 536 (93426-60-9) ; RET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1) ; Sulfones ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-024-09480-y
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Article ; Online: The Effect of Locking Screws on Distal Component Fixation in Total Wrist Arthroplasty Using a Cadaver Model.

Quigley, Ryan J / Ambrose, Catherine / Adams, Brian D

Journal of hand surgery global online

2022 Volume 4, Issue 6, Page(s) 348–354

Abstract: Purpose: The advent of total wrist arthroplasty has allowed for motion-sparing surgical treatment for wrist arthritis. The Integra Freedom Total Wrist Arthroplasty recently incorporated locking caps into its distal component fixation to minimize implant ...

Abstract	Purpose: The advent of total wrist arthroplasty has allowed for motion-sparing surgical treatment for wrist arthritis. The Integra Freedom Total Wrist Arthroplasty recently incorporated locking caps into its distal component fixation to minimize implant micromotion and improve osseous integration. The purpose of this study was to assess the kinematic effect of locking caps in a cadaveric model. Methods: The Integra Freedom was implanted in 4 matched-pair cadavers and tested with and without the use of the locking caps, with the testing order randomized. Each specimen was tested on a custom testing system in a position of 15° of radial deviation, neutral position, and 15° of ulnar deviation with 25 N, 50 N, 75 N, and 100 N of compressive force. The rotation of the capitate, trapezoid, and hamate at all positions was measured using a 3-dimensional digitizer. Results: Statistical analysis showed no difference in carpal rotation between the nonlocking cap and locking cap groups at all testing loads and wrist positions. The absolute motion of the distal row was minimal. However, of the total 216 loads/positions tested, only 4 (1.8%) showed a rotation of greater than 2° and only 34 (15.7%) showed a rotation of greater than 1°. Conclusions: This study shows that in a time zero cadaveric model, the initial osseous fixation of the distal component in the Integra Freedom is robust with or without locking caps. The addition of locking caps did not have a kinematic effect on distal carpal row fixation. However, further investigation into its clinical role is necessary. Clinical relevance: At time zero, there is minimal carpal motion after implantation of the Integra Freedom Total Wrist with functional loading. The addition of locking caps did not lead to any decrease in carpal motion.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ISSN	2589-5141
ISSN (online)	2589-5141
DOI	10.1016/j.jhsg.2022.08.002
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Article: Total Wrist Arthroplasty for Posttraumatic Arthritis with Radius Deformity.

Adams, Brian D

Journal of wrist surgery

2015 Volume 4, Issue 3, Page(s) 164–168

Abstract: Newer implant designs and expanding experience have led to a gradual increase in the use of total wrist arthroplasty (TWA) for the treatment of posttraumatic arthritis. New challenges, however, may be encountered with this application, including bony ... ...

Abstract	Newer implant designs and expanding experience have led to a gradual increase in the use of total wrist arthroplasty (TWA) for the treatment of posttraumatic arthritis. New challenges, however, may be encountered with this application, including bony deformities, previous or existing hardware, osteonecrosis, soft tissue injuries, and severe joint stiffness. Because the goals-to relieve pain and provide a functional range of motion-are the same as for more common TWA indications, these technical challenges, along with often higher patient expectations, are important considerations. This article presents possible solutions to these unique surgical challenges, including important preoperative planning to mitigate risks, and the expected outcomes in these patients.
Language	English
Publishing date	2015-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2678060-4
ISSN	2163-3924 ; 2163-3916
ISSN (online)	2163-3924
ISSN	2163-3916
DOI	10.1055/s-0035-1558842
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Article ; Online: Non-coding RNAs and neuroinflammation: implications for neurological disorders.

Chen, Yvonne / Mateski, Julia / Gerace, Linda / Wheeler, Jonathan / Burl, Jan / Prakash, Bhavna / Svedin, Cherie / Amrick, Rebecca / Adams, Brian D

Experimental biology and medicine (Maywood, N.J.)

2024 Volume 249, Page(s) 10120

Abstract: Neuroinflammation is considered a balanced inflammatory response important in the intrinsic repair process after injury or infection. Under chronic states of disease, injury, or infection, persistent neuroinflammation results in a heightened presence of ... ...

Abstract	Neuroinflammation is considered a balanced inflammatory response important in the intrinsic repair process after injury or infection. Under chronic states of disease, injury, or infection, persistent neuroinflammation results in a heightened presence of cytokines, chemokines, and reactive oxygen species that result in tissue damage. In the CNS, the surrounding microglia normally contain macrophages and other innate immune cells that perform active immune surveillance. The resulting cytokines produced by these macrophages affect the growth, development, and responsiveness of the microglia present in both white and gray matter regions of the CNS. Controlling the levels of these cytokines ultimately improves neurocognitive function and results in the repair of lesions associated with neurologic disease. MicroRNAs (miRNAs) are master regulators of the genome and subsequently control the activity of inflammatory responses crucial in sustaining a robust and acute immunological response towards an acute infection while dampening pathways that result in heightened levels of cytokines and chemokines associated with chronic neuroinflammation. Numerous reports have directly implicated miRNAs in controlling the abundance and activity of interleukins, TGF-B, NF-kB, and toll-like receptor-signaling intrinsically linked with the development of neurological disorders such as Parkinson's, ALS, epilepsy, Alzheimer's, and neuromuscular degeneration. This review is focused on discussing the role miRNAs play in regulating or initiating these chronic neurological states, many of which maintain the level and/or activity of neuron-specific secondary messengers. Dysregulated miRNAs present in the microglia, astrocytes, oligodendrocytes, and epididymal cells, contribute to an overall glial-specific inflammatory niche that impacts the activity of neuronal conductivity, signaling action potentials, neurotransmitter robustness, neuron-neuron specific communication, and neuron-muscular connections. Understanding which miRNAs regulate microglial activation is a crucial step forward in developing non-coding RNA-based therapeutics to treat and potentially correct the behavioral and cognitive deficits typically found in patients suffering from chronic neuroinflammation.
MeSH term(s)	Humans ; Neuroinflammatory Diseases ; Nervous System Diseases/genetics ; Microglia/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cytokines/metabolism ; Chemokines/metabolism
Chemical Substances	MicroRNAs ; Cytokines ; Chemokines
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.3389/ebm.2024.10120
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Article ; Online: Wrist arthroplasty: partial and total.

Adams, Brian D

Hand clinics

2013 Volume 29, Issue 1, Page(s) 79–89

Abstract: Although arthrodesis is the treatment preferred by most surgeons for severe wrist arthritis, some degree of functional impairment occurs from the resulting loss of motion, especially when multiple joints in the extremity are affected by arthritis. Total ... ...

Abstract	Although arthrodesis is the treatment preferred by most surgeons for severe wrist arthritis, some degree of functional impairment occurs from the resulting loss of motion, especially when multiple joints in the extremity are affected by arthritis. Total wrist arthroplasty may enhance the performance of daily activities and it is usually preferred by patients over arthrodesis. The newer generation of wrist prostheses has demonstrated improved performance and durability in properly selected patients. This article provides a review of the history, indications, techniques, and outcomes of wrist arthroplasty.
MeSH term(s)	Arthritis/physiopathology ; Arthritis/surgery ; Arthroplasty, Replacement/methods ; Hemiarthroplasty/methods ; Humans ; Joint Prosthesis ; Patient Selection ; Physical Therapy Modalities ; Postoperative Care ; Salvage Therapy ; Splints ; Treatment Failure ; Treatment Outcome ; Wrist Joint/physiopathology ; Wrist Joint/surgery
Language	English
Publishing date	2013-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1315374-2
ISSN	1558-1969 ; 0749-0712
ISSN (online)	1558-1969
ISSN	0749-0712
DOI	10.1016/j.hcl.2012.08.029
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Article ; Online: The regulatory role of miRNAs on VDR in breast cancer.

Singh, Tatyana / Adams, Brian D

Transcription

2017 Volume 8, Issue 4, Page(s) 232–241

Abstract: Triple negative breast cancer (TNBC) has been associated with the lack of three hormone receptors; estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2). However, a host of other steroid hormone ... ...

Abstract	Triple negative breast cancer (TNBC) has been associated with the lack of three hormone receptors; estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2). However, a host of other steroid hormone receptors such as vitamin D receptor (VDR) is present in TNBC, and the role of these hormone receptors in breast tumorigenesis is unclear. The levels of microRNAs (miRNAs) are also expressed differently than in normal mammary epithelial cells. miRNAs are regulatory RNAs involved in various cellular functions, mainly gene silencing. Here, we reviewed the literature surrounding miRNAs in breast cancer, and performed in silico analysis to determine whether there was a correlation between levels of VDR in relation to miRNAs important in breast cancer development and tumorigenesis. We identified three miRNAs of interest, specifically, miR-23, miR-124, and miR-125. Through this research we determined the possibility that these miRNAs play an important role in controlling VDR activity and by virtue the development of breast cancer.
MeSH term(s)	Female ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; MicroRNAs/genetics ; Receptors, Calcitriol/genetics ; Triple Negative Breast Neoplasms/genetics
Chemical Substances	MIRN124 microRNA, human ; MIRN125 microRNA, human ; MIRN23a microRNA, human ; MicroRNAs ; Receptors, Calcitriol ; VDR protein, human
Language	English
Publishing date	2017-06-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2646974-1
ISSN	2154-1272 ; 2154-1264
ISSN (online)	2154-1272
ISSN	2154-1264
DOI	10.1080/21541264.2017.1317695
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Article ; Online: Androgen receptor and miR-206 regulation in prostate cancer.

Chua, Fu Y / Adams, Brian D

Transcription

2017 Volume 8, Issue 5, Page(s) 313–327

Abstract: In the United States, prostate cancer is the second leading cause of cancer-related deaths among men with an approximately 220,000 patients diagnosed with the disease in 2015. Prostate cancer is a hormone-driven tumor, and a common therapy is androgen- ... ...

Abstract	In the United States, prostate cancer is the second leading cause of cancer-related deaths among men with an approximately 220,000 patients diagnosed with the disease in 2015. Prostate cancer is a hormone-driven tumor, and a common therapy is androgen-deprivation therapy (ADT) that involves anti-androgen treatments and/or castration therapy. Understanding the molecular basis for androgen-independent tumors is crucial toward developing new therapies for these patients. Understanding how androgen receptor itself functions is an important step in elucidating this process. Androgen receptor (AR), NR3C4, is a nuclear hormone receptor and functions as a DNA-binding transcription factor that regulates the expression of protein-coding genes. Translocation of AR to improper gene promoter elements or DNA-binding sites can result in an alteration in gene expression and thus normal prostate function. Therefore, it is crucial to understand which AR-promoter interactions are drivers of disease, as compared to promiscuous or benign AR-binding interactions. While a large portion of our genome is considered a gene desert, it is now appreciated that these regions of the genome contain non-coding RNA genes such as microRNAs (miRNAs). These non-coding RNAs have enormous regulatory potential, as they post-transcriptionally regulate gene expression by binding to messenger RNAs (mRNAs) to promote degradation or intervention of translational processes. In this review, we focus specifically on the notion that mis-regulation of non-coding RNAs such as miRNAs by improper AR-DNA binding are an important component that promotes prostate cancer. We also highlight the role of miR-206 and the interaction of miR-206 and AR within this process, given this is a miRNA known to be regulated by hormones in both breast and prostate cancer.
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	2646974-1
ISSN	2154-1272 ; 2154-1264
ISSN (online)	2154-1272
ISSN	2154-1264
DOI	10.1080/21541264.2017.1322668
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Article ; Online: Significant association of BRCA1 (rs1799950), BRCA2 (rs144848) and TP53 (rs1042522) polymorphism with breast cancer risk in Pashtun population of Khyber Pakhtunkhwa, Pakistan.

Khan, Yumna / Khan, Najeeb Ullah / Ali, Ijaz / Khan, Samiullah / Khan, Aakif Ullah / Iqbal, Aqib / Adams, Brian D

Molecular biology reports

2023 Volume 50, Issue 7, Page(s) 6087–6096

Abstract: Background: Single nucleotide polymorphism (SNPs) in BRCA1, BRCA2 and TP53 has been widely associated with breast cancer risk in different ethnicities with inconsistent results. There is no such study conducted so far in the Pashtun population of Khyber ...

Abstract	Background: Single nucleotide polymorphism (SNPs) in BRCA1, BRCA2 and TP53 has been widely associated with breast cancer risk in different ethnicities with inconsistent results. There is no such study conducted so far in the Pashtun population of Khyber Pakhtunkhwa, Pakistan. Therefore, this study was conducted to check BRCA1 (rs1799950), BRCA2 (rs144848) and TP53 (rs1042522) polymorphism with breast cancer risk in Pashtun population of Khyber Pakhtunkhwa, Pakistan. Methods: This study, consisting 140 breast cancer patients and 80 gender and age matched healthy controls were subjected to confirm BRCA1, BRCA2 and TP53 polymorphism. Clinicopathological data and blood samples were taken from all the participants. DNA was extracted and SNPs were confirmed using T-ARMS-PCR protocol. Results: Our data indicated that BRCA1, BRCA2, and TP53 selected SNPs risk allele and risk allele containing genotypes displayed significant association (p < 0.05) with breast cancer risk in the Pashtun population of Khyber Pakhtunkhwa, Pakistan. Conclusion: All the three selected SNPs of BRCA1, BRCA2 and TP53 showed significant association with breast cancer risk in the Pashtun population of Khyber Pakhtunkhwa, Pakistan. However, more investigation will be required on large data sets to confirm the selected SNPs and other SNPs in the selected and other related genes with the risk of breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Genetic Predisposition to Disease ; Pakistan ; Genotype ; Polymorphism, Single Nucleotide/genetics ; Tumor Suppressor Protein p53/genetics ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics
Chemical Substances	TP53 protein, human ; Tumor Suppressor Protein p53 ; BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein
Language	English
Publishing date	2023-06-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08463-9
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