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  1. Article ; Online: [No title information]

    Adamzik, Michael

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2024  Volume 59, Issue 2, Page(s) 76–77

    Title translation „Die Immunzelle ist, was sie isst!“.
    Language German
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-4648
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  2. Article: „Die Immunzelle ist, was sie isst!“

    Adamzik, Michael

    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

    2024  Volume 59, Issue 02, Page(s) 76–77

    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-4648
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  3. Article: The Impact of Pathogens on Sepsis Prevalence and Outcome.

    Dyck, Birte / Unterberg, Matthias / Adamzik, Michael / Koos, Björn

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: Sepsis, a severe global healthcare challenge, is characterized by significant morbidity and mortality. The 2016 redefinition by the Third International Consensus Definitions Task Force emphasizes its complexity as a "life-threatening organ dysfunction ... ...

    Abstract Sepsis, a severe global healthcare challenge, is characterized by significant morbidity and mortality. The 2016 redefinition by the Third International Consensus Definitions Task Force emphasizes its complexity as a "life-threatening organ dysfunction caused by a dysregulated host response to infection". Bacterial pathogens, historically dominant, exhibit geographic variations, influencing healthcare strategies. The intricate dynamics of bacterial immunity involve recognizing pathogen-associated molecular patterns, triggering innate immune responses and inflammatory cascades. Dysregulation leads to immunothrombosis, disseminated intravascular coagulation, and mitochondrial dysfunction, contributing to the septic state. Viral sepsis, historically less prevalent, saw a paradigm shift during the COVID-19 pandemic, underscoring the need to understand the immunological response. Retinoic acid-inducible gene I-like receptors and Toll-like receptors play pivotal roles, and the cytokine storm in COVID-19 differs from bacterial sepsis. Latent viruses like human cytomegalovirus impact sepsis by reactivating during the immunosuppressive phases. Challenges in sepsis management include rapid pathogen identification, antibiotic resistance monitoring, and balancing therapy beyond antibiotics. This review highlights the evolving sepsis landscape, emphasizing the need for pathogen-specific therapeutic developments in a dynamic and heterogeneous clinical setting.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13010089
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  4. Article ; Online: Immunmetabolismus in der Sepsis.

    Koos, Björn / Unterberg, Matthias / Rahmel, Tim / Adamzik, Michael

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2024  Volume 59, Issue 2, Page(s) 78–94

    Abstract: Immunometabolism is a fascinating field of research that investigates the interactions between metabolic processes and the immune response. This intricate connection plays a pivotal role in regulating inflammatory reactions and consequently exerts a ... ...

    Title translation Immunometabolism in Sepsis.
    Abstract Immunometabolism is a fascinating field of research that investigates the interactions between metabolic processes and the immune response. This intricate connection plays a pivotal role in regulating inflammatory reactions and consequently exerts a significant impact on the course of sepsis. The proinflammatory response during an immune reaction is closely tied to a high energy demand in immune cells. As a result, proinflammatory immune cells rapidly require substantial amounts of energy in the form of ATP, necessitating a fundamental and swift shift in their metabolism, i.e., their means of generating energy. This entails a marked increase in glycolysis within the proinflammatory response, thereby promptly meeting the energy requirements and providing essential metabolic building blocks for the biosynthesis of macromolecules. Alongside glycolysis, there is heightened activity in the pentose phosphate pathway (PPP). The PPP significantly contributes to NADPH production within the cell, thus maintaining redox equilibrium. Elevated PPP activity consequently leads to an increased NADPH level, resulting in enhanced production of reactive oxygen species (ROS) and nitric oxide (NO). While these molecules are crucial for pathogen elimination, an excess can also induce tissue damage. Simultaneously, there are dual interruptions in the citric acid cycle. In the cellular resting state, the citric acid cycle acts as a sort of "universal processor", where metabolic byproducts of glycolysis, fatty acid breakdown, and amino acid degradation are initially transformed into NADH and FADH2, subsequently yielding ATP. While the citric acid cycle and its connected oxidative phosphorylation predominantly generate energy at rest, it becomes downregulated in the proinflammatory phase of sepsis. The two interruptions lead to an accumulation of citrate and succinate within cells, reflecting mitochondrial dysfunction. Additionally, the significantly heightened glycolysis through fermentation yields lactate, a pivotal metabolite for sepsis diagnosis and prognosis. Conversely, cells in an anti-inflammatory state revert to a metabolic profile akin to the resting state: Glycolysis is attenuated, PPP is suppressed, and the citric acid cycle is reactivated. Of particular interest is that not only does the immune reaction influence metabolic pathways, but this connection also operates in reverse. Thus, modulation of metabolic pathways also modulates the immunity of the corresponding cell and thereby the state of the immune system itself. This could potentially serve as an intriguing avenue in sepsis therapy.
    MeSH term(s) Humans ; NADP ; Glycolysis/physiology ; Citric Acid Cycle/physiology ; Adenosine Triphosphate ; Sepsis
    Chemical Substances NADP (53-59-8) ; Adenosine Triphosphate (8L70Q75FXE)
    Language German
    Publishing date 2024-02-14
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-3170
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  5. Book ; Thesis: Vergleich der Elektronenstrahlcomputertomographie mit dem intervaskulären Ultraschall und der Koronarangiographie zur Erkennung von koronaratherosklerotischen Veränderungen auf Segmentebene

    Adamzik, Michael

    2000  

    Author's details vorgelegt von Michael Adamzik
    Language German
    Size 106 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Univ., Diss., 2002
    HBZ-ID HT013350618
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 3358 order for loan Magazin

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  6. Article ; Online: Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation.

    Rump, Katharina / Adamzik, Michael

    Cells

    2022  Volume 11, Issue 19

    Abstract: Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can be divided into postoperative delirium and postoperative cognitive dysfunction. Both phenomena are accompanied by neuroinflammation; however, the precise ... ...

    Abstract Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can be divided into postoperative delirium and postoperative cognitive dysfunction. Both phenomena are accompanied by neuroinflammation; however, the precise molecular mechanisms underlying cognitive impairment after anesthesia are not yet fully understood. Anesthesiological drugs can have a longer-term influence on protein transcription, thus, epigenetics is a possible mechanism that impacts on cognitive function. Epigenetic mechanisms may be responsible for long-lasting effects and may implicate novel therapeutic approaches. Hence, we here summarize the existing literature connecting postoperative cognitive impairment to anesthesia. It becomes clear that anesthetics alter the expression of DNA and histone modifying enzymes, which, in turn, affect epigenetic markers, such as methylation, histone acetylation and histone methylation on inflammatory genes (e.g., TNF-alpha, IL-6 or IL1 beta) and genes which are responsible for neuronal development (such as brain-derived neurotrophic factor). Neuroinflammation is generally increased after anesthesia and neuronal growth decreased. All these changes can induce cognitive impairment. The inhibition of histone deacetylase especially alleviates cognitive impairment after surgery and might be a novel therapeutic option for treatment. However, further research with human subjects is necessary because most findings are from animal models.
    MeSH term(s) Aged ; Anesthesia/adverse effects ; Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/metabolism ; Delirium/complications ; Delirium/metabolism ; Epigenesis, Genetic ; Hippocampus/metabolism ; Histone Deacetylases/metabolism ; Histones/metabolism ; Humans ; Interleukin-6/metabolism ; Neuroinflammatory Diseases ; Postoperative Cognitive Complications/genetics ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Brain-Derived Neurotrophic Factor ; Histones ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11192954
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  7. Article ; Online: Efficacy, safety, and side effects of oliceridine in acute postoperative pain, a protocol for a systematic review and meta-analysis.

    Wolf, Anne / Unterberg, Matthias / Witowski, Andrea / Adamzik, Michael / Wolf, Alexander

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0299320

    Abstract: This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine ...

    Abstract This will be the first meta-analysis on the efficacy, safety, and side effects of oliceridine on postoperative pain. Our aim with this work is to evaluate the clinical utility of this relatively new substance in a broad postoperative context. Oliceridine is a new so-called bias opioid that is approved for severe pain requiring an opioid. Due to its biased agonism, it is said to have fewer side effects than conventional opioids. This systematic review and meta-analysis will analyze the efficacy, safety, and side effects of oliceridine compared to placebo or morphine in acute postoperative pain for up to 72 hours. In January 2024, an extensive search in various databases will be performed without restrictions for randomized controlled trials with at least single blinding. After data extraction, data will be pooled and meta-analytic calculations performed. A random-effects model will be used. Dichotomous data will be presented as risk ratio and continuous data as standardized mean difference. Dose-dependent side effects will be evaluated with meta-regression. Heterogeneity will be assessed via the Q statistic and prediction interval in case of a sufficient number of included studies. Publication bias will be examined using funnel plot and Duval and Tweedie's trim and fill method.
    MeSH term(s) Humans ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Meta-Analysis as Topic ; Pain, Postoperative/drug therapy ; Spiro Compounds/adverse effects ; Spiro Compounds/therapeutic use ; Systematic Reviews as Topic ; Thiophenes/adverse effects ; Thiophenes/therapeutic use
    Chemical Substances ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine ; Analgesics, Opioid ; Spiro Compounds ; Thiophenes
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299320
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  8. Book ; Online ; Thesis: Charakterisierung epigenetischer Regulationsmechanismen von Schlüsselproteinen in der Sepsis

    Spellenberg, Theresa [Verfasser] / Adamzik, Michael [Gutachter] / Hahn, Stephan [Gutachter]

    Promotormethylierung des Aquaporin 5-Promotors

    2024  

    Author's details Theresa Spellenberg ; Gutachter: Michael Adamzik, Stephan Hahn ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Immunmetabolismus in der Sepsis

    Koos, Björn / Unterberg, Matthias / Rahmel, Tim / Adamzik, Michael

    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

    2024  Volume 59, Issue 02, Page(s) 78–94

    Keywords Immunmetabolismus ; Sepsis ; Stoffwechsel ; Zitratzyklus ; Pentosephosphatweg ; Glykolyse ; Proinflammation ; Antiinflammation ; immunometabolism ; sepsis ; metabolism ; citric acid cycle ; pentose phosphate pathway ; glycolysis ; pro-inflammation ; anti-inflammation
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-2070-3170
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  10. Article ; Online: [No title information]

    Palmowski, Lars / Adamzik, Michael / Rahmel, Tim

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS

    2022  Volume 57, Issue 5, Page(s) 360–370

    Abstract: The new Surviving Sepsis Campaign (SSC) guideline was substantially revised in 2021. These updated recommendations are intended to guide intensivists in providing adequate care to adult patients with sepsis or septic shock. In particular, the current SSC ...

    Title translation Die neue internationale Sepsis-Leitlinie der Surviving Sepsis Campaign 2021.
    Abstract The new Surviving Sepsis Campaign (SSC) guideline was substantially revised in 2021. These updated recommendations are intended to guide intensivists in providing adequate care to adult patients with sepsis or septic shock. In particular, the current SSC guideline emphasizes early recognition and stringent management in the first hours after the onset of sepsis. In particular, the implementation of acute interventions should help to improve the chances of survival of sepsis patients.This article summarizes the most important recommendations for acute therapy and presents them as a comparative overview to the previous SSC guideline and the German S3 guideline. This should allow the reader to adopt the knowledge from the new guideline into clinical practice as quickly as possible in order to improve the quality of treatment of patients with sepsis or septic shock.
    MeSH term(s) Adult ; Humans ; Sepsis/therapy ; Shock, Septic/therapy
    Language German
    Publishing date 2022-05-19
    Publishing country Germany
    Document type Journal Article ; Practice Guideline ; Review
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-1783-7212
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