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Article: Postdonation information during dengue outbreaks at a single blood center in Brazil: An ally against transfusion-transmitted infections.

Costa-Lima, Carolina / Benites, Bruno Deltreggia / Rocha, Daniele Ramos / Andrade, Elisabete / Alvarez, Patricia / Magnus, Mariana Munari / Addas-Carvalho, Marcelo

Asian journal of transfusion science

2021 Volume 15, Issue 1, Page(s) 82–86

Abstract: Background: Brazilian blood banks encourage donors to report postdonation information (PDI) regarding conditions that would lead to deferral in an attempt to retrieve distributed nonconforming blood.: Objectives: This study evaluated the profile of ... ...

Abstract	Background: Brazilian blood banks encourage donors to report postdonation information (PDI) regarding conditions that would lead to deferral in an attempt to retrieve distributed nonconforming blood. Objectives: This study evaluated the profile of donors reporting PDI, the impact on transfusion safety, and the possible impact on the discard of blood products. Subjects and methods: We analyzed 115 consecutive PDIs between May 2014 and July 2015, a period comprising two dengue-like syndrome (DLS) outbreaks. Results: These PDIs accounted for 87,780 blood donations. The average time for PDIs since donation was 4 (0-23) days and 190 blood components were discarded. DLS accounted for 21.7% of the PDIs analyzed; 11 of the 23 samples tested were nucleic acid test (NAT) positive for dengue and 2 positive for Conclusion: The high number of recovered blood components due to PDI suggests that PDI remains a great ally in the fight against transfusion-transmitted infections and may be particularly useful during outbreaks of emerging potentially blood-borne pathogens.
Language	English
Publishing date	2021-06-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2267310-6
ISSN	1998-3565 ; 0973-6247
ISSN (online)	1998-3565
ISSN	0973-6247
DOI	10.4103/ajts.AJTS_108_18
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Article: Evaluation of Molecular Methods to Identify Chagas Disease and Leishmaniasis in Blood Donation Candidates in Two Brazilian Centers.

Ferreira, Juliana de Jesus Guimarães / Costa, Sandra Cecília Botelho / Addas-Carvalho, Marcelo / Pereira, Mariane Barroso / França, Adriana de Oliveira / de Lima, Rodrigo Gonçalves / Andrade, Paula Durante / Wanderley, Jamiro da Silva / Martins, Luiz Cláudio / de Almeida, Eros Antonio / Marcon, Gláucia Elisete Barbosa

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: In Brazil, blood donation is regulated by the Brazilian Ministry of Health, and all States follow the same protocol for clinical and laboratory screening. Brazil is an endemic country for Chagas disease (CD), caused ... ...

Abstract	In Brazil, blood donation is regulated by the Brazilian Ministry of Health, and all States follow the same protocol for clinical and laboratory screening. Brazil is an endemic country for Chagas disease (CD), caused by
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12040508
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Article: Selection of plasma donors for the production of anti-SARS-CoV-2 immunoglobulin-based therapies: Strategies for quantitative antibody measurements.

Benites, Bruno Deltreggia / Costa-Lima, Carolina / Pinto, Fernanda Batista Rosa / da Costa, Vitor Antonio / Duarte, Adriana da Silva Santos / Zangirolami, Audrey Basso / Amaro, Emerson Clayton / Granja, Fabiana / Proenca-Modena, José Luiz / Saad, Sara Terezinha Olalla / Addas-Carvalho, Marcelo

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2022 Volume 61, Issue 6, Page(s) 103513

Abstract: Even after two years of the pandemic, a completely effective treatment against SARS-CoV-2 has not yet been established. Considering this fact and the emergence of successive new viral variants, the development of therapies based on natural polyclonal ... ...

Abstract	Even after two years of the pandemic, a completely effective treatment against SARS-CoV-2 has not yet been established. Considering this fact and the emergence of successive new viral variants, the development of therapies based on natural polyclonal antibodies recovered from convalescent plasma remains relevant. This study presents a comparison between different methods of screening antibodies in samples of 41 individuals previously diagnosed with COVID-19. We found a significant correlation between Abbot Architect anti-SARS-CoV-2 IgG and Abbott Allinity SARS-CoV-2 IgG II Quantitative assay intensity of reactivity and neutralizing antibody (nAb) titers. Thus, we propose an initial antibody screening with IgG anti-N Abbott Architect test, with an index of, for example, > 3.25 or SARS-CoV-2 IgG II Quantitative Abbott Allinity assay > 137.65 AU/mL as good predictors of Nab ≥ 1:80. For the quantitative method, this threshold demonstrated a 100 % sensitivity and 80 % specificity, with 97.3 % accuracy. An interesting observation was the increase in the neutralizing activity of the anti-SARS-CoV-2 antibodies with the longest interval between the end of the symptoms and the collection, demonstrating that the delay in plasma collection does not affect the achievement of adequate nAbs levels. These results demonstrate the possibility of using faster and more widely available commercial serological tests with a good correlation with viral neutralization tests in culture, allowing for optimized large-scale donor selection, which will be of utmost importance for the development of therapies such as hyperimmune immunoglobulin.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/therapy ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2022.103513
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Article ; Online: Zika Virus and the Safety of Blood Supply in Brazil: A Retrospective Epidemiological Evaluation.

Benites, Bruno Deltreggia / Rocha, Daniele / Andrade, Elisabete / Godoy, Daniela T / Alvarez, Patrícia / Addas-Carvalho, Marcelo

The American journal of tropical medicine and hygiene

2018 Volume 100, Issue 1, Page(s) 174–177

Abstract: The potential for transfusion transmission of dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) has raised concerns about the safety of the blood supply in endemic areas. In this study, nucleic acid testing (NAT) for ZIKV, DENV, and ... ...

Abstract	The potential for transfusion transmission of dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) has raised concerns about the safety of the blood supply in endemic areas. In this study, nucleic acid testing (NAT) for ZIKV, DENV, and CHIKV RNA was performed in asymptomatic blood donor samples in the city of Campinas, located in the southeast region of Brazil (1962 in 2015 and 1775 in 2016). The prevalence of reactive NAT was 0.15% in 2015 and 0.62% in 2016 for dengue, 0.05% in 2015 and 0.17% in 2016 for Zika, and 0% in both years for chikungunya. These results demonstrate the weakness of the clinical interview in screening these blood donors. Furthermore, positivity for ZIKV was detected in March 2015, 1 year before the first reported cases in the region. These data attest the feasibility of using donor samples held in library as a tool for retrospective epidemiological evaluation, which is particularly interesting considering emerging pathogens, for which data on their spread and penetrance are initially scarce.
MeSH term(s)	Antibodies, Viral/blood ; Blood Donors ; Blood Safety ; Brazil/epidemiology ; Chikungunya Fever/blood ; Chikungunya Fever/epidemiology ; Chikungunya virus/isolation & purification ; Coinfection/blood ; Coinfection/epidemiology ; Coinfection/virology ; Dengue/blood ; Dengue/epidemiology ; Dengue Virus/isolation & purification ; Disease Outbreaks/prevention & control ; Female ; Genotype ; Humans ; Male ; Mass Screening ; Molecular Diagnostic Techniques/statistics & numerical data ; RNA, Viral/genetics ; Retrospective Studies ; Surveys and Questionnaires ; Zika Virus/isolation & purification ; Zika Virus Infection/blood ; Zika Virus Infection/epidemiology ; Zika Virus Infection/transmission
Chemical Substances	Antibodies, Viral ; RNA, Viral
Language	English
Publishing date	2018-11-06
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.17-0843
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Article: Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma.

Ribeiro, Luciana C / Benites, Bruno Deltreggia / Ulaf, Raisa G / Nunes, Thyago A / Costa-Lima, Carolina / Addas-Carvalho, Marcelo / Proenca-Modena, José Luiz / Granja, Fabiana / da Costa, Vitor Antonio / Duarte, Adriana da Silva Santos / Zangirolami, Audrey Basso / Amaro, Emerson Clayton / Mansour, Eli / Zollner, Ricardo L / Velloso, Licio A

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2021 Volume 17, Issue 1, Page(s) 14

Abstract: Background: Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious diseases and recent reports have ... ...

Abstract	Background: Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious diseases and recent reports have provided data supporting the increased susceptibility of these patients to severe SARS-CoV-2 infections. In this context, the infusion of COVID-19 convalescent plasma could represent an effective therapeutic strategy. Case presentation: 25-year old woman diagnosed with common variable immunodeficiency in 2013, developed severe COVID-19 that rapidly progressed to pneumonia presenting with multiple bilateral lung opacities that were both central and peripheral and presented as ground-glass and consolidation types involving all lobes, bilaterally. As blood oxygen saturation decayed and lung abnormalities were not responsive to large spectrum antibiotics and corticosteroids, patient was placed on mechanical ventilation and compassionate-use of approved COVID-19 convalescent donor plasma was introduced. The patient presented a rapid response to the approach and mechanical ventilation could be interrupted 24 h after first dose of COVID-19 convalescent donor plasma. As a whole, the patient received four doses of 200 mL convalescent plasma during a period of 6 days. There was rapid improvement of clinical status, with interruption of supplemental oxygen therapy after 6 days and reduction of lung abnormalities as evidence by sequential computed tomography scans. Conclusions: This is a single patient report that adds to other few reports on common variable immunodeficiency and agammaglobulinemia, suggesting that COVID-19 convalescent donor plasma could be a valuable therapeutic approach to treat patients affected by dysgammaglobulinemias and presenting severe COVID-19.
Language	English
Publishing date	2021-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-021-00518-5
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Article ; Online: Low SARS-CoV-2 seroprevalence in a cohort of Brazilian sickle cell disease patients: Possible effects of emphasis on social isolation for a population initially considered to be at very high risk.

Trafane, Luiza Francisco / da Costa, Vitor Antonio / da Silva Santos Duarte, Adriana / Zangirolami, Audrey Basso / Proenca-Modena, José Luiz / de Melo Campos, Paula / de Souza Medina, Samuel / Saad, Sara Terezinha Olalla / Addas-Carvalho, Marcelo / Benites, Bruno Deltreggia

EJHaem

2021 Volume 2, Issue 3, Page(s) 478–482

Abstract: Despite being initially considered at higher risk for severe COVID-19, sickle cell disease (SCD) patients have mostly presented clinical severity similar to the general population. As their vulnerability to become infected remains uncertain, we assessed ... ...

Abstract	Despite being initially considered at higher risk for severe COVID-19, sickle cell disease (SCD) patients have mostly presented clinical severity similar to the general population. As their vulnerability to become infected remains uncertain, we assessed the seroreactivity for SARS-CoV-2 to estimate the prevalence of infection and possible phenotypic and socioeconomic determinants for their contagion. Serologic evaluation was performed on 135 patients with an overall prevalence of 11%; positivity was associated with older age and use of public transportation. We speculate that social distancing instructions recommended by our clinic may have contributed to lower levels of infection, but potential protection factors need further investigation.
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.254
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Article ; Online: Clearance of Persistent SARS-CoV-2 RNA Detection in a NFκB-Deficient Patient in Association with the Ingestion of Human Breast Milk: A Case Report.

Viruses

2022 Volume 14, Issue 5

Abstract: Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific ... ...

Abstract	Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients.
MeSH term(s)	Antibodies, Viral ; COVID-19/complications ; Eating ; Female ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Milk, Human ; NF-kappa B ; RNA, Viral ; SARS-CoV-2/genetics ; Post-Acute COVID-19 Syndrome
Chemical Substances	Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; NF-kappa B ; RNA, Viral
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14051042
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Article ; Online: Cytokine polymorphisms in sickle cell disease and the relationship with cytokine expression.

Olenscki Gilli, Simone Cristina / Pericole, Fernando Vieira / Benites, Bruno Deltreggia / Sippert, Emilia Ângela / Castilho, Lilian Maria / Addas-Carvalho, Marcelo / Olalla Saad, Sara Teresinha

Experimental hematology

2016 Volume 44, Issue 7, Page(s) 583–589

Abstract: Sickle cell disease is a chronic inflammatory condition characterized by elevated levels of inflammatory cytokines, which may be regulated by genetic polymorphisms and could be associated with diverse disease presentations and alloimmunization. The aim ... ...

Abstract	Sickle cell disease is a chronic inflammatory condition characterized by elevated levels of inflammatory cytokines, which may be regulated by genetic polymorphisms and could be associated with diverse disease presentations and alloimmunization. The aim of this study was to evaluate Treg and Th17 cell frequencies, cytokine gene polymorphisms, and their association with cytokine expression profile in patients with sickle cell disease. For that purpose, we evaluated the IL intron 3 variable number tandem repeat (VNTR, genotypes 1.1, 1.2, 2.2, and 2.3), IL4-T590C>T, IL6-174G>C, TNFα-308G>A, IL10-819T>C, IL10-592A>C, and IL10-1082A>G polymorphisms and their correlation with TGFβ, IL4, IL6, and IL10 gene expression in sickle cell patients. We observed a significant decrease in Treg frequency together with a substantial increase in Th17 response in patients with sickle cell disease compared with healthy controls (p < 0.001 and p = 0.014, respectively). There was also a higher prevalence of the IL4-590T/T genotype in patients with sickle cell disease than in Afro-Brazilian descendent controls (p < 0.001) and higher expression of IL4 in patients with the 1.1 genotype of IL4 intron 3 VNTR (p = 0.06). Significantly greater gene expression of TGFβ, IL6, and IL10 was observed in sickle cell patients when compared with controls (p = 0.01, 0.03, and <0.001, respectively). Moreover, higher levels of interleukin-6 and -10 were observed in the group of alloimmunized patients. These new data bring insights into the deregulation in the immune system affecting sickle cell patients and must be further investigated in larger cohorts to better characterize individual variations in immune responses and new markers for disease morbidity.
MeSH term(s)	Adult ; Alleles ; Anemia, Sickle Cell/genetics ; Anemia, Sickle Cell/immunology ; Anemia, Sickle Cell/metabolism ; Biomarkers ; Cohort Studies ; Cytokines/genetics ; Female ; Gene Expression Regulation ; Gene Frequency ; Genotype ; Humans ; Immunization ; Lymphocyte Count ; Male ; Polymorphism, Single Nucleotide ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Young Adult
Chemical Substances	Biomarkers ; Cytokines
Language	English
Publishing date	2016-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2016.03.008
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Zs.A 922: Show issues

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Article ; Online: Risk of Zika virus transmission by blood donations in Brazil.

Magnus, Mariana Munari / Espósito, Danillo Lucas Alves / Costa, Victor Antonio da / Melo, Priscila Silva de / Costa-Lima, Carolina / Fonseca, Benedito Antonio Lopes da / Addas-Carvalho, Marcelo

Hematology, transfusion and cell therapy

2018 Volume 40, Issue 3, Page(s) 250–254

Abstract: Background: Zika, a disease caused by Zika virus infections, has recently emerged and caused outbreaks in many parts of the world. The clinical manifestations of Zika are usually mild, mostly presenting as an exanthematic febrile disease, but on some ... ...

Abstract	Background: Zika, a disease caused by Zika virus infections, has recently emerged and caused outbreaks in many parts of the world. The clinical manifestations of Zika are usually mild, mostly presenting as an exanthematic febrile disease, but on some occasions, it might be associated with microcephaly after intrauterine infection, and Guillain-Barré Syndrome. Zika virus is primarily transmitted by mosquito bites, but other means of transmission have been described, and potential risk for blood transmission has been reported in French Polynesia and Brazil. Methods: To investigate the risk of Zika virus infection after a blood transfusion in an area of Brazil where a possible transmission by a platelet concentrate has been described. Using a mini-pool format, 1857 blood donations were evaluated by real-time reverse transcriptase polymerase chain reaction designed to detect Zika virus RNA. Results: After testing samples individually from positive mini-pools, the prevalence of Zika virus RNA was only 0.16%, a result probably associated to the low circulation of this virus in the study area. In addition, it was evident that the implementation of post-surveillance programs is important to detect Zika virus infections in blood donors, as the post-donation surveillance program detected two blood donors with the disease in this study. Conclusion: This study shows that the risk for Zika virus transmission by blood transfusion is real, even in regions with a low circulation of the disease, but the combination of the detection of Zika virus RNA by polymerase chain reaction and post-donation surveillance might reduce the risk of transmission by blood transfusions.
Language	English
Publishing date	2018-04-23
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2018.01.011
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Article ; Online: An international review of the characteristics of viral nucleic acid-amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT.

Faddy, Helen M / Osiowy, Carla / Custer, Brian / Busch, Michael / Stramer, Susan L / Dean, Melinda M / Acutt, Jessika / Viennet, Elvina / van de Laar, Thijs / Tsoi, Wai-Chiu / Styles, Claire / Kiely, Phil / Margaritis, Angelo / Kwon, So-Yong / Qiu, Yan / Deng, Xuelian / Lewin, Antoine / Jørgensen, Signe Winther / Erikstrup, Christian /

Juhl, David / Sauleda, Silvia / Camacho Rodriguez, Bernardo Armando / Soto Coral, Lisbeth Jennifer Catherine / Gaviria García, Paula Andrea / Oota, Sineenart / O'Brien, Sheila F / Wendel, Silvano / Castro, Emma / Navarro Pérez, Laura / Harvala, Heli / Davison, Katy / Reynolds, Claire / Jarvis, Lisa / Grabarczyk, Piotr / Kopacz, Aneta / Łętowska, Magdalena / O'Flaherty, Niamh / Young, Fiona / Williams, Padraig / Burke, Lisa / Chua, Sze Sze / Muylaert, An / Page, Isabel / Jones, Ann / Niederhauser, Christoph / Vermeulen, Marion / Laperche, Syria / Gallian, Pierre / Satake, Masahiro / Addas-Carvalho, Marcelo / Blanco, Sebastián / Gallego, Sandra V / Seltsam, Axel / Weber-Schehl, Marijke / Al-Riyami, Arwa Z / Al Maamari, Khuloud / Alawi, Fatma Ba / Pandey, Hem Chandra / França, Rochele Azevedo / Charlewood, Richard

Vox sanguinis

2024

Abstract: Background and objectives: Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators.: ... ...

Abstract	Background and objectives: Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators. Materials and methods: NAT characteristics and NAT-yield confirmatory testing used during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases. Reported characteristics are presented herein. Results: NAT was mainly performed under government mandate. Human immunodeficiency virus (HIV), hepatitis C virus (HCV) and hepatitis B virus (HBV) NAT was performed on all donors and donation types, while selective testing was reported for West Nile virus, hepatitis E virus (HEV), and Zika virus. Individual donation NAT was used for HIV, HCV and HBV by ~50% of responders, while HEV was screened in mini-pools by 83% of responders performing HEV NAT. Confirmatory testing for NAT-yield samples was generally performed by NAT on a sample from the same donation or by NAT and serology on samples from the same donation and a follow-up sample. Conclusion: In the last decade, there has been a trend towards use of smaller pool sizes or individual donation NAT. We captured characteristics of NAT internationally in 2019 and provide insights into confirmatory testing approaches used for NAT-yields, potentially benefitting blood operators seeking to implement NAT.
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13617
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