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  1. Article: Geo-Demographic and Socioeconomic Determinants of Diagnosed Hypertension among Urban Dwellers in Ibadan, Nigeria: A Community-based Study.

    Owolabi, Mayowa / Taiwo, Olalekan / Akinyemi, Joshua / Adebayo, Ayodeji / Popoola, Oluwafemi / Akinyemi, Rufus / Akpa, Onoja / Olowoyo, Paul / Okekunle, Akinkunmi / Uvere, Ezinne / Nwimo, Chukwuemeka / Ajala, Omotolani / Adebajo, Olayinka / Ayodele, Adewale / Ayodeji, Salami / Arulogun, Oyedunni / Olaniyan, Olanrewaju / Walker, Richard / Jenkins, Carolyn /
    Ovbiagele, Bruce

    Research square

    2023  

    Abstract: Background: The relationship between diagnosed high blood pressure (HBP) and proximity to health facilities and noise sources is poorly understood. We investigated the relationship between proximity to noise sources, sociodemographic and economic ... ...

    Abstract Background: The relationship between diagnosed high blood pressure (HBP) and proximity to health facilities and noise sources is poorly understood. We investigated the relationship between proximity to noise sources, sociodemographic and economic factors, and diagnosed HBP in Ibadan, Nigeria.
    Methods: We investigated 13,531 adults from the African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) study in Ibadan. Using a Geographic Information System (GIS), the locations of healthcare facilities, pharmaceutical shops, bus stops, churches, and mosques were buffered at 100m intervals, and coordinates of persons diagnosed with HBP were overlaid on the buffered features. The number of persons with diagnosed HBP living at every 100m interval was estimated. Gender, occupation, marital status, educational status, type of housing, age, and income were used as predictor variables. Analysis was conducted using Spearman rank correlation and binary logistic regression at p<0.05.
    Results: There was a significant inverse relationship between the number of persons diagnosed with HBP and distance from pharmaceutical shops (r=-0.818), churches (r=-0.818), mosques (r=-0.893) and major roads (r=-0.667). The odds of diagnosed HBP were higher among the unemployed (AOR=1.58, 95% CI: 1.11-2.24), currently married (AOR=1.45, CI: 1.11-1.89), and previously married (1.75, CI: 1.29-2.38). The odds of diagnosed HBP increased with educational level and age group.
    Conclusion: Proximity to noise sources, being unemployed and educational level were associated with diagnosed HBP. Reduction in noise generation, transmission, and exposure could reduce the burden of hypertension in urban settings.
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3692586/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ACHIEVE conference proceedings: implementing action plans to reduce and control hypertension burden in Africa.

    Olowoyo, Paul / Dzudie, Anastase / Okekunle, Akinkunmi Paul / Obiako, Reginald / Mocumbi, Ana / Beheiry, Hind / Parati, Gianfranco / Lackland, Daniel T / Sarfo, Fred S / Odili, Augustine / Adeoye, Abiodun M / Wahab, Kolawole / Agyemang, Charles / Campbell, Norman / Kengne, Andre Pascal / Whelton, Paul K / Pellicori, Pierpaolo / Ebenezer, Ad Adams / Adebayo, Oladimeji /
    Olalusi, Oladotun / Jegede, Ayodele / Uvere, Ezinne / Adebajo, Olayinka / Awuah, Baffour / Moran, Andrew / Williams, Bryan / Guzik, Tomasz J / Kokuro, Collins / Bukachi, Fred / Ogah, Okechukwu S / Delles, Christian / Maffia, Pasquale / Akinyemi, Rufus / Barango, Prebo / Ojji, Dike / Owolabi, Mayowa

    Journal of human hypertension

    2024  Volume 38, Issue 3, Page(s) 193–199

    Abstract: The prevalence of hypertension, the commonest risk factor for preventable disability and premature deaths, is rapidly increasing in Africa. The African Control of Hypertension through Innovative Epidemiology, and a Vibrant Ecosystem [ACHIEVE] conference ... ...

    Abstract The prevalence of hypertension, the commonest risk factor for preventable disability and premature deaths, is rapidly increasing in Africa. The African Control of Hypertension through Innovative Epidemiology, and a Vibrant Ecosystem [ACHIEVE] conference was convened to discuss and initiate the co-implementation of the strategic solutions to tame this burden toward achieving a target of 80% for awareness, treatment, and control by the year 2030. Experts, including the academia, policymakers, patients, the WHO, and representatives of various hypertension and cardiology societies generated a 12-item communique for implementation by the stakeholders of the ACHIEVE ecosystem at the continental, national, sub-national, and local (primary) healthcare levels.
    MeSH term(s) Humans ; Africa/epidemiology ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/prevention & control ; Prevalence
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-024-00903-8
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  3. Article ; Online: Dietary patterns associated with hypertension among stroke-free indigenous Africans: insights from the Stroke Investigative Research and Educational Network study.

    Okekunle, Akinkunmi Paul / Asowata, Osahon Jeffery / Akpa, Onoja Matthew / Fakunle, Adekunle Gregory / Bodunde, Ifeoluwa / Komolafe, Morenikeji / Arulogun, Oyedunni / Sarfo, Fred Stephen / Obiako, Reginald / Osaigbovo, Godwin / Ogbole, Godwin / Bello, Abiodun / Adeniyi, Sunday / Calys-Tagoe, Benedict / Appiah, Lambert / Jenkins, Carolyn / Oyinloye, Olalekan / Dambatta, Hamisu / Balogun, Olayemi /
    Singh, Arti / Olalere, Abimbola / Mensah, Yaw / Ogah, Okechukwu S / Ibinaiye, Philip / Adebayo, Oladimeji / Adebajo, Olayinka / Adebayo, Philip / Chukwuonye, Ijezie / Akinyemi, Rufus / Ovbiagele, Bruce / Owolabi, Mayowa

    Journal of hypertension

    2024  Volume 42, Issue 4, Page(s) 620–628

    Abstract: Background: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans.: Method: In this ... ...

    Abstract Background: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans.
    Method: In this study, 1550 participants with hypertension matched (for age: ± 5 years, sex and ethnicity) with 1550 participants without hypertension were identified from the stroke-free population in the Stroke Investigative Research and Educational Network study in Ghana and Nigeria. Food consumption was assessed using a food frequency questionnaire, and dietary information was summarized using principal component analysis to identify seven dietary patterns. Conditional logistic regression was applied to compute the odds ratio (OR) and 95% confidence interval (CI) for the risk of hypertension by tertiles of dietary patterns adjusting for age, education, income, smoking, alcohol use, physical inactivity, family history of cardiovascular diseases, obesity and salt intake at a two-sided P less than 0.05.
    Results: Multivariable-adjusted OR [95% confidence interval (CI)] for risk of hypertension by second and third tertiles [using the lowest (first) tertile as reference] of dietary patterns were 0.62 (0.48-0.80), 0.70 (0.54-0.90) for whole grains and fruit drinks; 0.87 (0.68-1.12), 0.83 (0.64-1.08) for fruits; 0.85 (0.65-1.10), 0.97 (0.75-1.26) for vegetables, legumes and potatoes; 0.78 (0.60-1.00), 0.84 (0.65-1.08) for fried foods and sweetened drinks; 1.13 (0.88-1.45), 0.80 (0.62-1.03) for poultry product and organ meat; 1.11 (0.86-1.43), 0.88 (0.68-1.14) for red meat; and 1.14 (0.88-1.48), 1.09 (0.84-1.43) for processed foods ( P  < 0.05).
    Conclusion: A higher adherence to dietary consumption of whole grains and fruits was inversely associated with low odds of hypertension in this population.
    MeSH term(s) Humans ; Dietary Patterns ; Diet/adverse effects ; Vegetables ; Fruit ; Stroke/epidemiology ; Hypertension/epidemiology ; Feeding Behavior ; Risk Factors
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003662
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 614: Show issues

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  4. Article ; Online: Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.

    Akinyemi, Rufus O / Tiwari, Hemant K / Srinivasasainagendra, Vinodh / Akpa, Onoja / Sarfo, Fred S / Akpalu, Albert / Wahab, Kolawole / Obiako, Reginald / Komolafe, Morenikeji / Owolabi, Lukman / Osaigbovo, Godwin O / Mamaeva, Olga A / Halloran, Brian A / Akinyemi, Joshua / Lackland, Daniel / Obiabo, Olugbo Y / Sunmonu, Taofik / Chukwuonye, Innocent I / Arulogun, Oyedunni /
    Jenkins, Carolyn / Adeoye, Abiodun / Agunloye, Atinuke / Ogah, Okechukwu S / Ogbole, Godwin / Fakunle, Adekunle / Uvere, Ezinne / Coker, Motunrayo M / Okekunle, Akinkunmi / Asowata, Osahon / Diala, Samuel / Ogunronbi, Mayowa / Adeleye, Osi / Laryea, Ruth / Tagge, Raelle / Adeniyi, Sunday / Adusei, Nathaniel / Oguike, Wisdom / Olowoyo, Paul / Adebajo, Olayinka / Olalere, Abimbola / Oladele, Olayinka / Yaria, Joseph / Fawale, Bimbo / Ibinaye, Philip / Oyinloye, Olalekan / Mensah, Yaw / Oladimeji, Omotola / Akpalu, Josephine / Calys-Tagoe, Benedict / Dambatta, Hamisu A / Ogunniyi, Adesola / Kalaria, Rajesh / Arnett, Donna / Rotimi, Charles / Ovbiagele, Bruce / Owolabi, Mayowa O

    Genome medicine

    2024  Volume 16, Issue 1, Page(s) 25

    Abstract: Background: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 ... ...

    Abstract Background: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans.
    Methods: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed) release2 from BioData Catalyst. Furthermore, we performed fine-mapping, trans-ethnic meta-analysis, and in silico functional characterization to identify likely causal variants with a functional interpretation.
    Results: We observed genome-wide significant (P-value < 5.0E-8) SNPs associations near AADACL2 and miRNA (MIR5186) genes in chromosome 3 after adjusting for hypertension, diabetes, dyslipidemia, and cardiac status in the base model as covariates. SNPs near the miRNA (MIR4458) gene in chromosome 5 were also associated with stroke (P-value < 1.0E-6). The putative genes near AADACL2, MIR5186, and MIR4458 genes were protective and novel. SNPs associations with stroke in chromosome 2 were more than 77 kb from the closest gene LINC01854 and SNPs in chromosome 7 were more than 116 kb to the closest gene LINC01446 (P-value < 1.0E-6). In addition, we observed SNPs in genes STXBP5-AS1 (chromosome 6), GALTN9 (chromosome 12), FANCA (chromosome 16), and DLGAP1 (chromosome 18) (P-value < 1.0E-6). Both genomic regions near genes AADACL2 and MIR4458 remained significant following fine mapping.
    Conclusions: Our findings identify potential roles of regulatory miRNA, intergenic non-coding DNA, and intronic non-coding RNA in the biology of ischemic stroke. These findings reveal new molecular targets that promise to help close the current gaps in accurate African ancestry-based genetic stroke's risk prediction and development of new targeted interventions to prevent or treat stroke.
    MeSH term(s) Adult ; Humans ; Genome-Wide Association Study ; Ischemic Stroke/complications ; Genetic Predisposition to Disease ; Stroke/genetics ; Genomics ; Polymorphism, Single Nucleotide ; MicroRNAs ; DNA ; Multicenter Studies as Topic
    Chemical Substances MicroRNAs ; DNA (9007-49-2) ; MIRN-4458 microRNA, human
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2484394-5
    ISSN 1756-994X ; 1756-994X
    ISSN (online) 1756-994X
    ISSN 1756-994X
    DOI 10.1186/s13073-023-01273-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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