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  1. Article ; Online: Water-soluble phenolics from

    Adewale, Omowumi Oyeronke / Oyelola, Roseline Fadera / Adetuyi, Oluwatosin Adefunke / Adebisi, Oluwaseun Abraham / Adekomi, Damilare Adedayo / Oladele, Johnson Olaleye

    Drug and chemical toxicology

    2024  , Page(s) 1–14

    Abstract: Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal ... ...

    Abstract Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.1080/01480545.2024.2329762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1380: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate.

    Adewale, Omowumi Oyeronke / Adebisi, Oluwaseun Abraham / Ojurongbe, Taiwo A / Adekomi, Damilare Adedayo / Babatunde, Isaac Olawale / Adebayo, Emmanuel O

    Environmental science and pollution research international

    2023  Volume 30, Issue 21, Page(s) 60946–60957

    Abstract: The herbicide "Roundup" is used extensively in agriculture to control weeds. However, by translocation, it can be deposited in plants, their proceeds, and the soil, thus provoking organ toxicities in exposed individuals. Neurotoxicity among others is one ...

    Abstract The herbicide "Roundup" is used extensively in agriculture to control weeds. However, by translocation, it can be deposited in plants, their proceeds, and the soil, thus provoking organ toxicities in exposed individuals. Neurotoxicity among others is one of the side effects of roundup which has led to an increasing global concern about the contamination of food by herbicides. Xylopia aethiopica is known to have medicinal properties due to its antioxidative and anti-inflammatory properties, and it is hypothesized to neutralize roundup-induced neurotoxicity. Thirty-six (36) Wistar rats were used for this study. The animals were shared equally into six groups with six rats each. Glyphosate administration to three of the six groups was done orally and for 1 week. Either Xylopia aethiopica or vitamin C was co-administered to two of the three groups and also administered to two other groups and the final group served as the control. Our studies demonstrated that glyphosate administration led to a significant decrease in antioxidants such as catalase, superoxide dismutase, glutathione, and glutathione peroxidase. We also observed a significant increase in inflammatory markers such as tumor necrosis factor-α, interleukin 6, C-reactive protein, and immunohistochemical expression of caspase-3, cox-2, and p53 proteins (p < 0.05). However, Xylopia aethiopica co-administration with glyphosate was able to ameliorate the aforementioned changes when compared to the control (p < 0.05). Degenerative changes were also observed in the cerebellum, hippocampus, and cerebral cortex upon glyphosate administration. These changes were not observed in the groups treated with Xylopia aethiopica and vitamin C. Taken together, Xylopia aethiopica could possess anti-oxidative and anti-inflammatory properties that could be used in combating glyphosate neurotoxicity.
    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Xylopia/chemistry ; Plant Extracts/pharmacology ; Oxidative Stress ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Brain ; Anti-Inflammatory Agents/pharmacology ; Cell Death ; Herbicides/toxicity ; Glyphosate
    Chemical Substances Plant Extracts ; Antioxidants ; Ascorbic Acid (PQ6CK8PD0R) ; Anti-Inflammatory Agents ; Herbicides
    Language English
    Publishing date 2023-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-26470-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  3. Article ; Online: Ficus exasperata

    Adetuyi, Babatunde Oluwafemi / Adebisi, Oluwaseun Abraham / Adetuyi, Oluwatosin Adefunke / Ogunlana, Olubanke Olujoke / Toloyai, Pere-Ebi / Egbuna, Chukwuebuka / Uche, Chukwuemelie Zedech / Khan, Johra / Adumanya, Obinna Chukwuemeka Uchenna / Patrick-Iwuanyanwu, Kingsley C

    BioMed research international

    2022  Volume 2022, Page(s) 6032511

    Abstract: ... Ficus ... ...

    Abstract Ficus exasperata
    MeSH term(s) Acetaminophen/pharmacology ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Chemical and Drug Induced Liver Injury/drug therapy ; Ficus ; NF-kappa B ; Rats
    Chemical Substances Antioxidants ; NF-kappa B ; Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/6032511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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