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Article ; Online: Boucher-Neuhauser Syndrome: Chorioretinal Changes in a Single Case Over Time.

Adeghate, Jennifer O / Sherman, Jerome / Bass, Sherry / Liu, James / Hufnagel, Robert B / Yannuzzi, Lawrence A

Retinal cases & brief reports

2024

Abstract: Purpose: To describe chorioretinal changes in a single case of Boucher-Neuhauser Syndrome (BNHS) over 45 years of follow-up. Methods: Retrospective chart review was performed. Color fundus photography from 1977 to 2003 was obtained and digitized. ... ...

Abstract	Purpose: To describe chorioretinal changes in a single case of Boucher-Neuhauser Syndrome (BNHS) over 45 years of follow-up. Methods: Retrospective chart review was performed. Color fundus photography from 1977 to 2003 was obtained and digitized. Current fundus photography was obtained with widefield imaging. High-resolution spectral-domain optical coherence tomography (OCT) was performed. Genetic analysis was performed using an inherited retinal disorders panel. Results: Fundus examination demonstrated central chorioretinal atrophy with sclerotic choroidal vessels. Short posterior ciliary arteries became more prominent and tortuous over time. Mid-peripheral atrophy extends to the equator and demonstrates a scalloped pattern with islands of atrophy intervening with areas of normal retina. The far periphery remained minimally affected. High-resolution OCT demonstrated outer retinal atrophy and choriocapillaris loss. Genetic testing showed a homozygous variant for PNPLA6 and a heterozygous variant for TYRP1. Conclusion: Chorioretinal changes in BNHS vary in onset and severity. It is important to diagnose this condition in order to begin timely management of visual and systemic sequelae.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001556
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Article ; Online: An Update on the Molecular and Cellular Basis of Pharmacotherapy in Type 2 Diabetes Mellitus.

Mahgoub, Mohamed Omer / Ali, Ifrah Ismail / Adeghate, Jennifer O / Tekes, Kornélia / Kalász, Huba / Adeghate, Ernest A

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is ... ...

Abstract	Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than 537 million cases of diabetes were reported worldwide in 2021, and the number is steadily increasing. The worldwide number of people suffering from DM is projected to reach 783 million in 2045. In 2021 alone, more than USD 966 billion was spent on the management of DM. Reduced physical activity due to urbanization is believed to be the major cause of the increase in the incidence of the disease, as it is associated with higher rates of obesity. Diabetes poses a risk for chronic complications such as nephropathy, angiopathy, neuropathy and retinopathy. Hence, the successful management of blood glucose is the cornerstone of DM therapy. The effective management of the hyperglycemia associated with type 2 diabetes includes physical exercise, diet and therapeutic interventions (insulin, biguanides, second generation sulfonylureas, glucagon-like peptide 1 agonists, dipeptidyl-peptidase 4 inhibitors, thiazolidinediones, amylin mimetics, meglitinides, α-glucosidase inhibitors, sodium-glucose cotransporter-2 inhibitors and bile acid sequestrants). The optimal and timely treatment of DM improves the quality of life and reduces the severe burden of the disease for patients. Genetic testing, examining the roles of different genes involved in the pathogenesis of DM, may also help to achieve optimal DM management in the future by reducing the incidence of DM and by enhancing the use of individualized treatment regimens.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Quality of Life ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
Chemical Substances	Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Dipeptidyl-Peptidase IV Inhibitors
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119328
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Article ; Online: Repair of a Tractional Retinal Detachment in the Setting of an Idiopathic Vasoproliferative Tumor.

Adeghate, Jennifer O / Goldburg, Samantha R / Marr, Brian / Sheyman, Alan / Winokur, Jules / Kaden, Talia R

Ophthalmic surgery, lasers & imaging retina

2023 Volume 54, Issue 8, Page(s) 485–488

Abstract: Vasoproliferative tumors (VPT) are benign retinal lesions that may cause epiretinal membrane proliferation and tractional retinal detachments (TRD). We describe a case of a 71-year-old woman who presented with a macula involving TRD in the setting of a ... ...

Abstract	Vasoproliferative tumors (VPT) are benign retinal lesions that may cause epiretinal membrane proliferation and tractional retinal detachments (TRD). We describe a case of a 71-year-old woman who presented with a macula involving TRD in the setting of a VPT. Given the limited number of publications on the management of these cases, we aim to articulate some principles we believe may be helpful in planning a surgical approach that maximizes postoperative anatomic and functional outcomes. We hope that our video provides useful guidance in preparing the vitreoretinal surgeon for managing this uncommon entity.
MeSH term(s)	Female ; Humans ; Aged ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Retinal Detachment/surgery ; Vitrectomy/methods ; Retinal Diseases/surgery ; Neoplasms/complications ; Neoplasms/surgery ; Epiretinal Membrane/complications ; Epiretinal Membrane/diagnosis ; Epiretinal Membrane/surgery ; Retrospective Studies
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20230726-02
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Zs.A 756: Show issues

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Article: Retinal neovascularization in Susac's syndrome: A rare imaging finding.

Adeghate, Jennifer O / Bonhomme, Gabrielle R / Indermill, Chad / Taylor, Steven L / Rocha, Marcelo / Moghadam-Kia, Siamak / Errera, Marie-Hélène

Oman journal of ophthalmology

2023 Volume 16, Issue 3, Page(s) 570–572

Language	English
Publishing date	2023-10-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2484272-2
ISSN	0974-7842 ; 0974-620X
ISSN (online)	0974-7842
ISSN	0974-620X
DOI	10.4103/ojo.ojo_330_22
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Article ; Online: Early (5-Day) Onset of Diabetes Mellitus Causes Degeneration of Photoreceptor Cells, Overexpression of Incretins, and Increased Cellular Bioenergetics in Rat Retina.

Adeghate, Jennifer O / D'Souza, Crystal / Kántor, Orsolya / Tariq, Saeed / Souid, Abdul-Kader / Adeghate, Ernest

Cells

2021 Volume 10, Issue 8

Abstract: The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission ... ...

Abstract	The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission electron microscopy. Tissue localization of glucagon-like-peptide-1 (GLP-1), exendin-4 (EXE-4), and catalase (CAT) in non-diabetic and diabetic rat retinas was conducted using immunohistochemistry, while the retinal and plasma concentration of GLP-1, EXE-4, and CAT were measured with ELISA. Lipid profiles and kidney and liver function markers were measured from the blood of non-diabetic and diabetic rats with an automated biochemical analyzer. Oxygen consumption was monitored using a phosphorescence analyzer, and the adenosine triphosphate (ATP) level was determined using the Enliten ATP assay kit. Blood glucose and cholesterol levels were significantly higher in diabetic rats compared to control. The number of degenerated photoreceptor cells was significantly higher in the diabetic rat retina. Tissue levels of EXE-4, GLP-1 and CAT were significantly (
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Biomarkers/blood ; Blood Glucose/analysis ; Catalase/blood ; Catalase/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glucagon-Like Peptide 1/blood ; Glucagon-Like Peptide 1/metabolism ; Incretins/blood ; Incretins/genetics ; Incretins/metabolism ; Male ; Microscopy, Electron, Transmission ; Oxygen Consumption ; Photoreceptor Cells/cytology ; Photoreceptor Cells/metabolism ; Rats ; Rats, Wistar ; Retina/metabolism ; Retina/pathology ; Retina/ultrastructure
Chemical Substances	Biomarkers ; Blood Glucose ; Incretins ; Glucagon-Like Peptide 1 (89750-14-1) ; Adenosine Triphosphate (8L70Q75FXE) ; Catalase (EC 1.11.1.6)
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10081981
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Article: Similar Strains of Coagulase-Negative Staphylococci Found in the Gastrointestinal Tract and Bloodstream of Bacteremic Neonates.

Adeghate, Jennifer O / Juhász, Emese / Iván, Miklós Á / Pongrácz, Júlia / Kristóf, Katalin

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2020 Volume 2020, Page(s) 3509676

Abstract: Objectives: Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial ... ...

Abstract	Objectives: Premature neonates are susceptible to opportunistic and nosocomial infections. Efforts have been made to determine whether the neonatal gut microbiome possesses potential for causing bloodstream infections in newborns via microbial translocation from the gastrointestinal tract. We aimed to examine similarities in coagulase-negative staphylococci (CoNS) strains found in the gastrointestinal tract and bloodstream in bacteremic neonates. Methods: CoNS strains isolated from blood cultures and perianal and pharyngeal swab samples of neonates from two neonatal intensive care units were investigated using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and pulsed-field gel electrophoresis. Molecular mass and genetic similarities of CoNS strains were compared. Results: Marked similarity was found in the molecular mass and genetic profile of examined CoNS isolates from blood cultures and perianal/pharyngeal samples. The percentage of neonates developing bacteremia following perianal and pharyngeal colonization by CoNS was significantly higher when compared to those colonized by Enterobacteriales species ( Conclusions: CoNS colonizing the gut may be a source of bacteremia in neonates. Enterobacteriales species do not contribute as significantly to bacteremia when compared to CoNS, and may be protective against gut mucosa-originated systemic infection.
Language	English
Publishing date	2020-07-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2020/3509676
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Zs.A 3099: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Monocular Vision-Based Retinal Membrane Peeling With a Handheld Robot.

Han, Yuqiao / Routray, Arpita / Adeghate, Jennifer O / MacLachlan, Robert A / Martel, Joseph N / Riviere, Cameron N

Journal of medical devices

2021 Volume 15, Issue 3, Page(s) 31014

Abstract: Retinal membrane peeling requires delicate manipulation. The presence of the surgeon's physiological tremor, the high variability and often low quality of the ophthalmic image, and excessive forces make the tasks more challenging. Preventing unintended ... ...

Abstract	Retinal membrane peeling requires delicate manipulation. The presence of the surgeon's physiological tremor, the high variability and often low quality of the ophthalmic image, and excessive forces make the tasks more challenging. Preventing unintended movement caused by tremor and unintentional forces can reduce membrane injury. With the use of an actively stabilized handheld robot, we employ a monocular camera-based surface reconstruction method to estimate the retinal plane and we propose the use of a virtual fixture with the application of a hard stop and motion scaling to improve control of the tool tip during delaminating in a laboratory simulation of retinal membrane peeling. A hard stop helps to limit downward force exerted on the surface. Motion scaling also improves the user's control of contact force when delaminating. We demonstrate a reduction of maximum force and maximum surface-penetration distance from the estimated retinal plane using the proposed technique.
Language	English
Publishing date	2021-07-27
Publishing country	United States
Document type	Journal Article
ISSN	1932-6181
ISSN	1932-6181
DOI	10.1115/1.4051686
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Article ; Online: Manhattan Vision Screening and Follow-Up Study: (NYC-SIGHT)Tele-Retinal Image Findings and Importance of Photography.

Horowitz, Jason D / Adeghate, Jennifer O / Karani, Rabia / Henriquez, Desiree R / Gorroochurn, Prakash / Sharma, Tarun / Park, Lisa / Wang, Qing / Diamond, Daniel F / Harizman, Noga / Auran, James D / Maruri, Stefania C / Liebmann, Jeffrey M / Cioffi, George A / Hark, Lisa A

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2023 Volume 30, Issue 3, Page(s) 664–676

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Aged ; Vision Screening ; Follow-Up Studies ; Prospective Studies ; Glaucoma/diagnosis ; Telemedicine/methods ; Photography ; Mass Screening/methods
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2023.0134
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Zs.A 4576: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Coagulase-negative staphylococcal endophthalmitis: clinical severity and outcomes based on speciation.

Adeghate, Jennifer O / Yadav, Sanya / Kowalski, Regis P / Juhász, Emese / Kristóf, Katalin / Olsen, Karl R / Bergren, Robert L / Knickelbein, Jared E / Chhablani, Jay / Martel, Joseph N / Anetakis, Alexander / Dansingani, Kunal K / Rosin, Boris / Gallagher, Denise S / Prensky, Colin / Eller, Andrew W / Friberg, Thomas / Sahel, José-Alain / Errera, Marie-Hélène

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2023

Abstract: Objective: To identify characteristics and visual outcomes of coagulase-negative staphylococcal (CoNS) endophthalmitis in the era after the Endophthalmitis Vitrectomy Study.: Design: Single-centre retrospective analysis.: Participants: Forty-two ... ...

Abstract	Objective: To identify characteristics and visual outcomes of coagulase-negative staphylococcal (CoNS) endophthalmitis in the era after the Endophthalmitis Vitrectomy Study. Design: Single-centre retrospective analysis. Participants: Forty-two samples from 40 patients with documented CoNS endophthalmitis. Methods: Visual acuity outcomes of CoNS endophthalmitis were assessed in relation to species and type of treatment instituted (i.e., pars plana vitrectomy [PPV] versus vitreous tap and injection of intravitreal antibiotics [T&I]) on 42 samples from 40 patients. Results: Staphylococcus epidermidis was the most prevalent CoNS in our study. Cataract surgery and intravitreal injections were the most common sources for acute CoNS endophthalmitis. Eyes presenting with hand motion or better vision had similar mean final vision after either intravitreal antibiotics or PPV, whereas those with light perception or worse vision at onset had better outcomes after PPV only. Subanalysis showed that patients with S. epidermidis endophthalmitis (n = 39 eyes) had similar visual outcomes with either intravitreal injections or PPV regardless of visual acuity. Hypopyon and vitritis are not always present. Conclusions: Patients with S. epidermidis endophthalmitis may benefit similarly from either early vitrectomy or intravitreal antibiotic injections regardless of visual acuity. This finding may be a supplement to the complements the management standards set forth by the Endophthalmitis Vitrectomy Study.
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2023.05.014
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Zs.A 588: Show issues

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Article ; Online: Philadelphia glaucoma detection and treatment project: ocular outcomes and adherence to follow-up at a single health centre.

Adeghate, Jennifer O / Hark, Lisa A / Brown, Helayna / Henderer, Jeffrey D / Waisbourd, Michael / Molineaux, Jeanne / Malik, Kunal / Maity, Alisha / Chuang, Danielle / Donches, Katherine / Heres, Caroline / Eburuoh, Rita / Schardt, Martin / Yu, Daohai / Ramsey, Frederick / Myers, Jonathan S / Katz, L Jay

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2019 Volume 54, Issue 6, Page(s) 717–722

Abstract: Objectives: To determine ocular outcomes and factors associated with adherence to ophthalmic follow-up in a medically underserved population at a single health centre in Philadelphia.: Design: Retrospective chart review.: Participants: Patients ... ...

Abstract	Objectives: To determine ocular outcomes and factors associated with adherence to ophthalmic follow-up in a medically underserved population at a single health centre in Philadelphia. Design: Retrospective chart review. Participants: Patients from a community glaucoma screening program. Methods: Chart review was conducted for participants who received a complete eye examination at the Philadelphia District Health Center 5 between January 1, 2012 and May 31, 2014 within the Philadelphia Glaucoma Detection and Treatment Project. Multivariate logistic regression was used to determine factors related to ophthalmic follow-up adherence. Results: A total of 249 participants completed an eye examination (mean age = 57.7 ± 6.9 years). Most were African American (n = 220; 88.4%); female (n = 129; 51.8%). Forty-seven participants (18.9%) received glaucoma-related diagnoses, 20 (8.0%) were prescribed ocular medication, and 26 (10.4%) underwent laser therapy. Ninety (36.1%) attended their recommended follow-up eye examination at the health centre. Glaucoma-related diagnosis (p ≤ 0.001), recommendation of a 4- to 6-week follow-up period (p < 0.001), prescribed eye drops (p < 0.001), or received laser therapy (p = 0.047) were factors most predictive of ophthalmic follow-up adherence. Conclusions: The collaborative effort of eye care providers and health centres offers an important opportunity to detect, treat, and manage glaucoma and other ocular pathology in medically underserved communities. Having a glaucoma-related diagnosis, initiating treatment, and scheduling regular follow-up visits are the most important factors influencing adherence to follow-up eye appointments.
MeSH term(s)	Adult ; Aftercare ; Aged ; Antihypertensive Agents/therapeutic use ; Community Health Services/methods ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/physiopathology ; Glaucoma, Open-Angle/therapy ; Humans ; Intraocular Pressure/physiology ; Laser Coagulation ; Male ; Medically Underserved Area ; Middle Aged ; Patient Compliance/statistics & numerical data ; Philadelphia ; Retrospective Studies ; Tonometry, Ocular ; Trabeculectomy ; Visual Acuity
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2019-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2019.03.003
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Zs.A 588: Show issues

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ab Jg. 2022: Lesesaal (EG)

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