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  1. Article ; Online: Advancing pediatric healthcare in Brazil: establishing reliable reference intervals for serum immunoglobulins.

    Adeli, Khosrow

    Jornal de pediatria

    2024  Volume 100, Issue 3, Page(s) 229–230

    MeSH term(s) Humans ; Brazil ; Reference Values ; Child ; Immunoglobulins/blood
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2024-03-10
    Publishing country Brazil
    Document type Editorial ; Journal Article
    ZDB-ID 731324-x
    ISSN 1678-4782 ; 0021-7557
    ISSN (online) 1678-4782
    ISSN 0021-7557
    DOI 10.1016/j.jped.2024.03.001
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  2. Article ; Online: Clinical Chemistry and Laboratory Medicine

    Adeli, Khosrow

    Clinical chemistry and laboratory medicine

    2023  Volume 61, Issue 5, Page(s) 711–712

    MeSH term(s) Humans ; History, 20th Century ; Chemistry, Clinical/history ; Anniversaries and Special Events ; Laboratories
    Language English
    Publishing date 2023-02-14
    Publishing country Germany
    Document type Historical Article ; Editorial
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0143
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  3. Article ; Online: Critical role of laboratory medicine in the global response to the COVID-19 pandemic.

    Adeli, Khosrow

    Clinical chemistry and laboratory medicine

    2020  Volume 58, Issue 7, Page(s) 1019–1020

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/etiology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/etiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0742
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  4. Article: Comprehensive Pediatric Reference Limits for High-Sensitivity Cardiac Troponin I and NT-proBNP in the CALIPER Cohort.

    Bohn, Mary Kathryn / Adeli, Khosrow

    The journal of applied laboratory medicine

    2023  Volume 8, Issue 3, Page(s) 443–456

    Abstract: Background: Cardiac biomarkers have increasing application in pediatric populations, including congenital heart disease, myocarditis, and heart failure. Clinical practice is limited by evidence gaps in pediatric reference limits to inform clinical ... ...

    Abstract Background: Cardiac biomarkers have increasing application in pediatric populations, including congenital heart disease, myocarditis, and heart failure. Clinical practice is limited by evidence gaps in pediatric reference limits to inform clinical decision-making. The current study aimed to establish comprehensive pediatric reference limits for N-terminal (NT)-pro hormone brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (hs-cTnI) in the CALIPER cohort of healthy children and adolescents.
    Methods: Analytical immunoassay performance was assessed through precision, linearity, and method comparison (Abbott Alinity ci system). Subsequently, approximately 200 serum samples collected from apparently healthy children (birth to 18 years) were analyzed for hs-cTnI and NT-proBNP. Reference limits (2.5th, 97.5th, and 99th percentiles) were established as per Clinical and Laboratory Standards Institute EP-28A3c guidelines with associated 90% confidence intervals.
    Results: Of all pediatric serum samples analyzed, 46% had detectable hs-cTnI concentrations (limit of detection: 1.3 ng/L). Both hs-cTnI and NT-proBNP demonstrated markedly elevated neonatal concentrations with 99th percentiles of 55.8 and 1785 ng/L, respectively. No statistically significant age-specific differences were observed beyond 1 year of age across all cardiac biomarkers examined. No sex-specific association was observed between hs-cTnI and NT-proBNP concentration and adolescence.
    Conclusions: We report age-specific reference limits for hs-cTnI and NT-proBNP in a healthy Canadian cohort of children and adolescents measured using Alinity immunoassays for the first time. These data support the need for pediatric-specific interpretation to reduce misinformed clinical decision-making and calls to action larger cohort studies such that reference limits can be more robustly defined.
    MeSH term(s) Infant, Newborn ; Humans ; Child ; Adolescent ; Natriuretic Peptide, Brain ; Troponin I ; Biomarkers ; Canada
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; Troponin I ; Biomarkers
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfad012
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  5. Article: GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk.

    Abdalqadir, Nyan / Adeli, Khosrow

    Microorganisms

    2022  Volume 10, Issue 10

    Abstract: The intestine represents the body's largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and ... ...

    Abstract The intestine represents the body's largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine-microbiota-immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10102061
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  7. Article ; Online: Critical role of laboratory medicine in the global response to the COVID-19 pandemic

    Adeli, Khosrow

    Clinical Chemistry and Laboratory Medicine (CCLM)

    2020  Volume 58, Issue 7, Page(s) 1019–1020

    Keywords Clinical Biochemistry ; Biochemistry, medical ; General Medicine ; covid19
    Publisher Walter de Gruyter GmbH
    Publishing country de
    Document type Article ; Online
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0742
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  8. Article ; Online: Laboratory medicine - A hidden treasure in healthcare.

    Adeli, Khosrow

    Clinical biochemistry

    2017  Volume 50, Issue 12, Page(s) 645–647

    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2017.03.022
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  9. Article ; Online: SARS-CoV-2 serology in pediatrics: Seroprevalence studies in unvaccinated children and humoral antibody response post vaccination.

    Bohn, Mary Kathryn / Steele, Shannon / Adeli, Khosrow

    Clinical biochemistry

    2023  Volume 119, Page(s) 110630

    Abstract: Background: Humoral response against SARS-CoV-2 is increasingly accepted as the central correlate of immune protection. Recent pediatric seroprevalence data are extremely limited. Significant knowledge gaps also exist in immune response to mRNA SARS-CoV- ...

    Abstract Background: Humoral response against SARS-CoV-2 is increasingly accepted as the central correlate of immune protection. Recent pediatric seroprevalence data are extremely limited. Significant knowledge gaps also exist in immune response to mRNA SARS-CoV-2 vaccination in children. As children demonstrate distinct response to naïve infection relative to adults, it is essential to investigate age-specific differences in seroprevalence and antibody response to SARS-CoV-2 vaccination.
    Methods: Seroprevalence was assessed through two cross-sectional serosurveys prior to COVID-19 vaccination approval in children <5 years using residual patient specimens (n = 2902). To assess antibody response post-vaccination, 842 participants (580 children, 262 adults) were prospectively recruited with informed consent. Participation required completion of a health questionnaire and blood donation. Samples were collected at varying times post-vaccination and assayed using the Abbott AdviseDx SARS-CoV-2 IgG II and DiaSorin LIAISON SARS-CoV-2 TrimericS IgG assays.
    Results: Significant increases in seroprevalence were observed between the first and second serosurveys in unvaccinated children <6 months to 5 years (38-75%). In the prospective vaccination cohort, serokinetic response decreased with time post-dose of an mRNA vaccine. Measured IgG titres were significantly higher in children relative to adults across all time points.
    Conclusions: This is the largest evaluation of quantitative SARS-CoV-2 antibody assays in a cohort of Canadian children, adolescents, and adults. Findings suggest high rates of SARS-CoV-2 exposure among unvaccinated young children in the Toronto community. Additional data supports children have higher antibody titres relative to adults post-vaccination.
    MeSH term(s) Adolescent ; Adult ; Humans ; Child ; Child, Preschool ; Antibody Formation ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Canada ; Cross-Sectional Studies ; Prospective Studies ; SARS-CoV-2 ; Seroepidemiologic Studies ; Antibodies, Viral ; Immunoglobulin G ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2023.110630
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  10. Article ; Online: Physiological and metabolic adaptations in pregnancy: importance of trimester-specific reference intervals to investigate maternal health and complications.

    Bohn, Mary Kathryn / Adeli, Khosrow

    Critical reviews in clinical laboratory sciences

    2021  Volume 59, Issue 2, Page(s) 76–92

    Abstract: Diagnosis, prognostication, and monitoring of maternal health throughout pregnancy relies on laboratory testing, including but not limited to key markers of thyroid, hepatic, cardiac, hematology, and renal function. Dynamic physiological processes during ...

    Abstract Diagnosis, prognostication, and monitoring of maternal health throughout pregnancy relies on laboratory testing, including but not limited to key markers of thyroid, hepatic, cardiac, hematology, and renal function. Dynamic physiological processes during gestation significantly influence the maternal biochemistry that supports both the mother and fetus. Resultant changes in blood biochemistry alter the expected values of common laboratory tests. However, the importance of pregnancy-specific reference intervals for laboratory test result interpretation and appropriate monitoring of maternal health and complications is underappreciated. Most clinical laboratories continue to use non-pregnant adult reference intervals for laboratory test interpretation in pregnancy. The current review summarizes and critically evaluates the available literature regarding physiological and metabolic adaptations in pregnancy and their influence on common biomarkers of health and disease. The main laboratory parameters discussed include thyroid, hepatic, metabolic, renal, hematology, inflammatory, and cardiac markers. Considering the available data, further studies are urgently needed to establish trimester-specific reference intervals in healthy pregnant women on updated analytical platforms. Without such data, the standard of clinical laboratory service in pregnancy remains compromised and affects the quality of maternal-fetal healthcare.
    MeSH term(s) Adult ; Biomarkers ; Female ; Humans ; Maternal Health ; Pregnancy ; Reference Values ; Thyroid Gland/physiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 280641-1
    ISSN 1549-781X ; 1040-8363 ; 0590-8191
    ISSN (online) 1549-781X
    ISSN 1040-8363 ; 0590-8191
    DOI 10.1080/10408363.2021.1978923
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