Result 1 - 4 of total 4
City Commun.
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #603029 |
| Database | COVID19 |
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The American journal of gastroenterology
2021 Volume 116, Issue 8, Page(s) 1638–1645
Abstract: Introduction: Proton pump inhibitor (PPI) use was recently reported to be associated with increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and worse clinical outcomes. The underlying mechanism(s) for this association are ... ...
| Abstract | Introduction: Proton pump inhibitor (PPI) use was recently reported to be associated with increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and worse clinical outcomes. The underlying mechanism(s) for this association are unclear. Methods: We performed a prospective study of hospitalized coronavirus disease 2019 (COVID-19) patients and COVID-negative controls to understand how PPI use may affect angiotensin-converting enzyme 2 (ACE2) expression and stool SARS-CoV-2 RNA. Analysis of a retrospective cohort of hospitalized patients with COVID-19 from March 15, 2020 to August 15, 2020 in 6 hospitals was performed to evaluate the association of PPI use and mortality. Covariates with clinical relevance to COVID-19 outcomes were included to determine predictors of in-hospital mortality. Results: Control PPI users had higher salivary ACE2 mRNA levels than nonusers, 2.39 ± 1.15 vs 1.22 ± 0.92 (P = 0.02), respectively. Salivary ACE2 levels and stool SARS-CoV-2 RNA detection rates were comparable between users and nonusers of PPI. In 694 hospitalized patients with COVID-19 (age = 58 years, 46% men, and 65% black), mortality rate in PPI users and nonusers was 30% (68/227) vs 12.1% (53/439), respectively. Predictors of mortality by logistic regression were PPI use (adjusted odds ratio [aOR] = 2.72, P < 0.001), age (aOR = 1.66 per decade, P < 0.001), race (aOR = 3.03, P = 0.002), cancer (aOR = 2.22, P = 0.008), and diabetes (aOR = 1.95, P = 0.003). The PPI-associated mortality risk was higher in black patients (aOR = 4.16, 95% confidence interval: 2.28-7.59) than others (aOR = 1.62, 95% confidence interval: 0.82-3.19, P = 0.04 for interaction). Discussion: COVID-negative PPI users had higher salivary ACE2 expression. PPI use was associated with increased mortality risk in patients with COVID-19, particularly African Americans. |
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| MeSH term(s) | Adult ; Aged ; Angiotensin-Converting Enzyme 2/blood ; COVID-19/blood ; COVID-19/mortality ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Proton Pump Inhibitors/adverse effects ; Retrospective Studies ; Risk Assessment |
| Chemical Substances | Proton Pump Inhibitors ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) |
| Language | English |
| Publishing date | 2021-05-31 |
| Publishing country | United States |
| Document type | Journal Article ; Multicenter Study |
| ZDB-ID | 390122-1 |
| ISSN | 1572-0241 ; 0002-9270 |
| ISSN (online) | 1572-0241 |
| ISSN | 0002-9270 |
| DOI | 10.14309/ajg.0000000000001311 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui V Zs.36: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2005 Volume 42, Issue 2, Page(s) 215–241
Abstract: Using historical census microdata, we present a unique analysis of racial and gender disparities in destination selection and an exploration of hypotheses regarding tied migration in the historical context of the Great Migration. Black migrants were more ...
| Abstract | Using historical census microdata, we present a unique analysis of racial and gender disparities in destination selection and an exploration of hypotheses regarding tied migration in the historical context of the Great Migration. Black migrants were more likely to move to metropolitan areas and central cities throughout the period, while white migrants were more likely to locate in nonmetropolitan and farm destinations. Gender differences were largely dependent on marital status. Consistent with the "tied-migration" thesis, married women had destination outcomes that were similar to those of men, whereas single women had a greater propensity to reside in metropolitan locations where economic opportunities for women were more plentiful. |
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| MeSH term(s) | African Americans/history ; Choice Behavior ; European Continental Ancestry Group/history ; Female ; History, 20th Century ; Humans ; Logistic Models ; Male ; Marriage/history ; Models, Psychological ; Population Dynamics ; Prejudice ; Race Relations/history ; Residence Characteristics ; Rural Population/history ; Sex Factors ; Social Mobility/history ; Socioeconomic Factors ; United States ; Urban Population/history |
| Language | English |
| Publishing date | 2005-06-11 |
| Publishing country | United States |
| Document type | Comparative Study ; Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. |
| ZDB-ID | 280612-5 |
| ISSN | 1533-7790 ; 0070-3370 |
| ISSN (online) | 1533-7790 |
| ISSN | 0070-3370 |
| DOI | 10.1353/dem.2005.0019 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 1487: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Social forces : SF; an international journal of social research associated with the Southern Sociological Society Vol. 78, No. 3 , p. 989-1015
The residential settlement patterns of black southern migrants to the North
2000 Volume 78, Issue 3, Page(s) 989–1015
| Author's details | Stewart E. Tolnay; Kyle D. Crowder; Robert M. Adelman |
|---|---|
| Keywords | Binnenwanderung ; Schwarze ; Wohnungsmarkt ; USA |
| Language | English |
| Publisher | Univ. of North Carolina Press |
| Publishing place | Chapel Hill, NC |
| Document type | Article |
| ZDB-ID | 212930-9 |
| Database | ECONomics Information System |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.