LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 175

Search options

  1. Article ; Online: Fake IDs? Widespread misannotation of DNA transposons as a general transcription factor.

    Hassan, Nozhat T / Adelson, David L

    Genome biology

    2023  Volume 24, Issue 1, Page(s) 260

    Abstract: Accurate annotation of genes and transposable elements (TEs) is vital for understanding genomes, but current annotation pipelines often misannotate TEs as genes. This study reveals how the general transcription factor II-I repeat domain-containing ... ...

    Abstract Accurate annotation of genes and transposable elements (TEs) is vital for understanding genomes, but current annotation pipelines often misannotate TEs as genes. This study reveals how the general transcription factor II-I repeat domain-containing protein 2 (GTF2IRD2) erroneously annotated DNA transposons in non-mammalian species, as it contains a 3' fused hAT transposase domain. We also demonstrate the generality of this problem by identifying misannotated TEs as genes in other vertebrate genomes. Such misannotations can lead to errors in phylogenetic analyses and wasted time for investigators. The study proposes adding a final TE-check to gene annotation pipelines to mitigate this problem.
    MeSH term(s) Animals ; DNA Transposable Elements ; Phylogeny ; Vertebrates/genetics ; Molecular Sequence Annotation ; Transcription Factors, General
    Chemical Substances DNA Transposable Elements ; Transcription Factors, General
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-023-03102-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Multiple horizontal transfer events of a DNA transposon into turtles, fishes, and a frog.

    Hassan, Nozhat T / Galbraith, James D / Adelson, David L

    Mobile DNA

    2024  Volume 15, Issue 1, Page(s) 7

    Abstract: Horizontal transfer of transposable elements (HTT) has been reported across many species and the impact of such events on genome structure and function has been well described. However, few studies have focused on reptilian genomes, especially HTT events ...

    Abstract Horizontal transfer of transposable elements (HTT) has been reported across many species and the impact of such events on genome structure and function has been well described. However, few studies have focused on reptilian genomes, especially HTT events in Testudines (turtles). Here, as a consequence of investigating the repetitive content of Malaclemys terrapin terrapin (Diamondback turtle) we found a high similarity DNA transposon, annotated in RepBase as hAT-6_XT, shared between other turtle species, ray-finned fishes, and a frog. hAT-6_XT was notably absent in reptilian taxa closely related to turtles, such as crocodiles and birds. Successful invasion of DNA transposons into new genomes requires the conservation of specific residues in the encoded transposase, and through structural analysis, these residues were identified indicating some retention of functional transposition activity. We document six recent independent HTT events of a DNA transposon in turtles, which are known to have a low genomic evolutionary rate and ancient repeats.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2536054-1
    ISSN 1759-8753
    ISSN 1759-8753
    DOI 10.1186/s13100-024-00318-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: History of the Kaiser Permanente medical care program / 1 / David Adelson ; conducted by Ora Huth

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1990  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size VIII, 66 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635282
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -1- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: History of the Kaiser Permanente medical care program / 10 / Benjamin Lewis ; conducted by Ora Huth

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1990  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size VII, 179 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635387
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -10- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Chromosomal level genome assembly of medicinal plant Sophora flavescens.

    Qu, Zhipeng / Wang, Wei / Adelson, David L

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 572

    Abstract: Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). In this study, ... ...

    Abstract Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). In this study, we used third-generation Nanopore long-read sequencing technology combined with Hi-C scaffolding technology to de novo assemble the S. flavescens genome. We obtained a chromosomal level high-quality S. flavescens draft genome. The draft genome size is approximately 2.08 Gb, with more than 80% annotated as Transposable Elements (TEs), which have recently and rapidly proliferated. This genome size is ~5x larger than its closest sequenced relative Lupinus albus L. . We annotated 60,485 genes and examined their expression profiles in leaf, stem and root tissues, and also characterised the genes and pathways involved in the biosynthesis of major bioactive compounds, including alkaloids, flavonoids and isoflavonoids. The assembled genome highlights the very different evolutionary trajectories that have occurred in recently diverged Fabaceae, leading to smaller duplicated genomes.
    MeSH term(s) Biological Evolution ; China ; DNA Transposable Elements ; Fabaceae ; Plants, Medicinal/genetics ; Sophora flavescens/genetics ; Genome, Plant
    Chemical Substances DNA Transposable Elements
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02490-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: History of the Kaiser Permanente medical care program / 2 / Morris F. Collen ; conducted by Sally Smith Hughes

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1988  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size VIII, 259 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635308
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -2- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book: History of the Kaiser Permanente medical care program / 12 / Berniece Oswald ; conducted by Malca Chall

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1987  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size VII, 41 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635411
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -12- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: History of the Kaiser Permanente medical care program / 5 / Alice D. Friedman ; conducted by Sally Smith Hughes

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1987  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size IX, 93 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635327
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -5- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: History of the Kaiser Permanente medical care program / 17 / John G. Smillie ; conducted by Ora Huth

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1987  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size IX, 145 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635567
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -17- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: History of the Kaiser Permanente medical care program / 13 / Sam Packer ; conducted by Malca Chall

    Adelson, David

    an interview ; Kaiser Permanente medical care program oral history project

    1987  

    Institution Bancroft Library / Regional Oral History Office
    Author's details Regional Oral History Office, the Bancroft Library, University of California, Berkeley, California
    Collection History of the Kaiser Permanente medical care program
    Language English
    Size IX, 83 S. : Ill.
    Publisher Kaiser Permanente
    Publishing place Oakland, Calif.
    Publishing country United States
    Document type Book
    HBZ-ID HT006635427
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2645 -13- order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top