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  1. Article ; Online: Preoperative tumour size as a predictor of the presence of lymphovascular invasion in lung adenocarcinoma

    Kemal Grbić / Bakir Mehić / Dalma Udovičić-Gagula / Amina Valjevac / Adem Ćemerlić / Ferid Krupić

    Medicinski Glasnik, Vol 17, Iss 2, Pp 363-

    2020  Volume 368

    Abstract: Aim To examine whether preoperative tumour size may serve as a biomarker for the occurrence of lymphovascular invasion (LVI) in centrally and peripherally located lung adenocarcinoma. Method The study included 261 patients surgically treated for ... ...

    Abstract Aim To examine whether preoperative tumour size may serve as a biomarker for the occurrence of lymphovascular invasion (LVI) in centrally and peripherally located lung adenocarcinoma. Method The study included 261 patients surgically treated for diagnosed lung adenocarcinoma. A ROC curve was used to determine the biomarker potential of tumour size relative to the occurrence of LVI. Binary logistic regression was used to show changes of tumour size impact on the status of LVI. Result Tumour prevalence according to localization had no statistical significance (p=0.464), while the presence of LVI in central, as well as peripheral positions, was statistically significantly different (p<0.001). The area under the curve of 0.978 highlights the fact that tumour size is an excellent marker of the presence of LVI in centrally located adenocarcinomas of the lung. A similar finding was confirmed in peripherally located lung adenocarcinomas with an area below the curve of 0.943. Binary logistical regression showed that in centrally localized adenocarcinomas of the lung, each additional centimetre of tumour growth represents an increase in the likelihood of LVI+ by 17.14 times. In peripherally located adenocarcinomas of the lung, this increase in likelihood of LVI for each centimetre of growth was 5.46 times. Conclusion With a high degree of sensitivity and specificity, preoperative tumour size may serve as an important biomarker and positive predictor of the presence of LVI in lung adenocarcinoma of any location.
    Keywords binary logistical regression ; ct scanning ; histopathological examination ; surgical resection ; t-descriptor ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Medical Association of Zenica-Doboj Canton
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: ANTIBIOTIC SUSCEPTIBILITY/RESISTANCE AMONG SALMONELLA SPECIES ISOLATED IN NON-HOSPITALISED PATIENTS IN THE CANTON OF SARAJEVO

    Mufida Aljicevic / Armin Cikotic / Sabaheta Bektas / Sabina Mahmutovic Vranic / Velma Rebic / Amila Abduzaimovic / Adem Cemerlic

    Journal of IMAB, Vol 25, Iss 2, Pp 2532-

    2019  Volume 2536

    Abstract: Background: Salmonellosis, a disease which occurs following the consumption of food contaminated with salmonella, is most frequently present in young children and older immunocompromised individuals. This condition must be treated with antibiotics. The ... ...

    Abstract Background: Salmonellosis, a disease which occurs following the consumption of food contaminated with salmonella, is most frequently present in young children and older immunocompromised individuals. This condition must be treated with antibiotics. The increased degree of morbidity comes in relation to the increased resistance of Sallmonellae species to antibiotics. Resistance has considerably been increased in approximately the last twenty years, thanks mostly to the establishment of diagnoses ex juvantibus, the prescription of therapies without antimicrobial susceptibility/resistance testing, as well as the massive, unjustified usage of antibiotics. Purpose: The goal of this study was to examine the representation of antibiotic susceptibility/resistance of Salmonella species isolated in non-hospitalised patients. Materials and methods: In a microbiological laboratory in the Institute for Public Health Canton of Sarajevo (Bosnia and Herzegovina), analysed were samples of stool and urine of non-hospitalised patients with our without developed symptoms of salmonellosis in the period from one year. Results: Of the total 69 patients infected with salmonella, in 65 (94.2%) S. enteritidis group D was isolated, in 3 (4.3%) S. species group B, and in 1 (1.4%) patient there was a S. enteritidis group D and a S. species group C. Isolated strains were resistant to Ampicillin in 63 (91.3%) patients, while to Ciprofloxacin and Bactrim there was no established resistance. Conclusions: The most commonly isolated bacterial strain was S. enteritidis group D. Isolated strains show different susceptibility/resistance to tested antibiotics, and thus the completion of an antimicrobial susceptibility/resistance test is necessary before adding an antibiotic to the patient’s treatment.
    Keywords Salmonella species ; salmonellosis ; antimicrobial susceptibility test ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Peytchinski Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy

    Faruk Nisic / Nina Jovanovic / Milka Mavija / Emina Alimanovic-Halilovic / Aida Nisic / Orhan Lepara / Adem Cemerlic

    Archives of Medical Science, Vol 15, Iss 2, Pp 449-

    2019  Volume 456

    Abstract: Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically ...

    Abstract Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. A vitreous sample was obtained while performing the PPV procedure, using the Quantikine ELISA test to determine VEGF level, as a risk factor. Outcome measures were intraoperative and postoperative complications reported using categorical data: blunt and sharp dissection of membranes, intraoperative hemorrhage stopped by increasing infusion pressure, pressing with blunt instrument, or using diathermy. The following postoperative complications were assessed on the first day and at the 12-month follow-up visit: vitreous hemorrhage, fibrovascular proliferation (FVP), rubeosis iridis, and neovascular glaucoma (NVG). Results Levels of vitreous VEGF at the time of PPV were significantly higher in eyes with: vitreous hemorrhage on the first day after PPV (p = 0.003); FVP on the first day and 12 months after PPV (p = 0.002 and p < 0.001, respectively); iris rubeosis on the first day and 12 months after PPV surgery (p < 0.001, and p = 0.001, respectively); NVG on the first day and 12 months after PPV surgery (p = 0.043 and p = 0.011, respectively), compared to the eyes without complications. Conclusions Preoperative levels of VEGF in vitreous can be a useful biomarker and predictor of the postoperative outcome in terms of intraoperative and postoperative complications.
    Keywords vascular endothelial growth factor ; biomarker ; postoperative complications ; proliferative diabetic retinopathy ; pars plana vitrectomy ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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