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  1. Article ; Online: Increasing pediatric radiation oncology capacity in sub-saharan Africa using technology: a pilot of a pediatric radiation oncology virtual training course.

    Joseph, Adedayo O / Akinsete, Adeseye M / Ajose, Azeezat O / Oladipo, Aishat T / Maliki, Adeola / Akindele, Korede / Mangongolo, Michelle / Adeneye, Samuel / Ngwa, Wilfred

    BMC medical education

    2024  Volume 24, Issue 1, Page(s) 317

    Abstract: Background: The shortage of skilled healthcare professionals in pediatric oncology and the limited access to training programs remain significant challenges in Nigeria and sub-Saharan Africa. The the Pediatric Radiation Oncology (Virtual) Course, ' ... ...

    Abstract Background: The shortage of skilled healthcare professionals in pediatric oncology and the limited access to training programs remain significant challenges in Nigeria and sub-Saharan Africa. The the Pediatric Radiation Oncology (Virtual) Course, 'PedROC' project aims to contribute to improving pediatric cancer outcomes in Nigeria by increasing the capacity of radiation oncology professionals. To address the gap in access to pediatric radiation oncology professional development, the PedROC project was created, harnessing technology to improve radiation oncology training via a curriculum delivered through web-conferencing. This study aimed to evaluate the effectiveness of the PedROC pilot in enhancing the capacity, confidence, and skill of radiation oncologists in decision-making, prescribing, and treatment planning of radiotherapy for children diagnosed with cancer.
    Methods: A multidisciplinary faculty of specialists in radiation oncology, pediatric oncology, oncology nursing, radiation therapy technology, and medical physics collaborated to identify the key learning needs in pediatric radiation oncology in the country. The team collaborated to develop a comprehensive curriculum covering the most common pediatric cancers in sub-Saharan Africa for the training program. The training course was conducted over two days, delivering twenty-four half-hour sessions for a total of 12 h, from July 31 to August 01, 2021.
    Results: Analysis of pre and post - training surveys showed a significant increase in self-reported confidence measures across all domains among radiation oncologists. The program successfully improved participants' knowledge and confidence levels in managing common pediatric cancers using radiotherapy, particularly addressing radiotherapy-specific issues such as appropriate dose, target volume delineation, treatment planning, dose constraints, and plan evaluation.
    Conclusion: The PedROC pilot showed the efficacy of this model in enhancing the capacity and confidence of radiation oncology professionals involved in the treatment of pediatric cancer. The findings indicate that technology holds significant potential to increase pediatric radiation oncology capacity in Africa, ensuring improved access to proper treatment and ultimately improving pediatric cancer outcomes.
    MeSH term(s) Humans ; Child ; Radiation Oncology/education ; Medical Oncology/education ; Africa South of the Sahara ; Neoplasms/radiotherapy ; Curriculum
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-024-05313-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Landscape of Pediatric Radiation Oncology in Nigeria.

    Joseph, Adedayo / Akinsete, Adeseye M / Lasebikan, Nwamaka N / Adeneye, Samuel / Awofeso, Opeyemi M / Oladipo, Aishat T / Ajose, Azeezat O / Ojo, Oluwatimileyin / Merrell, Kenneth / Ngwa, Wilfred / Puthoff, David S / Onitilo, Adedayo A

    JCO global oncology

    2024  Volume 10, Page(s) e2300219

    Abstract: Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing ... ...

    Abstract Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing exposure to nearby organs at risk. These advances have led to improved treatment outcomes, increased survival, and reduced treatment-related toxicities. Advanced treatment techniques, however, require significant investment in infrastructural and personnel resources. This review documents what is currently available regarding expertise and infrastructure for pediatric radiation oncology practice in Nigeria. It was performed to serve as a foundation for the creation and design of tailored solutions (initiatives and policies) to increase pediatric radiation availability, accessibility, and equity in Nigeria and ultimately improve pediatric cancer treatment outcomes in the region.
    MeSH term(s) Humans ; Child ; Radiation Oncology ; Nigeria ; Neoplasms/radiotherapy ; Medical Oncology ; Treatment Outcome
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.23.00219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chest X-rays of newborns in a medical facility: variation between the entrance skin dose measurements using the indirect and direct methods for clinical dose audit.

    Omojola, Akintayo Daniel / Akpochafor, Michael Onoriode / Adeneye, Samuel Olaolu / Akala, Isiaka Olusola / Agboje, Azuka Anthonio

    Japanese journal of radiology

    2021  Volume 40, Issue 2, Page(s) 219–225

    Abstract: Purpose: This study aims to determine the mean and 75th percentile entrance skin dose (ESD: Materials and methods: The study determined the digital radiography (DR) X-ray machine output using a calibrated XR Multidetector (silicon photodiode). X-ray ... ...

    Abstract Purpose: This study aims to determine the mean and 75th percentile entrance skin dose (ESD
    Materials and methods: The study determined the digital radiography (DR) X-ray machine output using a calibrated XR Multidetector (silicon photodiode). X-ray machine milliampere-seconds (mAs), peak kilovoltage (kVp), focus to detector distance (FDD) and focus to skin distance (FSD) were used from a previous study. The mean kVp and mAs were 56.63 (52-60) and 5.7 (5-6.3) and the patient thickness was 9.5 (8-11.5) cm.
    Results: The mean ESDs of the newborn between 0 and 28 days were 0.67 ± 0.09 mGy, and the 75th percentile was 0.75 mGy. The effective dose (E) for the 40 patients was 0.19 mSv and the estimated prenatal cancer risk ranged from (5-24.7) 10
    Conclusion: The 75th percentile ESD was the highest compared to the American College of Radiology-American Association of Physicists in Medicine-Society for Pediatric Radiology (ACR-AAPM-SPR), European Commission (EC) and United Kingdom (UK) reports. Comparison of both methods for assessing ESD was within 40% as compared to other studies. Based on the above results, the indirect method can be implemented for clinical dose audit.
    MeSH term(s) Child ; Humans ; Infant, Newborn ; Radiation Dosage ; Radiographic Image Enhancement ; Radiography ; Skin ; X-Rays
    Language English
    Publishing date 2021-09-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-021-01193-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Feasibility and Safety of Implementing Volumetric Arc Therapy (VMAT) for Pediatric Craniospinal Irradiation in a Low-Middle-Income Region: The Nigerian Experience.

    Joseph, Adedayo / Akinsete, Adeseye / Adeneye, Samuel / Balogun, Onyinye / Awofeso, Opeyemi / Oladipo, Aishat / Ajose, Azeezat / Elhamamsi, Ibrahim / Merrell, Kenneth / Ngwa, Wilfred / Puthoff, David / Shour, Abdul R / Onitilo, Adedayo

    Advances in radiation oncology

    2023  Volume 9, Issue 2, Page(s) 101325

    Abstract: Purpose: Volumetric modulated arc therapy (VMAT) is a relatively new treatment technique in sub-Saharan Africa. Although craniospinal irradiation (CSI) in the pediatric population has been practiced in Nigeria for many years, the use of VMAT to deliver ... ...

    Abstract Purpose: Volumetric modulated arc therapy (VMAT) is a relatively new treatment technique in sub-Saharan Africa. Although craniospinal irradiation (CSI) in the pediatric population has been practiced in Nigeria for many years, the use of VMAT to deliver this treatment is previously undocumented. We reviewed the first set of patients to undergo CSI at a cancer center in Nigeria, detailing the treatment technique, the progress experienced, dose statistics achieved, treatment toxicities, and cancer outcomes to date.
    Methods and materials: This was a prospective case series of 5 children with histologically diagnosed cancers requiring CSI whose parents consented to the study. They were recruited at evaluation and followed through the process of their therapy. Toxicity was monitored at weekly review appointments using the Common Terminology Criteria for Adverse Events version 5.0. Follow-up of the children will continue in the long-term effects clinic.
    Results: Five patients with a median age of 6 were recruited. Diagnoses were intracranial germ cell tumor (n = 2), medulloblastoma (n = 1), pineoblastoma (n = 1), and ependymoma (n = 1). For all patients, a dose of 36.0 Gy in 1.8 Gy daily fractions was prescribed to the entire neuraxis. A subsequent boost of 18 Gy (n = 4) to 19.8 Gy (n = 1) in 10 daily fractions to the primary tumor bed (n = 2) and posterior fossa (n = 2) was delivered. Four patients had chemotherapy before, during, or after radiation therapy. No patient experienced grade 3 or greater toxicity.
    Conclusions: Our results indicate great progress has been made in the delivery of CSI in Nigeria, demonstrating tolerable acute side effects using VMAT. This series suggests the feasibility of implementing VMAT technology in low- or middle-income countries. Additional follow-up will be needed to determine whether survival rates and chronic toxicity rates are similar to those reported in the literature.
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Evaluation of Three-Dimensional Conformal Radiotherapy and Intensity Modulated Radiotherapy Techniques for Left Breast Post-Mastectomy Patients: Our Experience in Nigerian Sovereign Investment Authority-Lagos University Teaching Hospital Cancer Center, South-West Nigeria.

    Adeneye, Samuel / Akpochafor, Michael / Adegboyega, Bolanle / Alabi, Adewumi / Adedewe, Nusirat / Joseph, Adedayo / Fatiregun, Omolara / Omojola, Akintayo / Adebayo, Abe / Oluwadara, Esther

    European journal of breast health

    2021  Volume 17, Issue 3, Page(s) 247–252

    Abstract: Objective: This study aimed to evaluate the dosimetric properties of treatment plans obtained from three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy techniques (IMRT) plans for left chest wall breast cancer patients.! ...

    Abstract Objective: This study aimed to evaluate the dosimetric properties of treatment plans obtained from three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy techniques (IMRT) plans for left chest wall breast cancer patients.
    Materials and methods: A total of 20 patients with left-sided chest wall radiotherapy were randomly selected with the dose prescriptions: 42 Gy and 45 Gy in 15 and 18 fractions, respectively. Treatment plans were obtained using 3D-CRT and IMRT for each patient. Five to seven beams were used for IMRT, while tangential beams were used for 3D-CRT. Planning target volume, D
    Results: IMRT showed a significant improvement in HI compared to 3D-CRT (p<0.0001). Although there was no significant difference in sparing of the left lung between both plans for high-dose volumes (V20: 18.2 vs 30.55, p<0.0001), (V25: 11.17 vs 28.12, p<0.0001). IMRT however showed supremacy to 3D-CRT with high-dose volumes for the heart, including V20 (4.44 vs 10.29, p = 0.02), V25 (2.08 vs 8.94, p = 0.002). 3D-CRT was better than IMRT in low-dose volumes for left lung (V5: 92.23 vs 56.60, p<0.001; V10: 60.98 vs 47.20, p = 0.04) and heart (V5: 57.45 vs 30.39, p = 0.004).
    Conclusion: IMRT showed better homogeneity and sparing of high-dose volumes to OAR than 3D-CRT. On the other hand, 3D-CRT showed a reduction of low-dose volumes to OARs than IMRT.
    Language English
    Publishing date 2021-06-24
    Publishing country Turkey
    Document type Journal Article
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.4274/ejbh.galenos.2021.6357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Challenges and opportunities for implementing hypofractionated radiotherapy in Africa: lessons from the HypoAfrica clinical trial.

    Olatunji, Elizabeth / Swanson, William / Patel, Saloni / Adeneye, Samuel Olaolu / Aina-Tofolari, Funmilayo / Avery, Stephen / Kisukari, Jumaa Dachi / Graef, Katy / Huq, Saiful / Jeraj, Robert / Joseph, Adedayo O / Lehmann, Joerg / Li, Heng / Mallum, Abba / Mkhize, Thokozani / Ngoma, Twalib Athumani / Studen, Andrej / Wijesooriya, Krishni / Incrocci, Luca /
    Ngwa, Wilfred

    Ecancermedicalscience

    2023  Volume 17, Page(s) 1508

    Abstract: The rising cancer incidence and mortality in sub-Saharan Africa (SSA) warrants an increased focus on adopting or developing approaches that can significantly increase access to treatment in the region. One such approach recommended by the recent Lancet ... ...

    Abstract The rising cancer incidence and mortality in sub-Saharan Africa (SSA) warrants an increased focus on adopting or developing approaches that can significantly increase access to treatment in the region. One such approach recommended by the recent Lancet Oncology Commission for sub-Saharan Africa is hypofractionated radiotherapy (HFRT), which can substantially increase access to radiotherapy by reducing the overall duration of time (in days) each person spends being treated. Here we highlight challenges in adopting such an approach identified during the implementation of the HypoAfrica clinical trial. The HypoAfrica clinical trial is a longitudinal, multicentre study exploring the feasibility of applying HFRT for prostate cancer in SSA. This study has presented an opportunity for a pragmatic assessment of potential barriers and facilitators to adopting HFRT. Our results highlight three key challenges: quality assurance, study harmonisation and machine maintenance. We describe solutions employed to resolve these challenges and opportunities for longer term solutions that can facilitate scaling-up use of HFRT in SSA in clinical care and multicentre clinical trials. This report provides a valuable reference for the utilisation of radiotherapy approaches that increase access to treatment and the conduct of high-quality large-scale/multi-centre clinical trials involving radiotherapy.
    Trial registration: Not available yet.
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2023.1508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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