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  1. Article ; Online: Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors.

    Zhang, Wen / Sviripa, Vitaliy M / Xie, Yanqi / Yu, Tianxin / Haney, Meghan G / Blackburn, Jessica S / Adeniran, Charles A / Zhan, Chang-Guo / Watt, David S / Liu, Chunming

    iScience

    2020  Volume 23, Issue 12, Page(s) 101795

    Abstract: Aberrant activation of Wnt signaling triggered by mutations in ... ...

    Abstract Aberrant activation of Wnt signaling triggered by mutations in either
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2020.101795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice.

    Zhu, Jun / Quizon, Pamela M / Wang, Yingying / Adeniran, Charles A / Strauss, Matthew J / Jiménez-Torres, Ana C / Patel, Palak / Cirino, Thomas J / Eans, Shainnel O / Hammond, Haylee R / Deliscar, Laure S / O'Hara, Priscilla / Saini, Surendra K / Ofori, Edward / Vekariya, Rakesh H / Zhang, Sixue / Moukha-Chafiq, Omar / Nguyen, Theresa H / Ananthan, Subramaniam /
    Augelli-Szafran, Corinne E / Zhan, Chang-Guo / McLaughlin, Jay P

    Neuropharmacology

    2022  Volume 220, Page(s) 109239

    Abstract: Cocaine abuse increases the incidence of HIV-1-associated neurocognitive disorders. We have demonstrated that HIV-1 transactivator of transcription (Tat) allosterically modulates dopamine (DA) reuptake through the human DA transporter (hDAT), potentially ...

    Abstract Cocaine abuse increases the incidence of HIV-1-associated neurocognitive disorders. We have demonstrated that HIV-1 transactivator of transcription (Tat) allosterically modulates dopamine (DA) reuptake through the human DA transporter (hDAT), potentially contributing to Tat-induced cognitive impairment and potentiation of cocaine conditioned place preference (CPP). This study determined the effects of a novel allosteric modulator of DAT, SRI-32743, on the interactions of HIV-1 Tat, DA, cocaine, and [
    MeSH term(s) Animals ; Cocaine/metabolism ; Cocaine/pharmacology ; Cocaine-Related Disorders/drug therapy ; Cricetinae ; Cricetulus ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/genetics ; Doxycycline ; HIV-1 ; Humans ; Mice ; Mice, Transgenic ; Reward ; Trans-Activators ; Transcription Factor DP1/metabolism ; tat Gene Products, Human Immunodeficiency Virus/genetics
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; Trans-Activators ; Transcription Factor DP1 ; tat Gene Products, Human Immunodeficiency Virus ; Cocaine (I5Y540LHVR) ; Doxycycline (N12000U13O) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-09-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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