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  1. Book ; Conference proceedings: Ciba Foundation Discussion Meeting Non-Invasive Prenatal Diagnosis

    Adinolfi, M.

    20 October 1995, London

    1995  

    Title variant Non-invasive prenatal diagnosis
    Institution Ciba Foundation
    Event/congress Discussion Meeting Non-Invasive Prenatal Diagnosis (1995, London)
    Author's details guest eds.: M. Adinolfi
    Keywords Prenatal Diagnosis / congresses ; Blood Chemical Analysis / congresses
    Language English
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    Note In: Prenatal diagnosis. - ISSN 0197-3851. - 15 (1995),10, S. 889 - 965
    HBZ-ID HT006794816
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1625 -15- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Very High Resolution Projections over Italy under different CMIP5 IPCC scenarios.

    Raffa, Mario / Adinolfi, Marianna / Reder, Alfredo / Marras, Gian Franco / Mancini, Marco / Scipione, Gabriella / Santini, Monia / Mercogliano, Paola

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 238

    Abstract: This paper introduces VHR-PRO_IT (Very High-Resolution PROjections for ITaly), an open access hourly climate projection with a resolution of ≃2.2 km (i.e., Convection Permitting Scale) up to 2050, covering the Italian peninsula and some neighbouring ... ...

    Abstract This paper introduces VHR-PRO_IT (Very High-Resolution PROjections for ITaly), an open access hourly climate projection with a resolution of ≃2.2 km (i.e., Convection Permitting Scale) up to 2050, covering the Italian peninsula and some neighbouring areas. VHR-PRO_IT is produced within the Highlander project ( https://highlanderproject.eu/ ) by dynamically downscaling the Italy8km-CM climate projection (spatial resolution ≃8 km; output frequency = 6 h; driven CMIP5 GCM = CMCC-CM) with the Regional Climate Model COSMO-CLM under the IPCC RCP4.5 and RCP8.5 scenarios. It covers the 60-year period 1989-2050. VHR-PRO_IT is intended for research purposes in the field of climate studies. For example, it may be included in the ongoing activities to clarify the added value of running climate simulation at the convection-permitting scale.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02144-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sarcopenic obesity and its relation with muscle quality and mortality in patients on chronic hemodialysis.

    Sabatino, Alice / Avesani, Carla Maria / Regolisti, Giuseppe / Adinolfi, Marianna / Benigno, Giuseppe / Delsante, Marco / Fiaccadori, Enrico / Gandolfini, Ilaria

    Clinical nutrition (Edinburgh, Scotland)

    2023  Volume 42, Issue 8, Page(s) 1359–1368

    Abstract: Background & aims: Sarcopenia is prevalent in patients with end-stage kidney disease (ESKD) on hemodialysis (HD), and is associated with poor outcomes, while obesity may be protective. Sarcopenic obesity is associated with increased frailty, morbidity ... ...

    Abstract Background & aims: Sarcopenia is prevalent in patients with end-stage kidney disease (ESKD) on hemodialysis (HD), and is associated with poor outcomes, while obesity may be protective. Sarcopenic obesity is associated with increased frailty, morbidity and mortality in the general population. Myosteatosis, i.e., muscle fat infiltration, has major effects on muscle strength and physical performance, but is poorly investigated in the nephrology setting. In the present study we aimed to assess the association between sarcopenic obesity, as diagnosed by abdominal CT, and mortality. Moreover, the relationship between myosteatosis, sarcopenic obesity and mortality was also investigated.
    Methods: This is a retrospective study in which ESKD patients on HD submitted to unenhanced abdominal CT for clinical reasons at least 6 months after dialysis initiation were evaluated for sarcopenic obesity and myosteatosis, defined as intermuscular fat area and low attenuation muscle area. Sarcopenic obesity was diagnosed in cases of low abdominal skeletal muscle area and high total fat area. Receiver-operating characteristics (ROC) analysis with Youden index was used to determine the cut-off for high total fat area. Intermuscular fat area and low attenuation muscle area were evaluated by applying the Hounsfield unit of interest (-190; -30, and -29; +29 respectively). Cox regression analysis was used to evaluate the association between predictors and mortality risk.
    Results: We enrolled 212 patients, aged 68.8 (±14.7) years, 65.5% (139/212) male. Median follow-up was 19.7 (interquartile range [IQR] 2.7-35) months. Sarcopenic obesity was diagnosed in 19.8% of patients and was associated with increased mortality (HR: 3.29 (1.72; 6.27), P < 0.001), and with the presence of myosteatosis. Both intermuscular fat area and low attenuation muscle area were associated with increased mortality in adjusted analyses.
    Conclusions: Patients with sarcopenic obesity have increased myosteatosis. Sarcopenic obesity and myosteatosis are associated with increased mortality in patients on HD.
    MeSH term(s) Humans ; Male ; Sarcopenia/complications ; Sarcopenia/epidemiology ; Retrospective Studies ; Renal Dialysis ; Obesity/epidemiology ; Muscle, Skeletal/pathology
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2023.06.032
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  4. Book: Non-isotopic in situ hybridization

    Adinolfi, Matteo / Davies, Angela F.

    applications to clinical diagnosis and molecular genetics

    (Medical intelligence unit)

    1994  

    Author's details Matteo Adinolfi ; Angela F. Davies
    Series title Medical intelligence unit
    Keywords In Situ Hybridization ; DNA / diagnostic use ; Molecular Biology
    Language English
    Size 102 S. : Ill.
    Publisher Landes
    Publishing place Austin
    Publishing country United States
    Document type Book
    HBZ-ID HT006633114
    ISBN 1-879702-85-1 ; 978-1-879702-85-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2459 order for loan Magazin

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  5. Article: Ontogeny of human natural and acquired immunity.

    Adinolfi, M

    Current topics in microbiology and immunology

    1997  Volume 222, Page(s) 67–102

    MeSH term(s) Animals ; Antigen-Presenting Cells/cytology ; Antigen-Presenting Cells/immunology ; Complement System Proteins/immunology ; Female ; Fetus/immunology ; Humans ; Immune Tolerance ; Immunity, Innate ; Immunity, Maternally-Acquired ; Immunoglobulins/biosynthesis ; Immunoglobulins/immunology ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Pregnancy ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
    Chemical Substances Immunoglobulins ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 1997-08-01
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-60614-4_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Non- or minimally invasive prenatal diagnostic tests on maternal blood samples or transcervical cells.

    Adinolfi, M

    Prenatal diagnosis

    1995  Volume 15, Issue 10, Page(s) 889–896

    MeSH term(s) Female ; Fetal Diseases/diagnosis ; Fetus/cytology ; Humans ; Pregnancy ; Prenatal Diagnosis/methods
    Language English
    Publishing date 1995-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 82031-3
    ISSN 1097-0223 ; 0197-3851
    ISSN (online) 1097-0223
    ISSN 0197-3851
    DOI 10.1002/pd.1970151003
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    Zs.A 1625: Show issues Location:
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  7. Article: The artificial uterus.

    Adinolfi, Matteo

    Prenatal diagnosis

    2004  Volume 24, Issue 7, Page(s) 570–572

    MeSH term(s) Artificial Organs/utilization ; Female ; Humans ; Pregnancy ; Uterus
    Language English
    Publishing date 2004-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 82031-3
    ISSN 1097-0223 ; 0197-3851
    ISSN (online) 1097-0223
    ISSN 0197-3851
    DOI 10.1002/pd.800
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    Full text online

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  8. Article: Hunter syndrome: cloning of the gene, mutations and carrier detection.

    Adinolfi, M

    Developmental medicine and child neurology

    1993  Volume 35, Issue 1, Page(s) 79–85

    MeSH term(s) DNA, Recombinant/genetics ; Female ; Genetic Carrier Screening ; Genetic Therapy/trends ; Humans ; In Situ Hybridization ; Lysosomal Storage Diseases/complications ; Lysosomal Storage Diseases/genetics ; Male ; Mucopolysaccharidosis II/etiology ; Mucopolysaccharidosis II/genetics ; Mucopolysaccharidosis II/therapy
    Chemical Substances DNA, Recombinant
    Language English
    Publishing date 1993-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.1993.tb11557.x
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    Zs.B 5: Show issues Location:
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  9. Article: The maternal-fetal interaction: some controversies and solutions.

    Adinolfi, M

    Experimental and clinical immunogenetics

    1993  Volume 10, Issue 2, Page(s) 103–117

    Abstract: Recent studies have identified some of the mechanisms responsible for protecting the mammalian embryo against the potentially hostile immunological maternal environment. It is also apparent that these mechanisms vary at different stages of reproduction, ... ...

    Abstract Recent studies have identified some of the mechanisms responsible for protecting the mammalian embryo against the potentially hostile immunological maternal environment. It is also apparent that these mechanisms vary at different stages of reproduction, from fertilisation to implantation and to full development of the fetus. They are also unique since they vary from species to species and result from exceptional genetic and immunological processes. In this review, a few controversial topics have been selected for discussion. They include the role of suppressive factors and cells, the transfer of immunocompetent cells across the placenta, and claims that habitual recurrent abortion may result from the absence of a maternal immune response.
    MeSH term(s) Abortion, Habitual/immunology ; Animals ; Blastocyst/immunology ; Cell Movement ; Female ; Fertilization/immunology ; Fetus/immunology ; Humans ; Immune Tolerance ; Major Histocompatibility Complex/immunology ; Maternal-Fetal Exchange/immunology ; Mice/embryology ; Placenta/immunology ; Pregnancy/immunology ; Pregnancy, Animal/immunology
    Language English
    Publishing date 1993
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 605860-7
    ISSN 0254-9670
    ISSN 0254-9670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1997: Show issues Location:
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  10. Article ; Online: Relative Information Gain: Shannon entropy-based measure of the relative structural conservation in RNA alignments.

    Pietrosanto, Marco / Adinolfi, Marta / Guarracino, Andrea / Ferrè, Fabrizio / Ausiello, Gabriele / Vitale, Ilio / Helmer-Citterich, Manuela

    NAR genomics and bioinformatics

    2021  Volume 3, Issue 1, Page(s) lqab007

    Abstract: Structural characterization of RNAs is a dynamic field, offering many modelling possibilities. RNA secondary structure models are usually characterized by an encoding that depicts structural information of the molecule through string representations or ... ...

    Abstract Structural characterization of RNAs is a dynamic field, offering many modelling possibilities. RNA secondary structure models are usually characterized by an encoding that depicts structural information of the molecule through string representations or graphs. In this work, we provide a generalization of the BEAR encoding (a context-aware structural encoding we previously developed) by expanding the set of alignments used for the construction of substitution matrices and then applying it to secondary structure encodings ranging from fine-grained to more coarse-grained representations. We also introduce a re-interpretation of the Shannon Information applied on RNA alignments, proposing a new scoring metric, the Relative Information Gain (RIG). The RIG score is available for any position in an alignment, showing how different levels of detail encoded in the RNA representation can contribute differently to convey structural information. The approaches presented in this study can be used alongside state-of-the-art tools to synergistically gain insights into the structural elements that RNAs and RNA families are composed of. This additional information could potentially contribute to their improvement or increase the degree of confidence in the secondary structure of families and any set of aligned RNAs.
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Journal Article
    ISSN 2631-9268
    ISSN (online) 2631-9268
    DOI 10.1093/nargab/lqab007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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