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  1. Article ; Online: SARS-CoV-2 vaccines-induced thrombotic thrombocytopenia: should we consider immuno-hypersensitivity?

    Reuben, Rine Christopher / Adogo, Lillian Yami

    Revista de saude publica

    2021  Volume 55, Page(s) 70

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is significantly causing unprecedented clinical, socioeconomic, and public health challenges globally. The successful global administration of effective, safe and sustainable vaccine(s) is widely believed ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is significantly causing unprecedented clinical, socioeconomic, and public health challenges globally. The successful global administration of effective, safe and sustainable vaccine(s) is widely believed to be crucial in mitigating as well as preventing COVID-19. However, the rising cases of severe adverse events following immunization (AEFI) with COVID-19 vaccines including thrombosis, thrombocytopenia, and in some instances, death have created serious global concerns and could enormously contribute to vaccine hesitancy. Although the complete underlying pathophysiology and immunopathology of the COVID-19 vaccines related to AEFI, including thrombosis and/or anaphylaxis, are yet to be determined, exploring possible immuno-hypersensitivity could be crucial in the mechanisms associated with these reactions, thereby mitigating their occurrences as well as restoring confidence in vaccine administration for a COVID-19 free world.
    MeSH term(s) Brazil ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Thrombocytopenia ; Thrombosis ; Vaccines/adverse effects
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2021-10-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 732179-x
    ISSN 1518-8787 ; 0034-8910
    ISSN (online) 1518-8787
    ISSN 0034-8910
    DOI 10.11606/s1518-8787.2021055003855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Probiotics potentials in mitigating coronavirus disease (COVID-19) pandemic.

    Reuben, Rine Christopher / Makut, Makwin Danladi / Adogo, Lillian Yami

    The Pan African medical journal

    2021  Volume 38, Page(s) 186

    Abstract: Despite the adoption and use of different infection prevention and control measures, the coronavirus disease (COVID-19) pandemic keeps surging on with globally increasing morbidities and mortalities. The lack of a specific therapeutic intervention ... ...

    Abstract Despite the adoption and use of different infection prevention and control measures, the coronavirus disease (COVID-19) pandemic keeps surging on with globally increasing morbidities and mortalities. The lack of a specific therapeutic intervention against COVID-19 warrants the use of non-conventional potent alternatives. In recent times, probiotics have shown to mitigate numerous health challenges, including animal and human infectious diseases through competitive exclusion or antagonism of pathogens, modulation of host-microbiota, secretion of antimicrobial compounds and stimulation of immune responses. The presentation of COVID-19 as severe respiratory distress leading to gastrointestinal tract involvement could be mitigated through probiotics administration which beneficially modulates the microbiota and immune responses with an attendant reduction in morbidities, hence curtailing the COVID-19 pandemic.
    MeSH term(s) Animals ; COVID-19/complications ; COVID-19/immunology ; COVID-19/therapy ; Gastrointestinal Microbiome ; Humans ; Probiotics/administration & dosage ; Probiotics/pharmacology
    Language English
    Publishing date 2021-02-18
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2021.38.186.27953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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