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  1. Article ; Online: Uric acid transport, transporters, and their pharmacological targeting.

    Adomako, Emmanuel A / Moe, Orson W

    Acta physiologica (Oxford, England)

    2023  Volume 238, Issue 2, Page(s) e13980

    Abstract: Knowledge of uric acid (UA) crystallopathies preceded the identification of this compound. How the body handles and transports UA proved even more elusive. Over several decades, advances in molecular phenotyping have illuminated this hitherto nebulous ... ...

    Abstract Knowledge of uric acid (UA) crystallopathies preceded the identification of this compound. How the body handles and transports UA proved even more elusive. Over several decades, advances in molecular phenotyping have illuminated this hitherto nebulous field. Closely parallel to the characterization of the transport mechanisms of UA in the body was the development of drugs designed to manipulate UA levels. In this review, we highlight the study of UA transport and transporters. This is an evolving field, and we expect our knowledge of the transport mechanisms to both widen and deepen further. We focus on the best-characterized transporters rather than an exhaustive catalog of all suspected transporters. We review the established and novel compounds that modulate UA transport.
    MeSH term(s) Uric Acid ; Membrane Transport Proteins ; Glucose Transport Proteins, Facilitative
    Chemical Substances Uric Acid (268B43MJ25) ; Membrane Transport Proteins ; Glucose Transport Proteins, Facilitative
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs 229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Magnesium Disorders: Core Curriculum 2024.

    Adomako, Emmanuel A / Yu, Alan S L

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2024  

    Abstract: Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the ... ...

    Abstract Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia is common and often goes undiagnosed. This is in spite of epidemiologic data linking low magnesium with chronic diseases including diabetes mellitus. Clinically significant hypermagnesemia is encountered less frequently, but the presentation may be dramatic. Advances in molecular biology and the elucidation of the genetic causes of magnesium disorders have enhanced our understanding of their pathophysiology. Treatment approaches are also changing. The repurposing of newer medications, such as sodium/glucose cotransporter 2 inhibitors, offers new therapeutic options. In this review we integrate knowledge in this rapidly evolving field to provide clinicians and trainees with a resource for approaching common clinical scenarios involving magnesium disorders.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 468: Show issues

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  3. Article ; Online: Type 4 renal tubular acidosis and uric acid nephrolithiasis: two faces of the same coin?

    Adomako, Emmanuel A / Maalouf, Naim M

    Current opinion in nephrology and hypertension

    2022  Volume 32, Issue 2, Page(s) 145–152

    Abstract: Purpose of review: The present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally ... ...

    Abstract Purpose of review: The present review summarizes findings of recent studies examining the epidemiology, pathophysiology, and treatment of type 4 renal tubular acidosis (RTA) and uric acid nephrolithiasis, two conditions characterized by an abnormally acidic urine.
    Recent findings: Both type 4 RTA and uric acid nephrolithiasis disproportionately occur in patients with type 2 diabetes and/or chronic kidney disease. Biochemically, both conditions are associated with reduced renal ammonium excretion resulting in impaired urinary buffering and low urine pH. Reduced ammoniagenesis is postulated to result from hyperkalemia in type 4 RTA and from insulin resistance and fat accumulation in the renal proximal tubule in uric acid nephrolithiasis. The typical biochemical findings of hyperkalemia and systemic acidosis of type 4 RTA are rarely reported in uric acid stone formers. Additional clinical differences between the two conditions include findings of higher urinary uric acid excretion and consequent urinary uric acid supersaturation in uric acid stone formers but not in type 4 RTA.
    Summary: Type 4 RTA and uric acid nephrolithiasis share several epidemiological, clinical, and biochemical features. Although both conditions may be manifestations of diabetes mellitus and thus have a large at-risk population, the means to the shared biochemical finding of overly acidic urine are different. This difference in pathophysiology may explain the dissimilarity in the prevalence of kidney stone formation.
    MeSH term(s) Humans ; Uric Acid ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Acidosis, Renal Tubular/epidemiology ; Acidosis, Renal Tubular/complications ; Hyperkalemia ; Hydrogen-Ion Concentration ; Kidney Calculi/complications ; Nephrolithiasis/epidemiology
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Challenges in diuretic therapy: A case-based discussion.

    Adomako, Emmanuel A / Sambandam, Kamalanathan K

    The American journal of the medical sciences

    2022  Volume 364, Issue 4, Page(s) 386–393

    Abstract: Diuretics are amongst the most prescribed medications in both the inpatient and outpatient settings. They are used extensively in diverse disease states including heart failure, acute and chronic kidney disease, cirrhosis, and diseases of excess ... ...

    Abstract Diuretics are amongst the most prescribed medications in both the inpatient and outpatient settings. They are used extensively in diverse disease states including heart failure, acute and chronic kidney disease, cirrhosis, and diseases of excess capillary permeability such as sepsis, malignancy, and malnutrition. All are characterized by total body sodium overabundance which commonly manifests as edema. The use of diuretics is however not bereft of complications. These complications frequently limit the correction of hypervolemia, resulting in continued patient suffering and frustration for the clinician. In this review, we employ a case-based approach to discuss three common challenges encountered during diuretic therapy: diuretic resistance that characterizes the nephrotic syndrome, diuretic-induced metabolic alkalosis, and diuretic-associated hyponatremia. We empower the clinician to effectively meet these challenges by providing a mechanistic understanding of these complications and their solutions.
    MeSH term(s) Diuretics/adverse effects ; Edema ; Heart Failure/complications ; Heart Failure/drug therapy ; Humans ; Hyponatremia/drug therapy ; Sodium
    Chemical Substances Diuretics ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2022.04.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.2/10: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Urine pH and Citrate as Predictors of Calcium Phosphate Stone Formation.

    Adomako, Emmanuel A / Li, Xilong / Sakhaee, Khashayar / Moe, Orson W / Maalouf, Naim M

    Kidney360

    2023  Volume 4, Issue 8, Page(s) 1123–1129

    MeSH term(s) Citric Acid ; Phosphates ; Citrates ; Calcium Phosphates ; Hydrogen-Ion Concentration
    Chemical Substances Citric Acid (2968PHW8QP) ; Phosphates ; Citrates ; calcium phosphate (97Z1WI3NDX) ; Calcium Phosphates
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Collapsing Glomerulopathy Associated With Hydrophilic Polymer Emboli.

    Kudose, Satoru / Adomako, Emmanuel A / D'Agati, Vivette D / Santoriello, Dominick

    Kidney international reports

    2018  Volume 4, Issue 4, Page(s) 619–623

    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2018.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Idiopathic Hypokalemia in Lupus Nephritis: A Newly Recognized Entity.

    Adomako, Emmanuel A / Bilal, Saira / Liu, Yu-Lun / Malik, Ayesha / Van Buren, Peter N / Shastri, Shani / Sambandam, Kamalanathan K

    Kidney360

    2021  Volume 2, Issue 10, Page(s) 1553–1559

    Abstract: Background: Various causes of hypokalemia (HK) from renal potassium wasting, including distal renal tubular acidosis (RTA), have been described in lupus nephritis (LN). We report a phenomenon of otherwise unexplained HK among a population with LN.: ... ...

    Abstract Background: Various causes of hypokalemia (HK) from renal potassium wasting, including distal renal tubular acidosis (RTA), have been described in lupus nephritis (LN). We report a phenomenon of otherwise unexplained HK among a population with LN.
    Methods: From our population of 403 patients with LN, we identified a cohort of 20 patients with idiopathic HK, defined by serum potassium <3.5 mmol/L without any apparent explanation. This cohort is compared with 90 LN controls (CON) and ten patients with LN with distal RTA from the same population.
    Results: The patients with HK had lower median serum potassium compared with CON and RTA subjects (3.26 versus 4.00 versus 3.75 mmol/L, respectively;
    Conclusions: A syndrome of idiopathic HK was revealed in 20 out of 403 (5%) of patients within our LN population, and proved to be distinct from the RTA that occurs in LN. Furthermore, it was associated with a distinct pattern of autoantibodies. We speculate that idiopathic HK is the result of a novel target of autoimmunity in LN, affecting renal tubular potassium transport.
    MeSH term(s) Acidosis, Renal Tubular/complications ; Bicarbonates ; Humans ; Hypokalemia/etiology ; Lupus Nephritis/complications ; Potassium
    Chemical Substances Bicarbonates ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0004352021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Safe use of NSAIDs and RAS-inhibitors at Agogo Presbyterian Hospital, Ghana.

    Meulendijks, Lieke G / Adomako, Emmanuel A / Appiah, Emmanuel B / Kramers, Cornelis

    Ghana medical journal

    2016  Volume 50, Issue 1, Page(s) 22–30

    Abstract: Background: Preventable adverse events of medication are an important cause of hospital admissions in the developed world, in which non-steroidal anti-inflammatory drugs (NSAIDs) and renin-angiotensin system (RAS-) inhibitors are frequently involved. ... ...

    Abstract Background: Preventable adverse events of medication are an important cause of hospital admissions in the developed world, in which non-steroidal anti-inflammatory drugs (NSAIDs) and renin-angiotensin system (RAS-) inhibitors are frequently involved. NSAIDs and RAS-inhibitors are also often used in Ghana. The purpose of this study is to assess whether biochemical monitoring in patients on RAS-inhibitors, and co-administration of gastro protective agents (GPAs) in patients on NSAIDs, is done properly in Ghana.
    Material and methods: Two retrospective cross-sectional studies were carried out at the Agogo Presbyterian Hospital, Ghana, in 2013. In 114 out-and inpatients who are on NSAIDs, the risk for gastrointestinal side effects and the frequency of co-administration of GPAs were determined. In 301 outpatients who are on RAS-inhibitors, the risk for renal dysfunction and the frequency of biochemical monitoring were determined. Fisher's exact test was used to determine the statistical strength.
    Results: Co-administration of GPAs was done in 1.8% of patients on NSAIDs. Serum creatinine and potassium monitoring within one month after initiation of treatment with RAS-inhibitors were performed in 6.3% and 3.7%, respectively. Risk factors were neither associated with prescription of a GPA in patients on NSAIDs (p=0.134), nor in performing biochemical monitoring in patients on RAS-inhibitors (p=0.219 for creatinine, p=0.062 for potassium).
    Conclusions: Biochemical monitoring in patients on RAS-inhibitors and use of GPAs in patients on NSAIDs is poorly performed at the Agogo Presbyterian Hospital in Ghana. Improving the already existing Ghanaian guidelines, especially those for RAS-inhibitors, and encouraging their widespread use among prescribers should be pursued.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Ulcer Agents/adverse effects ; Creatinine/blood ; Cross-Sectional Studies ; Drug Monitoring/statistics & numerical data ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Female ; Ghana ; Hospitals ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Young Adult
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2016-09-08
    Publishing country Ghana
    Document type Journal Article
    ISSN 2616-163X
    ISSN (online) 2616-163X
    DOI 10.4314/gmj.v50i1.4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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