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  1. AU="Adotti, Valentina"
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  1. Article ; Online: Intrahepatic splenosis mimicking hepatocellular carcinoma.

    Rosi, Martina / Adotti, Valentina / Citone, Michele / Marra, Fabio

    United European gastroenterology journal

    2024  Volume 12, Issue 3, Page(s) 412–414

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Splenosis/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Trichobezoar causing gastric outlet obstruction in a patient with trichotillomania.

    Adotti, Valentina / Rosi, Martina / Prosperi, Paolo / Vizzutti, Francesco

    United European gastroenterology journal

    2023  Volume 11, Issue 5, Page(s) 482–483

    MeSH term(s) Humans ; Trichotillomania/complications ; Trichotillomania/diagnosis ; Bezoars/diagnosis ; Bezoars/diagnostic imaging ; Gastric Outlet Obstruction/diagnosis ; Gastric Outlet Obstruction/etiology ; Gastric Outlet Obstruction/surgery
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Management of a complex transjugular intrahepatic portosystemic shunt dysfunction with endotipsitis through rotational thrombectomy.

    Vizzutti, Francesco / Casamassima, Emanuele / Falcone, Gianmarco / Gabbani, Giacomo / Rosi, Martina / Adotti, Valentina / Marra, Fabio / Fanelli, Fabrizio

    BJR case reports

    2024  Volume 10, Issue 1, Page(s) uaae005

    Abstract: Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS ... ...

    Abstract Transjugular intrahepatic portosystemic shunting (TIPS) is an established strategy for the management of complications of portal hypertension. Endoprosthetic infection ("endotipsitis") is a rare but serious and difficult-to-treat complication of TIPS placement. Here we report the occurrence of an infected thrombus complicating TIPS placement in a patient with extra-hepatic portal vein obstruction, recurrent variceal bleeding and portal biliopathy accompanied by recurrent cholangitis. Infected thrombotic material within TIPS could be removed only by employing rotational thrombectomy. This procedure revealed the presence of a biliary fistula which carried pathogens in the systemic circulation. The multiple episodes of sepsis did no longer recur following exclusion of the biliary fistula. This case highlights the possibility to use rotational thrombectomy for the management of complex cases of TIPS dysfunction.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Case Reports
    ISSN 2055-7159
    ISSN (online) 2055-7159
    DOI 10.1093/bjrcr/uaae005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Episodic overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis.

    Nardelli, Silvia / Riggio, Oliviero / Marra, Fabio / Gioia, Stefania / Saltini, Dario / Bellafante, Daniele / Adotti, Valentina / Guasconi, Tomas / Ridola, Lorenzo / Rosi, Martina / Caporali, Cristian / Fanelli, Fabrizio / Roccarina, Davide / Bianchini, Marcello / Indulti, Federica / Spagnoli, Alessandra / Merli, Manuela / Vizzutti, Francesco / Schepis, Filippo

    Journal of hepatology

    2023  Volume 80, Issue 4, Page(s) 596–602

    Abstract: Background & aims: Overt hepatic encephalopathy (OHE) is a major complication of transjugular intrahepatic portosystemic shunt (TIPS) placement, given its high incidence and possibility of refractoriness to medical treatment. Nevertheless, the impact of ...

    Abstract Background & aims: Overt hepatic encephalopathy (OHE) is a major complication of transjugular intrahepatic portosystemic shunt (TIPS) placement, given its high incidence and possibility of refractoriness to medical treatment. Nevertheless, the impact of post-TIPS OHE on mortality has not been investigated in a large population.
    Methods: We designed a multicenter, non-inferiority, observational study to evaluate the mortality rate at 30 months in patients with and without OHE after TIPS. We analyzed a database of 614 patients who underwent TIPS in three Italian centers and estimated the cumulative incidence of OHE and mortality with competitive risk analyses, setting the non-inferiority limit at 0.12.
    Results: During a median follow-up of 30 months (IQR 12-30), 293 patients developed at least one episode of OHE. Twenty-seven (9.2%) of them experienced recurrent/persistent OHE. Patients with OHE were older (64 [57-71] vs. 59 [50-67] years, p <0.001), had lower albumin (3.1 [2.8-3.5] vs. 3.25 [2.9-3.6] g/dl, p = 0.023), and had a higher prevalence of pre-TIPS OHE (15.4% vs. 9.0%, p = 0.023). Child-Pugh and MELD scores were similar. The 30-month difference in mortality between patients with and without post-TIPS OHE was 0.03 (95% CI -0.042 to 0.102). Multivariable analysis showed that age (subdistribution hazard ratio 1.04, 95% CI 1.02-1.05, p <0.001) and MELD score (subdistribution hazard ratio 1.09, 95% CI 1.05-1.13, p <0.001), but not post-TIPS OHE, were associated with a higher mortality rate. Similar results were obtained when patients undergoing TIPS for variceal re-bleeding prophylaxis (n = 356) or refractory ascites (n = 258) were analyzed separately. The proportion of patients with persistent OHE after TIPS was significantly higher in the group of patients who died. The robustness of these results was increased following propensity score matching.
    Conclusion: Episodic OHE after TIPS is not associated with mortality in patients undergoing TIPS, regardless of the indication.
    Impact and implications: Overt hepatic encephalopathy (OHE) is a common complication in patients with advanced liver disease and it is particularly frequent following transjugular intrahepatic portosystemic shunt (TIPS) placement. In patients with cirrhosis outside the setting of TIPS, the development of OHE negatively impacts survival, regardless of the severity of cirrhosis or the presence of acute-on-chronic liver failure. In this multicenter, non-inferiority, observational study we demonstrated that post-TIPS OHE does not increase the risk of mortality in patients undergoing TIPS, irrespective of the indication. This finding alleviates concerns regarding the weight of this complication after TIPS. Intensive research to improve patient selection and risk stratification remains crucial to enhance the quality of life of patients and caregivers and to avoid undermining the positive effects of TIPS on survival.
    MeSH term(s) Humans ; Hepatic Encephalopathy/epidemiology ; Hepatic Encephalopathy/etiology ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Quality of Life ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Hemorrhage/etiology ; Treatment Outcome ; Gastrointestinal Hemorrhage/etiology ; Esophageal and Gastric Varices/etiology
    Language English
    Publishing date 2023-12-13
    Publishing country Netherlands
    Document type Multicenter Study ; Observational Study ; Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.11.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Dynamics of endothelial progenitor cells in patients with advanced hepatocellular carcinoma.

    Campani, Claudia / Capone, Manuela / Liotta, Francesco / Arena, Umberto / Adotti, Valentina / Di Bonaventura, Chiara / Aburas, Sami / Colagrande, Stefano / Calistri, Linda / Annunziato, Francesco / Marra, Fabio

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2021  Volume 54, Issue 7, Page(s) 911–917

    Abstract: Background and aims: Circulating endothelial progenitor cells (EPC) predict tumor vascularization and disease progression, but limited information is available on their dynamics in hepatocellular carcinoma (HCC) undergoing systemic treatment.: Methods! ...

    Abstract Background and aims: Circulating endothelial progenitor cells (EPC) predict tumor vascularization and disease progression, but limited information is available on their dynamics in hepatocellular carcinoma (HCC) undergoing systemic treatment.
    Methods: We prospectively analyzed different populations of EPC in 16 patients with advanced HCC receiving sorafenib. Patients were studied before therapy (T0, n = 16) and after two (T2, n = 12) and eight weeks (T8, n = 8), using high-performance flow-cytometry. The tumor response at T8 was categorized as progressive disease (PD) or clinical benefit (CB, all other responses).
    Results: At T0, higher levels of CD34
    Conclusion: In patients with advanced HCC, EPC are directly correlated with platelet count, suggesting a common activation of selected bone marrow pathways. Levels of a CD34
    MeSH term(s) Antigens, CD34 ; Biomarkers/metabolism ; Carcinoma, Hepatocellular ; Endothelial Progenitor Cells/metabolism ; Flow Cytometry ; Humans ; Liver Neoplasms/drug therapy ; Sorafenib
    Chemical Substances Antigens, CD34 ; Biomarkers ; Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2021-12-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2021.11.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Evaluating the best treatment for multifocal hepatocellular carcinoma: A propensity score-matched analysis.

    Risaliti, Matteo / Bartolini, Ilenia / Campani, Claudia / Arena, Umberto / Xodo, Carlotta / Adotti, Valentina / Rosi, Martina / Taddei, Antonio / Muiesan, Paolo / Amedei, Amedeo / Batignani, Giacomo / Marra, Fabio

    World journal of gastroenterology

    2011  Volume 28, Issue 29, Page(s) 3981–3993

    Abstract: Background: Hepatocellular carcinoma (HCC) is a common tumour often diagnosed with a multifocal presentation. Patients with multifocal HCC represent a heterogeneous group. Although Trans-Arterial ChemoEmbolization (TACE) is the most frequently employed ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) is a common tumour often diagnosed with a multifocal presentation. Patients with multifocal HCC represent a heterogeneous group. Although Trans-Arterial ChemoEmbolization (TACE) is the most frequently employed treatment for these patients, previous data suggested that liver resection (LR) could be a safe and effective procedure.
    Aim: To compare LR and TACE in patients with multifocal HCC in terms of procedure-related morbidity and oncologic outcomes.
    Methods: All patients with multifocal HCC who underwent LR or TACE as the first procedure between May 2011 and March 2021 were enrolled. The decision to perform surgery or TACE was made after a multidisciplinary team evaluation. Only patients in Child-Pugh class A or B7 and stage B (according to the Barcelona Clinic Liver Cancer staging system, without severe portal hypertension, vascular invasion, or extrahepatic spread) were included in the final analysis. Propensity score matching was used to adjust the baseline differences between patients undergoing LR and the TACE group [number and diameter of lesions, presence of cirrhosis, alpha-fetoprotein (AFP) levels, and Model for End-Stage Liver Disease score]. The Kaplan-Meier method was used to estimate overall survival (OS) and disease-free survival (DFS). The outcomes of LR and TACE were compared using the log-rank test.
    Results: After matching, 30 patients were eligible for the final analysis, 15 in each group. Morbidity rates were 42.9% and 40% for LR and TACE, respectively (
    Conclusion: In a small cohort of patients with multifocal HCC, LR confers longer DFS compared with TACE, with similar OS and post-procedural morbidity.
    MeSH term(s) Carcinoma, Hepatocellular/pathology ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; End Stage Liver Disease/surgery ; Hepatectomy/adverse effects ; Humans ; Liver Neoplasms/pathology ; Propensity Score ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; alpha-Fetoproteins
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2011-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i29.3981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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