Article ; Online: Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?
2021 Volume 20, Issue 4, Page(s) 669–678
Abstract: Purpose: This study aims to elaborate on the current knowledge concerning the mechanism, frequency, clinical manifestations, diagnostic procedures, prevention, and management of radioactive iodine (RAI)-induced sialadenitis in patients receiving ... ...
| Abstract | Purpose: This study aims to elaborate on the current knowledge concerning the mechanism, frequency, clinical manifestations, diagnostic procedures, prevention, and management of radioactive iodine (RAI)-induced sialadenitis in patients receiving treatment for differentiated thyroid cancer (DTC). Methods: A review of the literature was carried out through the " www.ncbi.nlm.nih.gov/pubmed " database focusing on the results of the past decade. Results: The high concentration of RAI in the salivary glands results in high beta radiation exposure of the striated duct cells and stem cells. This exposure leads to acute and/or chronic sialadenitis with obstructive symptoms and progressive loss of salivary gland function and xerostomia, with severe impact on patients' quality of life. No standard diagnostic method has been established. As far as prevention is concerned, many approaches have been proposed, such as sialogogues, local massage, vitamin E, and amifostine administration. Although there is no unanimity as to their effectiveness, the use of sialogogues is recommended. Treatment includes conservative drug therapy and sialendoscopy when necessary. Conclusion: RAI-induced sialadenitis has a major impact on patients' quality of life. Due to the good prognosis of DTC, the reduction of sialadenitis and its prognosis, prevention, and treatment constitute a priority for the overall treatment of these patients. Further studies that will establish a coherent treatment protocol for this condition are necessary. |
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| MeSH term(s) | Humans ; Iodine Radioisotopes/adverse effects ; Quality of Life ; Radiotherapy/adverse effects ; Salivary Glands ; Sialadenitis/etiology ; Thyroid Neoplasms/radiotherapy | |||||
| Chemical Substances | Iodine Radioisotopes | |||||
| Language | English | |||||
| Publishing date | 2021-06-18 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2075912-5 | |||||
| ISSN | 2520-8721 ; 1109-3099 | |||||
| ISSN (online) | 2520-8721 | |||||
| ISSN | 1109-3099 | |||||
| DOI | 10.1007/s42000-021-00304-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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