Article ; Online: Increased susceptibility to azithromycin of Pseudomonas aeruginosa biofilms using RPMI 1640 testing media.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
2024
Abstract: Azithromycin (AZM) is efficient for treatment of chronic Pseudomonas aeruginosa biofilm lung infections, despite of resistance in conventional susceptibility testing. It has been shown that planktonic P. aeruginosa are more susceptible to AZM when tested ...
Abstract | Azithromycin (AZM) is efficient for treatment of chronic Pseudomonas aeruginosa biofilm lung infections, despite of resistance in conventional susceptibility testing. It has been shown that planktonic P. aeruginosa are more susceptible to AZM when tested in RPMI 1640 medium. The aim of the study was to test the susceptibility to AZM of P. aeruginosa biofilms in LB vs RPMI 1640 media. We investigated the effect of AZM on planktonic and biofilms of (WT) P. aeruginosa (PAO1), the hypermutable (ΔmutS) and the antibiotic-resistant phenotype(ΔnfxB) mutants. The effect of AZM on young and mature biofilms was investigated in the modified Calgary Biofilm Device by estimation of the minimal biofilm inhibitory concentration (MBIC). The AZM MBIC |
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Language | English |
Publishing date | 2024-04-15 |
Publishing country | Denmark |
Document type | Journal Article |
ZDB-ID | 93340-5 |
ISSN | 1600-0463 ; 0903-4641 |
ISSN (online) | 1600-0463 |
ISSN | 0903-4641 |
DOI | 10.1111/apm.13413 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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