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Article ; Online: The use of minoxidil in diseases associated with hair loss

Alina Graczyk / Anna Waśkiel-Burnat / Adriana Rakowska / Lidia Rudnicka

Przegląd Dermatologiczny, Vol 109, Iss 6, Pp 437-

2023 Volume 452

Abstract: Minoxidil is a drug with a hypotensive effect. It was introduced in the 1970s in the treatment of hypertension. This drug is characterized by a multifaceted mechanism of action – including a vasodilatory effect, probably through the activation of the ATP- ...

Abstract	Minoxidil is a drug with a hypotensive effect. It was introduced in the 1970s in the treatment of hypertension. This drug is characterized by a multifaceted mechanism of action – including a vasodilatory effect, probably through the activation of the ATP-sensitive potassium channels in vascular smooth muscle cells. Hypertrichosis was observed in patients treated with minoxidil, which prompted research into the possibility of applying this drug to diseases associated with alopecia. The first attempts were unsuccessful due to side effects associated with its hypotensive effect. Introduction of local treatment, and in recent years also methods of oral treatment with low doses of minoxidil, has allowed it to achieve a good therapeutic effect without a significant risk of side effects. In dermatology, the effect of minoxidil associated with stimulation of the onset and prolongation of the anagen phase is used. Minoxidil is available in the form of 2% and 5% solutions, 5% foam and in the form of compound drug for either topical or oral treatment. Side effects are present in 15–20% of patients and in most cases, they do not lead to discontinuation of the treatment. The most common side effects of topical preparations include itching, erythema, and scaling, while in the oral form, hypertrichosis of the facial skin, dizziness, and swelling of the lower limbs are most often observed.
Keywords	treatment of hair diseases ; androgenetic alopecia ; telogen effluvium ; alopecia areata ; Medicine ; R ; Dermatology ; RL1-803
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quiz dermatologiczny

Anna Waśkiel-Burnat / Adriana Rakowska / Małgorzata Olszewska / Lidia Rudnicka

Przegląd Dermatologiczny, Vol 109, Iss 5, Pp 394-

2023 Volume 395

Keywords	Medicine ; R ; Dermatology ; RL1-803
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treatment of diseases associated with cicatricial alopecia

Lidia Rudnicka / Agnieszka Kaczorowska / Anna Waśkiel-Burnat / Adriana Rakowska / Małgorzata Olszewska

Przegląd Dermatologiczny, Vol 109, Iss 1, Pp 32-

2022 Volume 42

Abstract: Cicatricial (scarring) alopecia may result from perifollicular inflammation that destroys hair follicles and replaces them with connective tissue (primary cicatricial alopecia) or from damage done to follicles by other pathology that is not primarily ... ...

Abstract	Cicatricial (scarring) alopecia may result from perifollicular inflammation that destroys hair follicles and replaces them with connective tissue (primary cicatricial alopecia) or from damage done to follicles by other pathology that is not primarily directed against follicles (secondary cicatricial alopecia). Examples of such pathologies are: cutaneous tuberculosis, favus, morphea en coup de sabre. Hair follicle atrophy with clinical, trichoscopic and histological features of follicular drop out can also occur in the very late stage of non-cicatricial alopecia (e.g. androgenetic alopecia, alopecia areata). The fourth group of diseases with a similar clinical and sometimes also similar trichoscopic presentation, but of significantly different histology, is alopecia associated with neoplastic diseases (alopecia neoplastica). In this article, basic information about therapeutic methods that can be applied in selected diseases associated with cicatricial alopecia, with particular emphasis on primary cicatricial alopecia, has been summarized.
Keywords	treatment of cicatricial alopecia ; cicatricial alopecia ; hair diseases ; Medicine ; R ; Dermatology ; RL1-803
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quiz dermatologiczny

Adriana Rakowska / Marta Kurzeja / Magdalena Jasińska / Olga Warszawik-Hendzel / Lidia Rudnicka

Przegląd Dermatologiczny, Vol 108, Iss 6, Pp 570-

2022 Volume 571

Keywords	Medicine ; R ; Dermatology ; RL1-803
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lipocalin-2 and insulin as new biomarkers of alopecia areata.

Anna Waśkiel-Burnat / Anna Niemczyk / Paulina Chmielińska / Marta Muszel / Michał Zaremba / Adriana Rakowska / Małgorzata Olszewska / Lidia Rudnicka

PLoS ONE, Vol 17, Iss 5, p e

2022 Volume 0268086

Abstract: Lipocalin-2 and visfatin are proinflammatory adipokines involved in the regulation of glucose homeostasis. Their role has been described in numerous inflammatory skin diseases such as atopic dermatitis and psoriasis. Recently, an increased prevalence of ... ...

Abstract	Lipocalin-2 and visfatin are proinflammatory adipokines involved in the regulation of glucose homeostasis. Their role has been described in numerous inflammatory skin diseases such as atopic dermatitis and psoriasis. Recently, an increased prevalence of metabolic abnormalities has been reported in patients with alopecia areata. The aim of the study is to determine the serum levels of lipocalin-2 and visfatin in patients with alopecia areata in comparison with healthy controls. Moreover, the serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), triglycerides, fasting glucose, insulin, c-peptide, and homeostasis model assessment for insulin resistance (HOMA-IR) were evaluated. Fifty-two patients with alopecia areata and 17 control subjects were enrolled in the study. The serum levels of lipocalin-2 [mean ± standard deviation, SD: 224.55 ± 53.58 ng/ml vs. 188.64 ± 44.75, p = 0.01], insulin [median (interquartile range, IQR): 6.85 (4.7-9.8) μIU/ml vs. 4.5 (3.5-6.6), p<0.05], c-peptide [median (IQR): 1.63 (1.23-2.36) ng/ml vs. 1.37 (1.1-1.58), p<0.05)], and HOMA-IR [median (IQR): 1.44 (0.98-2.15) vs. 0.92 (0.79-1.44), p<0.05) were significantly higher in patients with alopecia areata compared to the controls. The serum concentration of insulin and HOMA-IR correlated with the number of hair loss episodes (r = 0.300, p<0.05 and r = 0.322, p<0.05, respectively). Moreover, a positive correlation occurred between insulin, HOMA-IR, c-peptide and BMI (r = 0.436, p <0.05; r = 0.384, p<0.05 and r = 0.450, p<0.05, respectively). In conclusion, lipocalin-2 and insulin may serve as biomarkers for alopecia areata. Further studies are needed to evaluate the role of insulin as a prognostic factor in alopecia areata.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lipocalin-2 and insulin as new biomarkers of alopecia areata

Anna Waśkiel-Burnat / Anna Niemczyk / Paulina Chmielińska / Marta Muszel / Michał Zaremba / Adriana Rakowska / Małgorzata Olszewska / Lidia Rudnicka

PLoS ONE, Vol 17, Iss

2022 Volume 5

Abstract	Lipocalin-2 and visfatin are proinflammatory adipokines involved in the regulation of glucose homeostasis. Their role has been described in numerous inflammatory skin diseases such as atopic dermatitis and psoriasis. Recently, an increased prevalence of metabolic abnormalities has been reported in patients with alopecia areata. The aim of the study is to determine the serum levels of lipocalin-2 and visfatin in patients with alopecia areata in comparison with healthy controls. Moreover, the serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), triglycerides, fasting glucose, insulin, c-peptide, and homeostasis model assessment for insulin resistance (HOMA-IR) were evaluated. Fifty-two patients with alopecia areata and 17 control subjects were enrolled in the study. The serum levels of lipocalin-2 [mean ± standard deviation, SD: 224.55 ± 53.58 ng/ml vs. 188.64 ± 44.75, p = 0.01], insulin [median (interquartile range, IQR): 6.85 (4.7–9.8) μIU/ml vs. 4.5 (3.5–6.6), p<0.05], c-peptide [median (IQR): 1.63 (1.23–2.36) ng/ml vs. 1.37 (1.1–1.58), p<0.05)], and HOMA-IR [median (IQR): 1.44 (0.98–2.15) vs. 0.92 (0.79–1.44), p<0.05) were significantly higher in patients with alopecia areata compared to the controls. The serum concentration of insulin and HOMA-IR correlated with the number of hair loss episodes (r = 0.300, p<0.05 and r = 0.322, p<0.05, respectively). Moreover, a positive correlation occurred between insulin, HOMA-IR, c-peptide and BMI (r = 0.436, p <0.05; r = 0.384, p<0.05 and r = 0.450, p<0.05, respectively). In conclusion, lipocalin-2 and insulin may serve as biomarkers for alopecia areata. Further studies are needed to evaluate the role of insulin as a prognostic factor in alopecia areata.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trichoscopy of scalp dysesthesia

Adriana Rakowska / Małgorzata Olszewska / Lidia Rudnicka

Advances in Dermatology and Allergology, Vol 34, Iss 3, Pp 245-

2017 Volume 247

Abstract: Introduction: Scalp dysesthesia is characterized by localized pruritus, burning sensations or even pain. Aim : To describe characteristic trichoscopic features of scalp dysesthesia. Material and methods: The study was a retrospective analysis (2010–2016) ...

Abstract	Introduction: Scalp dysesthesia is characterized by localized pruritus, burning sensations or even pain. Aim : To describe characteristic trichoscopic features of scalp dysesthesia. Material and methods: The study was a retrospective analysis (2010–2016) of 9 patients (8 females and 1 male; median age: 52 years; range: 38–66 years). A total of 61 trichoscopic images were analyzed by two independent evaluators. Results: In all cases, oval or round areas covered with short hairs: broom hairs (77%; 7/9), block hairs (88%; 8/9), short hairs with trichorrhexis nodosa (78%; 7/9) were found. In 4 of 9 cases these areas were circumscribed by brownish linear discoloration. Background features included: areas lacking hair shafts (44%; 4/9) covered by wavy-shaped scaling, whitish areas with prominent perifollicular yellow discoloration and cloud vessels arranged around follicular openings and around empty follicles (33%, 3/9); focal brownish discoloration with darker wavy lines (78%; 7/9). Conclusions : Trichoscopy can be helpful in establishing the diagnosis of scalp dysesthesia – broom hairs, block hairs and short hairs with trichorrhexis nodosa covering the alopecia patch, uniform in length, can be considered as characteristic for this condition.
Keywords	scalp dysesthesia ; alopecia ; dermoscopy ; trichoscopy ; pruritus ; Dermatology ; RL1-803 ; Internal medicine ; RC31-1245
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adiponectin as a novel biomarker of disease severity in alopecia areata

Anna Stochmal / Anna Waśkiel-Burnat / Sylwia Chrostowska / Michał Zaremba / Adriana Rakowska / Joanna Czuwara / Lidia Rudnicka

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 7

Abstract: Abstract The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum ... ...

Abstract	Abstract The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in patients with alopecia areata in comparison to healthy controls. The study included 65 patients with alopecia areata and 71 healthy controls. The concentration of adipokines was determined with the enzyme-linked immunosorbent assay. The mean concentrations of adiponectin and resistin were significantly lower in the sera of patients with alopecia areata when compared to healthy controls (7966 $$\pm$$ ± 4087 vs 9947 $$\pm$$ ± 5692 ng/ml; p = 0.0312 and 11.04 $$\pm$$ ± 3.88 vs 14.11 $$\pm$$ ± 8.69 ng/ml; p = 0.0176, respectively). A negative correlation between the serum level of adiponectin and severity of alopecia tool (SALT) score was observed (r = − 0.26; p < 0.05). The concentration of adiponectin was significantly lower in patients with alopecia universalis than in patients with patchy alopecia areata (4951 $$\pm$$ ± 2499 vs 8525 $$\pm$$ ± 4085 ng/ml; p = 0.0135). No significant difference in the serum concentration of leptin was observed between patients with alopecia areata and healthy controls. The negative correlation between the serum level of adiponectin and hair loss severity indicates that adiponectin may be considered a marker of hair loss severity in alopecia areata. Further studies are needed to evaluate the role of resistin in patients with alopecia areata and its decreased level irregardless of severity or activity of the disease.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis

Lidia Rudnicka / Małgorzata Olszewska / Mohamad Goldust / Anna Waśkiel-Burnat / Olga Warszawik-Hendzel / Przemysław Dorożyński / Jadwiga Turło / Adriana Rakowska

Journal of Clinical Medicine, Vol 10, Iss 5589, p

Gel, Foam, and Ointment

2021 Volume 5589

Abstract: Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these ... ...

Abstract	Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis.
Keywords	calcipotriol ; betamethasone dipropionate ; long-term treatment ; nail psoriasis ; proactive treatment ; psoriasis ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pili Torti

Aleksandra Hoffmann / Anna Waśkiel-Burnat / Jakub Żółkiewicz / Leszek Blicharz / Adriana Rakowska / Mohamad Goldust / Małgorzata Olszewska / Lidia Rudnicka

Journal of Clinical Medicine, Vol 10, Iss 3901, p

A Feature of Numerous Congenital and Acquired Conditions

2021 Volume 3901

Abstract: Pili torti is a rare condition characterized by the presence of the hair shaft, which is flattened at irregular intervals and twisted 180° along its long axis. It is a form of hair shaft disorder with increased fragility. The condition is classified into ...

Abstract	Pili torti is a rare condition characterized by the presence of the hair shaft, which is flattened at irregular intervals and twisted 180° along its long axis. It is a form of hair shaft disorder with increased fragility. The condition is classified into inherited and acquired. Inherited forms may be either isolated or associated with numerous genetic diseases or syndromes (e.g., Menkes disease, Björnstad syndrome, Netherton syndrome, and Bazex-Dupré-Christol syndrome). Moreover, pili torti may be a feature of various ectodermal dysplasias (such as Rapp-Hodgkin syndrome and Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome). Acquired pili torti was described in numerous forms of alopecia (e.g., lichen planopilaris, discoid lupus erythematosus, dissecting cellulitis, folliculitis decalvans, alopecia areata) as well as neoplastic and systemic diseases (such as cutaneous T-cell lymphoma, scalp metastasis of breast cancer, anorexia nervosa, malnutrition, cataracts, and chronic graft-vs.-host disease). The condition may also be induced by several drugs (epidermal growth factor receptor inhibitors, oral retinoids, sodium valproate, and carbamide perhydrate). The diagnosis of pili torti is based on trichoscopic or microscopic examination. As pili torti is a marker of numerous congenital and acquired disorders, in every case, the search for the signs of underlying conditions is recommended.
Keywords	pili torti ; trichoscopy ; hair shaft abnormalities ; hair shaft disorder ; hair disease ; twisted hair ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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