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Article: Repetitive Transcranial Magnetic Stimulation for the Treatment of Resistant Depression: A Scoping Review.

Adu, Medard Kofi / Shalaby, Reham / Chue, Pierre / Agyapong, Vincent I O

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 6

Abstract: Treatment-resistant depression (TRD) is associated with significant disability, and due to its high prevalence, it results in a substantive socio-economic burden at a global level. TRD is the inability to accomplish and/or achieve remission after an ... ...

Abstract	Treatment-resistant depression (TRD) is associated with significant disability, and due to its high prevalence, it results in a substantive socio-economic burden at a global level. TRD is the inability to accomplish and/or achieve remission after an adequate trial of antidepressant treatments. Studies comparing repetitive transcranial magnetic stimulation (rTMS) with electroconvulsive therapy (ECT) and pharmacotherapy have revealed evidence of the therapeutic efficacy of rTMS in TRD. These findings suggest a crucial role for rTMS in the management of TRD. This article aims to conduct a comprehensive scoping review of the current literature concerning the use of rTMS and its therapeutic efficacy as a treatment modality for TRD. PubMed, PsycINFO, Medline, Embase, and Cinahl were used to identify important articles on rTMS for TRD. The search strategy was limited to English articles within the last five years of data publication. Articles were included if they reported on a completed randomized controlled trial (RCT) of rTMS intervention for TRD. The exclusion criteria involved studies with rTMS for the treatment of conditions other than TRD, and study and experimental protocols of rTMS on TRD. In total, 17 studies were eligible for inclusion in this review. The search strategy spanned studies published in the last five years, to the date of the data search (14 February 2022). The regional breakdown of the extracted studies was North American (n = 9), European (n = 5), Asian (n = 2) and Australian (n = 1). The applied frequencies of rTMS ranged from 5 Hz to 50 Hz, with stimulation intensities ranging from 80% MT to 120% MT. Overall, 16 out of the 17 studies suggested that rTMS treatment was effective, safe and tolerated in TRD. For patients with TRD, rTMS appears to provide significant benefits through the reduction of depressive symptoms, and while there is progressive evidence in support of the same, more research is needed in order to define standardized protocols of rTMS application in terms of localization, frequency, intensity, and pulse parameters.
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12060195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Use of Repetitive Transcranial Magnetic Stimulations for the Treatment of Bipolar Disorder: A Scoping Review.

Adu, Medard Kofi / Eboreime, Ejemai / Sapara, Adegboyega Oyekunbi / Agyapong, Vincent Israel Opoku

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 8

Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that involves the application of magnetic pulses on hyperactive or hypoactive cortical brain areas. rTMS is considered a high therapeutic tool in many ... ...

Abstract	Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that involves the application of magnetic pulses on hyperactive or hypoactive cortical brain areas. rTMS is considered a high therapeutic tool in many neuropsychiatric conditions. Despite its wide and continuous usage for the treatment of psychiatric disorders, information about the use of rTMS in bipolar disorders is limited and not well-established in the literature.
Language	English
Publishing date	2022-07-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12080263
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Article ; Online: Mobile Apps to Support Mental Health Response in Natural Disasters: Scoping Review.

Ezeonu, Nwamaka Alexandra / Hertelendy, Attila J / Adu, Medard Kofi / Kung, Janice Y / Itanyi, Ijeoma Uchenna / Dias, Raquel da Luz / Agyapong, Belinda / Hertelendy, Petra / Ohanyido, Francis / Agyapong, Vincent Israel Opoku / Eboreime, Ejemai

Journal of medical Internet research

2024 Volume 26, Page(s) e49929

Abstract: Background: Disasters are becoming more frequent due to the impact of extreme weather events attributed to climate change, causing loss of lives, property, and psychological trauma. Mental health response to disasters emphasizes prevention and ... ...

Abstract	Background: Disasters are becoming more frequent due to the impact of extreme weather events attributed to climate change, causing loss of lives, property, and psychological trauma. Mental health response to disasters emphasizes prevention and mitigation, and mobile health (mHealth) apps have been used for mental health promotion and treatment. However, little is known about their use in the mental health components of disaster management. Objective: This scoping review was conducted to explore the use of mobile phone apps for mental health responses to natural disasters and to identify gaps in the literature. Methods: We identified relevant keywords and subject headings and conducted comprehensive searches in 6 electronic databases. Studies in which participants were exposed to a man-made disaster were included if the sample also included some participants exposed to a natural hazard. Only full-text studies published in English were included. The initial titles and abstracts of the unique papers were screened by 2 independent review authors. Full texts of the selected papers that met the inclusion criteria were reviewed by the 2 independent reviewers. Data were extracted from each selected full-text paper and synthesized using a narrative approach based on the outcome measures, duration, frequency of use of the mobile phone apps, and the outcomes. This scoping review was reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). Results: Of the 1398 papers retrieved, 5 were included in this review. A total of 3 studies were conducted on participants exposed to psychological stress following a disaster while 2 were for disaster relief workers. The mobile phone apps for the interventions included Training for Life Skills, Sonoma Rises, Headspace, Psychological First Aid, and Substance Abuse and Mental Health Services Administration (SAMHSA) Behavioural Health Disaster Response Apps. The different studies assessed the effectiveness or efficacy of the mobile app, feasibility, acceptability, and characteristics of app use or predictors of use. Different measures were used to assess the effectiveness of the apps' use as either the primary or secondary outcome. Conclusions: A limited number of studies are exploring the use of mobile phone apps for mental health responses to disasters. The 5 studies included in this review showed promising results. Mobile apps have the potential to provide effective mental health support before, during, and after disasters. However, further research is needed to explore the potential of mobile phone apps in mental health responses to all hazards.
MeSH term(s)	Humans ; Mobile Applications ; Mental Health ; Cell Phone ; Text Messaging ; Natural Disasters ; Telemedicine/methods
Language	English
Publishing date	2024-04-17
Publishing country	Canada
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/49929
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Article: The use of repetitive transcranial magnetic stimulation for treatment of obsessive-compulsive disorder: a scoping review.

Adu, Medard Kofi / Eboreime, Ejemai / Sapara, Adegboyega Oyekunbi / Greenshaw, Andrew James / Chue, Pierre / Agyapong, Vincent Israel Opoku

Mental illness

2021 Volume 13, Issue 1, Page(s) 1–13

Abstract: Purpose: This paper aims to explore the relevant literature available regarding the use of repetitive transcranial magnetic stimulation (rTMS) as a mode of treatment for obsessive-compulsive disorder (OCD); to evaluate the evidence to support the use of ...

Abstract	Purpose: This paper aims to explore the relevant literature available regarding the use of repetitive transcranial magnetic stimulation (rTMS) as a mode of treatment for obsessive-compulsive disorder (OCD); to evaluate the evidence to support the use of rTMS as a treatment option for OCD. Design/methodology/approach: The authors electronically conducted data search in five research databases (MEDLINE, CINAHL, Psych INFO, SCOPUS and EMBASE) using all identified keywords and index terms across all the databases to identify empirical studies and randomized controlled trials. The authors included articles published with randomized control designs, which aimed at the treatment of OCD with rTMS. Only full-text published articles written in English were reviewed. Review articles on treatment for conditions other than OCD were excluded. The Covidence software was used to manage and streamline the review. Findings: Despite the inconsistencies in the published literature, the application of rTMS over the supplementary motor area and the orbitofrontal cortex has proven to be promising in efficacy and tolerability compared with other target regions such as the prefrontal cortex for the treatment of OCD. Despite the diversity in terms of the outcomes and clinical variability of the studies under review, rTMS appears to be a promising treatment intervention for OCD. Research limitations/implications: The authors of this scoping review acknowledge several limitations. First, the search strategy considered only studies published in English and the results are up to date as the last day of the electronic data search of December 10, 2020. Though every effort was made to identify all relevant studies for the purposes of this review per the eligibility criteria, the authors still may have missed some relevant studies, especially those published in other languages. Originality/value: This review brought to bare the varying literature on the application of rTMS and what is considered gaps in the knowledge in this area in an attempt to evaluate and provide information on the potential therapeutic effects of rTMS for OCD.
Language	English
Publishing date	2021-09-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2576817-7
ISSN	2036-7465 ; 2036-7457
ISSN (online)	2036-7465
ISSN	2036-7457
DOI	10.1108/MIJ-05-2021-0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Apparent Lack of Benefit of Combining Repetitive Transcranial Magnetic Stimulation with Internet-Delivered Cognitive Behavior Therapy for the Treatment of Resistant Depression: Patient-Centered Randomized Controlled Pilot Trial.

Adu, Medard Kofi / Shalaby, Reham / Eboreime, Ejemai / Sapara, Adegboyega / Lawal, Mobolaji A / Chew, Corina / Daubert, Shelley / Urichuck, Liana / Surood, Shireen / Li, Daniel / Snaterse, Mark / Mach, Mike / Chue, Pierre / Greenshaw, Andrew J / Agyapong, Vincent I O

Brain sciences

2023 Volume 13, Issue 2

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13020293
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Article: Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Protocol for a Patient-Centered Multicenter Randomized Controlled Pilot Trial.

Adu, Medard Kofi / Dias, Raquel da Luz / Agyapong, Belinda / Eboreime, Ejemai / Sapara, Adegboyega O / Lawal, Mobolaji A / Chew, Corina / Diamond Frost, Karen / Li, Daniel / Flynn, Michael / Hassan, Sameh / Saleh, Ahmed / Sridharan, Sanjana / White, Matt / Agyapong, Vincent Io

JMIR research protocols

2023 Volume 12, Page(s) e46830

Abstract: Background: Treatment-resistant depression (TRD) is the inability of a patient with major depressive disorder (MDD) to accomplish or achieve remission after an adequate trial of antidepressant treatments. Several combinations and augmentation treatment ... ...

Abstract	Background: Treatment-resistant depression (TRD) is the inability of a patient with major depressive disorder (MDD) to accomplish or achieve remission after an adequate trial of antidepressant treatments. Several combinations and augmentation treatment strategies for TRD exist, including the use of repetitive transcranial magnetic stimulation (rTMS), and new therapeutic options are being introduced. Text4Support, a text message-based form of cognitive behavioral therapy that allows patients with MDD to receive daily supportive text messages for correcting or altering negative thought patterns through positive reinforcement, may be a useful augmentation treatment strategy for patients with TRD. It is however currently unknown if adding the Text4Support intervention will enhance the response of patients with TRD to rTMS treatment. Objective: This study aims to assess the initial comparative clinical effectiveness of rTMS with and without the Text4Support program as an innovative patient-centered intervention for the management of patients diagnosed with TRD. Methods: This study is a multicenter, prospective, parallel-design, 2-arm, rater-blinded randomized controlled pilot trial. The recruitment process is scheduled to last 12 months. It will involve active treatment for 6 weeks, observation, and a follow-up period of 6 months for participants in the study arms. In total, 200 participants diagnosed with TRD at rTMS care clinics in Edmonton, Alberta, and rTMS clinics in Halifax, Nova Scotia will be randomized to 1 of 2 treatment arms (rTMS sessions alone or rTMS sessions plus Text4Support intervention). Participants in each group will be made to complete evaluation measures at baseline, and 1, 3, and 6 months. The primary outcome measure will be the mean change in the scores of the Patient Health Questionnaire-9 (PHQ-9). The secondary outcome measures will involve the scores of the 7-item Generalized Anxiety Disorders Scale (GAD-7), Columbia-Suicide Severity Rating Scale (CSSRS), and World Health Organization-Five Well-Being Index (WHO-5). Patient data will be analyzed with descriptive statistics, repeated measures, and correlational analyses. Qualitative data will be analyzed using the thematic analysis framework. Results: The results of the study are expected to be available 18 months from the start of recruitment. We hypothesize that participants enrolled in the rTMS plus Text4Support intervention treatment arm of the study will achieve superior outcomes compared with the outcomes of participants enrolled in the rTMS alone arm. Conclusions: The application of the combination of rTMS and Text4Support has not been investigated previously. Therefore, we hope that this study will provide a concrete base of data to evaluate the practical application and efficacy of using the novel combination of these 2 treatment modalities. International registered report identifier (irrid): PRR1-10.2196/46830.
Language	English
Publishing date	2023-12-07
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/46830
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Article: Five Years after the Fort McMurray Wildfire: Prevalence and Correlates of Low Resilience.

Adu, Medard Kofi / Eboreime, Ejemai / Shalaby, Reham / Sapara, Adegboyega / Agyapong, Belinda / Obuobi-Donkor, Gloria / Mao, Wanying / Owusu, Ernest / Oluwasina, Folajinmi / Pazderka, Hannah / Agyapong, Vincent I O

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: Background: The Fort McMurray wildfire of 3 May 2016 was one of the most devastating natural disasters in Canadian history. Although resilience plays a crucial role in the daily functioning of individuals by acting as a protective shield that lessens ... ...

Abstract	Background: The Fort McMurray wildfire of 3 May 2016 was one of the most devastating natural disasters in Canadian history. Although resilience plays a crucial role in the daily functioning of individuals by acting as a protective shield that lessens the impact of disasters on their mental well-being, to date little is known about the long-term impact of wildfires on resilience and associated predictors of low resilience. Objectives: The objective of the study was to assess the prevalence and predictors of resilience among residents of Fort McMurray five years after the wildfires. Method: This was a quantitative cross-sectional study. A self-administered online survey which included standardized rating scales for resilience (BRS), anxiety (GAD-7), depression (PHQ-9), and post-traumatic stress disorder (PTSD)(PCL-C) was used to determine the prevalence of resilience as well as its demographic, clinical, and wildfire-related predictors. The data were collected between 24 April and 2 June 2021 and analyzed using the Statistical Package for Social Sciences (SPSS) version 25 using univariate analysis with a chi-squared test and binary logistic regression analysis. Results: A total of 186 residents completed the survey out of 249 who accessed the online survey, producing a response rate of 74.7%. Most of the respondents were females (85.5%, 159), above 40 years of age (81.6%, 80), employed (94.1%, 175), and in a relationship (71%, 132). Two variables-having had PTSD symptoms (OR = 2.85; 95% CI: 1.06-7.63), and age-were significant predictors of low resilience in our study. The prevalence of low resilience in our sample was 37.4%. Conclusions: Our results suggest that age and the presence of PTSD symptoms were the independent significant risk factors associated with low resilience five years after the Fort McMurray wildfire disaster. Further research is needed to enhance understanding of the pathways to resilience post-disaster to identify the robust predictors and provide appropriate interventions to the most vulnerable individuals and communities.
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12040096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Isolation, Economic Precarity, and Previous Mental Health Issues as Predictors of PTSD Status in Females Living in Fort McMurray During COVID-19.

Pazderka, Hannah / Shalaby, Reham / Eboreime, Ejemai / Mao, Wanying / Obuobi-Donkor, Gloria / Agyapong, Belinda / Oluwasina, Folajinmi / Adu, Medard Kofi / Owusu, Ernest / Sapara, Adegboyega / Agyapong, Vincent I O

Frontiers in psychiatry

2022 Volume 13, Page(s) 837713

Abstract: Objectives: The COVID-19 pandemic represents an instance of collective trauma across the globe; as such, it is unique to our lifetimes. COVID-19 has made clear systemic disparities in terms of access to healthcare and economic precarity. Our objective ... ...

Abstract	Objectives: The COVID-19 pandemic represents an instance of collective trauma across the globe; as such, it is unique to our lifetimes. COVID-19 has made clear systemic disparities in terms of access to healthcare and economic precarity. Our objective was to examine the mental health repercussions of COVID-19 on adult females living in Fort McMurray, Canada in light of their unique circumstances and challenges. Method: To investigate this issue, we analyzed responses gathered from an anonymous cross-section of online survey questionnaire responses gathered from females living in the Fort McMurray area ( Results: 159 females completed the survey. The prevalence of putative PTSD in our sample was 40.8%. A regression analysis revealed 4 variables with significant, unique contributions to PTSD. These were: a Conclusions: Overall, these results support our hypothesis that volatility in factors such as social support, economic stability, and mental health work together to increase the probability of women developing PTSD in response to a collective trauma such as COVID-19.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.837713
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Article: COVID-19 Pandemic in a Vulnerable Population: Prevalence and Correlates of Anxiety.

Shalaby, Reham / Eboreime, Ejemai / Nkire, Nnamdi / Agyapong, Belinda / Pazderka, Hannah / Obuobi-Donkor, Gloria / Adu, Medard Kofi / Mao, Wanying / Owusu, Ernest / Oluwasina, Folajinmi / Agyapong, Vincent I O

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 1

Abstract: Background: The COVID-19 pandemic has produced negative mental health outcomes. These effects were more prominent in vulnerable communities that experienced prior similar disasters. The study aimed to examine the likelihood and correlates of anxiety ... ...

Abstract	Background: The COVID-19 pandemic has produced negative mental health outcomes. These effects were more prominent in vulnerable communities that experienced prior similar disasters. The study aimed to examine the likelihood and correlates of anxiety symptoms among Fort McMurray (FMM) residents, during the COVID-19 pandemic. Methods: A cross-sectional online survey questionnaire was applied between 24 April and 2 June 2021, at FMM, to gather sociodemographic, COVID-19, and clinical information, including generalized anxiety disorder (using GAD-7 scale). Results: Overall, 186 individuals completed the survey (response rate 74.7%). Most of the respondents were females (159, 85.5%); above 40 years (98, 52.7%); employed (175, 94.1%); and in relationship (132, 71%). The prevalence of moderate-to-severe anxiety was (42.5%, 71) on GAD-7 self-reported scale. Subscribers who reported that they would like to receive mental health support; have received no family support since COVID-19 declaration; and have lost their job during the pandemic were all more likely to report moderate-to-severe anxiety (OR = 3.39; 95% CI: 1.29-8.88), (OR = 4.85; 95% CI: 1.56-15.03), and (OR = 4.40; 95% CI: 1.01-19.24), respectively. Conclusions: Anxiety levels were high among FMM residents, compared to levels before COVID-19. Clinical and social factors significantly predicted likely anxiety in the Fort McMurray population, during the COVID-19 pandemic. It is imperative that resources are mobilized to support vulnerable communities during the COVID-19 pandemic.
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12010013
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Article: Correction: Text Messaging Versus Email Messaging to Support Patients With Major Depressive Disorder: Protocol for a Randomized Hybrid Type II Effectiveness-Implementation Trial.

Adu, Medard Kofi / Shalaby, Reham / Eboreime, Ejemai / Sapara, Adegboyega / Nkire, Nnamdi / Chawla, Rajan / Chima, Chidi / Achor, Michael / Osiogo, Felix / Chue, Pierre / Greenshaw, Andrew J / Agyapong, Vincent Israel

JMIR research protocols

2021 Volume 10, Issue 11, Page(s) e34515

Abstract: This corrects the article DOI: 10.2196/29495.]. ...

Abstract	[This corrects the article DOI: 10.2196/29495.].
Language	English
Publishing date	2021-11-08
Publishing country	Canada
Document type	Published Erratum
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/34515
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