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  1. Article ; Online: Urolithiasis and intracorporeal lithotripsy in 37 Military Hospital, Accra, Ghana.

    Adusei, Ben / Mante, Sunny / Yegbe, Paul / Amegbor, Joshua

    Ghana medical journal

    2020  Volume 53, Issue 4, Page(s) 304–307

    Abstract: Objective: The purpose of this study was to determine the indications and complications of intracorporeal lithotripsy in our institution.: Methods: Retrospective study carried out at the urology unit of the 37 Military Hospital between 2012-2015. 42 ... ...

    Abstract Objective: The purpose of this study was to determine the indications and complications of intracorporeal lithotripsy in our institution.
    Methods: Retrospective study carried out at the urology unit of the 37 Military Hospital between 2012-2015. 42 patients had intracorporeal lithotripsy out of 359 patients who had surgery within the period. Records of all patients who had intracorporeal lithotripsy between December 2012 to December 2015 were collected and analysed. An endourology log sheet was used to record data of patient's name, age, sex, indication for operation, location of stone, intraoperative complications, type of instruments/materials used, stone analysis and follow-up dates. All patients between the ages of six months to seventy years presenting with urinary stones diseases within the period were included, whilst patients with urinary stone disease who were managed with open surgery were excluded.Ethical clearance was obtained from the 37 Military Hospital institutional review board.
    Results: Lithotripsy constituted 42/359(11.7%) of the methods used in the surgical cases done within the period.The commonest age of presentation was between 31-40 years (26.2%), with a male to female ratio of 2:1. The commonest indications for lithotripsy were pain (92.8%) and hydronephrosis (61.9%). Ureteric stones are more common (50%), followed by renal stones (45%) with the commonest site being the proximal ureter. The commonest procedure was ureteroscopy. Ureteral mucosal injury (5/43) (11.62%), was the commonest intraoperative complication. Postoperative complications were reno-cutaneous fistula (1/43) (2.32%), severe bleeding (1/43) (2.32%) haematuria (4/43) (9.30%).
    Conclusion: Pain was the commonest indication for intra-corporeal lithotripsy (92.8%) and also the commonest post-operative complication (9.30%).
    Funding: None declared.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cutaneous Fistula/etiology ; Female ; Ghana ; Hematuria/etiology ; Hospitals, Military ; Humans ; Hydronephrosis/etiology ; Infant ; Intraoperative Complications/etiology ; Kidney Calculi/complications ; Kidney Calculi/therapy ; Lithotripsy/adverse effects ; Male ; Middle Aged ; Mucous Membrane/injuries ; Pain/etiology ; Patient Selection ; Postoperative Hemorrhage/etiology ; Retrospective Studies ; Surgical Wound/etiology ; Ureter/injuries ; Ureteral Calculi/complications ; Ureteral Calculi/therapy ; Ureteroscopy/adverse effects ; Urinary Fistula/etiology ; Young Adult
    Language English
    Publishing date 2020-03-02
    Publishing country Ghana
    Document type Journal Article
    ZDB-ID 2259233-7
    ISSN 2616-163X ; 2616-163X
    ISSN (online) 2616-163X
    ISSN 2616-163X
    DOI 10.4314/gmj.v53i4.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men.

    Opoku Mensah, Bismark / Fondjo, Linda Ahenkorah / Owiredu, W K B A / Adusei, Ben

    Disease markers

    2022  Volume 2022, Page(s) 1686991

    Abstract: Introduction: Prostate cancer is one of the most commonly diagnosed cancers in men. Prostate-specific antigen (PSA) has been the biomarker of choice for screening and diagnosis of prostate cancer. However, inefficiencies exist with its diagnostic ... ...

    Abstract Introduction: Prostate cancer is one of the most commonly diagnosed cancers in men. Prostate-specific antigen (PSA) has been the biomarker of choice for screening and diagnosis of prostate cancer. However, inefficiencies exist with its diagnostic capabilities. This study thus evaluated the diagnostic and prognostic potential of urinary PCA3 as an alternative biomarker for prostate cancer in the Ghanaian population.
    Methods: A hospital-based cross-sectional study was conducted at the Urology Department of the 37 Military Hospital, Accra, Ghana. A total of 237 participants aged 40 years and above with any form of suspected prostate disorder were recruited into the study after written informed consent was obtained. Total serum PSA levels was measured using the electrochemiluminescence method and transrectal ultrasound-guided systematic core needle biopsies were obtained from each study participant. Receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic accuracies of serum PSA, DRE, and PCA3 as diagnostic tools for prostate cancer. These three diagnostic tools were also evaluated in various combinations to ascertain the combinations with the best diagnostic accuracy.
    Results: Prostate cancer was diagnosed in 26.6% of the participants. Benign prostate hyperplasia and prostatitis were diagnosed in 48.5% and 24.9% participants, respectively. DRE had a sensitivity of 93.7% and a specificity of 12.1%. PSA had a sensitivity of 92.1% and a specificity of 16.1%. PCA3 had a sensitivity of 57.1% and a specificity of 85.6% and showed a better accuracy (AUC = 83.0) compared to PSA (AUC = 60.0) and DRE (AUC = 65.0) as individual diagnostic tools. The combination of DRE+PCA3 score had the best diagnostic accuracy (AUC = 0.80) with a sensitivity and specificity of 60.3% and 80.5%, respectively.
    Conclusion: The urinary PCA3 assay showed a better diagnostic performance compared to serum PSA and DRE. PCA3 as a stand-alone and in combination with DRE could be a suitable complimentary marker in diagnosis and management of prostate cancer.
    MeSH term(s) Humans ; Male ; Antigens, Neoplasm ; Biomarkers, Tumor ; Biopsy ; Cross-Sectional Studies ; Ghana ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatic Neoplasms/pathology
    Chemical Substances Antigens, Neoplasm ; Biomarkers, Tumor ; Prostate-Specific Antigen (EC 3.4.21.77) ; prostate cancer antigen 3, human
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/1686991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men.

    Janivara, Rohini / Hazra, Ujani / Pfennig, Aaron / Harlemon, Maxine / Kim, Michelle S / Eaaswarkhanth, Muthukrishnan / Chen, Wenlong C / Ogunbiyi, Adebola / Kachambwa, Paidamoyo / Petersen, Lindsay N / Jalloh, Mohamed / Mensah, James E / Adjei, Andrew A / Adusei, Ben / Joffe, Maureen / Gueye, Serigne M / Aisuodionoe-Shadrach, Oseremen I / Fernandez, Pedro W / Rohan, Thomas E /
    Andrews, Caroline / Rebbeck, Timothy R / Adebiyi, Akindele O / Agalliu, Ilir / Lachance, Joseph

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male pattern baldness comes from individuals of European descent. Here, we examined a novel dataset comprising 2,136 men from Ghana, Nigeria, ... ...

    Abstract Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male pattern baldness comes from individuals of European descent. Here, we examined a novel dataset comprising 2,136 men from Ghana, Nigeria, Senegal, and South Africa that were genotyped using a custom array. We first tested how genetic predictions of baldness generalize from Europe to Africa, finding that polygenic scores from European GWAS yielded AUC statistics that ranged from 0.513 to 0.546, indicating that genetic predictions of baldness in African populations performed notably worse than in European populations. Subsequently, we conducted the first African GWAS of androgenetic alopecia, focusing on self-reported baldness patterns at age 45. After correcting for present age, population structure, and study site, we identified 266 moderately significant associations, 51 of which were independent (p-value < 10
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.12.575396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of localized prostate cancer and use of nomograms among urologists in the West Africa sub-region.

    Kyei, Mathew Yamoah / Adusei, Ben / Klufio, George Oko / Mensah, James Edward / Gepi-Attee, Samuel / Asante, Emmanuel

    The Pan African medical journal

    2020  Volume 36, Page(s) 251

    Abstract: Introduction: there is a high incidence of prostate cancer among men of African descent. The disease tends to occur at an early age with a tendency to be aggressive. The objective was to determine the practice of urologists in the West African sub- ... ...

    Abstract Introduction: there is a high incidence of prostate cancer among men of African descent. The disease tends to occur at an early age with a tendency to be aggressive. The objective was to determine the practice of urologists in the West African sub-region regarding treatment of localized prostate cancer, the use of nomograms and their perception of the usefulness of nomograms.
    Methods: this was a cross-sectional study that involved urologists practicing in the West African sub-region attending urology and surgery conferences of the "Société Internationale d´Urologie", West African college of surgeons and the Ghana association of urological surgeons. A structured questionnaire was used that sort to ascertain the treatment modalities used for localized prostate cancer and the use of nomograms in the sub-region. The study period spanned the years 2018 and 2019.
    Results: fifty-six urologists practicing in eleven West African countries responded. Fifty percent had been in practice for less than 5 years. Sixty eight percent (38/56) had been involved in the treatment of localized prostate cancer. Radical prostatectomy was widely available and the treatment modality most used 94.7% (36/38). Nomograms was used by 57.9% of them (22/38) with the Partin tables being the most commonly used nomogram (34.2%). No Locally developed nomogram for treatment of localized prostate cancer was identified.
    Conclusion: radical prostatectomy is the commonest treatment modality used for the management of localized prostate cancer in the West Africa sub-region. Majority of the urologists used nomograms with the Partin tables being the most used.
    MeSH term(s) Africa, Western ; Cross-Sectional Studies ; Humans ; Male ; Nomograms ; Prostatectomy/statistics & numerical data ; Prostatic Neoplasms/therapy ; Surveys and Questionnaires ; Urologists/statistics & numerical data
    Language English
    Publishing date 2020-08-06
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2020.36.251.21419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations.

    Chen, Fei / Darst, Burcu F / Madduri, Ravi K / Rodriguez, Alex A / Sheng, Xin / Rentsch, Christopher T / Andrews, Caroline / Tang, Wei / Kibel, Adam S / Plym, Anna / Cho, Kelly / Jalloh, Mohamed / Gueye, Serigne Magueye / Niang, Lamine / Ogunbiyi, Olufemi J / Popoola, Olufemi / Adebiyi, Akindele O / Aisuodionoe-Shadrach, Oseremen I / Ajibola, Hafees O /
    Jamda, Mustapha A / Oluwole, Olabode P / Nwegbu, Maxwell / Adusei, Ben / Mante, Sunny / Darkwa-Abrahams, Afua / Mensah, James E / Adjei, Andrew Anthony / Diop, Halimatou / Lachance, Joseph / Rebbeck, Timothy R / Ambs, Stefan / Gaziano, J Michael / Justice, Amy C / Conti, David V / Haiman, Christopher A

    eLife

    2022  Volume 11

    Abstract: Background: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and ... ...

    Abstract Background: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and additional independent studies.
    Methods: Within each ancestry population, the association of PRS with prostate cancer risk was evaluated separately in each case-control study and then combined in a fixed-effects inverse-variance-weighted meta-analysis. We further assessed the effect modification by age and estimated the age-specific absolute risk of prostate cancer for each ancestry population.
    Results: The PRS was evaluated in 31,925 cases and 490,507 controls, including men from European (22,049 cases, 414,249 controls), African (8794 cases, 55,657 controls), and Hispanic (1082 cases, 20,601 controls) populations. Comparing men in the top decile (90-100% of the PRS) to the average 40-60% PRS category, the prostate cancer odds ratio (OR) was 3.8-fold in European ancestry men (95% CI = 3.62-3.96), 2.8-fold in African ancestry men (95% CI = 2.59-3.03), and 3.2-fold in Hispanic men (95% CI = 2.64-3.92). The PRS did not discriminate risk of aggressive versus nonaggressive prostate cancer. However, the OR diminished with advancing age (European ancestry men in the top decile: ≤55 years, OR = 7.11; 55-60 years, OR = 4.26; >70 years, OR = 2.79). Men in the top PRS decile reached 5% absolute prostate cancer risk ~10 years younger than men in the 40-60% PRS category.
    Conclusions: Our findings validate the multi-ancestry PRS as an effective prostate cancer risk stratification tool across populations. A clinical study of PRS is warranted to determine whether the PRS could be used for risk-stratified screening and early detection.
    Funding: This work was supported by the National Cancer Institute at the National Institutes of Health (grant numbers U19 CA214253 to C.A.H., U01 CA257328 to C.A.H., U19 CA148537 to C.A.H., R01 CA165862 to C.A.H., K99 CA246063 to B.F.D, and T32CA229110 to F.C), the Prostate Cancer Foundation (grants 21YOUN11 to B.F.D. and 20CHAS03 to C.A.H.), the Achievement Rewards for College Scientists Foundation Los Angeles Founder Chapter to B.F.D, and the Million Veteran Program-MVP017. This research has been conducted using the UK Biobank Resource under application number 42195. This research is based on data from the Million Veteran Program, Office of Research and Development, and the Veterans Health Administration. This publication does not represent the views of the Department of Veteran Affairs or the United States Government.
    MeSH term(s) Age Factors ; Case-Control Studies ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Multifactorial Inheritance ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Risk Factors ; United States/epidemiology
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.78304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Heterogeneous genetic architectures and evolutionary genomics of prostate cancer in Sub-Saharan Africa.

    Rebbeck, Timothy / Janivara, Rohini / Chen, Wenlong / Hazra, Ujani / Baichoo, Shakuntala / Agalliu, Ilir / Kachambwa, Paidamoyo / Simonti, Corinne / Brown, Lyda / Tambe, Saanika / Kim, Michelle / Harlemon, Maxine / Jalloh, Mohamed / Muzondiwa, Dillon / Naidoo, Daphne / Ajayi, Olabode / Snyper, Nana / Niang, Lamine / Diop, Halimatou /
    Ndoye, Medina / Mensah, James / Darkwa-Abrahams, Afua / Biritwum, Richard / Adjei, Andrew / Adebiyi, Akindele / Shittu, Olayiwola / Ogunbiyi, Olufemi / Adebayo, Sikiru / Nwegbu, Maxwell / Ajibola, Hafees / Oluwole, Olabode / Jamda, Mustapha / Pentz, Audrey / Haiman, Christopher / Spies, Petrus / Van der Merwe, Andre / Cook, Michael / Chanock, Stephen J / Berndt, Sonja I / Watya, Stephen / Lubwama, Alex / Muchengeti, Mazvita / Doherty, Sean / Smyth, Natalie / Lounsbury, David / Fortier, Brian / Rohan, Thomas / Jacobson, Judith / Neugut, Alfred / Hsing, Ann / Gusev, Alexander / Aisuodionoe-Shadrach, Oseremen / Joffe, Maureen / Adusei, Ben / Gueye, Serigne / Fernandez, Pedro / McBride, Jo / Andrews, Caroline / Petersen, Lindsay / Lachance, Joseph

    Research square

    2023  

    Abstract: Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates, yet the genetic basis of CaP in African men has been understudied. We used genomic data from 3,963 CaP cases and 3,509 controls recruited in Ghana, Nigeria, ... ...

    Abstract Men of African descent have the highest prostate cancer (CaP) incidence and mortality rates, yet the genetic basis of CaP in African men has been understudied. We used genomic data from 3,963 CaP cases and 3,509 controls recruited in Ghana, Nigeria, Senegal, South Africa, and Uganda, to infer ancestry-specific genetic architectures and fine-mapped disease associations. Fifteen independent associations at 8q24.21, 6q22.1, and 11q13.3 reached genome-wide significance, including four novel associations. Intriguingly, multiple lead SNPs are private alleles, a pattern arising from recent mutations and the out-of-Africa bottleneck. These African-specific alleles contribute to haplotypes with odds ratios above 2.4. We found that the genetic architecture of CaP differs across Africa, with effect size differences contributing more to this heterogeneity than allele frequency differences. Population genetic analyses reveal that African CaP associations are largely governed by neutral evolution. Collectively, our findings emphasize the utility of conducting genetic studies that use diverse populations.
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3378303/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction.

    Hoffmann, Thomas J / Graff, Rebecca E / Madduri, Ravi K / Rodriguez, Alex A / Cario, Clint L / Feng, Karen / Jiang, Yu / Wang, Anqi / Klein, Robert J / Pierce, Brandon L / Eggener, Scott / Tong, Lin / Blot, William / Long, Jirong / Rebbeck, Timothy / Lachance, Joseph / Andrews, Caroline / Adebiyi, Akindele O / Adusei, Ben /
    Aisuodionoe-Shadrach, Oseremen I / Fernandez, Pedro W / Jalloh, Mohamed / Janivara, Rohini / Chen, Wenlong C / Mensah, James E / Agalliu, Ilir / Berndt, Sonja I / Shelley, John P / Schaffer, Kerry / Machiela, Mitchell J / Freedman, Neal D / Huang, Wen-Yi / Li, Shengchao A / Goodman, Phyllis J / Till, Cathee / Thompson, Ian / Lilja, Hans / Van Den Eeden, Stephen K / Chanock, Stephen J / Mosley, Jonathan D / Conti, David V / Haiman, Christopher A / Justice, Amy C / Kachuri, Linda / Witte, John S

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the ... ...

    Abstract We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (p≤5e-8) variants, 184 of which were novel. Most demonstrated evidence of replication in an independent cohort (n=95,768). Meta-analyzing discovery and replication (n=392,522) identified 447 variants, of which a further 111 were novel. Out-of-sample variance in PSA explained by our new polygenic risk score reached 16.9% (95% CI=16.1%-17.8%) in European ancestry, 9.5% (95% CI=7.0%-12.2%) in African ancestry, 18.6% (95% CI=15.8%-21.4%) in Hispanic/Latino, and 15.3% (95% CI=12.7%-18.1%) in Asian ancestry, and lower for higher age. Our study highlights how including proportionally more participants from underrepresented populations improves genetic prediction of PSA levels, with potential to personalize prostate cancer screening.
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.27.23297676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Overall and central obesity and prostate cancer risk in African men.

    Agalliu, Ilir / Lin, Wei-Kaung Jerry / Zhang, Janice S / Jacobson, Judith S / Rohan, Thomas E / Adusei, Ben / Snyper, Nana Yaa F / Andrews, Caroline / Sidahmed, Elkhansa / Mensah, James E / Biritwum, Richard / Adjei, Andrew A / Okyne, Victoria / Ainuson-Quampah, Joana / Fernandez, Pedro / Irusen, Hayley / Odiaka, Emeka / Folasire, Oluyemisi Folake / Ifeoluwa, Makinde Gabriel /
    Aisuodionoe-Shadrach, Oseremen I / Nwegbu, Maxwell Madueke / Pentz, Audrey / Chen, Wenlong Carl / Joffe, Maureen / Neugut, Alfred I / Diallo, Thierno Amadou / Jalloh, Mohamed / Rebbeck, Timothy R / Adebiyi, Akindele Olupelumi / Hsing, Ann W

    Cancer causes & control : CCC

    2021  Volume 33, Issue 2, Page(s) 223–239

    Abstract: Purpose: African men are disproportionately affected by prostate cancer (PCa). Given the increasing prevalence of obesity in Africa, and its association with aggressive PCa in other populations, we examined the relationship of overall and central ... ...

    Abstract Purpose: African men are disproportionately affected by prostate cancer (PCa). Given the increasing prevalence of obesity in Africa, and its association with aggressive PCa in other populations, we examined the relationship of overall and central obesity with risks of total and aggressive PCa among African men.
    Methods: Between 2016 and 2020, we recruited 2,200 PCa cases and 1,985 age-matched controls into a multi-center, hospital-based case-control study in Senegal, Ghana, Nigeria, and South Africa. Participants completed an epidemiologic questionnaire, and anthropometric factors were measured at clinic visit. Multivariable logistic regression was used to examine associations of overall and central obesity with PCa risk, measured by body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), respectively.
    Results: Among controls 16.4% were obese (BMI ≥ 30 kg/m
    Discussion: The high prevalence of overall and central obesity in African men and their association with intermediate-risk PCa represent an emerging public health concern in Africa. Large cohort studies are needed to better clarify the role of obesity and PCa in various African populations.
    MeSH term(s) Body Mass Index ; Case-Control Studies ; Humans ; Male ; Obesity/complications ; Obesity/epidemiology ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/etiology ; Risk Factors ; Waist Circumference ; Waist-Hip Ratio
    Language English
    Publishing date 2021-11-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-021-01515-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

    Kim, Michelle S. / Naidoo, Daphne / Hazra, Ujani / Quiver, Melanie H. / Chen, Wenlong C. / Simonti, Corinne N. / Kachambwa, Paidamoyo / Harlemon, Maxine / Agalliu, Ilir / Baichoo, Shakuntala / Fernandez, Pedro / Hsing, Ann W. / Jalloh, Mohamed / Gueye, Serigne M. / Niang, Lamine / Diop, Halimatou / Ndoye, Medina / Snyper, Nana Yaa / Adusei, Ben /
    Mensah, James E. / Abrahams, Afua O. D. / Biritwum, Richard / Adjei, Andrew A. / Adebiyi, Akindele O. / Shittu, Olayiwola / Ogunbiyi, Olufemi / Adebayo, Sikiru / Aisuodionoe-Shadrach, Oseremen I. / Nwegbu, Maxwell M. / Ajibola, Hafees O. / Oluwole, Olabode P. / Jamda, Mustapha A. / Singh, Elvira / Pentz, Audrey / Joffe, Maureen / Darst, Burcu F. / Conti, David V. / Haiman, Christopher A. / Spies, Petrus V. / van der Merwe, André / Rohan, Thomas E. / Jacobson, Judith / Neugut, Alfred I. / McBride, Jo / Andrews, Caroline / Petersen, Lindsay N. / Rebbeck, Timothy R. / Lachance, Joseph

    Genome biology. 2022 Dec., v. 23, no. 1

    2022  

    Abstract: BACKGROUND: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of ... ...

    Abstract BACKGROUND: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we evaluated test characteristics of PRS from three previous studies using data from the UK Biobank and a novel dataset of 1298 prostate cancer cases and 1333 controls from Ghana, Nigeria, Senegal, and South Africa. RESULTS: Allele frequency differences cause predicted risks of prostate cancer to vary across populations. However, natural selection is not the primary driver of these differences. Comparing continental datasets, we find that polygenic predictions of case vs. control status are more effective for European individuals (AUC 0.608–0.707, OR 2.37–5.71) than for African individuals (AUC 0.502–0.585, OR 0.95–2.01). Furthermore, PRS that leverage information from African Americans yield modest AUC and odds ratio improvements for sub-Saharan African individuals. These improvements were larger for West Africans than for South Africans. Finally, we find that existing PRS are largely unable to predict whether African individuals develop aggressive forms of prostate cancer, as specified by higher tumor stages or Gleason scores. CONCLUSIONS: Genetic predictions of prostate cancer perform poorly if the study sample does not match the ancestry of the original GWAS. PRS built from European GWAS may be inadequate for application in non-European populations and perpetuate existing health disparities.
    Keywords ancestry ; data collection ; gene frequency ; genome ; mortality ; natural selection ; odds ratio ; prostatic neoplasms ; risk ; Ghana ; Nigeria ; Senegal ; South Africa
    Language English
    Dates of publication 2022-12
    Size p. 194.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2040529-7
    ISSN 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-022-02766-z
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa.

    Kim, Michelle S / Naidoo, Daphne / Hazra, Ujani / Quiver, Melanie H / Chen, Wenlong C / Simonti, Corinne N / Kachambwa, Paidamoyo / Harlemon, Maxine / Agalliu, Ilir / Baichoo, Shakuntala / Fernandez, Pedro / Hsing, Ann W / Jalloh, Mohamed / Gueye, Serigne M / Niang, Lamine / Diop, Halimatou / Ndoye, Medina / Snyper, Nana Yaa / Adusei, Ben /
    Mensah, James E / Abrahams, Afua O D / Biritwum, Richard / Adjei, Andrew A / Adebiyi, Akindele O / Shittu, Olayiwola / Ogunbiyi, Olufemi / Adebayo, Sikiru / Aisuodionoe-Shadrach, Oseremen I / Nwegbu, Maxwell M / Ajibola, Hafees O / Oluwole, Olabode P / Jamda, Mustapha A / Singh, Elvira / Pentz, Audrey / Joffe, Maureen / Darst, Burcu F / Conti, David V / Haiman, Christopher A / Spies, Petrus V / van der Merwe, André / Rohan, Thomas E / Jacobson, Judith / Neugut, Alfred I / McBride, Jo / Andrews, Caroline / Petersen, Lindsay N / Rebbeck, Timothy R / Lachance, Joseph

    Genome biology

    2022  Volume 23, Issue 1, Page(s) 194

    Abstract: Background: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of ...

    Abstract Background: Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we evaluated test characteristics of PRS from three previous studies using data from the UK Biobank and a novel dataset of 1298 prostate cancer cases and 1333 controls from Ghana, Nigeria, Senegal, and South Africa.
    Results: Allele frequency differences cause predicted risks of prostate cancer to vary across populations. However, natural selection is not the primary driver of these differences. Comparing continental datasets, we find that polygenic predictions of case vs. control status are more effective for European individuals (AUC 0.608-0.707, OR 2.37-5.71) than for African individuals (AUC 0.502-0.585, OR 0.95-2.01). Furthermore, PRS that leverage information from African Americans yield modest AUC and odds ratio improvements for sub-Saharan African individuals. These improvements were larger for West Africans than for South Africans. Finally, we find that existing PRS are largely unable to predict whether African individuals develop aggressive forms of prostate cancer, as specified by higher tumor stages or Gleason scores.
    Conclusions: Genetic predictions of prostate cancer perform poorly if the study sample does not match the ancestry of the original GWAS. PRS built from European GWAS may be inadequate for application in non-European populations and perpetuate existing health disparities.
    MeSH term(s) Africa South of the Sahara/epidemiology ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Prostatic Neoplasms/genetics ; Risk Factors
    Language English
    Publishing date 2022-09-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1474-760X
    ISSN (online) 1474-760X
    ISSN 1474-760X
    DOI 10.1186/s13059-022-02766-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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