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  1. Article ; Online: Fleischner Society Glossary: The Power of Standardization of Nomenclature for Thoracic Surgical Communications.

    Adusumilli, Prasad S

    Radiology

    2024  Volume 310, Issue 3, Page(s) e240410

    MeSH term(s) Humans ; Reference Standards
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.240410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Chimeric antigen receptor T-cell therapy plus checkpoint blockade in thoracic cancers.

    Adusumilli, Prasad S

    Clinical advances in hematology & oncology : H&O

    2021  Volume 19, Issue 5, Page(s) 295–297

    MeSH term(s) B7-H1 Antigen ; Cell- and Tissue-Based Therapy ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy, Adoptive ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; Thoracic Neoplasms/therapy
    Chemical Substances B7-H1 Antigen ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  3. Article ; Online: Commentary: Preoperative identification of spread through air spaces (STAS): An elusive biomarker.

    Drake, Lauren / Adusumilli, Prasad S

    The Journal of thoracic and cardiovascular surgery

    2023  

    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2023.12.011
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  4. Article: DLL3-targeted CAR T-cell therapy in pre-clinical models for small cell lung cancer: safety, efficacy, and challenges.

    Bellis, Rebecca Y / Adusumilli, Prasad S / Amador-Molina, Alfredo

    Translational lung cancer research

    2024  Volume 13, Issue 3, Page(s) 694–698

    Language English
    Publishing date 2024-03-20
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-820
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  5. Article: Some like it hot: the potential role of hyperthermic intrathoracic chemotherapy in the multimodality treatment of pleural mesothelioma.

    Branch, Kevin / Adusumilli, Prasad S / Zauderer, Marjorie G

    Translational lung cancer research

    2023  Volume 12, Issue 2, Page(s) 187–189

    Language English
    Publishing date 2023-02-09
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-46
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  6. Article ; Online: Response to Letter to the Editor: "Which Percentage of Micropapillary and Solid Histological Patterns in Lymph Node Metastases Is Significantly Associated With Poor Outcomes?"

    Choe, Jennie K / Li, Yan / Adusumilli, Prasad S

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 7, Page(s) e76–e77

    MeSH term(s) Humans ; Lung Neoplasms/pathology ; Lymphatic Metastasis ; Adenocarcinoma of Lung ; Adenocarcinoma/pathology
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.04.017
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  7. Article ; Online: Arming T cells to infiltrate pancreatic tumours.

    Cherkassky, Leonid / Adusumilli, Prasad S

    Nature biomedical engineering

    2021  Volume 5, Issue 11, Page(s) 1243–1245

    MeSH term(s) Humans ; Pancreatic Neoplasms ; T-Lymphocytes
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-021-00821-x
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  8. Article ; Online: Quantifying Interrater Agreement and Reliability Between Thoracic Pathologists: Paradoxical Behavior of Cohen's Kappa in the Presence of a High Prevalence of the Histopathologic Feature in Lung Cancer.

    Tan, Kay See / Yeh, Yi-Chen / Adusumilli, Prasad S / Travis, William D

    JTO clinical and research reports

    2023  Volume 5, Issue 1, Page(s) 100618

    Abstract: Introduction: Cohen's kappa is often used to quantify the agreement between two pathologists. Nevertheless, a high prevalence of the feature of interest can lead to seemingly paradoxical results, such as low Cohen's kappa values despite high "observed ... ...

    Abstract Introduction: Cohen's kappa is often used to quantify the agreement between two pathologists. Nevertheless, a high prevalence of the feature of interest can lead to seemingly paradoxical results, such as low Cohen's kappa values despite high "observed agreement." Here, we investigate Cohen's kappa using data from histologic subtyping assessment of lung adenocarcinomas and introduce alternative measures that can overcome this "kappa paradox."
    Methods: A total of 50 frozen sections from stage I lung adenocarcinomas less than or equal to 3 cm in size were independently reviewed by two pathologists to determine the absence or presence of five histologic patterns (lepidic, papillary, acinar, micropapillary, solid). For each pattern, observed agreement (proportion of cases with concordant "absent" or "present" ratings) and Cohen's kappa were calculated, along with Gwet's AC1.
    Results: The prevalence of any amount of the histologic patterns ranged from 42% (solid) to 97% (acinar). On the basis of Cohen's kappa, there was substantial agreement for four of the five patterns (lepidic, 0.65; papillary, 0.67; micropapillary, 0.64; solid, 0.61). Acinar had the lowest Cohen's kappa (0.43, moderate agreement), despite having the highest observed agreement (88%). In contrast, Gwet's AC1 values were close to or higher than Cohen's kappa across patterns (lepidic, 0.64; papillary, 0.69; micropapillary, 0.71; solid, 0.73; acinar, 0.85). The proportion of positive versus negative agreement was 93% versus 50% for acinar.
    Conclusions: Given the dependence of Cohen's kappa on feature prevalence, interrater agreement studies should include complementary indices such as Gwet's AC1 and proportions of specific agreement, especially in settings with a high prevalence of the feature of interest.
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2023.100618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Advancing together and moving forward: Combination gene and cellular immunotherapies.

    Priceman, Saul J / Cheema, Waseem / Adusumilli, Prasad S

    Molecular therapy oncolytics

    2022  Volume 25, Page(s) 330–334

    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Editorial
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2022.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pathologic node-negative lung cancer: Adequacy of lymph node yield and a tool to assess the risk of occult nodal disease.

    Tan, Kay See / Hsu, Meier / Adusumilli, Prasad S

    Lung cancer (Amsterdam, Netherlands)

    2022  Volume 174, Page(s) 60–66

    Abstract: Introduction: Accurate lymph node (LN) staging is crucial for prognostication in NSCLC. Diagnosis of pN0 disease is based on the absence of positive LNs, irrespective of the number of LNs excised, and is thus susceptible to sampling error. Tumors that ... ...

    Abstract Introduction: Accurate lymph node (LN) staging is crucial for prognostication in NSCLC. Diagnosis of pN0 disease is based on the absence of positive LNs, irrespective of the number of LNs excised, and is thus susceptible to sampling error. Tumors that are assumed to be pN0 may in fact be understaged. We developed a tool to quantify the risk of occult nodal disease (OND) among patients with pN0 NSCLC in terms of the number of LNs examined.
    Methods: Patients treated surgically for stage I-III primary NSCLC between 2004 and 2014 (n = 49,356) were extracted from the Surveillance, Epidemiology, and End Results database. The probability of missing a positive node in terms of the number of LNs examined was modeled using a beta-binomial model. A mathematical tool was then used to calculate the negative predictive value (NPV) corresponding to the number of LNs examined. Ranging from 0 to 100%, higher NPV reflects greater confidence in the pN0 diagnosis and a lower probability of OND.
    Results: The median number of LNs examined was 7 for N0, 10 for N1/N2, and 8 for N3 disease. The probability of missing a positive node decreased as LNs examined increased. Additionally, higher T stage required more LNs to confirm an N0 diagnosis. After accounting for false-negative diagnoses, the prevalence of node-positive disease was readjusted from 16% to 22% among patients with T1 disease. According to our tool, with 10 LNs examined, the NPV was 85% (15% probability of OND) for a patient with T3 disease, compared with 95% (5% probability of OND) for a patient with T1 disease.
    Conclusions: Accurate pN0 diagnosis depends on the number of LNs examined. The proposed tool offers the ability to quantify, in a patient-specific manner, the confidence in a diagnosis of node-negative disease on the basis of the number of LNs examined.
    MeSH term(s) Humans ; Lymphatic Metastasis/pathology ; Neoplasm Staging ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/surgery ; Lymph Nodes/pathology ; Probability ; Lymph Node Excision ; Prognosis
    Language English
    Publishing date 2022-10-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2022.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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