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  1. Article ; Online: Bat4RCT

    Jenna Kim / Jinmo Kim / Aejin Lee / Jinseok Kim

    PLoS ONE, Vol 18, Iss 3, p e

    A suite of benchmark data and baseline methods for text classification of randomized controlled trials.

    2023  Volume 0283342

    Abstract: Randomized controlled trials (RCTs) play a major role in aiding biomedical research and practices. To inform this research, the demand for highly accurate retrieval of scientific articles on RCT research has grown in recent decades. However, correctly ... ...

    Abstract Randomized controlled trials (RCTs) play a major role in aiding biomedical research and practices. To inform this research, the demand for highly accurate retrieval of scientific articles on RCT research has grown in recent decades. However, correctly identifying all published RCTs in a given domain is a non-trivial task, which has motivated computer scientists to develop methods for identifying papers involving RCTs. Although existing studies have provided invaluable insights into how RCT tags can be predicted for biomedicine research articles, they used datasets from different sources in varying sizes and timeframes and their models and findings cannot be compared across studies. In addition, as datasets and code are rarely shared, researchers who conduct RCT classification have to write code from scratch, reinventing the wheel. In this paper, we present Bat4RCT, a suite of data and an integrated method to serve as a strong baseline for RCT classification, which includes the use of BERT-based models in comparison with conventional machine learning techniques. To validate our approach, all models are applied on 500,000 paper records in MEDLINE. The BERT-based models showed consistently higher recall scores than conventional machine learning and CNN models while producing slightly better or similar precision scores. The best performance was achieved by the BioBERT model when trained on both title and abstract texts, with the F1 score of 90.85%. This infrastructure of dataset and code will provide a competitive baseline for the evaluation and comparison of new methods and the convenience of future benchmarking. To our best knowledge, our study is the first work to apply BERT-based language modeling techniques to RCT classification tasks and to share dataset and code in order to promote reproducibility and improvement in text classification in biomedicine research.
    Keywords Medicine ; R ; Science ; Q
    Subject code 006
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Organic Memristor‐Based Flexible Neural Networks with Bio‐Realistic Synaptic Plasticity for Complex Combinatorial Optimization

    Hyeongwook Kim / Miseong Kim / Aejin Lee / Hea‐Lim Park / Jaewon Jang / Jin‐Hyuk Bae / In Man Kang / Eun‐Sol Kim / Sin‐Hyung Lee

    Advanced Science, Vol 10, Iss 19, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Hardware neural networks with mechanical flexibility are promising next‐generation computing systems for smart wearable electronics. Several studies have been conducted on flexible neural networks for practical applications; however, developing ... ...

    Abstract Abstract Hardware neural networks with mechanical flexibility are promising next‐generation computing systems for smart wearable electronics. Several studies have been conducted on flexible neural networks for practical applications; however, developing systems with complete synaptic plasticity for combinatorial optimization remains challenging. In this study, the metal‐ion injection density is explored as a diffusive parameter of the conductive filament in organic memristors. Additionally, a flexible artificial synapse with bio‐realistic synaptic plasticity is developed using organic memristors that have systematically engineered metal‐ion injections, for the first time. In the proposed artificial synapse, short‐term plasticity (STP), long‐term plasticity, and homeostatic plasticity are independently achieved and are analogous to their biological counterparts. The time windows of the STP and homeostatic plasticity are controlled by the ion‐injection density and electric‐signal conditions, respectively. Moreover, stable capabilities for complex combinatorial optimization in the developed synapse arrays are demonstrated under spike‐dependent operations. This effective concept for realizing flexible neuromorphic systems for complex combinatorial optimization is an essential building block for achieving a new paradigm of wearable smart electronics associated with artificial intelligent systems.
    Keywords artificial synapse ; combinatorial optimization ; flexible neural network ; organic memristor ; synaptic plasticity ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Epiregulin as an Alternative Ligand for Leptin Receptor Alleviates Glucose Intolerance without Change in Obesity

    No-Joon Song / Aejin Lee / Rumana Yasmeen / Qiwen Shen / Kefeng Yang / Shashi Bhushan Kumar / Danah Muhanna / Shanvanth Arnipalli / Sabrena F. Noria / Bradley J. Needleman / Jeffrey W. Hazey / Dean J. Mikami / Joana Ortega-Anaya / Rafael Jiménez-Flores / Jeremy Prokop / Ouliana Ziouzenkova

    Cells, Vol 11, Iss 425, p

    2022  Volume 425

    Abstract: The leptin receptor (LepR) acts as a signaling nexus for the regulation of glucose uptake and obesity, among other metabolic responses. The functional role of LepR under leptin-deficient conditions remains unclear. This study reports that epiregulin ( ... ...

    Abstract The leptin receptor (LepR) acts as a signaling nexus for the regulation of glucose uptake and obesity, among other metabolic responses. The functional role of LepR under leptin-deficient conditions remains unclear. This study reports that epiregulin (EREG) governed glucose uptake in vitro and in vivo in Lep ob mice by activating LepR under leptin-deficient conditions. Single and long-term treatment with EREG effectively rescued glucose intolerance in comparative insulin and EREG tolerance tests in Lep ob mice. The immunoprecipitation study revealed binding between EREG and LepR in adipose tissue of Lep ob mice. EREG/LepR regulated glucose uptake without changes in obesity in Lep ob mice via mechanisms, including ERK activation and translocation of GLUT4 to the cell surface. EREG-dependent glucose uptake was abolished in Lepr db mice which supports a key role of LepR in this process. In contrast, inhibition of the canonical epidermal growth factor receptor (EGFR) pathway implicated in other EREG responses, increased glucose uptake. Our data provide a basis for understanding glycemic responses of EREG that are dependent on LepR unlike functions mediated by EGFR, including leptin secretion, thermogenesis, pain, growth, and other responses. The computational analysis identified a conserved amino acid sequence, supporting an evolutionary role of EREG as an alternative LepR ligand.
    Keywords epiregulin ; leptin receptor ; ERK ; EGFR ; glucose uptake ; energy metabolism ; Biology (General) ; QH301-705.5
    Subject code 570 ; 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Thermogenic crosstalk occurs between adipocytes from different species

    Chen Gilor / Kefeng Yang / Aejin Lee / No-Joon Song / Paolo Fadda / Christopher A. Adin / Claire Herbert / Ryan Jennings / Kathleen Ham / James Lee / Ouliana Ziouzenkova

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 12

    Abstract: Abstract Visceral obesity increases risks for all-cause mortality worldwide. A small population of thermogenic adipocytes expressing uncoupling protein-1 (Ucp1) regulates energy dissipation in white adipose tissue (WAT) depots. Thermogenic adipocytes ... ...

    Abstract Abstract Visceral obesity increases risks for all-cause mortality worldwide. A small population of thermogenic adipocytes expressing uncoupling protein-1 (Ucp1) regulates energy dissipation in white adipose tissue (WAT) depots. Thermogenic adipocytes subsets decrease obesity in mice, but their efficacy has not been tested in obese large animals. Here we enclosed murine subcutaneous adipocytes with and without engineered thermogenic response in biocompatible microcapsules and implanted them into the left and right side of the visceral falciform depot in six obese dogs. After 28 days of treatment, dogs have markedly reduced waist circumference, body weight, and fat mass. Ucp1 expression in canine WAT was increased at sites implanted with thermogenic vs. wild type murine adipocytes. This site-specific thermogenic remodeling of canine tissue by thermogenic murine adipocytes suggests evolutionary conserved paracrine regulation of energy dissipation across species. These findings have translational potential aimed to reduce deleterious WAT depots in humans and pets.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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