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  1. Article ; Online: A Rare Cause of Mesenteric Vein Thrombosis.

    Plá Sánchez, Pau / Afonso Luis, Natalia

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2023  Volume 67, Issue 4, Page(s) 592

    MeSH term(s) Humans ; Mesenteric Veins/diagnostic imaging ; Mesenteric Veins/surgery ; Mesenteric Ischemia/diagnostic imaging ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/surgery ; Mesenteric Vascular Occlusion/diagnostic imaging ; Mesenteric Vascular Occlusion/etiology ; Mesenteric Vascular Occlusion/surgery ; Thrombosis/etiology
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2283: Show issues Location:
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    Zs.MO 381: Show issues

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  2. Article ; Online: Immune checkpoint inhibitor-induced myopericarditis.

    Alrayyashi, Mohamed / Uddin, Mohammed / Bdiwi, Mustafa / Afonso, Luis

    BMJ case reports

    2024  Volume 17, Issue 3

    Abstract: A woman in her 30s with a medical history of metastatic rectal adenocarcinoma, currently on pembrolizumab, which started a few weeks ago, was admitted for abdominal pain. During the hospital stay, she experienced sharp chest pain. Troponin was 1885 ng/mL ...

    Abstract A woman in her 30s with a medical history of metastatic rectal adenocarcinoma, currently on pembrolizumab, which started a few weeks ago, was admitted for abdominal pain. During the hospital stay, she experienced sharp chest pain. Troponin was 1885 ng/mL which peaked at 7338 ng/mL. ECG was unremarkable. The echocardiogram showed an Ejection fraction (EF) of 55%-60% and basal-inferior wall hypokinesis. Left heart catheterisation showed no coronary abnormalities. Cardiac MRI showed a non-coronary area of focal T1 and T2 hyperintense signal and transmural delayed gadolinium enhancement in the mid-basal inferior/inferoseptal wall consistent with myocardial damage. Pericardium showed increased thickness and adhesions at the right ventricular outflow tract consistent with pericarditis. Steroid therapy was initiated, and a marked clinical response was achieved. Immune checkpoint inhibitor-induced myocarditis and pericarditis is a rare complication associated with a high mortality rate, if untreated. Diagnosis requires a multidisciplinary approach, and early detection is critical to preventing a fatal outcome.
    MeSH term(s) Female ; Humans ; Myocarditis/diagnosis ; Myocarditis/diagnostic imaging ; Immune Checkpoint Inhibitors ; Contrast Media ; Gadolinium ; Pericarditis/chemically induced ; Pericarditis/diagnostic imaging ; Pericarditis/complications
    Chemical Substances Immune Checkpoint Inhibitors ; Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-259497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Skin Friction: Mechanical and Tribological Characterization of Different Papers Used in Everyday Life.

    Vilhena, Luís / Afonso, Luís / Ramalho, Amílcar

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 16

    Abstract: The coefficient of friction for different contacting materials against skin is mainly influenced by the nature of the materials (synthetic and natural fabrics), mechanical contact parameters (interfacial pressure and sliding velocities), and ... ...

    Abstract The coefficient of friction for different contacting materials against skin is mainly influenced by the nature of the materials (synthetic and natural fabrics), mechanical contact parameters (interfacial pressure and sliding velocities), and physiological skin conditions (ambient humidity and skin moisture content). In the present research work, seven different types of papers used in everyday life were analyzed. The physical properties of these materials were determined through tensile tests and friction tests. By comparing mechanical properties with coefficient of friction, it was possible to conclude that the coefficient of friction is strongly correlated with the mechanical properties.
    Language English
    Publishing date 2023-08-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16165724
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  4. Article ; Online: Overcoming a stubborn patent foramen ovale.

    Gallagher, John / Dawdy, John / Afonso, Luis

    Echocardiography (Mount Kisco, N.Y.)

    2023  Volume 40, Issue 10, Page(s) 1151–1155

    Abstract: Transesophageal echocardiography (TEE) with agitated saline contrast ("bubble study") is the gold standard for detection of patent foramen ovale (PFO). Standard provocative maneuvers help facilitate right-to-left shunting necessary for diagnosing PFO but ...

    Abstract Transesophageal echocardiography (TEE) with agitated saline contrast ("bubble study") is the gold standard for detection of patent foramen ovale (PFO). Standard provocative maneuvers help facilitate right-to-left shunting necessary for diagnosing PFO but may be difficult to implement during TEE. Hypovolemia related to preprocedural fasting may challenge detection of PFO in TEE, and additional optimization measures such as fluid replenishment with passive leg raise (PLR) can enhance PFO detection. We present a 57-year-old male with history of cryptogenic stroke and stubborn PFO which during TEE bubble study responded only to ample fluid replenishment with PLR following a period of prolonged preprocedural fasting.
    MeSH term(s) Male ; Humans ; Middle Aged ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Echocardiography, Transesophageal
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15688
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2170: Show issues Location:
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    Zs.MO 359: Show issues

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  5. Article ; Online: Detection of Carbapenem Resistance in Enterobacterales Directly From Positive Blood Cultures Using Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry.

    Moreira, Natália Kehl / Wilhelm, Camila Mörschbächer / Volpato, Fabiana Caroline Zempulski / Barth, Afonso Luís / Caierão, Juliana

    Archives of pathology & laboratory medicine

    2024  

    Abstract: Context.—: Carbapenem-resistant Enterobacterales are disseminated worldwide and associated with infections with high rates of morbidity and mortality. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a ... ...

    Abstract Context.—: Carbapenem-resistant Enterobacterales are disseminated worldwide and associated with infections with high rates of morbidity and mortality. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a useful tool for identification of pathogens directly from blood cultures in clinical microbiology laboratories. Furthermore, it has been applied for the detection of carbapenemase production, by evaluating carbapenem hydrolysis.
    Objective.—: To determine meropenem hydrolysis to detect carbapenemase production directly from positive blood cultures, using logRQ to establish a quantitative measure of hydrolysis.
    Design.—: We evaluated 100 Enterobacterales from positive blood cultures, with 81 carrying a carbapenemase gene (blaKPC, blaGES, blaNDM-1, blaIMP, blaVIM, and blaOXA-48-like), as determined by real-time multiplex polymerase chain reaction with high-resolution melting (HRM-qPCR). Bacterial proteins extracted from positive blood culture bottles were incubated in a meropenem solution (2-4 hours) followed by centrifugation for MALDI-TOF MS analysis. The intensity of peaks of the hydrolyzed and nonhydrolyzed forms were used to calculate the logRQ value.
    Results.—: Overall, sensitivity was 86.8% and specificity, 89.5%. Of note, sensitivity varied depending on enzyme type. For blaKPC-positive isolates, sensitivity was 97.9%, while it reduced significantly for blaNDM-1 and blaOXA-48-like isolates: 62.5% (10 of 16) and 66.7% (6 of 9), respectively. Indeed, logRQ was higher in blaKPC-positive isolates (0.37-1.97) than in blaNDM-1 (-1.37 to 0.83) and blaOXA-48-like isolates (-1.08 to 1.79).
    Conclusions.—: This is an inexpensive and rapid test to identify carbapenemase activity directly from blood culture bottles, which contributes to early adequate antimicrobial therapy and implementation of infection control measures.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0199-OA
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    Ud II Zs.36: Show issues Location:
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  6. Article: A Rare Case of Isolated Cardiac Sarcoidosis With Negative Biopsy: Diagnosis by Clinical Criteria.

    Le, Tiffany / Dayco, John / Ramaseshan, Karthik / Zunnu Rain, Mariam / Afonso, Luis C

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52088

    Abstract: Cardiac sarcoidosis (CS) is a potentially life-threatening condition that can cause sudden, fatal conduction abnormalities, arrhythmias, and heart failure. The diagnosis of CS is challenging due to nonspecific symptoms and an unclear diagnostic criterion. ...

    Abstract Cardiac sarcoidosis (CS) is a potentially life-threatening condition that can cause sudden, fatal conduction abnormalities, arrhythmias, and heart failure. The diagnosis of CS is challenging due to nonspecific symptoms and an unclear diagnostic criterion. Although biopsy is the gold standard method, the sensitivity of biopsy is low. About a portion of CS cases are detected through imaging. A unique aspect of our case is that our definitive diagnosis was made based on clinical and imaging criteria alone despite a negative biopsy. Our diagnosis was confirmed further on follow-up with improvement in cardiac function on imaging after a treatment course with corticosteroids. This case highlights the need to have a broad differential and more awareness of this rare etiology and the value of clinical criteria to make a definitive diagnosis.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52088
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  7. Article ; Online: An Unusual Etiology of Severe Right Heart Failure Deserving of Wider Recognition.

    Kang, Woosun / Zong, Yu / Patel, Dhruvil Ashishkumar / Mishra, Tushar / Afonso, Luis

    JACC. Case reports

    2024  Volume 29, Issue 5, Page(s) 102222

    Abstract: A previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of the antegrade right ventricular outflow Doppler envelope ... ...

    Abstract A previously healthy 31-year-old man presented with worsening shortness of breath and a petechial rash. Echocardiography showed severe right-sided heart failure with midsystolic notching of the antegrade right ventricular outflow Doppler envelope suggesting pulmonary hypertension. An extensive work-up revealed scurvy, with a dramatic resolution of symptoms shortly after vitamin C supplementation.
    Language English
    Publishing date 2024-01-31
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102222
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  8. Article ; Online: Role of Transesophageal Echocardiography in the Diagnosis of Coronary Ischemia in a Patient with History of Ross Procedure.

    Sebastian, Joseph / Dawdy, John / Ala, Chandra / Zehr, Kenton / Gupta, Pooja / Afonso, Luis

    CASE (Philadelphia, Pa.)

    2024  Volume 8, Issue 3Part A, Page(s) 109–116

    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.12.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Determination of aztreonam/ceftazidime-avibactam synergism and proposal of a new methodology for the evaluation of susceptibility in vitro.

    Collar, Gabriela da Silva / Moreira, Natália Kehl / Becker, Julia / Barth, Afonso Luís / Caierão, Juliana

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 2, Page(s) 116236

    Abstract: We proposed a new methodology, the microelution ATM/CZA (mATM/CZA), based on the antibiotic disc elution and the use of resazurin, for rapid (<4h) determination of in vitro susceptibility to aztreonam combined with ceftazidime-avibactam among ... ...

    Abstract We proposed a new methodology, the microelution ATM/CZA (mATM/CZA), based on the antibiotic disc elution and the use of resazurin, for rapid (<4h) determination of in vitro susceptibility to aztreonam combined with ceftazidime-avibactam among Enterobacterales. The mATM/CZA presented excellent accuracy with 1.9 %, 98.1 % and 100 % of major error, specificity and sensitivity, respectively. Furthermore, we assessed synergism between aztreonam and ceftazidime-avibactam in Enterobacterales and Pseudomonas aeruginosa, which was observed in 37/55 Enterobacterales and 31/56 P. aeruginosa. As reference methodologies (checkerboard, time-kill curve) are not compatible with the routine of the clinical microbiology laboratories, mATM/CZA is an important alternative to evaluate susceptibility of the combination in a scenario where its clinical use is increasingly important.
    MeSH term(s) Aztreonam/pharmacology ; Azabicyclo Compounds/pharmacology ; Drug Combinations ; Microbial Sensitivity Tests/methods ; Microbial Sensitivity Tests/standards ; Anti-Bacterial Agents/pharmacology ; Ceftazidime/pharmacology ; Humans ; Drug Synergism ; Pseudomonas aeruginosa/drug effects ; Enterobacteriaceae/drug effects ; Sensitivity and Specificity ; Xanthenes ; Oxazines
    Chemical Substances Aztreonam (G2B4VE5GH8) ; Azabicyclo Compounds ; Drug Combinations ; Anti-Bacterial Agents ; avibactam, ceftazidime drug combination ; Ceftazidime (9M416Z9QNR) ; resazurin (1FN9YD6968) ; Xanthenes ; Oxazines
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Evaluation Study
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1845: Show issues Location:
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  10. Article: Evaluation of Aztreonam and Ceftazidime/Avibactam Synergism against

    Wilhelm, Camila Mörschbächer / Inamine, Everton / Martins, Andreza Francisco / Barth, Afonso Luís

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Introduction: Resistance to carbapenems due to the co-production of NDM and ESBL or NDM and KPC is increasing. Therefore, combined therapy with aztreonam (ATM) plus ceftazidime/avibactam (CZA) has been recommended. Then, it is necessary to develop and ... ...

    Abstract Introduction: Resistance to carbapenems due to the co-production of NDM and ESBL or NDM and KPC is increasing. Therefore, combined therapy with aztreonam (ATM) plus ceftazidime/avibactam (CZA) has been recommended. Then, it is necessary to develop and evaluate fast and simple methods to determine synergism in vitro in microbiology laboratories.
    Objective: To develop a method to determine the synergism of ATM and CZA by MALDI-TOF MS (SynMALDI).
    Method: Klebsiella pneumoniae
    Results: The combination of ATM plus CZA proved to be synergic by time-kill curve assay. All isolates tested with the SynMALDI method also presented synergism.
    Conclusions: Detection of synergism for ATM plus CZA combination can be determined by MALDI-TOF MS, providing fast results in order to improve patient treatment.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12061063
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