Article ; Online: Conformational inhibitors of protein aggregation.
Current opinion in structural biology
2023 Volume 83, Page(s) 102700
Abstract: Amyloidoses are fatal conditions associated with the aggregation of proteins into amyloid fibrils that deposit systemically and/or locally. Possibly because the causal mechanism of protein aggregation and deposition is not fully understood, this group of ...
| Abstract | Amyloidoses are fatal conditions associated with the aggregation of proteins into amyloid fibrils that deposit systemically and/or locally. Possibly because the causal mechanism of protein aggregation and deposition is not fully understood, this group of diseases remains uncurable. Advances in structural biology, such as the use of nuclear magnetic resonance and cryo-electron microscopy, have enabled the study of the structures and the conformational nature of the proteins whose aggregation is associated with the underlying pathogenesis of amyloidosis. As a result, the last years of research have translated into the development of directed therapeutic strategies that target the specific conformations of precursors, fibrils, and intermediary species. Current efforts include the use of small molecules, peptides, and antibodies. This review summarizes the recent progress in developing strategies that target specific protein conformations for the treatment of amyloidoses. |
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| MeSH term(s) | Humans ; Protein Aggregates ; Cryoelectron Microscopy ; Amyloidosis/metabolism ; Amyloidosis/pathology ; Amyloid/chemistry ; Protein Conformation |
| Chemical Substances | Protein Aggregates ; Amyloid |
| Language | English |
| Publishing date | 2023-09-15 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 1068353-7 |
| ISSN | 1879-033X ; 0959-440X |
| ISSN (online) | 1879-033X |
| ISSN | 0959-440X |
| DOI | 10.1016/j.sbi.2023.102700 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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