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  1. Article ; Online: Juvenile-onset systemic lupus erythematosus and MEFV polymorphism: A case-control association study among Iranian children.

    Mohebichamkhorami, Fariba / Shiari, Reza / Afzali, Shervin / Farivar, Shirin

    Reumatologia clinica

    2023  Volume 19, Issue 6, Page(s) 306–311

    Abstract: Introduction and objectives: This study is designed to evaluate the potential influences of Mediterranean fever gene (MEFV) gene polymorphism on systemic lupus erythematosus (SLE) in a cohort of juvenile patients. A case-control study was performed on ... ...

    Abstract Introduction and objectives: This study is designed to evaluate the potential influences of Mediterranean fever gene (MEFV) gene polymorphism on systemic lupus erythematosus (SLE) in a cohort of juvenile patients. A case-control study was performed on Iranian patients with a mixed ethnicity population.
    Patients and methods: Genotypes of 50 juvenile cases, and 85 healthy controls were investigated for identifying M694V and R202Q polymorphism. Genotyping was done utilizing amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to detect M694V and R202Q mutations, respectively.
    Main findings: Our study indicates significant differences in the alleles and genotypes frequencies of MEFV polymorphism between SLE patients and healthy controls (P<0.05). Also, an association was found between renal involvement (50% vs. 8.3%, P=0.000, OR=0.91, 95% CI=0.30-0.278) in juvenile SLE patients and M694V polymorphism incident; But there was no association with other clinical manifestations.
    Principal conclusion: We found a significant association between R202Q and M694V polymorphism of the MEFV gene and susceptibility to SLE in the studied population; However, further studies on detailed characterization of these polymorphisms' impacts on the key elements responsible for SLE pathogenesis is of great importance.
    MeSH term(s) Humans ; Child ; Iran ; Case-Control Studies ; Polymorphism, Genetic ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/pathology ; Genotype ; Pyrin/genetics
    Chemical Substances MEFV protein, human ; Pyrin
    Language English
    Publishing date 2023-04-12
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5743
    ISSN (online) 2173-5743
    DOI 10.1016/j.reumae.2022.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line.

    Razzaghi, Mohammad Reza / Ghazimoradi, Mohammad Hossein / Afzali, Shervin / Kamani, Ehsan / Mohajerani, Ezeddin / Shirkavand, Afshan / Farivar, Shirin

    Journal of lasers in medical sciences

    2021  Volume 12, Page(s) e28

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-06-20
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2021.28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic COVID-19 Patients: A Systematic Literature Review.

    Zandi, Milad / Farahani, Abbas / Zakeri, Armin / Akhavan Rezayat, Sara / Mohammadi, Ramin / Das, Umashankar / Dimmock, Jonathan R / Afzali, Shervin / Nakhaei, Mohammadvala Ashtar / Doroudi, Alireza / Erfani, Yousef / Soltani, Saber

    International journal of microbiology

    2021  Volume 2021, Page(s) 5528786

    Abstract: Background: Currently, a novel coronavirus found in 2019 known as SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Various parameters including clinical manifestations and molecular evaluation can affect the accuracy of diagnosis. This ... ...

    Abstract Background: Currently, a novel coronavirus found in 2019 known as SARS-CoV-2 is the etiological agent of the COVID-19 pandemic. Various parameters including clinical manifestations and molecular evaluation can affect the accuracy of diagnosis. This review aims to discuss the various clinical symptoms and molecular evaluation results in COVID-19 patients, to point out the importance of onset symptoms, type, and timing of the sampling, besides the methods that are used for detection of SARS-CoV-2.
    Methods: A systematic literature review of current articles in the Web of Science, PubMed, Scopus, and EMBASE was conducted according to the PRISMA guideline.
    Results: Of the 12946 patients evaluated in this investigation, 7643 were confirmed to be COVID-19 positive by molecular techniques, particularly the RT-PCR/qPCR combined technique (qRT-PCR). In most of the studies, all of the enrolled cases had 100% positive results for molecular evaluation. Among the COVID-19 patients who were identified as such by positive PCR results, most of them showed fever or cough as the primary clinical signs. Less common symptoms observed in clinically confirmed cases were hemoptysis, bloody sputum, mental disorders, and nasal congestion. The most common clinical samples for PCR-confirmed COVID-19 patients were obtained from throat, oropharyngeal, and nasopharyngeal swabs, while tears and conjunctival secretions seem to be the least common clinical samples for COVID-19 diagnosis among studies. Also, different conserved SARS-CoV-2 gene sequences could be targeted for qRT-PCR detection. The suggested molecular assay being used by most laboratories for the detection of SARS-CoV-2 is qRT-PCR.
    Conclusion: There is a worldwide concern on the COVID-19 pandemic and a lack of well-managed global control. Hence, it is crucial to update the molecular diagnostics protocols for handling the situation. This is possible by understanding the available advances in assays for the detection of the SARS-CoV-2 infection. Good sampling procedure and using samples with enough viral loads, also considering the onset symptoms, may reduce the qRT-PCR false-negative results in symptomatic COVID-19 patients. Selection of the most efficient primer-probe for target genes and samples containing enough viral loads to search for the existence of SARS-CoV-2 helps detecting the virus on time using qRT-PCR.
    Language English
    Publishing date 2021-09-06
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2467270-1
    ISSN 1687-9198 ; 1687-918X
    ISSN (online) 1687-9198
    ISSN 1687-918X
    DOI 10.1155/2021/5528786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients.

    Soltani, Saber / Zakeri, Armin / Tabibzadeh, Alireza / Zandi, Milad / Ershadi, Elham / Akhavan Rezayat, Sara / Khaseb, Sanaz / Zakeri, Amir Mohammad / Ashtar Nakhaei, Mohammadvala / Afzali, Shervin / Farahani, Abbas

    Tropical medicine and health

    2020  Volume 48, Issue 1, Page(s) 96

    Abstract: Background: Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic ... ...

    Abstract Background: Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. We summarize current knowledge about the prevalence rates of the parvovirus B19 infection in sickle cell anemia and thalassemia patients.
    Methods: Several online databases were searched including, Scopus, EMBASE, Web of Science, Google Scholar, and PubMed, which were performed amidst 2009-2019 by using distinct keywords: "Thalassemia," "Parvovirus," "Anemia," "Sickle cell anemia," "parvoviridae," "parvoviridae infection," and "parvovirus B19."
    Results: Search results indicated 4 and 7 studies for the prevalence of the parvovirus B19 in β-thalassemia and SCD, respectively. Among the β-thalassemia patients, the B19V seroprevalence for IgG and IgM were ranged from 18.2-81% and 14.5-41.1%, respectively; meanwhile, B19V DNA positively results was 4-15.3%. Moreover, in the SCD group, the extent of B19V IgG was varied from 37.6 to 65.9% and that of IgM was in a range of 2.9-30%, and the DNA detection rate was 4-54%.
    Conclusion: B19V seroprevalence changes in several conditions including, different epidemiological features, socio-economic status, and overpopulation. Age can expand the incidence of anti-B19V IgG/IgM in SCD and beta-thalassemia patients. Reinfection and diverse genotypes are relevant factors in the seroprevalence of B19v. The patients' immunological-hematological station and higher abundance of transfusions can affect the B19V seroprevalence in SCD and beta-thalassemia group. Further investigations in this field could be suggested to better understand the virus distribution in this susceptible population of patients.
    Language English
    Publishing date 2020-12-02
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2209835-5
    ISSN 1349-4147 ; 1348-8945
    ISSN (online) 1349-4147
    ISSN 1348-8945
    DOI 10.1186/s41182-020-00284-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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