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  1. Artikel ; Online: Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth.

    Agapouda, Anastasia / Grimm, Amandine / Lejri, Imane / Eckert, Anne

    Publikation ZURÜCKGEZOGEN

    Oxidative medicine and cellular longevity

    2022  Band 2022, Seite(n) 5647599

    Abstract: Background: Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally ... ...

    Abstract Background: Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally affected by their overproduction. Neurons depend almost solely on ATP produced by mitochondria in order to satisfy their energy needs and to form synapses, while stress has been proven to alter synaptic plasticity. Emerging evidence underpins that
    Methods: In this study, the effect of
    Results: RRE increased bioenergetics as well as cell viability and scavenged ROS with a similar efficacy in both cells lines and counteracted the respective corticosteroid-induced dysregulation. The effect of RRE, both under dexamethasone-stress and under normal conditions, resulted in biphasic U-shape and inverted U-shape dose response curves, a characteristic feature of adaptogenic plant extracts. Additionally, RRE treatment promoted neurite outgrowth and induced an increase in BDNF levels.
    Conclusion: These findings indicate that RRE may constitute a candidate for the prevention of stress-induced pathophysiological processes as well as oxidative stress. Therefore, it could be employed against stress-associated mental disorders potentially leading to the development of a condition-specific supplementation.
    Mesh-Begriff(e) Animals ; Brain-Derived Neurotrophic Factor ; Dexamethasone ; Humans ; Mice ; Neuronal Outgrowth ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Reactive Oxygen Species ; Rhodiola
    Chemische Substanzen Brain-Derived Neurotrophic Factor ; Plant Extracts ; Reactive Oxygen Species ; Dexamethasone (7S5I7G3JQL)
    Sprache Englisch
    Erscheinungsdatum 2022-05-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Retracted Publication
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/5647599
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence.

    Lejri, Imane / Agapouda, Anastasia / Grimm, Amandine / Eckert, Anne

    Oxidative medicine and cellular longevity

    2019  Band 2019, Seite(n) 9695412

    Abstract: Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative disorder yet incurable to date. While its main postmortem brain ... ...

    Abstract Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative disorder yet incurable to date. While its main postmortem brain hallmarks are the presence of amyloid-
    Mesh-Begriff(e) Alzheimer Disease/drug therapy ; Animals ; Antioxidants/therapeutic use ; Clinical Trials as Topic ; Cognitive Dysfunction/prevention & control ; Drug Evaluation, Preclinical ; Energy Metabolism ; Evidence-Based Medicine ; Humans ; Mitochondria/drug effects ; Mitochondria/physiology ; Oxidative Stress/drug effects ; Phytoestrogens/therapeutic use ; Plant Extracts/therapeutic use ; Pregnanolone/therapeutic use ; Resveratrol/therapeutic use
    Chemische Substanzen Antioxidants ; Phytoestrogens ; Plant Extracts ; Ginkgo biloba extract (19FUJ2C58T) ; Pregnanolone (BXO86P3XXW) ; Resveratrol (Q369O8926L)
    Sprache Englisch
    Erscheinungsdatum 2019-05-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/9695412
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Honeybush Extracts (

    Agapouda, Anastasia / Butterweck, Veronika / Hamburger, Matthias / de Beer, Dalene / Joubert, Elizabeth / Eckert, Anne

    Oxidative medicine and cellular longevity

    2020  Band 2020, Seite(n) 1948602

    Abstract: Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging. There is evidence that oxidative stress and ... ...

    Abstract Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging. There is evidence that oxidative stress and mitochondrial dysfunction are the most upstream and common events in the pathomechanisms of neurodegeneration.
    Mesh-Begriff(e) Antioxidants/therapeutic use ; Energy Metabolism/drug effects ; Humans ; Mitochondria/drug effects ; Oxidative Stress/drug effects ; Plant Extracts/chemistry
    Chemische Substanzen Antioxidants ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2020-08-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2020/1948602
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: St John's wort (Hypericum perforatum) products - an assessment of their authenticity and quality.

    Booker, Anthony / Agapouda, Anastasia / Frommenwiler, Débora A / Scotti, Francesca / Reich, Eike / Heinrich, Michael

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2018  Band 40, Seite(n) 158–164

    Abstract: Background: St John's wort products (Hypericum perforatum L.) are widely available for sale in many countries including the UK via the internet. In the UK, these products are required to hold either a marketing authorisation or Traditional herbal ... ...

    Abstract Background: St John's wort products (Hypericum perforatum L.) are widely available for sale in many countries including the UK via the internet. In the UK, these products are required to hold either a marketing authorisation or Traditional herbal registration (THR) to be sold legally. The THR and other regulatory schemes help to ensure product safety and quality providing an example of best practice but there is a risk if both regulated and un-regulated products continue to be available to consumers.
    Aims: The project is embedded in a larger study aiming to investigate the quality of different herbal medicinal products along diverse value chains. Here we focus on a comparison of the quality of the finished products and assess phytochemical variation between registered products (THRs) and products obtained from the market without any registration.
    Methods: 47 commercial products (granulated powders and extracts) were sourced from different suppliers. We analysed these samples using high performance thin layer chromatography (HPTLC) and
    Results: The consistency of the products varies significantly. Adulteration of the products (36%), possibly with other Hypericum species obtained from China or use of chemically distinct H. perforatum cultivars or chemotypes, and adulteration of the products (19%) with food dyes (tartrazine, amaranth, brilliant blue, sunset yellow) were the principle findings of this study.
    Conclusions: There is significant compositional variation among commercial finished products and two main causative quality problems were identified as adulteration by incorrect species or adulteration with food dyes. Generally, food supplements and unlicensed products were found to be of poorer quality than the regulated ones including THRs.
    Mesh-Begriff(e) China ; Chromatography, Thin Layer ; Dietary Supplements ; Drug Contamination ; Hypericum/chemistry ; Magnetic Resonance Spectroscopy ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; Quality Control ; United Kingdom
    Chemische Substanzen Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2018-02-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2017.12.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Quality control of Hypericum perforatum L. analytical challenges and recent progress.

    Agapouda, Anastasia / Booker, Anthony / Kiss, Tivadar / Hohmann, Judit / Heinrich, Michael / Csupor, Dezső

    The Journal of pharmacy and pharmacology

    2017  Band 71, Heft 1, Seite(n) 15–37

    Abstract: Objectives: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches.: Key findings: Biologically ... ...

    Abstract Objectives: The most widely applied qualitative and quantitative analytical methods in the quality control of Hypericum perforatum extracts will be reviewed, including routine analytical tools and most modern approaches.
    Key findings: Biologically active components of H. perforatum are chemically diverse; therefore, different chromatographic and detection methods are required for the comprehensive analysis of St. John's wort extracts. Naphthodianthrones, phloroglucinols and flavonoids are the most widely analysed metabolites of this plant. For routine quality control, detection of major compounds belonging to these groups seems to be sufficient; however, closer characterization requires the detection of minor compounds as well.
    Conclusions: TLC and HPTLC are basic methods in the routine analysis, whereas HPLC-DAD is the most widely applied method for quantitative analysis due to its versatility. LC-MS is gaining importance in pharmacokinetic studies due to its sensitivity. Modern approaches, such as DNA barcoding, NIRS and NMR metabolomics, may offer new possibilities for the more detailed characterization of secondary metabolite profile of H. perforatum extracts.
    Mesh-Begriff(e) Animals ; Chromatography, Liquid/methods ; Humans ; Hypericum/chemistry ; Hypericum/metabolism ; Plant Extracts/analysis ; Plant Extracts/chemistry ; Plant Extracts/standards ; Quality Control ; Secondary Metabolism ; Spectrum Analysis/methods
    Chemische Substanzen Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2017-03-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1111/jphp.12711
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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