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  1. Article ; Online: LiCoO

    Agarwal, Ashutosh / Li, Xue

    Nanoscale

    2024  Volume 16, Issue 14, Page(s) 7019–7030

    Abstract: In this study, Kraft lignin-derived bio-oil was upgraded with ... ...

    Abstract In this study, Kraft lignin-derived bio-oil was upgraded with LiCoO
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00358f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparative Evaluation of Octenidine with Chlorhexidine Mouthwash in Gingivitis and Periodontitis Patients: A Randomized Clinical Trial.

    Amrita, Amrita / Agarwal, Prerna / Agarwal, Manvi Chandra / Agarwal, Ashutosh / Garg, Jaishree / Mehra, Parth

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S789–S791

    Abstract: Introduction: Chlorhexidine gluconate (CHX) has been still regarded as the most efficient mouthwash. Due to its recognized negative effects, it can only be used for a short duration. Octenidine dihydrochloride (OCT), an antiseptic substance found by ... ...

    Abstract Introduction: Chlorhexidine gluconate (CHX) has been still regarded as the most efficient mouthwash. Due to its recognized negative effects, it can only be used for a short duration. Octenidine dihydrochloride (OCT), an antiseptic substance found by Sterling Winthrop in the 1980s, has proven helpful in preventing the co-aggregation of dental plaque microbial invaders without disrupting the typical, healthy oral flora. However, there is very little research on octenidine's effectiveness as a mouthwash for preventing plaque. Therefore, this study is being conducted to examine the effectiveness of mouthwashes containing 0.1% Octenidine and 0.2% chlorhexidine.
    Methodology: In this clinical trial, subjects were divided into two groups, 60 patients each with gingivitis and periodontitis. Then, from each group, 30 patients were advised to use octenidine mouthwash, and 30 patients were prescribed chlorhexidine mouthwash as an adjunct to scaling and root planning. Clinical parameters like O'Leary plaque index, Bleeding index, Probing pocket depth, and clinical attachment loss were evaluated at baseline and after 3 months.
    Result: In both the gingivitis and periodontitis groups, the octenidine group significantly outperformed the chlorhexidine group in all clinical metrics.
    Conclusion: Octenidine showed better results in comparison to chlorhexidine with respect to all the above-mentioned clinical parameters. Hence, it can be considered a promising mouthwash for future therapeutic and research studies.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_1011_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Depthformer

    Agarwal, Ashutosh / Arora, Chetan

    Multiscale Vision Transformer For Monocular Depth Estimation With Local Global Information Fusion

    2022  

    Abstract: Attention-based models such as transformers have shown outstanding performance on dense prediction tasks, such as semantic segmentation, owing to their capability of capturing long-range dependency in an image. However, the benefit of transformers for ... ...

    Abstract Attention-based models such as transformers have shown outstanding performance on dense prediction tasks, such as semantic segmentation, owing to their capability of capturing long-range dependency in an image. However, the benefit of transformers for monocular depth prediction has seldom been explored so far. This paper benchmarks various transformer-based models for the depth estimation task on an indoor NYUV2 dataset and an outdoor KITTI dataset. We propose a novel attention-based architecture, Depthformer for monocular depth estimation that uses multi-head self-attention to produce the multiscale feature maps, which are effectively combined by our proposed decoder network. We also propose a Transbins module that divides the depth range into bins whose center value is estimated adaptively per image. The final depth estimated is a linear combination of bin centers for each pixel. Transbins module takes advantage of the global receptive field using the transformer module in the encoding stage. Experimental results on NYUV2 and KITTI depth estimation benchmark demonstrate that our proposed method improves the state-of-the-art by 3.3%, and 3.3% respectively in terms of Root Mean Squared Error (RMSE). Code is available at https://github.com/ashutosh1807/Depthformer.git.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2022-07-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Post-COVID mucormycosis in presentation of periodontal abscess.

    Agarwal, Ashutosh / Ratre, Madhu S / Uikey, Guruprasad / Newaskar, Vilas

    Journal of family medicine and primary care

    2023  Volume 12, Issue 1, Page(s) 168–170

    Abstract: COVID-19 pandemic has traumatized deep inside in minds and lives of human beings. Those who have survived are at risk of many post-COVID complications; mucormycosis being one of the most common as well as morbid infections. Mucormycosis is also known as ... ...

    Abstract COVID-19 pandemic has traumatized deep inside in minds and lives of human beings. Those who have survived are at risk of many post-COVID complications; mucormycosis being one of the most common as well as morbid infections. Mucormycosis is also known as black fungus, it is a life-threatening opportunistic fungal infection. Inoculation occurs by inhalation of spores in nose, paranasal air sinuses and in lungs. Mucormycosis is often associated in patients with compromised immunity and it presents with characteristic black necrotic eschar and necrosis. Disease affecting the facial region possess a challenge because it often disseminates with sino-orbital and cranial involvement at the time of diagnosis. Dental practice occasionally encounters unusual and subtle symptoms with non-pathognomonic clinical signs of several fatal diseases which may pretend like a common oral disease. Hence, the key knowledge to oral and primary care physicians and its precise application is necessary for the early diagnosis of such fatal infections to prevent untoward consequences in this COVID era. This article presents a case of mucormycosis with chief complaint of pain and swelling in right front tooth region, which mimicked as periodontal abscess in a patient, leading to delay in the diagnosis possess greater challenges during the treatment.
    Language English
    Publishing date 2023-02-15
    Publishing country India
    Document type Case Reports
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_1462_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Physiologically relevant microsystems to study viral infection in the human liver.

    McDuffie, Dennis / Barr, David / Agarwal, Ashutosh / Thomas, Emmanuel

    Frontiers in microbiology

    2022  Volume 13, Page(s) 999366

    Abstract: Viral hepatitis is a leading cause of liver disease and mortality. Infection can occur acutely or chronically, but the mechanisms that govern the clearance of virus or lack thereof are poorly understood and merit further investigation. Though cures for ... ...

    Abstract Viral hepatitis is a leading cause of liver disease and mortality. Infection can occur acutely or chronically, but the mechanisms that govern the clearance of virus or lack thereof are poorly understood and merit further investigation. Though cures for viral hepatitis have been developed, they are expensive, not readily accessible in vulnerable populations and some patients may remain at an increased risk of developing hepatocellular carcinoma (HCC) even after viral clearance. To sustain infection
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.999366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Immunohistochemical expression of paxillin in ameloblastoma and odontogenic keratocyst: An observational study.

    Singh, Arunima / Astekar, Madhusudan S / Sapra, Gaurav / Agarwal, Ashutosh / Murari, Aditi

    Journal of oral and maxillofacial pathology : JOMFP

    2023  Volume 27, Issue 4, Page(s) 727–734

    Abstract: Background: Cell adhesion molecules (CAMs) are found on the surface of all cells, where they allow dynamic processes to take place. These include cadherins, integrins, selectins and Immunoglobulin superfamily. Directly associated with β-integrin tails ... ...

    Abstract Background: Cell adhesion molecules (CAMs) are found on the surface of all cells, where they allow dynamic processes to take place. These include cadherins, integrins, selectins and Immunoglobulin superfamily. Directly associated with β-integrin tails is a multidomain protein known as paxillin. However, CAMs participate in cell-cell and extracellular matrix-cell interactions during histomorphogenesis in the various phases of odontogenesis. Some tumours or cysts like ameloblastoma (AB) or odontogenic keratocyst (OKC) having odontogenic origin show disturbance in the interaction of these CAMs. Hence, the assessment of paxillin expression in AB and OKC was carried out.
    Materials and methods: The present observational study comprised 30 clinically and histologically confirmed cases of AB and OKC. All the slides were stained immunohistochemically using a paxillin antibody.
    Results: Upon comparison of staining intensity of paxillin among AB and OKC showed statistically significant result, whereas quantitative staining and final summation showed non-significant result. Gender-wise comparison of paxillin staining intensity, quantitative staining and final summation among OKC showed significant result; however, in AB, staining intensity showed non-significant result, whereas quantitative staining and final summation showed significant result.
    Conclusion: Paxillin has the greatest influence on tissue morphogenesis and development. The regulation of cell mobility is aided by the multiple roles that paxillin plays in a range of cells and tissues. However, further studies using a large sample size, along with other molecular analytical methods, may be essential to draw a definite conclusion about the association of paxillin and its exact function in OKC and AB.
    Language English
    Publishing date 2023-12-20
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.jomfp_312_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Microelectrode Array based Functional Testing of Pancreatic Islet Cells.

    Alassaf, Ahmad / Ishahak, Matthew / Bowles, Annie / Agarwal, Ashutosh

    Micromachines

    2020  Volume 11, Issue 5

    Abstract: Electrophysiological techniques to characterize the functionality of islets of Langerhans have been limited to short-term, one-time recordings such as a patch clamp recording. We describe the use of microelectrode arrays (MEAs) to better understand the ... ...

    Abstract Electrophysiological techniques to characterize the functionality of islets of Langerhans have been limited to short-term, one-time recordings such as a patch clamp recording. We describe the use of microelectrode arrays (MEAs) to better understand the electrophysiology of dissociated islet cells in response to glucose in a real-time, non-invasive method over prolonged culture periods. Human islets were dissociated into singular cells and seeded onto MEA, which were cultured for up to 7 days. Immunofluorescent imaging revealed that several cellular subtypes of islets; β, δ, and γ cells were present after dissociation. At days 1, 3, 5, and 7 of culture, MEA recordings captured higher electrical activities of islet cells under 16.7 mM glucose (high glucose) than 1.1 mM glucose (low glucose) conditions. The fraction of the plateau phase (FOPP), which is the fraction of time with spiking activity recorded using the MEA, consistently showed distinguishably greater percentages of spiking activity with high glucose compared to the low glucose for all culture days. In parallel, glucose stimulated insulin secretion was measured revealing a diminished insulin response after day 3 of culture. Additionally, MEA spiking profiles were similar to the time course of insulin response when glucose concentration is switched from 1.1 to 16.7 mM. Our analyses suggest that extracellular recordings of dissociated islet cells using MEA is an effective approach to rapidly assess islet functionality, and could supplement standard assays such as glucose stimulate insulin response.
    Language English
    Publishing date 2020-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11050507
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  8. Article: Evaluation of association between potential stress markers and periodontal health in medical and dental students: A questionnaire-based study.

    Agarwal, Prerna / Bhattacharya, Hirak S / Rastogi, Pavitra / Agarwal, Manvi Chandra / Agarwal, Ashutosh

    National journal of maxillofacial surgery

    2022  Volume 13, Issue 1, Page(s) 90–94

    Abstract: Aims and objectives: Psychological conditions, particularly psychosocial stress, have been implicated as risk indicators for periodontal disease. The aim of the present study was to explore the role of psychosocial stress on periodontium through ... ...

    Abstract Aims and objectives: Psychological conditions, particularly psychosocial stress, have been implicated as risk indicators for periodontal disease. The aim of the present study was to explore the role of psychosocial stress on periodontium through questionnaire and serum cortisol level.
    Subjects and methods: Two hundred medical and dental undergraduates were recruited for the study. Case group included 82 examination going and control group had 79 nonexam going students. Their stress level was evaluated using a standard questionnaire (perceived stress scale). Gingival index, periodontal disease index, bleeding on probing index, serum cortisol level, and serum alpha-amylase level were also measured.
    Statistical analysis used: Bivariate correlations and multiple regression tests were done.
    Results: A positive correlation was found among stress scores, salivary cortisol, alpha-amylase, and periodontal disease measures.
    Conclusion: Periodontitis can be related to immunologic changes related to psychological states.
    Language English
    Publishing date 2022-04-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2653583-X
    ISSN 2229-3418 ; 0975-5950
    ISSN (online) 2229-3418
    ISSN 0975-5950
    DOI 10.4103/njms.NJMS_101_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Treatment of COVID-19 Pneumonia and Acute Respiratory Distress With Ramatroban, a Thromboxane A

    Ogletree, Martin L / Chander Chiang, Kate / Kulshrestha, Rashmi / Agarwal, Aditya / Agarwal, Ashutosh / Gupta, Ajay

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 904020

    Abstract: Hypoxemia in COVID-19 pneumonia is associated with hospitalization, mechanical ventilation, and mortality. COVID-19 patients exhibit marked increases in fatty acid levels and inflammatory lipid mediators, predominantly arachidonic acid metabolites, ... ...

    Abstract Hypoxemia in COVID-19 pneumonia is associated with hospitalization, mechanical ventilation, and mortality. COVID-19 patients exhibit marked increases in fatty acid levels and inflammatory lipid mediators, predominantly arachidonic acid metabolites, notably thromboxane B
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.904020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Physiomimetic In Vitro Human Models for Viral Infection in the Liver.

    McDuffie, Dennis / Barr, David / Helm, Madeline / Baumert, Thomas / Agarwal, Ashutosh / Thomas, Emmanuel

    Seminars in liver disease

    2022  Volume 43, Issue 1, Page(s) 31–49

    Abstract: Viral hepatitis is a leading cause of liver morbidity and mortality globally. The mechanisms underlying acute infection and clearance, versus the development of chronic infection, are poorly understood. In vitro models of viral hepatitis circumvent the ... ...

    Abstract Viral hepatitis is a leading cause of liver morbidity and mortality globally. The mechanisms underlying acute infection and clearance, versus the development of chronic infection, are poorly understood. In vitro models of viral hepatitis circumvent the high costs and ethical considerations of animal models, which also translate poorly to studying the human-specific hepatitis viruses. However, significant challenges are associated with modeling long-term infection in vitro. Differentiated hepatocytes are best able to sustain chronic viral hepatitis infection, but standard two-dimensional models are limited because they fail to mimic the architecture and cellular microenvironment of the liver, and cannot maintain a differentiated hepatocyte phenotype over extended periods. Alternatively, physiomimetic models facilitate important interactions between hepatocytes and their microenvironment by incorporating liver-specific environmental factors such as three-dimensional ECM interactions and co-culture with non-parenchymal cells. These physiologically relevant interactions help maintain a functional hepatocyte phenotype that is critical for sustaining viral hepatitis infection. In this review, we provide an overview of distinct, novel, and innovative in vitro liver models and discuss their functionality and relevance in modeling viral hepatitis. These platforms may provide novel insight into mechanisms that regulate viral clearance versus progression to chronic infections that can drive subsequent liver disease.
    MeSH term(s) Animals ; Humans ; Liver ; Hepatocytes ; Liver Diseases ; Virus Diseases ; Hepatitis, Viral, Human
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603177-8
    ISSN 1098-8971 ; 0272-8087
    ISSN (online) 1098-8971
    ISSN 0272-8087
    DOI 10.1055/a-1981-5944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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