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  1. Article ; Online: The 0.2-μg/day Fluocinolone Acetonide Intravitreal Implant in Chronic Noninfectious Posterior Uveitis: A 3-year Randomized Trial in India.

    Biswas, Jyotirmay / Tyagi, Mudit / Agarwal, Manisha

    Ophthalmology science

    2023  Volume 4, Issue 1, Page(s) 100403

    Abstract: Objective: To examine the long-term efficacy and safety of the intravitreal 0.2-μg/day fluocinolone acetonide implant (FAi) to treat noninfectious uveitis (NIU) of the posterior segment (PS).: Design: Three-year, phase III, multicenter, randomized, ... ...

    Abstract Objective: To examine the long-term efficacy and safety of the intravitreal 0.2-μg/day fluocinolone acetonide implant (FAi) to treat noninfectious uveitis (NIU) of the posterior segment (PS).
    Design: Three-year, phase III, multicenter, randomized, double-masked, controlled, prospective study (clinicaltrials.gov, NCT02746991).
    Participants: Overall, 153 patients in India with NIU-PS in ≥ 1 eye (with or without anterior uveitis) for ≥ 1 year who had ≥ 2 separate recurrences of uveitis requiring ocular injections or systemic therapy in the prior 12 months.
    Methods: Patients were randomized 2:1 for baseline FAi or sham injection and monitored for main outcome measures.
    Main outcome measures: Incidence and timing of uveitis recurrence, use of adjunctive therapy, best-corrected visual acuity, central foveal thickness, and monitoring of intraocular pressure (IOP)- and cataract-related events over 36 months.
    Results: Overall, 153 patients (FAi, n = 101; treated sham, n = 52) were enrolled. Fluocinolone acetonide implant-treated eyes had significantly reduced uveitis recurrence rates versus treated sham (46.5% vs. 75.0%, respectively;
    Conclusions: In patients with NIU-PS, the 0.2-μg/day FAi is associated with reduced-uveitis recurrence and increased time to first recurrence while controlling macular edema, maintaining stable IOP levels, and providing an expected safety profile, including a higher occurrence of cataract formation over 36 months.
    Financial disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.
    Language English
    Publishing date 2023-09-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2023.100403
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  2. Article: Prebiotics-A Primeval Measure to Combat Dental Caries: A Short-term Clinical Study.

    Konde, Sapna / Ravindran, Shruthi / Agarwal, Manisha / Peethambar, Preetha

    International journal of clinical pediatric dentistry

    2022  Volume 15, Issue Suppl 2, Page(s) S234–S238

    Abstract: Background: Prevention of dental caries is paramount in reducing the global burden of the disease. The consumption of probiotics as a prophylactic and therapeutic agent for dental caries, has certain limitations. Prebiotics are nondigestible food ... ...

    Abstract Background: Prevention of dental caries is paramount in reducing the global burden of the disease. The consumption of probiotics as a prophylactic and therapeutic agent for dental caries, has certain limitations. Prebiotics are nondigestible food ingredients, that enhance the growth and activity of probiotic microorganism, thereby help in the establishment of a healthy oral environment.
    Aim: The aim of this study was to evaluate and compare the effect of prebiotics, probiotics, and synbiotics on the salivary
    Methodology: Children of age-group 6-9 years with DMFT score of 5 and above were divided into three groups of 10 each: Group 1 (prebiotics), Group 2 (probiotics), and Group 3 (synbiotics). The functional food therapy was done for a period of 1 month twice daily. The
    Results: A statistically significant reduction of
    Conclusion: Prebitoics can serve as an unfortified and natural means of combating dental caries.
    How to cite this article: Konde S, Ravindran S, Agarwal M,
    Language English
    Publishing date 2022-05-24
    Publishing country India
    Document type Journal Article
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-2165
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  3. Article: Diagnosis of 22q11.2 deletion syndrome in children with congenital heart diseases and facial dysmorphisms.

    Agarwal, Manisha / Kumar, Vivek / Dwivedi, Aradhana

    Medical journal, Armed Forces India

    2022  Volume 79, Issue Suppl 1, Page(s) S196–S201

    Abstract: Background: Congenital heart diseases (CHDs) are the leading cause of birth defects. Approximately, 30% of CHDs are related to genetic syndromes accompanied by extracardiac anomalies. Aneuploidies and 22q11.2 deletions account for majority of cases. ... ...

    Abstract Background: Congenital heart diseases (CHDs) are the leading cause of birth defects. Approximately, 30% of CHDs are related to genetic syndromes accompanied by extracardiac anomalies. Aneuploidies and 22q11.2 deletions account for majority of cases. 22q11.2 deletion involves deletion of 30-40 genes, and varying deletions in this region lead to different phenotypes. Fluorescent in situ hybridization probes span a narrow region on chromosome 22 as compared to other recent techniques like multiplex ligation probe amplification assay (MLPA) which may also identify any gene duplications if present.
    Methods: Present study was a cross-sectional descriptive study. In total, 350 children with CHD reported to pediatric cardiology clinic during the study period. Of these, 60 children had associated facial dysmorphism. Out of these 60 children, 18 children had clinical phenotype characteristic of Down syndrome and hence these children were excluded from the study. Forty-two children with CHDs (conotruncal and other defects) and craniofacial features (subtle or obvious) suggestive of 22q11.2 deletion spectrum disorder were included in this study.
    Results: Nineteen percent of children presenting with CHDs and facial dysmorphisms had 22q11.2 deletion syndrome. All the samples were subjected to karyotyping.
    Conclusion: Metaphase FISH has been the method of choice for microdeletions. However, apart from technical challenges and longer turnaround time, FISH probes span a very narrow region in 22q11.2 chromosome (LCR22 D) and provide information about DiGeorge syndrome (DGS) only. Take home message is that patients of CHDs with facial dysmorphism should be investigated in an approach-based manner.
    Language English
    Publishing date 2022-08-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/j.mjafi.2022.05.014
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  4. Article: Subacute Sclerosing Panencephalitis manifesting as Bell's palsy and bilateral macular necrotizing retinitis: an atypical presenting feature.

    Paul, Lagan / Jain, Tanya / Agarwal, Manisha / Singh, Shalini

    Journal of ophthalmic inflammation and infection

    2021  Volume 11, Issue 1, Page(s) 2

    Abstract: Background: Subacute sclerosing panencephalitis (SSPE) is a potentially lethal complication of measles infection. Neurological complications take years to manifest after primary viral infection of brain and can lead to blindness in some individuals.: ... ...

    Abstract Background: Subacute sclerosing panencephalitis (SSPE) is a potentially lethal complication of measles infection. Neurological complications take years to manifest after primary viral infection of brain and can lead to blindness in some individuals.
    Findings: A 13-year-old female patient with history of Bell's palsy 2 months prior, presented with rapidly progressing necrotizing retinitis in both eyes. Soon after, she was unable to walk, developed myoclonic jerks, altered sensorium and loss of bowel and bladder control. Her clinical history, CSF IgG measles antibody analysis, MRI brain and EEG findings confirmed the diagnosis of SSPE.
    Conclusion: SSPE in our case presented as Bell's palsy and sudden painless diminution of vision due to ocular involvement, and developed full blown disease within 2 months. SSPE can present as a diagnostic challenge and warrants early identification and referral for timely diagnosis and management.
    Language English
    Publishing date 2021-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2592309-2
    ISSN 1869-5760
    ISSN 1869-5760
    DOI 10.1186/s12348-020-00223-1
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  5. Article ; Online: Correspondence.

    Muralidhar, Alankrita / Saxena, Rushil Kumar / Agarwal, Manisha

    Retina (Philadelphia, Pa.)

    2021  Volume 41, Issue 9, Page(s) e64–e65

    Language English
    Publishing date 2021-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003211
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  6. Article ; Online: Choroidal thickness in thyroid eye disease and its correlation with disease activity.

    Muralidhar, Alankrita / Singh, Shalini / Das, Sima / Mondal, Kheyali / Kumar, Brajesh / Agarwal, Manisha / Majumdar, Atanu

    Indian journal of ophthalmology

    2023  Volume 72, Issue 2, Page(s) 281–286

    Abstract: Context: This study adds to the existing body of literature on the role of optical coherence tomography (OCT) parameters in active thyroid eye disease (TED) among the Indian population.: Purpose: Comparison of choroidal vascularity index (CVI) and ... ...

    Abstract Context: This study adds to the existing body of literature on the role of optical coherence tomography (OCT) parameters in active thyroid eye disease (TED) among the Indian population.
    Purpose: Comparison of choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in active and inactive TED.
    Settings and design: An observational, cross-sectional analytical study conducted at a tertiary eye care hospital in North India that included patients with active and inactive TED.
    Methods: Demographic details and clinical evaluation were performed for all TED patients. SFCT was determined with OCT by using the Cirrus linear measurement tool. CVI was calculated using Image J software. The SFCT and CVI measurements were compared between both groups.
    Statistical analysis used: Comparison between active and inactive TED groups was done using Mann-Whitney U test for non-parametric data and Student t test for parametric data. Multivariate regression analysis was performed with SFCT and CVI as dependent variables.
    Results: Sixty-two eyes of 31 patients were included. Thirteen eyes had active TED, and 49 eyes had inactive TED. SFCT was significantly lower in eyes with higher clinical activity score (CAS) and older age. No significant difference was found in CVI between active and inactive TED eyes.
    Conclusion: SFCT was lower in eyes with higher CAS and older age. Our findings differ from previous studies, which showed a positive correlation between SFCT and CAS. There was no significant difference in CVI between active and inactive TED eyes.
    MeSH term(s) Humans ; Graves Ophthalmopathy/diagnosis ; Cross-Sectional Studies ; Choroid ; Tomography, Optical Coherence/methods ; Follow-Up Studies
    Language English
    Publishing date 2023-12-26
    Publishing country India
    Document type Observational Study ; Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_848_23
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  7. Article ; Online: Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity.

    Agarwal, Manisha / Roth, Katherine / Yang, Zhao / Sharma, Rahul / Maddipati, Krishnarao / Westrick, Judy / Petriello, Michael C

    Environmental research

    2024  Volume 250, Page(s) 118492

    Abstract: Dioxin-like pollutants (DLPs), such as polychlorinated biphenyl 126 (PCB 126), are synthetic chemicals classified as persistent organic pollutants. They accumulate in adipose tissue and have been linked to cardiometabolic disorders, including fatty liver ...

    Abstract Dioxin-like pollutants (DLPs), such as polychlorinated biphenyl 126 (PCB 126), are synthetic chemicals classified as persistent organic pollutants. They accumulate in adipose tissue and have been linked to cardiometabolic disorders, including fatty liver disease. The toxicity of these compounds is associated with activation of the aryl hydrocarbon receptor (Ahr), leading to the induction of phase I metabolizing enzyme cytochrome P4501a1 (Cyp1a1) and the subsequent production of reactive oxygen species (ROS). Recent research has shown that DLPs can also induce the xenobiotic detoxification enzyme flavin-containing monooxygenase 3 (FMO3), which plays a role in metabolic homeostasis. We hypothesized whether genetic deletion of Fmo3 could protect mice, particularly in the liver, where Fmo3 is most inducible, against PCB 126 toxicity. To test this hypothesis, male C57BL/6 wild-type (WT) mice and Fmo3 knockout (Fmo3 KO) mice were exposed to PCB 126 or vehicle (safflower oil) during a 12-week study, at weeks 2 and 4. Various analyses were performed, including hepatic histology, RNA-sequencing, and quantitation of PCB 126 and F2-isoprostane concentrations. The results showed that PCB 126 exposure caused macro and microvesicular fat deposition in WT mice, but this macrovesicular fatty change was absent in Fmo3 KO mice. Moreover, at the pathway level, the hepatic oxidative stress response was significantly different between the two genotypes, with the induction of specific genes observed only in WT mice. Notably, the most abundant F2-isoprostane, 8-iso-15-keto PGE2, increased in WT mice in response to PCB 126 exposure. The study's findings also demonstrated that hepatic tissue concentrations of PCB 126 were higher in WT mice compared to Fmo3 KO mice. In summary, the absence of FMO3 in mice led to a distinctive response to dioxin-like pollutant exposure in the liver, likely due to alterations in lipid metabolism and storage, underscoring the complex interplay of genetic factors in the response to environmental toxins.
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118492
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  8. Article ; Online: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

    Ranjan, Richa / Agarwal, Manisha

    Indian journal of ophthalmology

    2018  Volume 66, Issue 6, Page(s) 863–865

    Abstract: A 43-year-old male with chronic Vogt-Koyanagi-Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone ... ...

    Abstract A 43-year-old male with chronic Vogt-Koyanagi-Harada syndrome (VKH) presented with subfoveal choroidal neovascular membrane (CNVM) in the right eye with no evidence of active inflammation. He underwent intravitreal bevacizumab and dexamethasone injections. Postinjection he developed fresh keratic precipitates and exudative retinal detachment (RD). He received two more bevacizumab injections with oral corticosteroids and immunosuppressants causing resolution of exudative RD with scarred CNVM. We report this case to highlight that intravitreal injection may act as a trigger for rebound inflammation in VKH patients and may require anti-inflammatory drugs to be started even in the absence of an active inflammation.
    MeSH term(s) Adult ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Bevacizumab/administration & dosage ; Bevacizumab/adverse effects ; Choroidal Neovascularization/chemically induced ; Choroidal Neovascularization/diagnosis ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Inflammation/chemically induced ; Inflammation/diagnosis ; Intravitreal Injections ; Male ; Retinal Detachment/chemically induced ; Retinal Detachment/diagnosis ; Tomography, Optical Coherence ; Uveomeningoencephalitic Syndrome/drug therapy ; Visual Acuity
    Chemical Substances Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2018-05-21
    Publishing country India
    Document type Case Reports
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1145_17
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  9. Article ; Online: Response to comment on: Rebound inflammation after an intravitreal injection in Vogt-Koyanagi-Harada syndrome.

    Ranjan, Richa / Agarwal, Manisha

    Indian journal of ophthalmology

    2018  Volume 66, Issue 10, Page(s) 1523

    MeSH term(s) Humans ; Inflammation ; Intravitreal Injections ; Uveomeningoencephalitic Syndrome ; Visual Acuity
    Language English
    Publishing date 2018-09-24
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1221_18
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  10. Article: Recent Advances in Molecular Diagnosis and Prognosis of Childhood B Cell Lineage Acute Lymphoblastic Leukemia (B-ALL).

    Agarwal, Manisha / Seth, Rachna / Chatterjee, Tathagata

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2020  Volume 37, Issue 1, Page(s) 10–20

    Abstract: B cell lineage acute lymphoblastic leukemia is the most common leukemia occurring in children and young adults and is the leading cause of cancer related deaths. The 5 year overall survival outcome in children with B-ALL has improved significantly in the ...

    Abstract B cell lineage acute lymphoblastic leukemia is the most common leukemia occurring in children and young adults and is the leading cause of cancer related deaths. The 5 year overall survival outcome in children with B-ALL has improved significantly in the last few decades. In the past, the discovery of various genetic alterations and targeted therapy have played a major role in decreasing disease-related deaths. In addition, numerous advances in the pathogenesis of B-ALL have been found which have provided better understanding of the genes involved in disease biology with respect to diagnostic and prognostic implications. Present review will summarize current understanding of risk stratification, genetic factors including cytogenetics in diagnosis and prognosis of B-ALL.
    Language English
    Publishing date 2020-06-03
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-020-01295-8
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