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  1. Article ; Online: SGLT inhibitors: a serendipitous glycaemic tale.

    Agarwal, Shubham / Lingvay, Ildiko

    Nature reviews. Endocrinology

    2023  Volume 20, Issue 2, Page(s) 65

    MeSH term(s) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00923-3
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    Zs.MG 93: Show issues

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  2. Article ; Online: A revolution in obesity treatment.

    Lingvay, Ildiko / Agarwal, Shubham

    Nature medicine

    2023  Volume 29, Issue 10, Page(s) 2406–2408

    MeSH term(s) Humans ; Obesity/therapy
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02538-7
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  3. Article: Covid-19: What the pandemic has taught us and the way forward.

    Guleria, Randeep / Agarwal, Shubham

    The National medical journal of India

    2023  Volume 35, Issue 4, Page(s) 193–196

    MeSH term(s) Humans ; Pandemics/prevention & control ; COVID-19/epidemiology ; COVID-19/prevention & control
    Language English
    Publishing date 2023-01-30
    Publishing country India
    Document type Editorial
    ZDB-ID 645116-0
    ISSN 0970-258X
    ISSN 0970-258X
    DOI 10.25259/NMJI_1064_22
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  4. Article ; Online: Diabetes Technology in People with Type 2 Diabetes: Novel Indications.

    Agarwal, Shubham / Galindo, Rodolfo J / Shah, Amy V / Abreu, Marconi

    Current diabetes reports

    2024  Volume 24, Issue 5, Page(s) 85–95

    Abstract: Purpose of review: Diabetes technology has been continuously evolving. Current versions of continuous glucose monitors (CGM) use minimally invasive designs, monitor glucose values with high accuracy, and can be used to guide insulin dosing. Extensive ... ...

    Abstract Purpose of review: Diabetes technology has been continuously evolving. Current versions of continuous glucose monitors (CGM) use minimally invasive designs, monitor glucose values with high accuracy, and can be used to guide insulin dosing. Extensive evidence supports the use of diabetes technology for monitoring and insulin administration in people with type 1 diabetes. However, there is emerging evidence for people with type 2 diabetes. In this review, we present the different technological devices used to monitor glucose and deliver insulin and the evidence supporting their use in people with type 2 diabetes.
    Recent findings: The use of CGMs in people with type 2 diabetes treated with insulin or non-insulin therapies has been associated with improvements in glycemic control and time spent in hypoglycemia. Smart insulin pens and smart connected devices are options to track compliance and guide insulin delivery in people who do not require insulin pump therapy. Mechanical patch pumps can be used to reduce the burden of multiple daily insulin injections. Automated insulin delivery algorithms improve glycemic control without an increase in hypoglycemia. The use of technology in the management of type 2 diabetes generates glycemic data previously inaccessible, reduces barriers for insulin initiation, improves glycemic control, tracks adherence to therapy, and improves user satisfaction.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/drug therapy ; Blood Glucose Self-Monitoring/methods ; Insulin Infusion Systems ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Insulin/therapeutic use ; Blood Glucose/analysis ; Glycemic Control/methods
    Chemical Substances Hypoglycemic Agents ; Insulin ; Blood Glucose
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2065167-3
    ISSN 1539-0829 ; 1534-4827
    ISSN (online) 1539-0829
    ISSN 1534-4827
    DOI 10.1007/s11892-024-01536-4
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    Zs.A 5628: Show issues Location:
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  5. Article ; Online: Chronic Pancreatitis Associated With a Variant of

    Agarwal, Shubham / Lingvay, Ildiko / Mirfakhraee, Sasan / Jain, Raksha

    AACE clinical case reports

    2023  Volume 9, Issue 3, Page(s) 93–96

    Abstract: Background/objective: Total pancreatectomy is performed for pain relief in chronic pancreatitis. Concomitant autologous islet cell transplantation can be performed to improve glycemic control. We report the case of a patient with chronic pancreatitis ... ...

    Abstract Background/objective: Total pancreatectomy is performed for pain relief in chronic pancreatitis. Concomitant autologous islet cell transplantation can be performed to improve glycemic control. We report the case of a patient with chronic pancreatitis who underwent a total pancreatectomy with autologous islet cell transplantation with increasing insulin requirements and its association with cystic fibrosis transmembrane conductance regulator (CFTR)-related disorder.
    Case report: A 40-year-old woman presented with abdominal pain and had elevated levels of serum lipase. She was treated for acute pancreatitis. In the subsequent 2 years, she had 4 additional episodes of pancreatitis and eventually developed chronic abdominal pain. She underwent total pancreatectomy for pain relief with autologous intrahepatic islet cell transplantation. She experienced repeated episodes of pneumonia and underwent screening for cystic fibrosis, which showed a 7T/7T polymorphic variant at
    Discussion: Chronic pancreatitis can be a manifestation of an undiagnosed CFTR-related disorder, which in this case was followed by total pancreatectomy. Autologous islet cell transplantation was performed with declining postprocedural glycemic control. Interval failure of the transplanted islets is present in up to two thirds of the patients but is not affected by the presence of cystic fibrosis.
    Conclusion: A gradual decline in glycemic control may be expected in patients with autologous islet cell transplantation and can be improved with the use of continuous subcutaneous insulin infusion.
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.1016/j.aace.2023.04.007
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  6. Article ; Online: Elimination of Aspirin From PCI Pharmacotherapy.

    Agarwal, Sanjeev Kumar / Agarwal, Shubham

    JACC. Cardiovascular interventions

    2021  Volume 14, Issue 2, Page(s) 230

    MeSH term(s) Aspirin/adverse effects ; Coronary Vessels ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Pilot Projects ; Platelet Aggregation Inhibitors/adverse effects ; Prasugrel Hydrochloride ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors ; Prasugrel Hydrochloride (G89JQ59I13) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.11.010
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    Zs.A 6669: Show issues Location:
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  7. Article: Serial Estimation of Serum Calcium and Ionic Calcium Level for Early Detection of Hypocalcemia After Total/Completion Thyroidectomy.

    Sonkhya, Nishi / Agarwal, Shubham / Choudhary, Mahaveer Prasad / Gupta, Nishant

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 75, Issue 4, Page(s) 3493–3496

    Abstract: Hypocalcemia is an important and common complication following thyroid surgery. The development of postoperative hypocalcemia is likely to be multifactorial in nature. Patients with acute hypocalcemia may present with numbness of the distal extremities, ... ...

    Abstract Hypocalcemia is an important and common complication following thyroid surgery. The development of postoperative hypocalcemia is likely to be multifactorial in nature. Patients with acute hypocalcemia may present with numbness of the distal extremities, circumoral paresthesia, and/or carpopedal spasm, laryngospasm, seizure and arrhythmias. In most cases, post-thyroidectomy hypocalcemia is temporary, but small percentage (0-12%) are permanent. The present study was a 1-year prospective interventional study conducted at tertiary care center, Jaipur, India. Total 42 patients who underwent thyroidectomy were included in study. Evaluation of Serum and Ionic Calcium Level done Preoperatively and Postoperative at 6, 12, 24 and 48 h and patients who develops hypocalcemia symptoms were recorded and data were analyzed. In our study hypocalcemia was seen in 13 (31%) out of 42 subjects. Ionic calcium in 'All patients' gradually decreased from pre operative 1.28 ± 0.04 mmol/l to 1.14 ± 0.08 mmol/l by 24 h. Highest incidence of hypocalcemia was seen in patients who had Total thyroidectomy + neck dissection (83.3%) compared to other type of thyroid surgery. we concluded that post thyroidectomy transient hypocalcemia is a frequent complication. Serial monitoring of calcium levels preoperatively and postoperatively combined with careful monitoring of signs and symptoms of hypocalcemia is an efficient and cost-effective tool to detect early post thyroidectomy hypocalcemia.
    Language English
    Publishing date 2023-07-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-023-04031-6
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    Zs.A 5300: Show issues Location:
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  8. Article ; Online: Lopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications.

    Agarwal, Shubham / Agarwal, Sanjeev Kumar

    Cardiovascular drugs and therapy

    2020  Volume 35, Issue 3, Page(s) 427–440

    Abstract: Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. A low dose of ritonavir is added to other protease inhibitors to take advantage of potent inhibition of cytochrome (CYP) P450 3A4, thereby significantly increasing ... ...

    Abstract Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. A low dose of ritonavir is added to other protease inhibitors to take advantage of potent inhibition of cytochrome (CYP) P450 3A4, thereby significantly increasing the plasma concentration of coadministered lopinavir. Ritonavir also inhibits CYP2D6 and induces CYP2B6, CYP2C19, CYP2C9, and CYP1A2. This potent, time-dependent interference of major hepatic drug-metabolizing enzymes by ritonavir leads to several clinically important drug-drug interactions. A number of patients presenting with acute coronary syndrome and acute heart failure may have SARS-CoV-2 infection simultaneously. Lopinavir-ritonavir is added to their prescription of multiple cardiac medications leading to potential drug-drug interactions. Many cardiology, pulmonology, and intensivist physicians have never been exposed to clinical scenarios requiring co-prescription of cardiac and antiviral therapies. Therefore, it is essential to enumerate these drug-drug interactions, to avoid any serious drug toxicity, to consider alternate and safer drugs, and to ensure better patient care.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/drug therapy ; Drug Interactions ; Drug Therapy, Combination ; Heart Diseases/drug therapy ; Humans ; Hypolipidemic Agents/therapeutic use ; Lopinavir/administration & dosage ; Platelet Aggregation Inhibitors/therapeutic use ; Ritonavir/administration & dosage ; SARS-CoV-2
    Chemical Substances Anticoagulants ; Hypolipidemic Agents ; Platelet Aggregation Inhibitors ; Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825)
    Keywords covid19
    Language English
    Publishing date 2020-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-020-07070-1
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  9. Article ; Online: Endocrine changes in SARS-CoV-2 patients and lessons from SARS-CoV.

    Agarwal, Shubham / Agarwal, Sanjeev Kumar

    Postgraduate medical journal

    2020  Volume 96, Issue 1137, Page(s) 412–416

    Abstract: Coronavirus infection outbreaks have occurred frequently in the last two decades and have led to significant mortality. Despite the focus on reducing mortality by preventing the spread of the virus, patients have died due to several other complications ... ...

    Abstract Coronavirus infection outbreaks have occurred frequently in the last two decades and have led to significant mortality. Despite the focus on reducing mortality by preventing the spread of the virus, patients have died due to several other complications of the illness. The understanding of pathological mechanisms and their implications is continuously evolving. A number of symptoms occur in these patients due to the involvement of various endocrine glands. These clinical presentations went largely unnoticed during the first outbreak of severe acute respiratory syndrome (SARS) in 2002-2003. A few of these derangements continued during the convalescence phase and sometimes occurred after recovery. Similar pathological and biochemical changes are being reported with the novel coronavirus disease outbreak in 2020. In this review, we focus on these endocrine changes that have been reported in both SARS coronavirus and SARS coronavirus-2. As we battle the pandemic, it becomes imperative to address these underlying endocrine disturbances that are contributing towards or predicting mortality of these patients.
    MeSH term(s) Adrenal Gland Diseases/metabolism ; Adrenal Gland Diseases/physiopathology ; Adrenal Gland Diseases/virology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus/virology ; Humans ; Hyperglycemia ; Pandemics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Practice Guidelines as Topic ; Severe acute respiratory syndrome-related coronavirus/physiology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/metabolism ; Severe Acute Respiratory Syndrome/physiopathology ; Severe Acute Respiratory Syndrome/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2020-137934
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  10. Article ; Online: STEMI with flush occlusion of a coronary artery: An interventional dilemma.

    Agarwal, Shubham / Agarwal, Sanjeev Kumar

    Journal of cardiology cases

    2020  Volume 23, Issue 3, Page(s) 108–111

    Abstract: Flush occlusions of coronary arteries present with multiple challenges during primary percutaneous coronary intervention (PPCI). We describe a case of anterior ST-elevation myocardial infarction in cardiogenic shock, where it was not possible to identify ...

    Abstract Flush occlusions of coronary arteries present with multiple challenges during primary percutaneous coronary intervention (PPCI). We describe a case of anterior ST-elevation myocardial infarction in cardiogenic shock, where it was not possible to identify the origin of left anterior descending artery (LAD) as it was flush occluded and initial attempts to place a coronary guidewire in the LAD during PPCI were unsuccessful. After failed attempts with multiple guidewires, a combined pharmacological-mechanical approach resulted in successful timely revascularization and subsequent recovery of the patient. <
    Language English
    Publishing date 2020-11-03
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2020.10.007
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