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  1. Article ; Online: Effects of

    Ismail, Hammad / Khalid, Dania / Ayub, Saad Bin / Ijaz, Muhammad Umar / Akram, Samra / Bhatti, Muhammad Zeeshan / Taqi, Malik Mumtaz / Dilshad, Erum / Anwaar, Sadaf / Batiha, Gaber El-Saber / Aggad, Sarah S / Yousef, Fatimah M / Waard, Michel De

    BioMed research international

    2023  Volume 2023, Page(s) 1725638

    Abstract: ... Phoenix ... ...

    Abstract Phoenix dactylifera
    MeSH term(s) Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Phoeniceae/chemistry ; Streptozocin/pharmacology ; Aluminum Chloride/pharmacology ; Rats, Wistar ; Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Glutathione/metabolism ; Oxidative Stress
    Chemical Substances Antioxidants ; Streptozocin (5W494URQ81) ; Aluminum Chloride (3CYT62D3GA) ; Plant Extracts ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2023/1725638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats.

    Abdulrasheed-Adeleke, Tawakaltu / Lawal, Bashir / Agwupuye, Eyuwa Ignatius / Kuo, Yucheng / Eni, Amarachi Mary / Ekoh, Okwukwe Faith / Lukman, Halimat Yusuf / Onikanni, Amos S / Olawale, Femi / Saidu, Sani / Ibrahim, Yunusa O / Al Ghamdi, Maliha Abdullah Saleh / Aggad, Sarah S / Alsayegh, Abdulrahman A / Aljarba, Nada H / Batiha, Gaber El-Saber / Wu, Alexander T H / Huang, Hsu-Shan

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 162, Page(s) 114582

    Abstract: In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent ... ...

    Abstract In the present study, in vitro, in vivo, and in silico models were used to evaluate the therapeutic potential of Pulmeria alba methanolic (PAm) extract, and we identified the major phytocompound, apigetrin. Our in vitro studies revealed dose-dependent increased glucose uptake and inhibition of α-amylase (50% inhibitory concentration (IC
    MeSH term(s) Rats ; Humans ; Animals ; Diabetes Mellitus, Experimental/drug therapy ; Acetylcholinesterase/metabolism ; Rats, Wistar ; Blood Glucose/metabolism ; Oxidative Stress ; Antioxidants/pharmacology ; Brain/metabolism ; Inflammation/drug therapy ; Streptozocin/therapeutic use ; Plant Extracts/pharmacology
    Chemical Substances apigetrin (7OF2S66PCH) ; Acetylcholinesterase (EC 3.1.1.7) ; Blood Glucose ; Antioxidants ; Streptozocin (5W494URQ81) ; Plant Extracts
    Language English
    Publishing date 2023-03-28
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Eugenia sonderiana O. Berg leaves: Phytochemical characterization, evaluation of in vitro and in vivo antidiabetic effects, and structure-activity correlation.

    Bastos, Renan G / Rodrigues, Sarah de O / Marques, Larissa A / Oliveira, Carla M de / Salles, Bruno C C / Zanatta, Ana C / Rocha, Fabíola D / Vilegas, Wagner / Pagnossa, Jorge P / de A Paula, Fernanda B / da Silva, Geraldo A / Batiha, Gaber E / Aggad, Sarah S / Alotaibi, Badriyah S / Yousef, Fatimah M / da Silva, Marcelo A

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 165, Page(s) 115126

    Abstract: Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications of diabetes mellitus. In this context, plants of the Myrtaceae family popularly used in Brazil ... ...

    Abstract Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications of diabetes mellitus. In this context, plants of the Myrtaceae family popularly used in Brazil for the treatment of diabetes mellitus, including Eugenia sonderiana, have shown beneficial effects due to the presence of phenolic compounds and saponins in their chemical constitution. Thus, the present work aimed to perform the phytochemical characterization of the hydroethanolic extract of E. sonderiana leaves using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), along with in vitro and in vivo studies of antidiabetic activity. The chemical characterization revealed the presence of phenolic compounds, flavonoids, neolignans, tannins, and saponins. In addition, the extract exhibited minimum inhibitory concentrations of alpha-amylase and alpha-glycosidase higher than the acarbose in the in vitro tests. Also, the in vivo tests revealed a slight increase in body mass in diabetic rats, as well as a significant decrease in water and feed consumption provided by the extract. Regarding serum biochemical parameters, the extract showed significant activity in decreasing the levels of glucose, hepatic enzymes, and triglycerides, in addition to maintaining HDL cholesterol levels within normal ranges, protecting the cell membranes against oxidative damage. Thus, the extract of E. sonderiana leaves was considered promising pharmaceutical ingredient in the production of a phytotherapy medication.
    MeSH term(s) Rats ; Animals ; Hypoglycemic Agents/therapeutic use ; Plant Extracts/therapeutic use ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Phytochemicals/therapeutic use ; Phenols/pharmacology ; Plant Leaves/chemistry ; Saponins/therapeutic use ; Eugenia
    Chemical Substances Hypoglycemic Agents ; Plant Extracts ; Phytochemicals ; Phenols ; Saponins
    Language English
    Publishing date 2023-07-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115126
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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