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Article ; Online: Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (

Aggarwal, Diwakar / Upadhyay, Sushil K / Singh, Raj / Tuli, Hardeep S

Pharmaceutical patent analyst

2021 Volume 10, Issue 1, Page(s) 37–49

Abstract: There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti- ... ...

Abstract	There is expanding proof that specific natural compounds found in plants have additional conventional medicinal properties. One such compound is xanthohumol (XN), which is being explored as an antimicrobial, anticarcinogenic, antidiabetic and anti-inflammatory agent - aside from its utilization in dealing with conditions like autism, bone and skin improvement and microbial infections, lipid-related illnesses, and so on. XN is reported to suppress the uncontrolled production of inflammatory mediators responsible for diseases including cardiovascular disease, neurodegeneration and tumors. Further, it is accounted to limit adipogenesis and control obesity by focusing on principal adipocyte marker proteins. It is most generally utilized in the brewing industry as an additive and flavoring agent to add bitterness and aroma to beer. Present investigation sum up the patents filed in most recent 2 years on development of different pharmaceutical mixes and strategies dependent on various therapeutic potentials of XN.
Language	English
Publishing date	2021-01-15
Publishing country	England
Document type	Journal Article
ISSN	2046-8962
ISSN (online)	2046-8962
DOI	10.4155/ppa-2020-0026
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Article ; Online: Correction: Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives.

Tuli, Hardeep Singh / Garg, Vivek Kumar / Kumar, Ajay / Aggarwal, Diwakar / Anand, Uttpal / Parashar, Nidarshana Chaturvedi / Saini, Adesh K / Mohapatra, Ranjan K / Dhama, Kuldeep / Kumar, Manoj / Singh, Tejveer / Kaur, Jagjit / Sak, Katrin

Naunyn-Schmiedeberg's archives of pharmacology

2024

Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-03083-x
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Article: Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements.

Sethi, Gautam / Rath, Prangya / Chauhan, Abhishek / Ranjan, Anuj / Choudhary, Renuka / Ramniwas, Seema / Sak, Katrin / Aggarwal, Diwakar / Rani, Isha / Tuli, Hardeep Singh

Pharmaceutics

2023 Volume 15, Issue 2

Abstract: Due to rising incidence rates of liver cancer and worries about the toxicity of current chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy has escalated. Compared to chemotherapy, quercetin, a flavonoid, is ... ...

Abstract	Due to rising incidence rates of liver cancer and worries about the toxicity of current chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy has escalated. Compared to chemotherapy, quercetin, a flavonoid, is relatively less harmful to normal cells and is regarded as an excellent free-radical scavenger. Apoptotic cell death of cancer cells caused by quercetin has been demonstrated by many prior studies. It is present in many fruits, vegetables, and herbs. Quercetin targets apoptosis, by upregulating Bax, caspase-3, and p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, and Bcl-2. Additionally, it has been reported to increase STAT3 protein degradation in liver cancer cells while decreasing STAT3 activation. Quercetin has a potential future in chemoprevention, based on substantial research on its anticancer effects. The current review discusses quercetin's mechanisms of action, nanodelivery strategies, and other potential cellular effects in liver cancer.
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020712
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Article ; Online: Genistein: a promising modulator of apoptosis and survival signaling in cancer.

Joshi, Hemant / Gupta, Dhruv Sanjay / Abjani, Nosheen Kamruddin / Kaur, Ginpreet / Mohan, Chakrabhavi Dhananjaya / Kaur, Jagjit / Aggarwal, Diwakar / Rani, Isha / Ramniwas, Seema / Abdulabbas, Hadi Sajid / Gupta, Madhu / Tuli, Hardeep Singh

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 396, Issue 11, Page(s) 2893–2910

Abstract: Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its ...

Abstract	Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely evaluated for its anti-cancer potential. Several studies have established the potential for its usage in the management of breast, lung, and prostate cancers, and its usage has significantly evolved from early applications in traditional systems of medicine. This review offers an insight into its current status of usage, the chemistry, and pharmacokinetics of the molecule, an exploration of its apoptotic mechanisms in cancer management, and opportunities for synergism to improve therapeutic outcomes. In addition to this, the authors have presented an overview of recent clinical trials, to offer an understanding of contemporary studies and explore prospects for a greater number of focused trials, moving forward. Advancements in the application of nanotechnology as a strategy to improve safety and efficacy have also been highlighted, with a brief discussion of results from safety and toxicology studies.
MeSH term(s)	Male ; Humans ; Genistein/pharmacology ; Genistein/therapeutic use ; Isoflavones/pharmacology ; Phytoestrogens/pharmacology ; Phytoestrogens/therapeutic use ; Prostatic Neoplasms/drug therapy ; Apoptosis
Chemical Substances	Genistein (DH2M523P0H) ; Isoflavones ; Phytoestrogens
Language	English
Publishing date	2023-06-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02550-1
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Article ; Online: Wogonin, as a potent anticancer compound: From chemistry to cellular interactions.

Tuli, Hardeep Singh / Rath, Prangya / Chauhan, Abhishek / Parashar, Gaurav / Parashar, Nidarshana Chaturvedi / Joshi, Hemant / Rani, Isha / Ramniwas, Seema / Aggarwal, Diwakar / Kumar, Manoj / Rana, Rashmi

Experimental biology and medicine (Maywood, N.J.)

2023 Volume 248, Issue 9, Page(s) 820–828

Abstract: Chinese native ... ...

Abstract	Chinese native medicine
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology
Chemical Substances	wogonin (POK93PO28W) ; Drugs, Chinese Herbal ; Antineoplastic Agents, Phytogenic
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702231179961
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Article ; Online: Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models.

Haque, Shafiul / Hussain, Arif / Joshi, Hemant / Sharma, Ujjawal / Sharma, Bunty / Aggarwal, Diwakar / Rani, Isha / Ramniwas, Seema / Gupta, Madhu / Tuli, Hardeep Singh

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 19, Page(s) 17709–17726

Abstract: Background: Melittin is a water-soluble cationic peptide derived from bee venom that has been thoroughly studied for the cure of different cancers. However, the unwanted interactions of melittin produce hemolytic and cytotoxic effects that hinder their ... ...

Abstract	Background: Melittin is a water-soluble cationic peptide derived from bee venom that has been thoroughly studied for the cure of different cancers. However, the unwanted interactions of melittin produce hemolytic and cytotoxic effects that hinder their therapeutic applications. To overcome the shortcomings, numerous research groups have adopted different approaches, including conjugation with tumor-targeting proteins, gene therapy, and encapsulation in nanoparticles, to reduce the non-specific cytotoxic effects and potentiate their anti-cancerous activity. Purpose: This article aims to provide mechanistic insights into the chemopreventive activity of melittin and its nanoversion in combination with standard anti-cancer drugs for the treatment of cancer. Methods: We looked over the pertinent research on melittin's chemopreventive properties in online databases such as PubMed and Scopus. Conclusion: In the present article, the anti-cancerous effects of melittin on different cancers have been discussed very nicely, as have their possible mechanisms of action to act against different tumors. Besides, it interacts with different signal molecules that regulate the diverse pathways of cancerous cells, such as cell cycle arrest, apoptosis, metastasis, angiogenesis, and inflammation. We also discussed the recent progress in the synergistic combination of melittin with standard anti-cancer drugs and a nano-formulated version of melittin for targeted delivery to improve its anticancer potential.
MeSH term(s)	Animals ; Melitten/pharmacology ; Melitten/chemistry ; Melitten/genetics ; Neoplasms/pathology ; Antineoplastic Agents/therapeutic use ; Cell Culture Techniques ; Models, Animal ; Cell Proliferation
Chemical Substances	Melitten (20449-79-0) ; Antineoplastic Agents
Language	English
Publishing date	2023-11-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05458-8
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Article ; Online: Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives.

Datta, Sonal / Aggarwal, Diwakar / Sehrawat, Nirmala / Yadav, Mukesh / Sharma, Varruchi / Sharma, Ajay / Zghair, Abdulrazzaq N / Dhama, Kuldeep / Sharma, Aanchal / Kumar, Vikas / Sharma, Anil K / Wang, Hailian

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 121, Page(s) 155100

Abstract: Background: The liver is a well-known player in the metabolism and removal of drugs. Drug metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the acquisition of homeostasis. However, liver toxicity and cell damage are ...

Abstract	Background: The liver is a well-known player in the metabolism and removal of drugs. Drug metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the acquisition of homeostasis. However, liver toxicity and cell damage are not only related to the nature and dosage of a particular drug but are also influenced by other factors such as aging, immune status, environmental contaminants, microbial metabolites, gender, obesity, and expression of individual genes Furthermore, factors such as drugs, alcohol, and environmental contaminants could induce oxidative stress, thereby impairing the regenerative potential of the liver and causing several diseases. Persons suffering from other ailments and those with comorbidities are found to be more prone to drug-induced toxicities. Moreover, drug composition and drug-drug interactions could further aggravate the risk of drug-induced hepatotoxicity. A plethora of mechanisms are responsible for initiating liver cell damage and further aggravating liver cell injury, followed by impairment of homeostasis, ultimately leading to the generation of reactive oxygen species, immune-suppression, and oxidative stress. Objective: To summarize the potential of phytochemicals and natural bioactive compounds to treat hepatotoxicity and other liver diseases. Study design: A deductive qualitative content analysis approach was employed to assess the overall outcomes of the research and review articles pertaining to hepatoprotection induced by natural drugs, along with analysis of the interventions. Methods: An extensive literature search of bibliographic databases, including Web of Science, PUBMED, SCOPUS, GOOGLE SCHOLAR, etc., was carried out to understand the role of hepatoprotective effects of natural drugs. Results: Bioactive natural products, including curcumin, resveratrol, etc., have been seen as neutralizing agents against the side effects induced by the drugs. Moreover, these natural products are dietary and are readily available; thus, could be supplemented along with drugs to reduce toxicity to cells. Probiotics, prebiotics, and synbiotics have shown promise of improving overall liver functioning, and these should be evaluated more extensively for their hepatoprotective potential. Therefore, selecting an appropriate natural product or a bioactive compound that is free of toxicity and offers a reliable solution for drug-induced liver toxicity is quintessential. Conclusions: The current review highlights the role of natural bioactive products in neutralizing drug-induced hepatotoxicity. Efforts have been made to delineate the possible underlying mechanism associated with the neutralization process.
MeSH term(s)	Humans ; Liver Diseases/drug therapy ; Antioxidants/therapeutic use ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/prevention & control ; Biological Products/pharmacology
Chemical Substances	Antioxidants ; Biological Products
Language	English
Publishing date	2023-09-18
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155100
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Article ; Online: Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies.

Joshi, Hemant / Gupta, Dhruv Sanjay / Kaur, Ginpreet / Singh, Tejveer / Ramniwas, Seema / Sak, Katrin / Aggarwal, Diwakar / Chhabra, Raunak Singh / Gupta, Madhu / Saini, Adesh K / Tuli, Hardeep Singh

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 396, Issue 12, Page(s) 3443–3458

Abstract: One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinical and clinical research, including anti- ... ...

Abstract	One of the well-studied older molecules, quercetin, is found in large quantities in many fruits and vegetables. Natural anti-oxidant quercetin has demonstrated numerous pharmacological properties in preclinical and clinical research, including anti-inflammatory and anti-cancer effects. Due to its ability to control cell signaling pathways, including NF-κB, p53, activated protein-1 (AP-1), STAT3, and epidermal growth response-1 (Egr-1), which is essential in the initiation and proliferation of cancer, it has gained a lot of fame as an anticancer molecule. Recent research suggests that using nanoformulations can help quercetin to overcome its hydrophobicity while also enhancing its stability and cellular bioavailability both in vitro and in vivo. The main aim of this review is to focus on the comprehensive insights of several nanoformulations, including liposomes, nano gels, micelles, solid lipid nanoparticles (SLN), polymer nanoparticles, gold nanoparticles, and cyclodextrin complexes, to transport quercetin for application in cancer.
MeSH term(s)	Humans ; Quercetin/pharmacology ; Gold ; Metal Nanoparticles ; Nanoparticles ; Antioxidants/pharmacology ; Neoplasms/drug therapy
Chemical Substances	Quercetin (9IKM0I5T1E) ; Gold (7440-57-5) ; Antioxidants
Language	English
Publishing date	2023-07-25
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02625-z
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Article ; Online: Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines.

Tuli, Hardeep Singh / Sak, Katrin / Aggarwal, Poonam / Iqubal, Ashif / Upadhaya, Sushil K / Kaur, Jagjit / Kaur, Ginpreet / Aggarwal, Diwakar

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 763687

Abstract: Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of ... ...

Abstract	Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of people, COVID-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education, and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite the availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thoroughly compiled, highlighting the changes that the virus has undergone during the last 2 years and discussing the approaches that the medical community has undertaken in the fight against virus-induced damages.
MeSH term(s)	COVID-19 ; Evolution, Molecular ; Humans ; Pandemics ; Pharmaceutical Preparations ; SARS-CoV-2 ; Vaccines
Chemical Substances	Pharmaceutical Preparations ; Vaccines
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.763687
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Article ; Online: Gallic Acid: A Dietary Polyphenol that Exhibits Anti-neoplastic Activities by Modulating Multiple Oncogenic Targets.

Tuli, Hardeep Singh / Mistry, Hiral / Kaur, Ginpreet / Aggarwal, Diwakar / Garg, Vivek Kumar / Mittal, Sonam / Yerer, Mükerrem Betül / Sak, Katrin / Khan, Md Asaduzzaman

Anti-cancer agents in medicinal chemistry

2021 Volume 22, Issue 3, Page(s) 499–514

Abstract: Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side effects of existing allopathic treatment have also initiated intense research in the field of bioactive phytochemicals. Gallic acid, a natural polyphenolic compound, ...

Abstract	Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side effects of existing allopathic treatment have also initiated intense research in the field of bioactive phytochemicals. Gallic acid, a natural polyphenolic compound, exists freely as well as in polymeric forms. The anti-cancer properties of gallic acid are indomitable by a variety of cellular pathways such as induction of programmed cell death, cell cycle apprehension, reticence of vasculature and tumor migration, and inflammation. Furthermore, gallic acid is found to show synergism with other existing chemotherapeutic drugs. Therefore, the antineoplastic role of gallic acid suggests its promising therapeutic candidature in the near future. The present review describes all these aspects of gallic acid at a single platform. In addition nanotechnology-mediated approaches are also discussed to enhance bioavailability and therapeutic efficacy.
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Proliferation/drug effects ; Gallic Acid/chemistry ; Gallic Acid/pharmacology ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Oncogenes/drug effects ; Phytochemicals/chemistry ; Phytochemicals/pharmacology
Chemical Substances	Antineoplastic Agents, Phytogenic ; Phytochemicals ; Gallic Acid (632XD903SP)
Language	English
Publishing date	2021-11-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/1871520621666211119085834
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