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Article ; Online: Anatomical approach to PCNL: concept of ideal puncture zone in a 3D perspective.

Nayyar, Rishi / Sachan, Ankit / Aggarwal, Nitish / Seth, Amlesh

2023 Volume 51, Issue 1, Page(s) 99

Abstract: To describe a concept of ideal 'puncture zone' as against any single ideal 'puncture tract' for percutaneous nephro-lithotomy (PCNL) and present our results. Through this narrative, we aim to reduce the gaps in inter-understanding of an erstwhile ... ...

Abstract	To describe a concept of ideal 'puncture zone' as against any single ideal 'puncture tract' for percutaneous nephro-lithotomy (PCNL) and present our results. Through this narrative, we aim to reduce the gaps in inter-understanding of an erstwhile description of ideal tract and real-life puncture making. The puncture zone principle was applied for our novel puncture making technique during PCNL. The largest imaginary cone that can fit into a respective calyx, with its tip in the pelvis defines the 'puncture zone' for that calyx. This concept allows fine-tuning of the ideal puncture tract based upon the desired corresponding manipulation zone and also shifts the focus of puncture making to infundibulum anatomy from the tip of calyx. The surgical technique and retrospective review of 136 cases done between 2015 and 2021 using this concept are presented. Primary outcome included stone-free rate, pseudo-aneurysm and blood transfusion at 3 months of follow-up. 33 cases had multiple (> 3) stones, 21 only calyceal/infundibular stones, eight partial staghorn and 12 were complete staghorn stones. Mean stone size was 29 ± 15 (Range: 5-53) mm. Complete clearance was achieved in 127 cases, four of which required two tracts. Blood transfusion was required in one case. No pseudo-aneurysms were encountered. The puncture zone concept has provided good results in our hands. It may help easier understanding of PCN puncture making and provides a background for reconciliation between description of an ideal tract and practical puncturing techniques used by different surgeons.
MeSH term(s)	Humans ; Nephrostomy, Percutaneous/methods ; Treatment Outcome ; Kidney Calculi/surgery ; Punctures ; Staghorn Calculi ; Retrospective Studies
Language	English
Publishing date	2023-08-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-023-01477-9
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Article ; Online: Local anesthetics systemic toxicity association with exparel (bupivacaine liposome)- a pharmacovigilance evaluation.

Aggarwal, Nitish

Expert opinion on drug safety

2017 Volume 17, Issue 6, Page(s) 581–587

Abstract: Background: Local anesthetic systemic toxicity (last) is a rare life threatening complication usually from intra-arterial or intravenous injection leading to systemic absorption of regional anesthesia drug. the objective of this research was to ... ...

Abstract	Background: Local anesthetic systemic toxicity (last) is a rare life threatening complication usually from intra-arterial or intravenous injection leading to systemic absorption of regional anesthesia drug. the objective of this research was to statistically quantify the association between exparel (bupivacaine liposome) injectable suspension and last. Methods: Adverse Event Reporting System database of FDA, which houses public and industry submitted adverse event case reports, was queried and analyzed to quantify the passive pharmacovigilance signal for Local Anesthetic Systemic Toxicity as associated with use of bupivacaine Liposome. Results: A dis-proportionality analysis of the signals yielded a significant association between Local Anesthetic Systemic Toxicity and Exparel. The Chi-Squared with Yates' correction was 596.66 and Proportional Reporting Ratio was 6.23 [95% CI: 5.41-7.18]). Conclusion: The health care provider, including anesthetists, should be made aware that as with bupivacaine HCl, Local Anesthetic Systemic Toxicity, including seizures and cardiac arrest, could be induced by Exparel as well.
MeSH term(s)	Adverse Drug Reaction Reporting Systems ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/adverse effects ; Bupivacaine/administration & dosage ; Bupivacaine/adverse effects ; Databases, Factual ; Humans ; Injections ; Liposomes ; Pharmacovigilance ; United States ; United States Food and Drug Administration
Chemical Substances	Anesthetics, Local ; Liposomes ; Bupivacaine (Y8335394RO)
Language	English
Publishing date	2017-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2088728-0
ISSN	1744-764X ; 1474-0338
ISSN (online)	1744-764X
ISSN	1474-0338
DOI	10.1080/14740338.2017.1335304
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Article ; Online: Real world adverse events of interspinous spacers using Manufacturer and User Facility Device Experience data.

Aggarwal, Nitish / Chow, Robert

Anesthesia and pain medicine

2021 Volume 16, Issue 2, Page(s) 177–183

Abstract: Background: Lumbar spinal stenosis is a condition of progressive neurogenic claudication that can be managed with lumbar decompression surgery or less invasive interspinous process devices after failed conservative therapy. Popular interspinous process ... ...

Abstract	Background: Lumbar spinal stenosis is a condition of progressive neurogenic claudication that can be managed with lumbar decompression surgery or less invasive interspinous process devices after failed conservative therapy. Popular interspinous process spacers include X-Stop, Vertiflex and Coflex, with X-Stop being taken off market due to its adverse events profile. Methods: A disproportionality analysis was conducted to determine whether a statistically significant signal exists in the three interspinous spacers and the reported adverse events using the Manufacturer and User Facility Device Experience (MAUDE) database maintained by the US Food and Drug Administration. Results: Statistically significant signals were found with each of the three interspinous spacer devices (Coflex, Vertiflex, and X-Stop) and each of the following adverse events: fracture, migration, and pain/worsening symptoms. Conclusions: Further studies such as randomized controlled trials are needed to validate the findings.
Language	English
Publishing date	2021-04-19
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2383-7977
ISSN (online)	2383-7977
DOI	10.17085/apm.20093
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Article: Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors.

Aggarwal, Nitish

Drugs - real world outcomes

2016 Volume 3, Issue 2, Page(s) 145–154

Abstract: Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune disease that may be induced by proton pump inhibitors (PPIs) in at-risk populations. The US FDA does not recognize SCLE as an adverse event associated with PPIs. We queried the FDA Adverse ... ...

Abstract	Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune disease that may be induced by proton pump inhibitors (PPIs) in at-risk populations. The US FDA does not recognize SCLE as an adverse event associated with PPIs. We queried the FDA Adverse Event Reporting System database, which contains adverse event case reports submitted by the public as well as by industry, and analyzed the data to quantify passive pharmacovigilance signals for SCLE associated with PPIs. A disproportionality analysis of the signals yielded a significant association between SCLE and PPIs. Discontinuation of PPI resulted in remission, with PPI re-challenge causing SCLE to reoccur. A follow-up analysis also yielded a significant association between SCLE and H2 receptor antagonists. We conducted a brief literature survey of published case reports and studies to discern the validity of PPI-induced SCLE signals. Healthcare prescribers and patients should be made aware that SCLE can be induced by PPIs. In such cases, PPIs should be discontinued and alternative clinical treatment sought. Regulatory bodies such as the FDA should incorporate the adverse reaction in PPI prescription labels.
Language	English
Publishing date	2016-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806600-5
ISSN	2198-9788 ; 2199-1154
ISSN (online)	2198-9788
ISSN	2199-1154
DOI	10.1007/s40801-016-0067-4
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Article: Incidence and Possible Predictive Factors of Facial Nerve Paralysis after Superficial Parotidectomy for Benign Tumours: Our Experience.

Kumar, Pankaj / Gupta, Ajay / Aggarwal, Nitish / Vijay, Saurabh / Kumar, Pallika

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 3, Page(s) 2000–2005

Abstract: Salivary gland tumors represent 3-10% of all head and neck neoplasms. Most of the tumours are benign with parotid gland being most commonly affected. Surgical intervention in the form of parotidectomy forms the mainstay of treatment. Among the various ... ...

Abstract	Salivary gland tumors represent 3-10% of all head and neck neoplasms. Most of the tumours are benign with parotid gland being most commonly affected. Surgical intervention in the form of parotidectomy forms the mainstay of treatment. Among the various postoperative complications that may occur after parotidectomy, facial nerve weakness is the most dreaded one for both the surgeon as well as the patient. In the literature, the incidence of transient facial weakness after parotid surgery ranges from 10 to 68%, and long-term dysfunction ranges from 0 to 19%. Apart from injury mechanisms such as nerve division, stretch, thermal injuries, ischemia, several other risk factors such as tumour size, disease duration etc. have also been identified for post parotidectomy facial nerve dysfunction which vary considerably from study to study. Thus, facial nerve injury despite being a common and dreaded complication is also a preventable one. We in our institute conducted a retrospective study from January 2018 to December 2021 to evaluate the incidence of facial nerve weakness and possible predictive factors among 60 patients who underwent superficial parotidectomy for benign tumours and found that when it comes to benign tumours surgical technique rather than tumour factors are more important in preventing nerve injury. Undertaking this study was important in order to emphasize the importance of extensive preoperative planning and better surgical practices among budding head and neck surgeons in our country.
Language	English
Publishing date	2023-04-24
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03690-9
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Article ; Online: COVID-19 pandemic - did we sign up for "this"?

Aggarwal, Nitish / Boppana, Tarun Krishna / Mittal, Saurabh

Advances in respiratory medicine

2021 Volume 89, Issue 1, Page(s) 96

MeSH term(s)	COVID-19/epidemiology ; Curriculum ; Humans ; Internal Medicine/education ; Internship and Residency/statistics & numerical data ; Personnel Staffing and Scheduling/statistics & numerical data
Language	English
Publishing date	2021-03-03
Publishing country	Poland
Document type	Letter
ZDB-ID	2893877-X
ISSN	2543-6031 ; 2451-4934
ISSN (online)	2543-6031
ISSN	2451-4934
DOI	10.5603/ARM.a2021.0030
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Article: COVID-19 pandemic: The testing times for healthcare workers.

Aggarwal, Nitish / Boppana, Tarun Krishna / Mittal, Saurabh

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2021 Volume 91, Issue 1

Abstract: Dear Editor, There is an increasing pressure on healthcare systems around the globe since the onset of the current coronavirus disease 2019 (COVID-19) pandemic to cope up with the increasing workload ... ...

Abstract	Dear Editor, There is an increasing pressure on healthcare systems around the globe since the onset of the current coronavirus disease 2019 (COVID-19) pandemic to cope up with the increasing workload...
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/psychology ; COVID-19/virology ; Delivery of Health Care/organization & administration ; Delivery of Health Care/statistics & numerical data ; Health Personnel/education ; Health Personnel/psychology ; Humans ; India/epidemiology ; Preceptorship/methods ; SARS-CoV-2/genetics ; Workload/psychology
Language	English
Publishing date	2021-01-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2021.1515
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Article: Tuberculosis and Short Bowel: A Therapeutic Challenge.

Mittal, Saurabh / Madan, Karan / Aggarwal, Nitish / Dhar, Anita

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2019 Volume 23, Issue 4, Page(s) 199

Abstract: How to cite this article: ...

Abstract	How to cite this article:
Language	English
Publishing date	2019-04-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-23157
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Article: A Study on the Prevalence and Clinical Features of Fungal Sinusitis in Chronic Rhinosinusitis.

Shetty, Sandeep / Chandrashekar, Shilpa / Aggarwal, Nitish

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2019 Volume 72, Issue 1, Page(s) 117–122

Abstract: Chronic sinusitis is a common disorder worldwide a significant proportion of which is secondary to fungal aetiology contrary to popular belief that fungal sinusitis is a rare entity, more so in a country like India where warm moist climate in a number of ...

Abstract	Chronic sinusitis is a common disorder worldwide a significant proportion of which is secondary to fungal aetiology contrary to popular belief that fungal sinusitis is a rare entity, more so in a country like India where warm moist climate in a number of states and ever rising incidence of diabetes mellitus gives the fungal organisms a perfect environment to grow. This study aims to find the incidence and clinical features of fungal rhinosinusitis in chronic rhinosinusitis reinstating the fact that it should be kept as a differential diagnosis in every patient presenting with symptoms of chronic rhinosinusitis. Aim of the study was to find out the incidence and clinical manifestations of fungal sinusitis in chronic rhinosinusitis. A prospective study was conducted in JSS Academy of Higher Education and Research, Mysore during a time period of 37 months i.e. November 2015 to December 2018. Total of 190 patients with chronic rhinosinusitis were evaluated with relevant investigations to reach the diagnosis. All patients were subjected to diagnostic nasal endoscopy and CT scan of paranasal sinuses. Patients were then subjected to functional endoscopic sinus surgery and sample collected was sent for KOH stain and fungal culture with histopathology. Fungal rhinosinusitis is on the rise now and it is important to evaluate all cases with caution and keep an eye out for features suggestive of fungal sinusitis as an accurate diagnosis is the key to proper management.
Language	English
Publishing date	2019-12-05
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-019-01769-w
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Article: A Study on Surgical Implications and Variations of Suprameatal Spine and Other Landmarks on the Lateral Surface of Temporal Bone.

Prakash, B G / Aggarwal, Nitish / Babu, A R / Sandhya, D / Amulya, T M

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2021 Volume 74, Issue Suppl 3, Page(s) 3850–3855

Abstract: Mastoidectomy forms the main surgical procedure for eradication of disease in chronic otitis media. Such a surgery which contemplates a complete exenteration of all the tympano-mastoid cavities is rightly considered as a difficult one mainly because a ... ...

Abstract	Mastoidectomy forms the main surgical procedure for eradication of disease in chronic otitis media. Such a surgery which contemplates a complete exenteration of all the tympano-mastoid cavities is rightly considered as a difficult one mainly because a large number of vitally important structures are crowded together in the small field of operation and there is always a risk of damaging them. It is therefore, extremely important that the otologist who would undertake this surgery be thorough with the details of the surgical relations of this region. Out of the various structures seen on the lateral surface of temporal bone one very important structure is the suprameatal spine. It is shown to have great variations in shape and size and has been a mystery to researchers due to the implications it is known to have on mastoid region anatomy. In this study we have evaluated the various types of suprameatal spine, prevalence of each type and the effect of each to other landmarks encountered during surgery and also the effect of mastoid pneumatisation on the same.
Language	English
Publishing date	2021-06-08
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-021-02672-z
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