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Article ; Online: Liquid-based cytology in lung adenocarcinoma: The way forward.

Aggarwal, Phiza

2019 Volume 47, Issue 10, Page(s) 1119

MeSH term(s)	Adenocarcinoma of Lung ; Cytodiagnosis ; Genotype ; Humans ; Lung Neoplasms
Language	English
Publishing date	2019-08-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.24300
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Article ; Online: Cytomorphological features of anaplastic lymphoma kinase-positive lung cancer.

Aggarwal, Phiza

Cytopathology : official journal of the British Society for Clinical Cytology

2019 Volume 30, Issue 6, Page(s) 685

MeSH term(s)	Anaplastic Lymphoma Kinase ; Carcinoma, Non-Small-Cell Lung ; Humans ; Lung Neoplasms
Chemical Substances	Anaplastic Lymphoma Kinase (EC 2.7.10.1)
Language	English
Publishing date	2019-04-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.12687
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Article ; Online: Morphological markers of chromosomal instability as predictors of malignancy in pleural effusion.

Aggarwal, Phiza / Handa, Uma / Bhagat, Ranjeev / Aggarwal, Deepak

Diagnostic cytopathology

2023 Volume 52, Issue 2, Page(s) 76–81

Abstract: Background: Malignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of ... ...

Abstract	Background: Malignancy in pleural effusion is an indication of poor prognosis. The distinction between malignant cells and reactive mesothelial cells in effusion cytology is sometimes difficult and requires ancillary techniques. Evaluation of morphological indicators of chromosomal instability (CI) like micronuclei (MN), chromatin bridging (CB), nuclear budding (NB), and multipolar mitosis (MM) on routine cytology smears is a promising tool to distinguish malignant from benign ascitic fluids. However, it has been scarcely evaluated in pleural effusions. The present study was conducted to evaluate the diagnostic value of these markers in differentiating between malignant and benign pleural fluids. Methods: It is a cross sectional study in which a total of 72 pleural fluid samples over a period of 2 years received in the cytology department of the hospital were evaluated. The cytological analysis was done by two independent cytopathologists and interpreted as either malignant or benign. Four morphological markers of CI were counted in the May-Grünwald Giemsa (MGG) stained smears of all the cases and the score was compared with the conventional cyto-morphological diagnosis. Results: Out of 72 cases, there were 42 malignant and 30 benign effusions on cytological examination. The mean score of micronuclei count, nuclear budding, chromatin bridging and multipolar mitosis in malignant effusions were 7.26 ± 2.74, 9.55 ± 5.53, 1.83 ± 1.17, and 2.21 ± 1.62 respectively that was significantly higher than the benign effusions (1 ± 0.71, 1.1 ± 0.86, 0.38 ± 0.50, and 0.15 ± 0.37 respectively) (p < .05). On Receiver operating characteristic (ROC) curve analysis, a cut-off of 5 for the MN count had a sensitivity of 88% and specificity of 100% in detecting malignant pleural effusion [Area under curve (AUC) 95.8%, p < .001]. Conclusion: Evaluation of morphological indicators of CI on routine MGG stained smears is a simple and cost-effective method to differentiate between benign and malignant pleural fluids.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Pleural Effusion/diagnosis ; Pleural Effusion, Malignant/pathology ; Chromosomal Instability ; Chromatin ; Sensitivity and Specificity
Chemical Substances	Chromatin
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.25249
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Article: Comparative Analysis of Conventional Cytology and Liquid-Based Cytology in the Detection of Carcinoma Cervix and its Precursor Lesions.

Maheshwari, Yashika / Handa, Uma / Aggarwal, Phiza / Goel, Bharti

Journal of cytology

2023 Volume 40, Issue 3, Page(s) 114–118

Abstract: Context: The conventional smears (CS) and Liquid based cytology (LBC) are important tools to detect carcinoma cervix and its precursor lesions.: Aims: The present study was done to compare the cytomorphological features of cervical lesions using both ...

Abstract	Context: The conventional smears (CS) and Liquid based cytology (LBC) are important tools to detect carcinoma cervix and its precursor lesions. Aims: The present study was done to compare the cytomorphological features of cervical lesions using both techniques and compare with the histopathological diagnosis. Settings and design: This was a prospective observational study over a period of 1.5 years at a tertiary care hospital. Methods and material: A total of 969 women in the age group of 21-65 years presenting with either routine screening or complaints of vaginal bleeding, discharge, or pelvic pain were enrolled for the study. Both the CS and LBC smears were analyzed and compared with the corresponding histopathology diagnosis. The data was analyzed using Statistical Package for the Social Sciences (SPSS) software and Results: There were 8.57% unsatisfactory smears in CS as compared to 0.5% in LBC smears. Liquid-based cytology was superior to conventional preparations in terms of smear adequacy, lesser hemorrhagic and inflammatory background, and presence of more endocervical cells. Liquid-based cytology showed a better yield in detecting all the types of epithelial cell lesions with a concordance rate of 73.9% between the two techniques. On histopathology correlation of these lesions, LBC had a higher sensitivity (96.67%) and diagnostic accuracy (99.08%) as compared to CS (73.33% and 92.66%, respectively). Conclusions: Liquid-based cytology is superior to conventional cytology for the detection of epithelial cell lesions. Reduction in the unsatisfactory smears, a cleaner background, and better representation of the sample are more significantly appreciated on LBC in contrast to CS.
Language	English
Publishing date	2023-08-14
Publishing country	India
Document type	Journal Article
ZDB-ID	645018-0
ISSN	0970-9371
ISSN	0970-9371
DOI	10.4103/joc.joc_29_23
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Article ; Online: Clinico-pathological Spectrum of Primary Skin Malignancies in an Indian Tertiary Care Hospital.

Sharma, Pooja / Aggarwal, Phiza / Punia, Rajpal Singh / Bhagat, Ranjeev / Handa, Uma / Sandhu, Jasleen K

Indian journal of dermatology

2024 Volume 68, Issue 6, Page(s) 723

Abstract: Background: Skin malignancies are the most common form of malignant disease in the western world, predominantly affecting older age groups. The majority of skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant ... ...

Abstract	Background: Skin malignancies are the most common form of malignant disease in the western world, predominantly affecting older age groups. The majority of skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma, which account for more than 95% of total skin malignancies. However, in India, these constitute only 1-2% of all cancers. There is an increase in incidence in India over 10 years of period. There is scarcity of data on the clinico-pathological profile of these tumours from this geographical region. Materials and methods: This was a retrospective study conducted in a tertiary care teaching hospital in which archival records and histopathology sections of all patients of skin carcinomas diagnosed over a period of 5 years (January 2016 to December 2020) were analysed. The clinical parameters and histopathological features of the cases were analysed and correlated for any possible association. Results: Out of the 230 skin malignancies studied, SCC constituted the most common type ( Conclusion: SCC is likely the most common histological type of skin malignancies in India. The clinico-pathological profile of skin malignancies of patients depends on multiple factors, notably the skin colour and the geographical location.
Language	English
Publishing date	2024-01-09
Publishing country	India
Document type	Journal Article
ZDB-ID	416069-1
ISSN	1998-3611 ; 0019-5154
ISSN (online)	1998-3611
ISSN	0019-5154
DOI	10.4103/ijd.ijd_401_23
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Article ; Online: Unusual case of intraocular medulloepithelioma in an adult male.

Rehman, Obaidur / Narang, Subina / Nayyar, Shifali / Aggarwal, Phiza

Romanian journal of ophthalmology

2022 Volume 65, Issue 3, Page(s) 296–299

Abstract: Medulloepithelioma is a rare tumor of the eye, arising from the posterior segment. This embryonic tumor is mostly seen in children and is very rare in adult population. This case report presents the case of a 39-year-old Indian male, who had gradual ... ...

Abstract	Medulloepithelioma is a rare tumor of the eye, arising from the posterior segment. This embryonic tumor is mostly seen in children and is very rare in adult population. This case report presents the case of a 39-year-old Indian male, who had gradual vision loss over 4 years in his left eye with new onset of pain. He was referred to our center in view of secondary cataract and intraocular mass. Vision in right eye was 20/ 20 while left eye had no light perception at presentation. Ocular examination of the left eye revealed shallow anterior chamber, florid iris neovascularization, raised intraocular pressure and cataractous lens. B-scan ultrasonography showed a heterogenous mass filling the entire globe. MRI scan confirmed the finding, showing a mass hyper-intense to vitreous. No invasion of optic nerve or sclera was observed. Left eye enucleation with PMMA implant placement was performed and histopathology confirmed the diagnosis of benign teratoid medulloepithelioma. At the time of submission of this report, the patient was still under follow-up and had no detectable metastases at 15 months follow-up. This report highlights a very rare case of embryonic tumor in adult male, which could be managed successfully with a high index of suspicion and timely intervention.
MeSH term(s)	Adult ; Child ; Ciliary Body/surgery ; Eye Enucleation ; Humans ; Intraocular Pressure ; Male ; Neuroectodermal Tumors, Primitive/diagnosis ; Neuroectodermal Tumors, Primitive/surgery ; Uveal Neoplasms/diagnosis ; Uveal Neoplasms/surgery
Language	English
Publishing date	2022-01-07
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2021.61
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Article ; Online: Primary leiomyosarcoma of the thyroid gland.

Kaur, Manveen / Chatterjee, Debajyoti / Aggarwal, Phiza / Saini, Vaibhav

Indian journal of pathology & microbiology

2022 Volume 65, Issue 1, Page(s) 142–144

Abstract: Sarcoma is a rare tumor of the thyroid gland, primary thyroid leiomyosarcoma (LMS) being even rarer. We present a case of LMS of the thyroid in a middle-aged female. Histopathologic examination in conjunction with immunohistochemistry helped to clinch ... ...

Abstract	Sarcoma is a rare tumor of the thyroid gland, primary thyroid leiomyosarcoma (LMS) being even rarer. We present a case of LMS of the thyroid in a middle-aged female. Histopathologic examination in conjunction with immunohistochemistry helped to clinch the diagnosis. Knowledge of this entity is important to distinguish it from anaplastic thyroid carcinoma (ATC) and other sarcomas arising in the thyroid and adjacent soft tissue. The prognosis of thyroid LMS is dismal with an extremely poor survival rate.
MeSH term(s)	Biomarkers, Tumor ; Female ; Histological Techniques ; Humans ; Immunohistochemistry ; Leiomyosarcoma/diagnostic imaging ; Magnetic Resonance Imaging ; Middle Aged ; Neck/pathology ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-01-24
Publishing country	India
Document type	Case Reports
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/IJPM.IJPM_1380_20
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Article ; Online: Fine needle aspiration cytology of a gastric mass-A riddle wrapped up in an enigma.

Garima, Rakheja / Uma, Handa / Aggarwal, Phiza / Gupta, Rekha

Cytopathology : official journal of the British Society for Clinical Cytology

2022 Volume 33, Issue 5, Page(s) 643–646

MeSH term(s)	Biopsy, Fine-Needle ; Cytodiagnosis ; Cytological Techniques ; Humans ; Stomach Neoplasms/diagnosis
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.13130
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Article ; Online: Filariasis presenting as isolated pleural effusion: A case report and mini review.

Aggarwal, Phiza / Subramanian, Saravanan / Saini, Varinder / Aggarwal, Deepak

Tropical doctor

2020 Volume 51, Issue 1, Page(s) 111–114

Abstract: Isolated pleural effusion is a rare manifestation of filariasis that mimics tuberculosis, especially in endemic regions. We describe a case of lymphocytic and exudative pleural effusion showing microfilaria on pleural fluid cytology. A retrospective ... ...

Abstract	Isolated pleural effusion is a rare manifestation of filariasis that mimics tuberculosis, especially in endemic regions. We describe a case of lymphocytic and exudative pleural effusion showing microfilaria on pleural fluid cytology. A retrospective review of all cases of filarial pleural effusion reported after 2000 was conducted to evaluate the association between filariasis and pleural effusion as well as to screen the features that can help in accurate detection of these patients. The analysis suggested a causal association between the parasite and the development of pleural effusion with a high sensitivity of pleural fluid cytology for diagnosis.
MeSH term(s)	Adult ; Animals ; Diagnosis, Differential ; Filariasis/diagnosis ; Filariasis/parasitology ; Filariasis/pathology ; Humans ; Male ; Microfilariae/isolation & purification ; Pleural Effusion/diagnosis ; Pleural Effusion/parasitology ; Pleural Effusion/pathology ; Retrospective Studies ; Tuberculosis/diagnosis
Language	English
Publishing date	2020-10-27
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	193169-6
ISSN	1758-1133 ; 0049-4755
ISSN (online)	1758-1133
ISSN	0049-4755
DOI	10.1177/0049475520964399
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Article ; Online: A 16-Year-Old-Girl With Asthma, Palpable Purpura, and Hypereosinophilia.

Singh, Jasmine / Randev, Shivani / Kumar, Pankaj / Mahajan, Vidushi / Aggarwal, Phiza / Sharma, Aman / Guglani, Vishal

Chest

2022 Volume 161, Issue 5, Page(s) e305–e308

Abstract: Case presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received ...

Abstract	Case presentation: A 16-year-old girl presented to the ED with complaints of loose stools, abdominal pain, and rash over her legs for the last 7 days. There was no history of fever, vomiting, oral ulcers, or mucosal bleeds. In the past, she had received a diagnosis of asthma. She had been taking oral montelukast every day for the past year and using a formoterol-budesonide dry powder inhaler irregularly, only during episodes of acute exacerbations. There was a history of significant but undocumented weight loss. On day 3 of hospital admission, she developed numbness over her right foot.
MeSH term(s)	Administration, Inhalation ; Adolescent ; Asthma/diagnosis ; Asthma/drug therapy ; Bronchodilator Agents/therapeutic use ; Budesonide/therapeutic use ; Drug Combinations ; Eosinophilia/diagnosis ; Ethanolamines/therapeutic use ; Female ; Formoterol Fumarate ; Humans ; IgA Vasculitis ; Purpura
Chemical Substances	Bronchodilator Agents ; Drug Combinations ; Ethanolamines ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.12.632
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