Article ; Online: A population-based twin study of the symptomatic diagnostic criteria for major depression that occur within versus outside of major depressive episodes.
2023 Volume 53, Issue 15, Page(s) 7458–7465
Abstract: Background: Are genetic risk factors for current depressive symptoms good proxies for genetic risk factors for syndromal major depression (MD)?: Methods: In over 9000 twins from the population-based Virginia Adult Twin Study of Psychiatric and ... ...
Abstract | Background: Are genetic risk factors for current depressive symptoms good proxies for genetic risk factors for syndromal major depression (MD)? Methods: In over 9000 twins from the population-based Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, the occurrence of all nine DSM symptomatic criteria for MD in the last year was assessed at personal interview and then grouped by their temporal co-occurrence. The DSM criteria which occurred outside (OUT) Results: The mean twin correlations (±95% CIs) for IN depressive criteria were substantially higher than for OUT depressive criteria in both MZ [+0.35 (0.32-0.38) Conclusions: Depressive criteria occurring outside depressive episodes are less heritable than those occurring within. These two ways criteria can manifest are not closely genetically related. Current depressive symptoms - most of which are occurring outside of depressive episodes - are not, for genetic studies, good proxies for MD. |
---|---|
MeSH term(s) | Adult ; Humans ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/genetics ; Depression/genetics ; Twins, Monozygotic/genetics ; Twins, Monozygotic/psychology ; Twins, Dizygotic/genetics ; Twins, Dizygotic/psychology ; Diseases in Twins/diagnosis ; Diseases in Twins/genetics ; Diseases in Twins/epidemiology |
Language | English |
Publishing date | 2023-05-08 |
Publishing country | England |
Document type | Twin Study ; Journal Article |
ZDB-ID | 217420-0 |
ISSN | 1469-8978 ; 0033-2917 |
ISSN (online) | 1469-8978 |
ISSN | 0033-2917 |
DOI | 10.1017/S0033291723001241 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.B 1003: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.