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  1. Article ; Online: Effects of adjuvant ozone autohemotherapy combined with routine treatment on clinical and paraclinical features of mechanically ventilated COVID-19 patients in the intensive care unit: a pilot randomized controlled trial.

    Aghamohammadi, Dawood / Shakouri, Seyed Kazem / Jahanpanah, Negar / Dolatkhah, Neda

    Medical gas research

    2023  Volume 14, Issue 2, Page(s) 67–74

    Abstract: Until the availability of an effective and practical vaccine, there is a serious need to recognize alternative treatments for coronavirus disease 2019 (COVID-19). This study aimed to determine whether major ozonated autohemotherapy (MOAH) can improve the ...

    Abstract Until the availability of an effective and practical vaccine, there is a serious need to recognize alternative treatments for coronavirus disease 2019 (COVID-19). This study aimed to determine whether major ozonated autohemotherapy (MOAH) can improve the clinical and paraclinical parameters in critically-ill patients with COVID-19 requiring mechanical ventilation. In this controlled trial, we enrolled 40 critically ill COVID-19 patients receiving invasive mechanical ventilation. The enrolled patients were then randomized into the MOAH and control groups. The patients in the MOAH group received MOAH three times per week (10 times in total) in addition to routine treatment and standard critical supportive care. Patients in the control group were only given regular treatment and standard critical supportive care. The patients in the MOAH group had more days of breathing with no aid than those in the control group. Moreover, the length of stay in the intensive-care unit was significantly lower in the MOAH group than in the control group. MOAH resulted in higher ventilation-free days and less intensive-care unit stay compared with the control treatment. In COVID-19 patients undergoing mechanical ventilation, MOAH with routine treatment resulted in more ventilator-free days and less intensive-care unit stay compared with the standard therapy.
    MeSH term(s) Humans ; COVID-19/therapy ; Respiration, Artificial/adverse effects ; Pilot Projects ; Intensive Care Units
    Language English
    Publishing date 2023-10-20
    Publishing country Australia
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2616230-1
    ISSN 2045-9912 ; 2045-9912
    ISSN (online) 2045-9912
    ISSN 2045-9912
    DOI 10.4103/2045-9912.385439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Autologous conditioned serum (Orthokine) injection for treatment of classical trigeminal neuralgia: results of a single-center case series.

    Aghamohammadi, Dawood / Sharifi, Shahrzad / Shakouri, Seyed Kazem / Eslampour, Yashar / Dolatkhah, Neda

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 183

    Abstract: Background: Despite some advances, treatment of trigeminal neuralgia remains a significant challenge. This study determines the efficacy and safety of autologous conditioned serum (Orthokine) injection into the foramen oval to treat refractory ... ...

    Abstract Background: Despite some advances, treatment of trigeminal neuralgia remains a significant challenge. This study determines the efficacy and safety of autologous conditioned serum (Orthokine) injection into the foramen oval to treat refractory trigeminal neuralgia.
    Case presentation: This is a consecutive case series from the Pain and Palliative Care Department of Imam Reza University Hospital, Tabriz, Iran. Eleven Iranian patients, eligible according to the inclusion and exclusion criteria, aged 45.64 ± 11.58 years (Four male and seven female, all Iranian) with established classical trigeminal neuralgia were injected with Orthokine (2 mL per injection) once a week for three consecutive weeks (total of four injections). Numeric rating scale scores for facial pain intensity and also carbamazepine daily dose were confirmed at pretreatment (T0) and at week 1 (T1), week 2 (T2), week 3 (T3), week 4 (T4), and month 2 (T5) posttreatment. Pain intensity was significantly reduced in the first 3 weeks of follow-up in comparison with baseline (T0 to T3) (8.18 ± 1.99 to 2.82 ± 2.13, p < 0.001), an effect that was retained at week 4 (T4) and month 2 (T5) follow-ups (2.82 ± 2.13 to 3.36 ± 2.69, p = 0.886). Carbamazepine consumption was significantly reduced in the first 3 weeks of follow-up in comparison with baseline (T0 to T3) (636.36 ± 307.48 to 200.00 ± 296.64, p = 0.003), an effect that was retained at week 4 and month 2 follow-ups (200.00 ± 296.64 to 200.00 ± 282.84, p = 0.802). There were no serious adverse events in participants.
    Conclusion: Orthokine injection led to consistent pain relief and reduced carbamazepine dosage in patients with trigeminal neuralgia, with acceptable safety.
    MeSH term(s) Carbamazepine/therapeutic use ; Female ; Humans ; Iran ; Male ; Pain ; Treatment Outcome ; Trigeminal Neuralgia/drug therapy
    Chemical Substances Carbamazepine (33CM23913M)
    Language English
    Publishing date 2022-05-08
    Publishing country England
    Document type Journal Article ; Case Reports
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03393-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pilot prospective open-label one-arm trial investigating intrathecal Adenosine in neuropathic pain after lumbar discectomy.

    Aghamohammadi, Dawood / Eydi, Mahmood / Pishgahi, Alireza / Esmaeilinejad, Azam / Dolatkhah, Neda

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 284

    Abstract: Objectives: Adenosine has an analgesic and anti-inflammatory role and its injections are used for perioperative pain management. We aimed to study efficacy of intrathecal injection of adenosine for post-operative radicular pain after lumbar discectomy. ... ...

    Abstract Objectives: Adenosine has an analgesic and anti-inflammatory role and its injections are used for perioperative pain management. We aimed to study efficacy of intrathecal injection of adenosine for post-operative radicular pain after lumbar discectomy. Forty patients with unilevel lumbar discectomy who had radicular lower limb pain were treated by 1000 micrograms of intrathecal injection of adenosine in this single-arm prospective open-label trial between November 2015 to October 2016. Radicular pain severity using visual analogue scale (VAS) and pain killer consumption per day were assessed during a 3 months follow up period.
    Results: Radicular pain severity was significantly reduced in 3 month follow-up period in comparison to the baseline (F = 19,760, df = 2.53, p-value < 0.001). Further, painkiller medication consumption rate in average during 3 month follow-up period after injection was significantly lower in comparison to baseline (F = 19.244, df = 1.98, p-value < 0.001). This study suggests that intrathecal injection of 1000 micrograms adenosine is a safe and effective method for post-operative neuropathic pain management after uni-level disk surgeries. Trial registration IRCT201608171772N20, Retrospectively registered on 2016-08-28.
    MeSH term(s) Adenosine/administration & dosage ; Adenosine/pharmacology ; Adult ; Aged ; Analgesics/administration & dosage ; Analgesics/pharmacology ; Diskectomy/adverse effects ; Female ; Follow-Up Studies ; Humans ; Injections, Spinal ; Lumbar Vertebrae ; Male ; Middle Aged ; Neuralgia/drug therapy ; Neuralgia/etiology ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Pilot Projects ; Prospective Studies ; Severity of Illness Index ; Spinal Nerve Roots/drug effects ; Spinal Nerve Roots/physiopathology ; Treatment Outcome
    Chemical Substances Analgesics ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05133-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dietary inflammatory index is associated with pain intensity and some components of quality of life in patients with knee osteoarthritis.

    Toopchizadeh, Vahideh / Dolatkhah, Neda / Aghamohammadi, Dawood / Rasouli, Mahrokh / Hashemian, Maryam

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 448

    Abstract: Objectives: We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was ... ...

    Abstract Objectives: We aim to measure dietary inflammatory index (DII) and its association with functional status, pain intensity and quality of life (QOL) in patients with knee osteoarthritis (KOA). Dietary information from 220 qualified patients with KOA was collected by a 168-item food frequency questionnaire. The functional status, pain intensity and QOL were evaluated by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, Visual Analogue Scale (VAS) and SF36 questionnaire respectively.
    Results: Linear regression analysis showed that the DII was significantly associated with VAS (p = 0.040; β = 0.151), and physical function (p = 0.039; β = - 0.184), emotional wellbeing (p = 0.048; β = - 0.158) and pain (p = 0.020; β = 0.161) scales and physical health (p = 0.047; β = 0.110) subscale of QOL after adjusting for age, sex, body mass index, and physical activity. There was no significant differences concerning WOMAC across the DII tertiles with and without adjustment to probable confounders (P
    MeSH term(s) Humans ; Osteoarthritis, Knee ; Pain/etiology ; Pain Measurement ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05277-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Lower serum levels of alpha tocopherol and lycopene are associated with higher pain and physical disability in subjects with primary knee osteoarthritis: A case-control study.

    Eftekharsadat, Bina / Aghamohammadi, Dawood / Dolatkhah, Neda / Hashemian, Maryam / Salami, Halale

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2020  Volume 91, Issue 3-4, Page(s) 304–314

    Language English
    Publishing date 2020-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nutraceutical supplements in management of pain and disability in osteoarthritis: a systematic review and meta-analysis of randomized clinical trials.

    Aghamohammadi, Dawood / Dolatkhah, Neda / Bakhtiari, Fahimeh / Eslamian, Fariba / Hashemian, Maryam

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 20892

    Abstract: This study designed to evaluate the effect of nutraceutical supplementation on pain intensity and physical function in patients with knee/hip OA. The MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, Google Scholar, Science direct, and ProQuest ... ...

    Abstract This study designed to evaluate the effect of nutraceutical supplementation on pain intensity and physical function in patients with knee/hip OA. The MEDLINE, Web of Science, Cochrane Library, Scopus, EMBASE, Google Scholar, Science direct, and ProQuest in addition to SID, Magiran, and Iranmedex were searched up to March 2020. Records (n = 465) were screened via the PICOS criteria: participants were patients with hip or knee OA; intervention was different nutritional supplements; comparator was any comparator; the outcome was pain intensity (Visual analogue scale [VAS]) and physical function (Western Ontario and McMaster Universities Arthritis [WOMAC] index); study type was randomized controlled trials. The random effects model was used to pool the calculated effect sizes. The standardized mean difference (SMD) of the outcome changes was considered as the effect size. The random effects model was used to combine the effect sizes. Heterogeneity between studies was assessed by Cochran's (Q) and I2 statistics. A total of 42 RCTs were involved in the meta-analysis. Nutritional supplementation were found to improve total WOMAC index (SMD = - 0.23, 95% CI - 0.37 to - 0.08), WOMAC pain (SMD = - 0.36, 95% CI - 0.62 to - 0.10) and WOMAC stiffness (SMD = - 0.47, 95% CI - 0.71 to - 0.23) subscales and VAS (SMD = - 0.79, 95% CI - 1.05 to - 0.05). Results of subgroup analysis according to the supplementation duration showed that the pooled effect size in studies with < 10 months, 10-20 months and > 20 months supplementation duration were 0.05, 0.27, and 0.36, respectively for WOMAC total score, 0.14, 0.55 and 0.05, respectively for WOAMC pain subscale, 0.59, 0.47 and 0.41, respectively for WOMAC stiffness subscale, 0.05, 0.57 and 0.53, respectively for WOMAC physical function subscale and 0.65, 0.99 and 0.12, respectively for VAS pain. The result suggested that nutraceutical supplementation of patients with knee/hip OA may lead to an improvement in pain intensity and physical function.
    MeSH term(s) Dietary Supplements ; Disabled Persons ; Female ; Humans ; Male ; Osteoarthritis, Hip/complications ; Osteoarthritis, Hip/physiopathology ; Osteoarthritis, Hip/therapy ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/physiopathology ; Osteoarthritis, Knee/therapy ; Pain Management/methods ; Pain Measurement ; Randomized Controlled Trials as Topic ; Visual Analog Scale
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-78075-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ginger (Zingiber officinale) and turmeric (Curcuma longa L.) supplementation effects on quality of life, body composition, bone mineral density and osteoporosis related biomarkers and micro-RNAs in women with postmenopausal osteoporosis: a study protocol for a randomized controlled clinical trial.

    Aghamohammadi, Dawood / Dolatkhah, Neda / Shakouri, Seyed Kazem / Hermann, Pernille / Eslamian, Fariba

    Journal of complementary & integrative medicine

    2020  Volume 18, Issue 1, Page(s) 131–137

    Abstract: Objectives: Phytomedicine is widely suggested for the prevention of chronic disease, but evidence for a favorable effect on bone health is lacking. The present study will investigate the : Methods: This study protocol is designed as prospective ... ...

    Abstract Objectives: Phytomedicine is widely suggested for the prevention of chronic disease, but evidence for a favorable effect on bone health is lacking. The present study will investigate the
    Methods: This study protocol is designed as prospective triple-blind randomized controlled trial. One hundred and 20 patients with PMO will be enrolled in a 4 month, prospective, triple-blind, placebo-controlled trial and randomly assigned to four groups: ZO (500 mg b.i.d.) + CL (500 mg b.i.d.) (ZO + CL); ZO (500 mg b.i.d.) + placebo CL (b.i.d.) (ZO + P); placebo ZO (b.i.d.) + CL (500 mg b.i.d.) (CL + P); and placebo ZO (b.i.d.) + placebo CL (b.i.d.) (P + P). Quality of life, body composition and BMD will be defined as the primary endpoints and osteoporosis related serum biomarkers and circulating micro-RNAs will be defined as the secondary endpoints. The ANCOVA statistical method will be used to investigate the effect of the interventional variables on the response variable.
    Conclusion: To our knowledge, this trial is the first clinical study exploring the effect of Ginger and turmeric on quality of life, body composition, BMD and osteoporosis related biomarkers and micro-RNAs in women with PMO. The findings of this trial could be the basis for the development of harmless and inexpensive preventive and therapeutic approaches for PMO.
    MeSH term(s) Biomarkers/blood ; Body Composition/drug effects ; Bone Density/drug effects ; Curcuma ; Dietary Supplements ; Female ; Zingiber officinale ; Humans ; MicroRNAs/drug effects ; Middle Aged ; Osteoporosis, Postmenopausal/blood ; Osteoporosis, Postmenopausal/therapy ; Plant Extracts/administration & dosage ; Prospective Studies ; Quality of Life ; Randomized Controlled Trials as Topic
    Chemical Substances Biomarkers ; MicroRNAs ; Plant Extracts ; turmeric extract (856YO1Z64F)
    Language English
    Publishing date 2020-06-22
    Publishing country Germany
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2197618-1
    ISSN 1553-3840 ; 2194-6329
    ISSN (online) 1553-3840
    ISSN 2194-6329
    DOI 10.1515/jcim-2020-0017
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  8. Article ; Online: Nutrition knowledge and attitude in medical students of Tabriz University of Medical Sciences in 2017-2018.

    Dolatkhah, Neda / Aghamohammadi, Dawood / Farshbaf-Khalili, Azizeh / Hajifaraji, Majid / Hashemian, Maryam / Esmaeili, Sepideh

    BMC research notes

    2019  Volume 12, Issue 1, Page(s) 757

    Abstract: Objectives: In this cross-sectional study among 220 medical students we aimed to determine the nutritional knowledge and attitude of medical students through clinical training courses (externship and internship) of Tabriz University of Medical Sciences, ...

    Abstract Objectives: In this cross-sectional study among 220 medical students we aimed to determine the nutritional knowledge and attitude of medical students through clinical training courses (externship and internship) of Tabriz University of Medical Sciences, Iran. A nutritional knowledge questionnaire included 51 questions was used to determine the correct, perceived and accuracy of knowledge of the participant in different aspects of nutrition sciences. The nutrition attitude questionnaire included 30 questions. Both questionnaires were confirmed in terms of the validity and reliability for assessing nutritional knowledge and attitude in this sample of Iranian medical students. Nutritional knowledge and attitude were calculated as percentage of correct or appropriate responses.
    Results: The correct knowledge was not significantly different among externs and interns (68.20 ± 7.50% and 67.87 ± 6.04% respectively, p = 0.729). Results showed that most of the participants (49.61% of externs and 57.14% of inters) had a poor nutritional knowledge, significantly varied by age (p = 0.035). The attitude index of the subjects was not significantly different among externs and interns (73.36 ± 9.42% and 74.59 ± 9.20%, p = 0.335). Most students (92.7%) had a very appropriate attitude toward nutrition, significantly varied by sex (p = 0.010). These findings indicate that there are multiple deficiencies in nutrition knowledge of medical students.
    MeSH term(s) Cross-Sectional Studies ; Demography ; Education, Medical ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Internship and Residency ; Iran ; Knowledge ; Male ; Nutritional Sciences/education ; Students, Medical ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-019-4788-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sclerosis: study protocol for a double-blind randomized controlled clinical trial.

    Aghamohammadi, Dawood / Ayromlou, Hormoz / Dolatkhah, Neda / Jahanjoo, Fatemeh / Shakouri, Seyed Kazem

    Trials

    2019  Volume 20, Issue 1, Page(s) 379

    Abstract: Background: The relationship between gut dysbiosis and inflammatory diseases including multiple sclerosis (MS) is presently recognized as an important health issue. It has been established that some bacterial probiotic strains are effective in treating ... ...

    Abstract Background: The relationship between gut dysbiosis and inflammatory diseases including multiple sclerosis (MS) is presently recognized as an important health issue. It has been established that some bacterial probiotic strains are effective in treating MS. This study will investigate the effect of yeast probiotic Saccharomyces boulardii (SB) supplements on mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in MS patients.
    Methods/design: In this double-blind randomized controlled two-group parallel trial, 50 MS patients who meet the inclusion criteria will be recruited from outpatient settings. They will be randomly allocated to 4 months of daily placebo or the SB probiotic intervention. Blood samples will be taken from each participant at the baseline and after the intervention period to assess inflammation and oxidative stress. The primary endpoint will be the changes in their mental health evaluated by the 28-item General Health Questionnaire. The secondary endpoints include changes in: (1) quality of life, evaluated by the 36-item Short Form Questionnaire, (2) fatigue, evaluated by the Fatigue Severity Scale, (3) pain, evaluated by a visual analogue scale, and (4) serum levels of indices of inflammatory stress (high-sensitivity C-reactive protein) and oxidative stress (malondialdehyde and total antioxidant capacity). Moreover, any adverse events and side effects due to the intervention will be documented.
    Discussion: There is a need to discover safe and practical methods for managing the symptoms of MS. This trial will gather evidence on the effects of a probiotic.
    Trial registration: Iranian Clinical Trial Registry, IRCT20161022030424N1 . Registered on 9 April 2018.
    MeSH term(s) Adolescent ; Adult ; C-Reactive Protein/analysis ; Dietary Supplements ; Double-Blind Method ; Fatigue/prevention & control ; Humans ; Mental Health ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/psychology ; Multiple Sclerosis/therapy ; Outcome Assessment, Health Care ; Oxidative Stress ; Pain/prevention & control ; Probiotics/administration & dosage ; Prospective Studies ; Quality of Life ; Randomized Controlled Trials as Topic ; Saccharomyces boulardii ; Young Adult
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-019-3454-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    Sahin, Fikrettin / Pirouzpanah, Mohammad Bagher / Bijanpour, Hossein / Mohammadzadeh, Mohammad / Eghdam Zamiri, Reza / Ghasemi Jangjoo, Amir / Nasiri, Behnam / Saboori, Hojjatollah / Doğan, Ayşegül / Demirci, Selami / Ayşan, Erhan / Çağrı Büke, Ahmet / Naseri, Ali Reza / Shakouri, Seyed Kazem / Aghamohammadi, Dawood / Alizade-Harakiyan, Mostafa / Seyed Nejad, Farshad

    Oncology research and treatment

    2022  Volume 45, Issue 4, Page(s) 197–204

    Abstract: Introduction: Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative effects of a boron- ... ...

    Abstract Introduction: Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative effects of a boron-based gel on several different clinical outcomes (dermatitis, erythema, dry desquamation, and moist desquamation) after 25 radiotherapy sessions.
    Methods: This research used a double-blind parallel-group design with a placebo control (n = 76) and randomized group (n = 181), with all participants being between 18 and 75 years old. Fifteen minutes before each radiotherapy, participants in the intervention group were given a gel containing 3% sodium pentaborate pentahydrate, while those in the placebo group received a gel with no chemical substance. Dermatitis, erythema, dry desquamation, and moist desquamation were compared between the 2 groups.
    Results: At baseline, there were no significant differences between the groups (p > 0.05), except for body mass index. After 14 days of treatment, dermatitis (98.7% vs. 9.9%; p < 0.001), erythema (96.1% vs. 12.2%; p < 0.001), dry desquamation (50% vs. 3.9%; p < 0.001), and moist desquamation (18.4% vs. 0.6%; p < 0.001) were much more common in the placebo group than the intervention group. To prevent dermatitis, erythema, dry desquamation, and moist desquamation in 1 patient, on average, 1.1 (95% confidence interval [CI]: 1.1-1.2), 1.2 (95% CI: 1.1-1.3), 2.2 (95% CI: 1.7-2.9), and 5.6 (95% CI: 3.8-11.0) patients need to be treated, respectively.
    Conclusion: The boron-based gel has a significant preventive effect on several categories of RD which might be used by clinicians in breast cancer.
    MeSH term(s) Adolescent ; Adult ; Aged ; Boron/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/radiotherapy ; Double-Blind Method ; Female ; Humans ; Middle Aged ; Radiodermatitis/drug therapy ; Radiodermatitis/etiology ; Radiodermatitis/prevention & control ; Young Adult
    Chemical Substances Boron (N9E3X5056Q)
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000520363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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