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  1. Book ; Online ; E-Book: Acromegaly

    Blevins Jr., Lewis S. / Aghi, Manish K.

    a guide to diagnosis and treatment

    (Contemporary endocrinology)

    2022  

    Author's details Lewis S. Blevins Jr., Manish K. Aghi editors
    Series title Contemporary endocrinology
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (x, 298 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021684818
    ISBN 978-3-031-16258-9 ; 9783031162572 ; 3-031-16258-7 ; 3031162579
    DOI 10.1007/978-3-031-16258-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Pituitary adenomas

    Aghi, Manish K.

    (Neurosurgery clinics of North America ; volume 30, number 4 (October 2019))

    2019  

    Author's details editors Manish K. Aghi, Lewis S. Blevins Jr
    Series title Neurosurgery clinics of North America ; volume 30, number 4 (October 2019)
    Collection
    Language English
    Size xiii Seiten, Seite 392-524, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020252691
    ISBN 978-0-323-68168-1 ; 0-323-68168-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1200 -30,4- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Lymphatic endothelial-like cells in the glioblastoma tumor niche drive metabolic alterations that promote stem cell proliferation and survival.

    Kidwell, Reilly L / Aghi, Manish K

    Neuro-oncology

    2024  Volume 26, Issue 5, Page(s) 783–784

    MeSH term(s) Glioblastoma/pathology ; Glioblastoma/metabolism ; Humans ; Cell Proliferation ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/metabolism ; Endothelial Cells/pathology ; Endothelial Cells/metabolism ; Cell Survival ; Animals ; Tumor Microenvironment ; Stem Cell Niche
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Research Support, N.I.H., Extramural ; Journal Article
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noae020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book: Management of pituitary tumors

    Aghi, Manish K. / Blevins, Lewis S.

    (Neurosurgery clinics of North America ; 23,4)

    2012  

    Author's details guest ed. Manish K. Aghi ; Lewis S. Blevins
    Series title Neurosurgery clinics of North America ; 23,4
    Collection
    Language English
    Size VIII S., S. 530 - 696 : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT017449105
    ISBN 978-1-4557-4946-1 ; 1-4557-4946-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1200 -23,4- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Facility Volume and Pituitary Surgery.

    Chalif, Eric J / Aghi, Manish K

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 168, Issue 6, Page(s) 1567–1568

    MeSH term(s) Humans ; Treatment Outcome ; Postoperative Complications ; Retrospective Studies ; Pituitary Neoplasms/surgery
    Language English
    Publishing date 2023-01-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998221120379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.83/a: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Chronic convection-enhanced intratumoural delivery of chemotherapy for glioblastoma.

    Young, Jacob S / Aghi, Manish K

    The Lancet. Oncology

    2022  Volume 23, Issue 11, Page(s) 1347–1348

    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Convection ; Brain Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Drug Delivery Systems
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00626-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

    Order via subito

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  7. Article ; Online: Lateral orientation of Rathke cleft cysts may be associated with high rates of recurrence after surgery.

    Carrete, Luis R / Aghi, Manish K

    Pituitary

    2022  Volume 25, Issue 4, Page(s) 684–686

    Abstract: Rathke cleft cysts (RCC) arise from the remnants of Rathke's pouch, a structure that is midline in the pituitary. Therefore, an off-midline location on imaging is a finding that is often used to distinguish Rathke cleft cysts from pituitary adenomas, ... ...

    Abstract Rathke cleft cysts (RCC) arise from the remnants of Rathke's pouch, a structure that is midline in the pituitary. Therefore, an off-midline location on imaging is a finding that is often used to distinguish Rathke cleft cysts from pituitary adenomas, with RCCs being more commonly in the midline than in a purely lateral position. Given the rarity of these laterally oriented RCCs, the incidence and behavior of RCCs that are purely lateral have not been described in current literature. Retrospective investigation was performed through review of patient records of 122 patients who underwent surgical resection for RCCs. RCCs were classified as purely lateral or midline. Lateral RCCs were found have significantly higher rates of recurrence relative to RCCs in the midline group (p = .04). Although limited by statistical power due to the low amount of lateral RCCs (n = 13/122), our findings suggest that there may be an association between lateral RCC location and cyst recurrence.The orcid 0000-0002-2949-227 of author (Manish K. Aghi) is changed to 0000-0002-2949-2227. Kindly check and confirm.The correct orcid of Manish K. Aghi is 0000-0002-2949-2227.
    MeSH term(s) Carcinoma, Renal Cell ; Central Nervous System Cysts/complications ; Central Nervous System Cysts/diagnostic imaging ; Central Nervous System Cysts/surgery ; Humans ; Kidney Neoplasms/complications ; Magnetic Resonance Imaging/methods ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-07-04
    Publishing country United States
    Document type Letter
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-022-01247-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6139: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Metabolic Barriers to Glioblastoma Immunotherapy.

    Choudhary, Nikita / Osorio, Robert C / Oh, Jun Y / Aghi, Manish K

    Cancers

    2023  Volume 15, Issue 5

    Abstract: Glioblastoma (GBM) is the most common primary brain tumor with a poor prognosis with the current standard of care treatment. To address the need for novel therapeutic options in GBM, immunotherapies which target cancer cells through stimulating an anti- ... ...

    Abstract Glioblastoma (GBM) is the most common primary brain tumor with a poor prognosis with the current standard of care treatment. To address the need for novel therapeutic options in GBM, immunotherapies which target cancer cells through stimulating an anti-tumoral immune response have been investigated in GBM. However, immunotherapies in GBM have not met with anywhere near the level of success they have encountered in other cancers. The immunosuppressive tumor microenvironment in GBM is thought to contribute significantly to resistance to immunotherapy. Metabolic alterations employed by cancer cells to promote their own growth and proliferation have been shown to impact the distribution and function of immune cells in the tumor microenvironment. More recently, the diminished function of anti-tumoral effector immune cells and promotion of immunosuppressive populations resulting from metabolic alterations have been investigated as contributory to therapeutic resistance. The GBM tumor cell metabolism of four nutrients (glucose, glutamine, tryptophan, and lipids) has recently been described as contributory to an immunosuppressive tumor microenvironment and immunotherapy resistance. Understanding metabolic mechanisms of resistance to immunotherapy in GBM can provide insight into future directions targeting the anti-tumor immune response in combination with tumor metabolism.
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: An engineered glioblastoma model yields novel macrophage-secreted drivers of invasion.

    Akins, Erin A / Wilkins, Dana / Aghi, Manish K / Kumar, Sanjay

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Glioblastomas (GBMs) are highly invasive brain tumors replete with brain- and blood-derived macrophages, collectively known as tumor-associated macrophages (TAMs). Targeting TAMs has been proposed as a therapeutic strategy but has thus far yielded ... ...

    Abstract Glioblastomas (GBMs) are highly invasive brain tumors replete with brain- and blood-derived macrophages, collectively known as tumor-associated macrophages (TAMs). Targeting TAMs has been proposed as a therapeutic strategy but has thus far yielded limited clinical success in slowing GBM progression, due in part to an incomplete understanding of TAM function in GBM. Here, by using an engineered hyaluronic acid-based 3D invasion platform, patient-derived GBM cells, and multi-omics analysis of GBM tumor microenvironments, we show that M2-polarized macrophages stimulate GBM stem cell (GSC) mesenchymal transition and invasion. We identify TAM-derived transforming growth factor beta induced (TGFβI/BIGH3) as a pro-tumorigenic factor in the GBM microenvironment. In GBM patients, BIGH3 mRNA expression correlates with poor patient prognosis and is highest in the most aggressive GBM molecular subtype. Inhibiting TAM-derived BIGH3 signaling with a blocking antibody or small molecule inhibitor suppresses GSC invasion. Our work highlights the utility of 3D
    Language English
    Publishing date 2023-11-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.18.567683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Recent advancements in the molecular biology of pituitary adenomas.

    Zheng, Allison C / Wang, Elaina J / Aghi, Manish K

    Expert review of endocrinology & metabolism

    2022  Volume 17, Issue 4, Page(s) 293–304

    Abstract: Introduction: Pituitary adenomas are a common and diverse group of intracranial tumors arising from the anterior pituitary that are usually slow-growing and benign, but still pose a significant healthcare burden to patients. Additionally, they are ... ...

    Abstract Introduction: Pituitary adenomas are a common and diverse group of intracranial tumors arising from the anterior pituitary that are usually slow-growing and benign, but still pose a significant healthcare burden to patients. Additionally, they are increasing in both incidence and prevalence, leading to a need for better understanding of molecular changes in the development of these tumors.
    Areas covered: A PubMed literature search was conducted using the terms 'pituitary adenoma' in combination with keywords related to secretory subtype: lactotroph, somatotroph, corticotroph, gonadotroph and null cell, in addition to their transcription factor expression: PIT1, TPIT, and SF-1. Articles resulting from this search were analyzed, as well as relevant articles cited as their references. In this review, we highlight recent advances in the genetic and epigenetic characterization of individual pituitary adenoma subtypes and the effect it may have on guiding future clinical treatment of these tumors.
    Expert opinion: Understanding the molecular biology of pituitary adenomas is a fundamental step toward advancing the treatment of these tumors. Yet crucial knowledge gaps exist in our understanding of the underlying molecular biology of pituitary adenomas which can potentially be addressed by turning to differentially activated molecular pathways in tumor relative to normal gland.
    MeSH term(s) Adenoma/genetics ; Adenoma/pathology ; Humans ; Molecular Biology ; Pituitary Neoplasms/pathology
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2022.2082942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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