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Article ; Online: Ebola vaccines for mass immunisation in affected regions.

Agnandji, Selidji Todagbe / Loembe, Marguerite Massinga

2021 Volume 22, Issue 1, Page(s) 8–10

MeSH term(s)	Africa/epidemiology ; Clinical Trials as Topic ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks/prevention & control ; Ebola Vaccines/administration & dosage ; Ebola Vaccines/immunology ; Ebolavirus/immunology ; Ebolavirus/pathogenicity ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Mass Vaccination
Chemical Substances	Ebola Vaccines
Language	English
Publishing date	2021-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(21)00226-7
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Zs.A 5743: Show issues

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Article ; Online: Safety, immunogenicity and risk-benefit analysis of rVSV-ΔG-ZEBOV-GP (V920) Ebola vaccine in Phase I-III clinical trials across regions.

Bache, Bache Emmanuel / Grobusch, Martin P / Agnandji, Selidji Todagbe

Future microbiology

2020 Volume 15, Page(s) 85–106

Abstract: To evaluate the risk-benefits balance of the rVSV-ΔG-ZEBOV-GP vaccine. We performed a systematic review to summarize data on safety, immunogenicity and efficacy. About 17,600 adults and 234 children received 11 different doses of the V920 vaccine ranging ...

Abstract	To evaluate the risk-benefits balance of the rVSV-ΔG-ZEBOV-GP vaccine. We performed a systematic review to summarize data on safety, immunogenicity and efficacy. About 17,600 adults and 234 children received 11 different doses of the V920 vaccine ranging from 3000 to 100 million and 20 million plaque-forming units, respectively, during Phase I-III clinical trials. Cases of severe but transient arthritis were reported in about six and 0.08% of vaccinees in high-income countries (HICs) and low-middle-income countries (LMICs), respectively. The 20 million plaque-forming units dose yielded GP-specific antibody titres which peaked at day 28 with a pooled geometric mean titres of 2557.7 (95% CI: 1665.5-3934.2) versus 1156.9 (95% CI: 832.5-1649.2) but with similar seroconversion rates at 96% (95% CI: 87-100) versus 100% (95% CI: 90-100) for HICs and LMICs, respectively. Data from stringent Phase I-II clinical trials in LMICs and HICs and from the ring efficacy trials yielded a good risk-benefit balance of the V920 vaccine in adults, but also in children and pregnant and lactating women and HIV-infected people.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Clinical Trials as Topic ; Ebola Vaccines/adverse effects ; Ebola Vaccines/immunology ; Ebola Vaccines/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Immunogenicity, Vaccine ; Male ; Middle Aged ; Patient Safety ; Pregnancy ; Risk Assessment ; Treatment Outcome ; Vaccination/adverse effects ; Young Adult
Chemical Substances	Ebola Vaccines
Language	English
Publishing date	2020-02-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	1746-0921
ISSN (online)	1746-0921
DOI	10.2217/fmb-2019-0237
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Article ; Online: Assessing the Incidence of Snakebites in Rural Gabon-A Community-Based, Cross-Sectional Pilot Survey.

Davi, Saskia Dede / Lumeka, Anita / Hildebrandt, Teite Rebecca / Endamne, Lilian Rene / Otchague, Cedric / Okwu, Dearie Glory / Artus, Rica / Hunstig, Friederike / Manego, Rella Zoleko / Blessmann, Jörg / Kremsner, Peter G / Lell, Bertrand / Mombo-Ngoma, Ghyslain / Agnandji, Selidji Todagbe / Ramharter, Michael / Kreuels, Benno

Tropical medicine and infectious disease

2024 Volume 9, Issue 4

Abstract: Snakebite envenoming (SBE) is a neglected tropical disease (NTD). Community-based studies from sub-Saharan Africa are urgently required as data on the incidence are scarce. This study aimed to determine the lifetime prevalence of snakebites in rural ... ...

Abstract	Snakebite envenoming (SBE) is a neglected tropical disease (NTD). Community-based studies from sub-Saharan Africa are urgently required as data on the incidence are scarce. This study aimed to determine the lifetime prevalence of snakebites in rural Gabon by preparing the conduct of a larger regional survey. A cross-sectional community-based epidemiological survey in Sindara, Ngounie province, was conducted. Households were interviewed about the history of snakebites of household members to calculate lifetime prevalence. In addition, the average annual incidence rate per 100,000 over the last 5 years was calculated. A total of 771 inhabitants were enrolled, of which 5 (0.65%; 95% confidence interval (95% CI: 0.2-1.5%)) were victims of snakebites. Over the past 5 years, annual incidence was 77 bites per 100,000 (95% CI: 0-620). This study provides a first rough estimate of the incidence of SBE from rural central Gabon, demonstrating the importance of this NTD.
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed9040068
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Book ; Thesis: Malaria vaccine-induced immune responses and protection

Agnandji, Selidji Todagbe

RTS,S/AS01E for sub-Saharan African children

2012

Author's details	vorgelegt von Selidji Todagbe Agnandji
Language	English
Size	getr. Zählung, graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Tübingen, 2012
Note	Zsfassung in dt. und engl. Sprache ; enth. Zeitschriftenabdrucke
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Malaria vaccine-induced immune responses and protection

Agnandji, Selidji Todagbe

RTS,S/AS01E for sub-Saharan African children

2012

Author's details	vorgelegt von Selidji Todagbe Agnandji
Language	English
Size	getr. Zählung, graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Tübingen, 2012
Note	Zsfassung in dt. und engl. Sprache ; enth. Zeitschriftenabdrucke
Database	Special collection on veterinary medicine and general parasitology

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Article ; Online: Whole genome analysis of two sympatric human

Rodi, Miriam / Gross, Caspar / Sandri, Thaisa Lucas / Berner, Lilith / Marcet-Houben, Marina / Kocak, Ersoy / Pogoda, Michaela / Casadei, Nicolas / Köhler, Carsten / Kreidenweiss, Andrea / Agnandji, Selidji Todagbe / Gabaldón, Toni / Ossowski, Stephan / Held, Jana

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1159814

Abstract: Introduction: Mansonella: Methods: We screened individuals in the area of Fougamou, Gabon for Mansonella mono-infections and generated de novo assemblies from the respective samples. For evolutionary analysis, a phylogenetic tree was reconstructed, ... ...

Abstract	Introduction: Mansonella Methods: We screened individuals in the area of Fougamou, Gabon for Mansonella mono-infections and generated de novo assemblies from the respective samples. For evolutionary analysis, a phylogenetic tree was reconstructed, and the differences and divergence times are presented. In addition, mitogenomes were generated and phylogenies based on 12S rDNA and cox1 were created. Results: We successfully generated whole genomes for M. perstans and Discussion: The results presented indicate that
MeSH term(s)	Animals ; Humans ; Mansonella/genetics ; Phylogeny ; Sympatry ; DNA, Ribosomal ; Amino Acid Sequence
Chemical Substances	DNA, Ribosomal
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1159814
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Article ; Online: From the Spectroscopic Reassessment of Authentic Alkaloid Samples to the Molecular Networking-Guided Discovery of Criophylline-Related Analogues from

Otogo N'Nang, Elvis / Cauchie, Gaëla / Retailleau, Pascal / Agnandji, Selidji Todagbe / Gallard, Jean-François / Mouray, Elisabeth / Grellier, Philippe / Champy, Pierre / Le Pogam, Pierre / Beniddir, Mehdi A

Journal of natural products

2023 Volume 86, Issue 5, Page(s) 1202–1210

Abstract: The molecular network-guided exploration of the alkaloid extract ... ...

Abstract	The molecular network-guided exploration of the alkaloid extract of
MeSH term(s)	Alkaloids/chemistry ; Chloroquine ; Indole Alkaloids/chemistry ; Tabernaemontana ; Monoterpenes ; Antineoplastic Agents ; Molecular Structure
Chemical Substances	Alkaloids ; Chloroquine (886U3H6UFF) ; Indole Alkaloids ; Monoterpenes ; Antineoplastic Agents
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.2c01084
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Article ; Online: HHV-6 infections in hospitalized young children of Gabon.

Inoue, Juliana / Weber, David / Fernandes, José Francisco / Adegnika, Ayola Akim / Agnandji, Selidji Todagbe / Lell, Bertrand / Kremsner, Peter G / Grobusch, Martin Peter / Mordmüller, Benjamin / Held, Jana

Infection

2023 Volume 51, Issue 6, Page(s) 1759–1765

Abstract: Purpose: Fever is a common cause for hospitalization among the pediatric population. The spectrum of causative agents is diverse. Human herpesvirus 6 (HHV-6) is a ubiquitous virus that often causes hospitalization of children in western countries. ... ...

Abstract	Purpose: Fever is a common cause for hospitalization among the pediatric population. The spectrum of causative agents is diverse. Human herpesvirus 6 (HHV-6) is a ubiquitous virus that often causes hospitalization of children in western countries. Previously, we investigated the cause of fever of 600 febrile hospitalized children in Gabon, and in 91 cases the causative pathogen was not determined. In this study, we assessed HHV-6 infection as potential cause of hospitalization in this group. Methods: Blood samples were assessed for HHV-6 using real-time quantitative PCR. Three groups were investigated: (1) group of interest: 91 hospitalized children with febrile illness without a diagnosed causing pathogen; (2) hospitalized control: 91 age-matched children hospitalized with febrile illness with a potentially disease-causing pathogen identified; both groups were recruited at the Albert Schweitzer Hospital in Lambaréné, Gabon and (3) healthy control: 91 healthy children from the same area. Results: Samples from 273 children were assessed. Age range was two months to 14 years, median (IQR) age was 36 (12-71) months; 52% were female. HHV-6 was detected in 64% (58/91), 41% (37/91), and 26% (24/91) of the samples from groups 1, 2, and 3, respectively; with statistically significant odds of being infected with HHV-6 in group 1 (OR = 4.62, 95% CI [2.46, 8.90]). Only HHV-6B was detected. Conclusions: Although tropical diseases account for a large proportion of children's hospitalizations, considering common childhood diseases such as HHV-6 when diagnosing febrile illnesses in pediatric populations in tropical countries is of importance.
MeSH term(s)	Child ; Humans ; Female ; Infant ; Child, Preschool ; Male ; Herpesvirus 6, Human/genetics ; Child, Hospitalized ; Gabon/epidemiology ; Fever/epidemiology ; Real-Time Polymerase Chain Reaction ; Herpesviridae Infections/complications ; Herpesviridae Infections/diagnosis
Language	English
Publishing date	2023-07-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-02077-w
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Funding patterns for biomedical research and infectious diseases burden in Gabon.

Adegnika, Olouyomi Scherif / Honkpehedji, Yabo Josiane / Mougeni Lotola, Fabrice / Agnandji, Selidji Todagbe / Adegnika, Ayola Akim / Lell, Bertrand / Sicuri, Elisa

BMC public health

2021 Volume 21, Issue 1, Page(s) 2155

Abstract: Background: Biomedical research plays an important role in improving health. There seems to exist a negative correlation between the amount of biomedical research funding and disease burden from all Sub-Saharan African countries. In this study, we ... ...

Abstract	Background: Biomedical research plays an important role in improving health. There seems to exist a negative correlation between the amount of biomedical research funding and disease burden from all Sub-Saharan African countries. In this study, we describe funding patterns for biomedical research, explore the correlation between funding and burden of diseases, and quantify inequalities in funds distribution across diseases in Gabon over the period 2005-2015. Methods: Data on medical research funds from 2005 to 2015 were retrieved through a structured questionnaire distributed to Gabonese biomedical research institutions and by consulting online databases. Data on the burden of diseases were gathered from the World Health Organization and the Institute for Health Metrics and Evaluation. We used Kendall rank correlation coefficient to explore the correlation between cumulative funds over time and the burden of disease. The inequality distribution of funding across diseases was assessed through Gini coefficient and Lorenz curve. Results: Biomedical research funding was characterized by a remarkable growth from 2005 to 2010 and a decline from 2010 to 2014. Funds were mostly from external sources and from partnerships. There was inequality in research funds allocation across diseases and malaria was far the most funded disease. There was a significant negative correlation between cumulative funding and the burden of HIV, tuberculosis, and of Helminthiasis (from 2006 to 2010) suggesting that research may be contributing to the management of such diseases. A positive, although not significant, correlation was found between cumulative funds and malaria burden. Conclusions: The negative correlation between HIV and tuberculosis cumulative funding and burden suggests that research may be contributing to the management of such diseases but further research is needed to assess the causal direction of such as relationship. As the burden of non-communicable diseases is increasing, more research funds should be focused on those. While research partnerships have been and will remain fundamental, Gabon should increase the amount of national funds to overcome periods of reduced research funding flows from abroad.
MeSH term(s)	Biomedical Research ; Communicable Diseases/epidemiology ; Cost of Illness ; Financial Management ; Gabon/epidemiology ; Humans
Language	English
Publishing date	2021-11-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-021-12201-w
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Article: Impacts of Ecology, Parasite Antigenic Variation, and Human Genetics on RTS,S/AS01e Malaria Vaccine Efficacy.

Bell, Griffin J / Agnandji, Selidji Todagbe / Asante, Kwaku Poku / Ghansah, Anita / Kamthunzi, Portia / Emch, Michael / Bailey, Jeffrey A

Current epidemiology reports

2021 Volume 8, Issue 3, Page(s) 79–88

Abstract: Purpose of review: Global malaria elimination has little chance of success without an effective vaccine. The first malaria vaccine, RTS,S/AS01e, demonstrated moderate efficacy against clinical malaria in phase III trials and is undergoing large-scale ... ...

Abstract	Purpose of review: Global malaria elimination has little chance of success without an effective vaccine. The first malaria vaccine, RTS,S/AS01e, demonstrated moderate efficacy against clinical malaria in phase III trials and is undergoing large-scale effectiveness trials in Africa. Importantly, the vaccine did not perform equally well between phase III study sites. Though reasons for the moderate efficacy and this variation are unclear, various mechanisms have been suggested. This review summarizes the recent literature on such mechanisms, with a focus on those involving landscape ecology, parasite antigenic variation, and human host genetic differences. Recent findings: Transmission intensity may have a role pre- and post-vaccination in modulating immune responses to the vaccine. Furthermore, malaria incidence may "rebound" in vaccinated populations living in high transmission intensity settings. There is growing evidence that both genetic variation in the parasite circumsporozoite protein and variation of human host genetic factors affect RTS,S vaccine efficacy. These genetic factors may be interacting in complex ways to produce variation in the natural and vaccine-induced immune responses that protect against malaria. Summary: Due to the modest efficacy of RTS,S/AS01e, the combinations of factors (ecological, parasite, human host) impacting its effectiveness must be clearly understood, as this information will be critical for implementation policy and future vaccine designs.
Language	English
Publishing date	2021-07-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2196-2995
ISSN	2196-2995
DOI	10.1007/s40471-021-00271-8
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