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  1. AU="Agnarelli, Alessandro"
  2. AU="Rill, Nathaniel O"
  3. AU="Sarah Lyon-Caen"
  4. AU="Endharti, Agustina Tri"
  5. AU="Baez-Noyer, Nelson"
  6. AU="Kucherlapati, Raju S."
  7. AU="Loyaux, Romain"
  8. AU="Yaxin Long"
  9. AU="Vlasenkova, Ramilia"
  10. AU="Taheri, Fateme"
  11. AU="Berman, Robert F"
  12. AU="Resnick, Cory M"
  13. AU=Freeman Gordon J AU=Freeman Gordon J
  14. AU="Fangru Zhou"

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  1. Artikel ; Online: Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors.

    Hill, Bethany Rebekah / Ozgencil, Meryem / Buckley-Benbow, Lauryn / Skingsley, Sophie Louise Pamela / Tomlinson, Danielle / Eizmendi, Carmen Ortueta / Agnarelli, Alessandro / Bellelli, Roberto

    Cell reports

    2024  Band 43, Heft 5, Seite(n) 114205

    Abstract: The advent of PARP inhibitors (PARPis) has profoundly changed the treatment landscape of BRCA1/BRCA2-mutated cancers. Despite this, the development of resistance to these compounds has become a major challenge. Hence, a detailed understanding of the ... ...

    Abstract The advent of PARP inhibitors (PARPis) has profoundly changed the treatment landscape of BRCA1/BRCA2-mutated cancers. Despite this, the development of resistance to these compounds has become a major challenge. Hence, a detailed understanding of the mechanisms underlying PARPi sensitivity is crucially needed. Here, we show that loss of the POLE3-POLE4 subunits of DNA polymerase epsilon (Polε) strongly sensitizes cancer cells to PARPis in a Polε level-independent manner. Loss of POLE3-POLE4 is not associated with defective RAD51 foci formation, excluding a major defect in homologous recombination. On the contrary, treatment with PARPis triggers replicative gap accumulation in POLE3-POLE4 knockout (KO) cells in a PRIMPOL-dependent manner. In addition to this, the loss of POLE3-POLE4 further sensitizes BRCA1-silenced cells to PARPis. Importantly, the knockdown of 53BP1 does not rescue PARPi sensitivity in POLE3-POLE4 KO cells, bypassing a common PARPi resistance mechanism and outlining a potential strategy to sensitize cancer cells to PARPis.
    Sprache Englisch
    Erscheinungsdatum 2024-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Incorporating Immunotherapy in the Management of Gastric Cancer: Molecular and Clinical Implications.

    Agnarelli, Alessandro / Vella, Viviana / Samuels, Mark / Papanastasopoulos, Panagiotis / Giamas, Georgios

    Cancers

    2022  Band 14, Heft 18

    Abstract: Gastric cancer has a median survival of 11 months, and this poor prognosis has not improved over the last 30 years. Recent pre-clinical data suggest that there is high tumour-related neoantigen expression in gastric cancer cells, suggesting that a ... ...

    Abstract Gastric cancer has a median survival of 11 months, and this poor prognosis has not improved over the last 30 years. Recent pre-clinical data suggest that there is high tumour-related neoantigen expression in gastric cancer cells, suggesting that a clinical strategy that enhances the host's immune system against cancer cells may be a successful approach to improve clinical outcomes. Additionally, there has been an increasing amount of translational evidence highlighting the relevance of PD-L1 expression in gastric cancer cells, indicating that PD-1/PD-L1 inhibitors may be useful. Several molecular subgroups of gastric cancer have been identified to respond with excellent outcomes to immunotherapy, including microsatellite instable tumours, tumours bearing a high tumour mutational burden, and tumours related to a chronic EBV infection. In gastric cancer, immunotherapy has produced durable responses in chemo-refractory patients; however, most recently there has been a lot of enthusiasm as several large-scale clinical trials highlight the improved survival noted from the incorporation of immunotherapy in the first line setting for advanced gastric cancer. Our review aims to discuss current pre-clinical and clinical data supporting the innovative role of immunotherapy in gastric cancer.
    Sprache Englisch
    Erscheinungsdatum 2022-09-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14184378
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4.

    Agnarelli, Alessandro / El Omari, Kamel / Duman, Ramona / Wagner, Armin / Mancini, Erika J

    Acta crystallographica. Section F, Structural biology communications

    2021  Band 77, Heft Pt 7, Seite(n) 202–207

    Abstract: Pivotal to the regulation of key cellular processes such as the transcription, replication and repair of DNA, DNA-binding proteins play vital roles in all aspects of genetic activity. The determination of high-quality structures of DNA-binding proteins, ... ...

    Abstract Pivotal to the regulation of key cellular processes such as the transcription, replication and repair of DNA, DNA-binding proteins play vital roles in all aspects of genetic activity. The determination of high-quality structures of DNA-binding proteins, particularly those in complexes with DNA, provides crucial insights into the understanding of these processes. The presence in such complexes of phosphate-rich oligonucleotides offers the choice of a rapid method for the routine solution of DNA-binding proteins through the use of long-wavelength beamlines such as I23 at Diamond Light Source. This article reports the use of native intrinsic phosphorus and sulfur single-wavelength anomalous dispersion methods to solve the complex of the DNA-binding domain (DBD) of interferon regulatory factor 4 (IRF4) bound to its interferon-stimulated response element (ISRE). The structure unexpectedly shows three molecules of the IRF4 DBD bound to one ISRE. The sole reliance on native intrinsic anomalous scattering elements that belong to DNA-protein complexes renders the method of general applicability to a large number of such protein complexes that cannot be solved by molecular replacement or by other phasing methods.
    Mesh-Begriff(e) Binding Sites/physiology ; Crystallography, X-Ray/methods ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Humans ; Interferon Regulatory Factors/chemistry ; Interferon Regulatory Factors/metabolism ; Nucleic Acids/chemistry ; Nucleic Acids/metabolism ; Phosphorus/chemistry ; Phosphorus/metabolism ; Protein Domains/physiology ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Sulfur/chemistry ; Sulfur/metabolism
    Chemische Substanzen DNA-Binding Proteins ; Interferon Regulatory Factors ; Nucleic Acids ; interferon regulatory factor-4 ; Phosphorus (27YLU75U4W) ; Sulfur (70FD1KFU70)
    Sprache Englisch
    Erscheinungsdatum 2021-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2053-230X
    ISSN (online) 2053-230X
    DOI 10.1107/S2053230X21006506
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: IRF4 in multiple myeloma-Biology, disease and therapeutic target.

    Agnarelli, Alessandro / Chevassut, Tim / Mancini, Erika J

    Leukemia research

    2018  Band 72, Seite(n) 52–58

    Abstract: Multiple Myeloma (MM) is an incurable hematologic malignancy characterized by abnormal proliferation of plasma cells. Interferon Regulatory Factor 4 (IRF4), a member of the interferon regulatory family of transcription factors, is central to the genesis ... ...

    Abstract Multiple Myeloma (MM) is an incurable hematologic malignancy characterized by abnormal proliferation of plasma cells. Interferon Regulatory Factor 4 (IRF4), a member of the interferon regulatory family of transcription factors, is central to the genesis of MM. IRF4 is highly expressed in B cells and plasma cells where it plays essential roles in controlling B cell to plasma cell differentiation and immunoglobulin class switching. Overexpression of IRF4 is found in MM patients' derived cells, often as a result of activating mutations or translocations, where it is required for their survival. In this review, we first describe the roles of IRF4 in B cells and plasma cells and then analyse the subversion of the IRF4 transcriptional network in MM. Moreover, we discuss current therapies for MM as well as direct targeting of IRF4 as a potential new therapeutic strategy.
    Mesh-Begriff(e) Animals ; Disease-Free Survival ; Gene Expression Regulation, Neoplastic ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Multiple Myeloma/mortality ; Multiple Myeloma/pathology ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Plasma Cells/metabolism ; Plasma Cells/pathology ; Survival Rate
    Chemische Substanzen Interferon Regulatory Factors ; Neoplasm Proteins ; interferon regulatory factor-4
    Sprache Englisch
    Erscheinungsdatum 2018-08-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2018.07.025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1321: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4-MYC oncogenic axis in multiple myeloma.

    Agnarelli, Alessandro / Mitchell, Simon / Caalim, Gillian / Wood, C David / Milton-Harris, Leanne / Chevassut, Timothy / West, Michelle J / Mancini, Erika J

    Hematological oncology

    2022  Band 40, Heft 3, Seite(n) 417–429

    Abstract: B-cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of a ... ...

    Abstract B-cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of a positive auto-regulatory loop with oncogene MYC, drives a MM specific gene-expression program leading to the abnormal expansion of malignant immature plasma cells. Targeting the IRF4-MYC oncogenic loop has the potential to provide a selective and effective therapy for MM. Here we evaluate the use of bromodomain inhibitors to target the IRF4-MYC axis through combined inhibition of their known epigenetic regulators, BRD4 and CBP/EP300. Although all inhibitors induced cell death, we found no synergistic effect of targeting both of these regulators on the viability of MM cell-lines. Importantly, for all inhibitors over a time period up to 72 h, we detected reduced IRF4 mRNA, but a limited decrease in IRF4 protein expression or mRNA levels of downstream target genes. This indicates that inhibitor-induced loss of cell viability is not mediated through reduced IRF4 protein expression, as previously proposed. Further analysis revealed a long half-life of IRF4 protein in MM cells. In support of our experimental observations, gene network modeling of MM suggests that bromodomain inhibition is exerted primarily through MYC and not IRF4. These findings suggest that despite the autofeedback positive regulatory loop between IRF4 and MYC, bromodomain inhibitors are not effective at targeting IRF4 in MM and that novel therapeutic strategies should focus on the direct inhibition or degradation of IRF4.
    Mesh-Begriff(e) Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/pharmacology ; Cell Cycle Proteins/therapeutic use ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Multiple Myeloma/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA, Messenger ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemische Substanzen BRD4 protein, human ; Cell Cycle Proteins ; Interferon Regulatory Factors ; Nuclear Proteins ; Proto-Oncogene Proteins c-myc ; RNA, Messenger ; Transcription Factors ; interferon regulatory factor-4
    Sprache Englisch
    Erscheinungsdatum 2022-05-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1816: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Artikel ; Online: The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor.

    Agnarelli, Alessandro / Lauer Betrán, Andrea / Papakyriakou, Athanasios / Vella, Viviana / Samuels, Mark / Papanastasopoulos, Panagiotis / Giamas, Christina / Mancini, Erika J / Stebbing, Justin / Spencer, John / Cilibrasi, Chiara / Ditsiou, Angeliki / Giamas, Georgios

    International journal of molecular sciences

    2023  Band 24, Heft 1

    Abstract: Recently, the oncogenic role of lemur tyrosine kinase 3 (LMTK3) has been well established in different tumor types, highlighting it as a viable therapeutic target. In the present study, using in vitro and cell-based assays coupled with biophysical ... ...

    Abstract Recently, the oncogenic role of lemur tyrosine kinase 3 (LMTK3) has been well established in different tumor types, highlighting it as a viable therapeutic target. In the present study, using in vitro and cell-based assays coupled with biophysical analyses, we identify a highly selective small molecule LMTK3 inhibitor, namely C36. Biochemical/biophysical and cellular studies revealed that C36 displays a high in vitro selectivity profile and provides notable therapeutic effect when tested in the National Cancer Institute (NCI)-60 cancer cell line panel. We also report the binding affinity between LMTK3 and C36 as demonstrated via microscale thermophoresis (MST). In addition, C36 exhibits a mixed-type inhibition against LMTK3, consistent with the inhibitor overlapping with both the adenosine 5'-triphosphate (ATP)- and substrate-binding sites. Treatment of different breast cancer cell lines with C36 led to decreased proliferation and increased apoptosis, further reinforcing the prospective value of LMTK3 inhibitors for cancer therapy.
    Mesh-Begriff(e) Cell Line, Tumor ; Prospective Studies ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Humans
    Chemische Substanzen Protein Kinase Inhibitors ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; LMTK3 protein, human (EC 2.7.11.1)
    Sprache Englisch
    Erscheinungsdatum 2023-01-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24010865
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Protopine/Gemcitabine Combination Induces Cytotoxic or Cytoprotective Effects in Cell Type-Specific and Dose-Dependent Manner on Human Cancer and Normal Cells.

    Garcia-Gil, Mercedes / Turri, Benedetta / Gabriele, Morena / Pucci, Laura / Agnarelli, Alessandro / Lai, Michele / Freer, Giulia / Pistello, Mauro / Vignali, Robert / Batistoni, Renata / Marracci, Silvia

    Pharmaceuticals (Basel, Switzerland)

    2021  Band 14, Heft 2

    Abstract: The natural alkaloid protopine (PRO) exhibits pharmacological properties including anticancer activity. We investigated the effects of PRO, alone and in combination with the chemotherapeutic gemcitabine (GEM), on human tumor cell lines and non-tumor ... ...

    Abstract The natural alkaloid protopine (PRO) exhibits pharmacological properties including anticancer activity. We investigated the effects of PRO, alone and in combination with the chemotherapeutic gemcitabine (GEM), on human tumor cell lines and non-tumor human dermal fibroblasts (HDFs). We found that treatments with different PRO/GEM combinations were cytotoxic or cytoprotective, depending on concentration and cell type. PRO/GEM decreased viability in pancreatic cancer MIA PaCa-2 and PANC-1 cells, while it rescued the GEM-induced viability decline in HDFs and in tumor MCF-7 cells. Moreover, PRO/GEM decreased G1, S and G2/M phases, concomitantly with an increase of subG1 phase in MIA PaCa-2 and PANC-1 cells. Differently, PRO/GEM restored the normal progression of the cell cycle, altered by GEM, and decreased cell death in HDFs. PRO alone increased mitochondrial reactive oxygen species (ROS) in MIA PaCa-2, PANC-1 cells and HDFs, while PRO/GEM increased both intracellular and mitochondrial ROS in the three cell lines. These results indicate that specific combinations of PRO/GEM may be used to induce cytotoxic effects in pancreatic tumor MIA PaCa-2 and PANC-1 cells, but have cytoprotective or no effects in HDFs.
    Sprache Englisch
    Erscheinungsdatum 2021-01-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14020090
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Cell-specific pattern of berberine pleiotropic effects on different human cell lines.

    Agnarelli, Alessandro / Natali, Marco / Garcia-Gil, Mercedes / Pesi, Rossana / Tozzi, Maria Grazia / Ippolito, Chiara / Bernardini, Nunzia / Vignali, Robert / Batistoni, Renata / Bianucci, Anna Maria / Marracci, Silvia

    Scientific reports

    2018  Band 8, Heft 1, Seite(n) 10599

    Abstract: The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma ... ...

    Abstract The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibroblasts (HDF) were used as non-cancer cells. We show that berberine differentially affects cell viability, displaying a higher cytotoxicity on the two cancer cell lines than on HDF. Berberine also affects cell cycle progression, senescence, caspase-3 activity, autophagy and migration in a cell-specific manner. In particular, in HDF it induces cell cycle arrest in G2 and senescence, but not autophagy; in the U343 cells, berberine leads to cell cycle arrest in G2 and induces both senescence and autophagy; in MIA PaCa-2 cells, the alkaloid induces arrest in G1, senescence, autophagy, it increases caspase-3 activity and impairs migration/invasion. As demonstrated by decreased citrate synthase activity, the three cell lines show mitochondrial dysfunction following berberine exposure. Finally, we observed that berberine modulates the expression profile of genes involved in different pathways of tumorigenesis in a cell line-specific manner. These findings have valuable implications for understanding the complex functional interactions between berberine and specific cell types.
    Mesh-Begriff(e) Apoptosis/drug effects ; Autophagy/drug effects ; Berberine/pharmacology ; Berberine/therapeutic use ; Carcinogenesis/drug effects ; Carcinogenesis/pathology ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cellular Senescence/drug effects ; Citrate (si)-Synthase/metabolism ; Drug Screening Assays, Antitumor ; Fibroblasts ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology
    Chemische Substanzen Berberine (0I8Y3P32UF) ; Citrate (si)-Synthase (EC 2.3.3.1) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Sprache Englisch
    Erscheinungsdatum 2018-07-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-28952-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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