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Book ; Online: Sea Urchin

Agnello, Maria

From Environment to Aquaculture and Biomedicine

2017

Keywords	Aquaculture & fish-farming: practice & techniques ; neurodegeneration, ecology, proteins, lipids, eutrophication, phytoplankton
Language	English
Size	1 electronic resource (154 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030646420
ISBN	9789535146360 ; 953514636X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Removal of sacral neuromodulation quadripolar tined-lead using a straight stylet: description of a surgical technique.

Agnello, M / Vottero, M / Bertapelle, P

Techniques in coloproctology

2021 Volume 25, Issue 8, Page(s) 957–963

Abstract: Background: Up to 7.5% of tined-lead removals in patients having sacral neuromodulation (SNM) therapy are associated with a lead breakage. It is still unclear what adverse effects can be caused by unretrieved fragments. The aim of our study was to ... ...

Abstract	Background: Up to 7.5% of tined-lead removals in patients having sacral neuromodulation (SNM) therapy are associated with a lead breakage. It is still unclear what adverse effects can be caused by unretrieved fragments. The aim of our study was to describe the lead removal technique we have been using for the last 2 years in our centre. Methods: We retrospectively enrolled patients who had lead removal between January 2018 and January 2020 using our standardized technique. The novelty of the technique is in the use of the straight stylet, which is available in the quadripolar tined-lead kit. The stylet gives the electrode greater stiffness, reducing interactions with surrounding tissues and probability of damage or breakage during removal. Results: In 59 patients (42 women, mean age 57.2 years [range 40-79 years]) the lead was removed using our standardized technique. In 44 of 59 patients, the tined-lead was removed within 2 months from the SNM-test, due to lack of beneficial effects. In 15 patients the electrode was removed because of failure of definitive implantation. Meantime from definitive implantable pulse generator (IPG) implantation to lead removal was 67.9 months. We recorded only 1 case of lead-breakage during removal: a female patient with a non-tined lead fixed on sacral bone, placed 18 years previously using an open technique. Conclusions: Lead breakage during removal is not uncommon and adverse effects of retained fragments may occur. Our technique has been safely used for the last 2 years in our centre, with no episodes of lead breakage or retained fragments, except for one non-tined electrode.
MeSH term(s)	Adult ; Aged ; Electric Stimulation Therapy ; Electrodes, Implanted ; Female ; Humans ; Lumbosacral Plexus ; Middle Aged ; Prostheses and Implants ; Retrospective Studies ; Sacrococcygeal Region ; Sacrum/surgery
Language	English
Publishing date	2021-04-22
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2083309-X
ISSN	1128-045X ; 1123-6337
ISSN (online)	1128-045X
ISSN	1123-6337
DOI	10.1007/s10151-020-02403-6
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Article ; Online: Infection Rate of a Prolonged Sacral Neuromodulation Test: A Large Retrospective Study.

Agnello, Marco / Brugnano, Salvatore / Vottero, Mario / Bertapelle, Paola

Neuromodulation : journal of the International Neuromodulation Society

2022 Volume 26, Issue 8, Page(s) 1845–1850

Abstract: Objectives: It is estimated that 3.8% to 12.5% of patients develop a device infection during the two to four weeks of the sacral neuromodulation (SNM) test, leading to removal of the entire system. It is possible to prolong the test phase up to the ... ...

Abstract	Objectives: It is estimated that 3.8% to 12.5% of patients develop a device infection during the two to four weeks of the sacral neuromodulation (SNM) test, leading to removal of the entire system. It is possible to prolong the test phase up to the clinician's decision, particularly when benefits are unclear. The aim of our study is to assess the device infection rate in a prolonged SNM test. Materials and methods: We retrospectively enrolled patients who performed a prolonged SNM test (at least eight weeks) in the last five years (2017-2021). All procedures were performed using a standardized technique and the same prophylactic antibiotic protocol. In case of a clinical suspicion of infection, all components were explanted. Patient information (age at implantation, medical history of diabetes, metabolic syndrome, immunologic diseases, or chronic immunosuppressive therapy), surgical data (operative time, intraoperative complications), and infection data (timing of onset, symptoms reported, wound culture results) were recorded. Results: We enrolled 232 patients who underwent a prolonged SNM test (mean duration 65.5 days). A local infection that led to the removal of the entire system occurred in six patients (2.6%). The gluteal pocket was always involved, and in two cases, infection was also extended to the exit point of the extension wire. No significant correlations with clinical data were found. Infection occurred beyond four weeks in two cases, between three and four weeks in three cases, and within two weeks in one case. Intraoperative wound culture was performed in five of six patients, and Staphylococcus aureus (S aureus) was isolated in four cases. One culture test gave negative bacterial growth results. Conclusions: The infection rate of a prolonged eight-week SNM test is low and does not differ from that reported in the literature for a two-to-four-week SNM test. S aureus remains the most frequent bacterium involved.
MeSH term(s)	Humans ; Retrospective Studies ; Staphylococcal Infections ; Staphylococcus aureus ; Electric Stimulation Therapy/methods ; Sacrum ; Treatment Outcome
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500372-3
ISSN	1525-1403 ; 1094-7159
ISSN (online)	1525-1403
ISSN	1094-7159
DOI	10.1016/j.neurom.2022.08.453
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Article ; Online: Do you really want to deactivate your sacral neuromodulation device during pregnancy? A single center case series.

Agnello, Marco / Vottero, Mario / Bertapelle, Paola

International urogynecology journal

2020 Volume 32, Issue 3, Page(s) 709–717

Abstract: Introduction and hypothesis: The main objective of the study is to assess the efficacy and safety of sacral neuromodulation (SNM) during pregnancy.: Methods: We retrospectively enrolled patients who underwent SNM implantation in our center and ... ...

Abstract	Introduction and hypothesis: The main objective of the study is to assess the efficacy and safety of sacral neuromodulation (SNM) during pregnancy. Methods: We retrospectively enrolled patients who underwent SNM implantation in our center and subsequently became pregnant. The indication for SNM, timing of device de-activation (if performed), course of pregnancy and urological complications, duration of labor, childbirth term, delivery mode, congenital abnormalities and SNM dysfunctions after delivery were recorded. Results: Fourteen pregnancies were recorded among 11 women undergoing SNM. Indications for device implantation were urinary retention (7 cases) and dysfunctional voiding (4 cases). Two patients carried on two and three pregnancies, respectively, with the device turned off since the first trimester. They both had to return to self-catheterization and developed recurring urinary tract infections. No major urological complications were recorded among the remaining nine women that kept the device on during pregnancy. A cesarean section was performed in four cases for obstetric reasons, and in seven cases it was planned by the urologist and gynecologist to avoid lead damage/displacement. Three pregnancies resulted in a vaginal delivery, and no association with term of delivery or duration of labor was observed. No congenital abnormalities related to SNM or lead displacement are reported, and only one patient required device removal because of significant loss of efficacy after childbirth. Conclusions: The use of SNM during pregnancy appears to be safe, without morbidity for the fetus. Moreover, risks associated with switching the device off may be greater than benefits and justify maintaining the electrical stimulation throughout pregnancy.
MeSH term(s)	Cesarean Section ; Electric Stimulation Therapy/adverse effects ; Female ; Humans ; Lumbosacral Plexus ; Parturition ; Pregnancy ; Retrospective Studies ; Sacrum ; Treatment Outcome
Language	English
Publishing date	2020-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-020-04594-w
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Article ; Online: Sacral neuromodulation to treat voiding dysfunction in patients with previous pelvic surgery for deep infiltrating endometriosis: our centre's experience.

Agnello, Marco / Vottero, Mario / Bertapelle, Paola

International urogynecology journal

2020 Volume 32, Issue 6, Page(s) 1499–1504

Abstract: Introduction and hypothesis: Voiding symptoms/dysfunctions (VS/Ds) after surgery for deep-infiltrating endometriosis (DIE) are frequent (20% of patients) and, together with bowel dysfunctions, may represent a de novo disorder due to surgical damage of ... ...

Abstract	Introduction and hypothesis: Voiding symptoms/dysfunctions (VS/Ds) after surgery for deep-infiltrating endometriosis (DIE) are frequent (20% of patients) and, together with bowel dysfunctions, may represent a de novo disorder due to surgical damage of the pelvic plexus or a worsening of pre-existent functional damage. Sacral neuromodulation (SNM) might improve voiding symptoms by treating dysfunctional voiding. The aim of this study is to report our experience with SNM in patients treated with surgery for DIE. Methods: We retrospectively enrolled 13 patients with VS/Ds after surgery for DIE. All patients were investigated with urodynamic studies (UDS) and agreed to undergo SNM. Pre-existing VS/Ds, bowel disorders and pelvic pain, DIE surgical procedures, UDS and SNM test results were recorded. Results: After surgery for DIE, functional bladder outflow obstruction and detrusor acontractility were observed in nine and four patients, respectively. Chronic pelvic pain was present in seven cases. Twelve patients developed constipation, whilst one patient had de novo faecal incontinence. After the SNM testing period, nine patients (69.2%) experienced a significant improvement of symptoms that led to definitive implant. Four patients (30.8%) had no symptom relief and the system was removed. Conclusions: Functional bladder outflow obstruction and urinary retention are the most common VS/Ds after surgery for DIE. SNM may be an effective option for these patients, probably due to its action in improving the dysfunctional voiding, which was likely to be already present as part of the "endometriotic syndrome" and got worse after pelvic surgery. Results for pelvic pain control and gastrointestinal disorders should not be underestimated.
MeSH term(s)	Electric Stimulation Therapy ; Endometriosis ; Female ; Humans ; Lumbosacral Plexus ; Retrospective Studies ; Treatment Outcome ; Urinary Retention/therapy
Keywords	covid19
Language	English
Publishing date	2020-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-020-04478-z
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Article: Comparison Study between Artificial Urinary Sphincter and Adjustable Male Sling: A Propensity-Score-Matched Analysis.

Geretto, Paolo / Ammirati, Enrico / Falcone, Marco / Manassero, Alberto / Agnello, Marco / Della Corte, Marcello / Gontero, Paolo / Giammò, Alessandro

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Aims: This study aimed to compare the outcomes of the AUS and an adjustable male sling (ATOMS: Methods: It was a retrospective observational cohort study with two arms. Propensity score matching (PSM) was performed in order to limit selection bias ... ...

Abstract	Aims: This study aimed to compare the outcomes of the AUS and an adjustable male sling (ATOMS Methods: It was a retrospective observational cohort study with two arms. Propensity score matching (PSM) was performed in order to limit selection bias and, consequently, a comparison between groups in terms of functional outcomes (24 h pad test and perception of improvement questionnaires), complications (overall complications, high-grade complications, reinterventions and explantations) and device survival was performed. Results: 49 patients in both arms were included. The baseline characteristics were similar between the groups. The mean follow up was 43 ± 35 months. Dryness was achieved in 22 patients (44.9%) in the AUS group and 11 (22.5%) in the sling group ( Conclusions: While the AUS may be characterized by a higher dry rate, it has an increased risk of high-grade complications and reinterventions. It is proposed that the ATOMS prosthesis can be successfully used for patients who require a less invasive procedure that maintains good functional outcomes.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175489
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Article: Pilot study on selective antimicrobial effect of a halitosis mouthrinse: monospecies and saliva-derived microbiome in an in vitro model system.

Botelho Dinis, Márcia / Agnello, Melissa / He, Xuesong / Shi, Wenyuan / Chaichanasakul Tran, Nini

Journal of oral microbiology

2021 Volume 13, Issue 1, Page(s) 1996755

Abstract: Background: Halitosis refers to malodor emanating from the oral cavity. Several mouthrinses with halitosis-reduction exist on the market, but their effect on the oral microbiome is largely unknown. In this study, we used an efficient : Methods: ... ...

Abstract	Background: Halitosis refers to malodor emanating from the oral cavity. Several mouthrinses with halitosis-reduction exist on the market, but their effect on the oral microbiome is largely unknown. In this study, we used an efficient Methods: Single halitosis-associated species and other common oral microorganism cultures were exposed to the test mouthrinse over time, and their viability was determined by culture-based selective plating. Next, the saliva-derived microbiome from healthy and halitosis-associated individuals was cultured in the presence of the test mouthrinse over time using the previously developed Results: The test mouthrinse displayed antimicrobial activity against known anaerobic bacterial species producing halitosis-related compounds such as Conclusions: The test mouthrinse had promising anti-halitosis characteristics at the microbiome level, as demonstrated by the reduction in the relative abundance of halitosis-associated taxa while maintaining microbial diversity.
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2523919-3
ISSN	2000-2297
ISSN	2000-2297
DOI	10.1080/20002297.2021.1996755
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Article: Oral Microbiome:

Dinis, Márcia / Agnello, Melissa / Cen, Lujia / Shokeen, Bhumika / He, Xuesong / Shi, Wenyuan / Wong, David T W / Lux, Renate / Tran, Nini Chaichanasakul

Frontiers in microbiology

2022 Volume 13, Page(s) 782825

Abstract: Dental caries remains the most common chronic disease in children, and the respective etiology is not fully understood. ... ...

Abstract	Dental caries remains the most common chronic disease in children, and the respective etiology is not fully understood. Though
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.782825
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Article: Tooth-Specific

Dinis, Márcia / Traynor, William / Agnello, Melissa / Sim, Myung-Shin / He, Xuesong / Shi, Wenyuan / Lux, Renate / Tran, Nini Chaichanasakul

Microorganisms

2022 Volume 10, Issue 6

Abstract: Dental caries is multifactorial and polymicrobial in nature and remains one of the most common oral diseases. While caries research has focused ... ...

Abstract	Dental caries is multifactorial and polymicrobial in nature and remains one of the most common oral diseases. While caries research has focused on
Language	English
Publishing date	2022-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10061129
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Article ; Online: Survey on European studies of the chemical characterisation of tattoo ink products and the measurement of potentially harmful ingredients.

Agnello, Manuela / Fontana, Marco

Current problems in dermatology

2015 Volume 48, Page(s) 142–151

Abstract: The results of the detection of carcinogenic aromatic amines in about 300 ink samples are discussed. All analysed inks contained at least one or more azo compound pigments, and the presence of aromatic amines could only have originated from these ... ...

Abstract	The results of the detection of carcinogenic aromatic amines in about 300 ink samples are discussed. All analysed inks contained at least one or more azo compound pigments, and the presence of aromatic amines could only have originated from these compounds through a chemical process named 'reductive cleavage'. Sometimes, aromatic amines were also present as impurities derived from the processing of the pigments. A systematic surveillance programme in Italy, promoted by the Italian Ministry of Health with the involvement of Italian regions, local public health authorities and Agenzia Regionale per la Protezione Ambiente del Piemonte (Environmental Protection Agency), has shown that about 40% of the monitored inks are not regular according to European Resolution ResAP(2008):1. The method utilised for the detection of aromatic amines has allowed the identification of other substances that are not carcinogenic but are toxic or have sensitisation properties that are derived from reductive cleavage or that are present as impurities.
MeSH term(s)	Amines/analysis ; Azo Compounds/analysis ; Azo Compounds/chemistry ; Carcinogens/analysis ; Color ; Coloring Agents/adverse effects ; Coloring Agents/chemistry ; Drug Contamination ; Gas Chromatography-Mass Spectrometry ; Humans ; Hydrocarbons, Aromatic/analysis ; Ink ; Italy ; Oxidation-Reduction ; Tattooing
Chemical Substances	Amines ; Azo Compounds ; Carcinogens ; Coloring Agents ; Hydrocarbons, Aromatic
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Journal Article
ISSN	1662-2944 ; 0070-2064 ; 1421-5721
ISSN (online)	1662-2944
ISSN	0070-2064 ; 1421-5721
DOI	10.1159/000369197
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