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  1. AU="Agostini, Ludovico"
  2. AU="Vieira, Dorice"
  3. AU="Sharma, Arya M"
  4. AU="Lieve E. H. van der Donk"
  5. AU="Großer, Matthias"
  6. AU="Ong, Edison"
  7. AU=Lavery James V
  8. AU=Moss Arthur J
  9. AU="Ni, Dongchun"
  10. AU="Yang, Yanfan"
  11. AU="Shona Manning"
  12. AU=Charters Pia F P AU=Charters Pia F P
  13. AU="Adumuah, Naa N"
  14. AU="Rodrigues, Jonathan Carl Luis"
  15. AU=Seidel Bastian M
  16. AU="Duan Weimin"
  17. AU=Ioanas M
  18. AU="Nancy Zambon"
  19. AU="Kumawat, Sunita"
  20. AU=Bogliacino Francesco
  21. AU="Setter, Peter"
  22. AU=Shikata Chihiro
  23. AU="Jordan P. Metcalf"
  24. AU=Peri?i? Nanut Milica AU=Peri?i? Nanut Milica
  25. AU="Pramod, Ganapathiraju"
  26. AU="Fu, Chu-Jun"
  27. AU="Nejad, Harry G."
  28. AU="Zhang, Q E"
  29. AU="Oppenheim, Madeline"

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  1. Artikel ; Online: Coexistence of Trigonocephaly and Sylvian Arachnoid Cysts: A Coincidence?

    Bianchi, Federico / Agostini, Ludovico / Frassanito, Paolo / Massimi, Luca / Tamburrini, Gianpiero

    Pediatric neurosurgery

    2024  

    Abstract: Introduction The association between trigonocephaly and sylvian fissure arachnoid cysts (ACs) has been occasionally reported in the literature [1,2]. However, the real incidence of this association and its clinical relevance remain unknown. Methods The ... ...

    Abstract Introduction The association between trigonocephaly and sylvian fissure arachnoid cysts (ACs) has been occasionally reported in the literature [1,2]. However, the real incidence of this association and its clinical relevance remain unknown. Methods The authors collected and retrospectively reviewed all clinical charts and CT scans of patients surgically treated for trigonocephaly at the Pediatric Neurosurgical Department of Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS from January 2014 to June 2023. Results During the study period, 136 patients with trigonocephaly underwent surgery. Analysis of the clinical charts revealed that in 39.7% of the cases (54/136), pre-operative CT scan depicted the presence of a sylvian fissure arachnoid cyst. Of these, AC was bilateral in 23 cases and unilateral in the remaining 31. All unilateral ACs were on the left side. The ACs were classified as Galassi grade I in 52 cases (96.3%) and Galassi grade II in 2 cases (3.7%)[3]. Interestingly, in one case we reported a Galassi grade I AC enlargement during follow-up, thereby necessitating surgical fenestration. Conclusion ACs and trigonocephaly are well-known conditions for pediatric neurosurgeons; however, their association is poorly defined. Despite the lack of reports on the incidence and clinical significance of this association, it is worth knowing that radiological follow-up is essential be in monitoring AC evolution.
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000538559
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Iniencephaly and long-term survival: a possible association-case report and review of the literature.

    Agostini, Ludovico / Massimi, Luca / Tamburrini, Gianpiero / Frassanito, Paolo / Bianchi, Federico

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Band 39, Heft 8, Seite(n) 2027–2035

    Abstract: Background: Iniencephaly is a rare, complex, and severe form of neural tube defect (NTD), usually associated with wide systemic involvement and poor prognosis. The malformation involves the occiput and the inion, variably combined with rachischisis of ... ...

    Abstract Background: Iniencephaly is a rare, complex, and severe form of neural tube defect (NTD), usually associated with wide systemic involvement and poor prognosis. The malformation involves the occiput and the inion, variably combined with rachischisis of the upper cervical and thoracic spine. Although most patients are either stillborn or perish within a few hours after birth, there are reports linking iniencephaly and long survival. For the neurosurgeon, associated encephalocele and secondary hydrocephalus represent the main challenges in this setting of patients, together with proper prenatal counseling.
    Material and methods: Herein, the authors performed a thorough review of the pertinent literature, looking for reports of long-term survivors.
    Results: To date, only five long-term survivors have been reported, with surgical repair attempted in four of them. Furthermore, the authors added their personal experience about two children with long-term survival who underwent surgery, thus accurately comparing them with the analogous cases previously reported in literature, with the ultimate aim of providing novel information on the pathology and the therapeutic options needed to offer proper treatment to these patients.
    Conclusions: Although no distinctive anatomic differences have been prior identified between long-term survivors and other patients, some variations emerged to occur, regarding age of presentation, the extension of the CNS malformation, the systemic involvement, and the surgical procedures offered. Although the authors shed some light on the topic, further studies are warranted to better define this rare and complex disease, and survival.
    Mesh-Begriff(e) Pregnancy ; Child ; Female ; Humans ; Neural Tube Defects/surgery ; Neural Tube Defects/complications ; Encephalocele/surgery ; Spine ; Hydrocephalus/complications ; Facial Bones
    Sprache Englisch
    Erscheinungsdatum 2023-05-26
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06003-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2036: Hefte anzeigen Standort:
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  3. Artikel ; Online: Posterior cranial fossa surgery with a 3D Exoscope: a single-center survey-based analysis and a literature review.

    Mattogno, Pier Paolo / Della Pepa, Giuseppe Maria / Menna, Grazia / Agostini, Ludovico / Albanese, Alessio / Tamburrini, Gianpiero / Gaudino, Simona / Olivi, Alessandro / Doglietto, Francesco

    World neurosurgery

    2024  

    Abstract: Background: The potential advantages of exoscopy have been discussed theoretically for a long time. Such a concept holds significance, especially in the specific setting of the posterior cranial fossa (PCF), characterized by complex anatomy and long and ...

    Abstract Background: The potential advantages of exoscopy have been discussed theoretically for a long time. Such a concept holds significance, especially in the specific setting of the posterior cranial fossa (PCF), characterized by complex anatomy and long and narrow surgical corridors with relatively extreme working angles.
    Aim: We aimed to: 1) analyze the institutional preliminary case-based data on the use of the Robotic 3D Exoscope AEOS Aesculap in three different PCF approaches: retrosigmoid (RSA), midline suboccipital (MSA), and supra cerebellar infratentorial (SIA) via feedbacks was collected using a 20-point questionnaire. 2) perform a comprehensive review of the literature concerning the use of EX in PCF surgery RESULTS: A total of 38 patients with neurosurgical pathologies underwent a neurosurgical procedure using the EX (Robotic 3D exoscope AEOS Aesculap) at our institution between January and March 2022. 21 surgeons were involved in the abovementioned PCF surgeries and answered the questionnaire. The main perceived advantages were in terms of ergonomics (67%) and magnification (52%) and visualization of extreme angles. The main reported disadvantage was color vision (16, 76%), followed by manual mobility (24%). Concerning the review, the search of the literature yielded a total of 177 results. Upon full-text review, 17 articles were included, including 153 patients.
    Conclusions: In conclusion, our study provides a comprehensive evaluation of the advantages and challenges associated with using the exoscope in posterior fossa surgery, setting a precedent as the first to report on a questionnaire-based analysis of exoscope utilization in this specific domain.
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.05.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Hefte anzeigen Standort:
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  4. Artikel ; Online: A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.

    Della Pepa, Giuseppe Maria / Mattogno, Pierpaolo / Menna, Grazia / Agostini, Ludovico / Olivi, Alessandro / Doglietto, Francesco

    World neurosurgery

    2022  Band 170, Seite(n) 133–137

    Abstract: Background: The exoscope has been proposed as a valid tool in 5-aminolevulinic acid-guided resection of high-grade gliomas. However, it is not clear if, beyond ergonomics, the exoscope provides a real benefit over the optical microscope (OM). The aim of ...

    Abstract Background: The exoscope has been proposed as a valid tool in 5-aminolevulinic acid-guided resection of high-grade gliomas. However, it is not clear if, beyond ergonomics, the exoscope provides a real benefit over the optical microscope (OM). The aim of this study was to compare the exoscope with the OM in terms of surgical visualization and workflow in 5-aminolevulinic acid-guided brain surgery.
    Methods: Surgical videos of patients diagnosed with histopathologically confirmed, Shinoda stage I, high-grade gliomas who underwent surgery in from January to April 2022 were studied. Visualization under a 5-aminolevulinic acid blue filter for vessels, parenchyma, surgical instruments, and fluorescence was categorized for both superficial and deep fields. The following data were also recorded: median number of switches between white light and blue filter, average duration per switch, and amount of work under blue filter.
    Results: There were 5 surgeries performed under OM guidance and 5 performed under exoscope guidance. Under a blue filter, the exoscope was significantly better than the OM in visualizing vessels, parenchyma, and surgical instruments for both superficial and deep surgical fields. The median number of switches between blue and white light was lower compared with the OM. Both median switch duration and percentage of work under the blue filter were superior when using the exoscope.
    Conclusions: Within the limitations of a preliminary analysis, use of the exoscope in fluorescence-guided surgery for high-grade gliomas provided significant advantages in terms of visualization of the surgical field under a blue filter and linearity of surgical flow.
    Mesh-Begriff(e) Humans ; Aminolevulinic Acid ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Workflow ; Glioma/diagnostic imaging ; Glioma/surgery
    Chemische Substanzen Aminolevulinic Acid (88755TAZ87)
    Sprache Englisch
    Erscheinungsdatum 2022-11-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.11.043
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Molecular Analysis in a Glioblastoma Cohort-Results of a Prospective Analysis.

    Lauretti, Liverana / Cenci, Tonia / Montano, Nicola / Offi, Martina / Giordano, Martina / Caccavella, Valerio M / Mangraviti, Antonella / Agostini, Ludovico / Olivi, Alessandro / Gabriele, Lucia / Larocca, Luigi M / Pallini, Roberto / Martini, Maurizio / D'Alessandris, Quintino Giorgio

    Journal of personalized medicine

    2022  Band 12, Heft 5

    Abstract: The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma ... ...

    Abstract The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials.
    Sprache Englisch
    Erscheinungsdatum 2022-04-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12050685
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service.

    D'Alessandris, Quintino Giorgio / Ricciotti, Maria Adelaide / Palombi, Davide / Agostini, Ludovico / Mattogno, Pier Paolo / Della Pepa, Giuseppe Maria / Albanese, Alessio / Chiesa, Silvia / Dispenza, Sabrina / Meloni, Eleonora / Tummolo, Anita Maria / Pallini, Roberto / Barillaro, Christian / Olivi, Alessandro / Lauretti, Liverana

    Journal of personalized medicine

    2022  Band 12, Heft 10

    Abstract: The onco-functional balance in neuro-oncology requires maximizing tumor removal while rigorously preserving patients' neurological status. When postoperative worsening prevents the implementation of oncologic treatments, palliative care service offers an ...

    Abstract The onco-functional balance in neuro-oncology requires maximizing tumor removal while rigorously preserving patients' neurological status. When postoperative worsening prevents the implementation of oncologic treatments, palliative care service offers an individualized path for symptom and psychosocial distress relief. Here, we report on a series of 25 patients operated on for malignant brain tumor who did not undergo adjuvant treatments after neurosurgery; they represented 3.9% of the whole institutional surgical series. These patients were significantly older and had a lower preoperative Karnofsky performance status than the whole cohort. Importantly, in 22 out of 25 (88%) cases, a surgical complication occurred, leading to clinical worsening in 21 patients. For the end of life, the majority of patients chose a hospice care facility (72%). While a careful selection of brain tumor patients candidate to neurosurgery is required, palliative care service provided invaluable help in coping with patients' and caregivers' needs.
    Sprache Englisch
    Erscheinungsdatum 2022-09-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12101565
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways.

    Serioli, Simona / Agostini, Ludovico / Pietrantoni, Alberto / Valeri, Federico / Costanza, Flavia / Chiloiro, Sabrina / Buffoli, Barbara / Piazza, Amedeo / Poliani, Pietro Luigi / Peris-Celda, Maria / Iavarone, Federica / Gaudino, Simona / Gessi, Marco / Schinzari, Giovanni / Mattogno, Pier Paolo / Giampietro, Antonella / De Marinis, Laura / Pontecorvi, Alfredo / Fontanella, Marco Maria /
    Lauretti, Liverana / Rindi, Guido / Olivi, Alessandro / Bianchi, Antonio / Doglietto, Francesco

    International journal of molecular sciences

    2023  Band 24, Heft 21

    Abstract: Recently, advances in molecular biology and bioinformatics have allowed a more thorough understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) through the identification of specific essential genes, crucial molecular ... ...

    Abstract Recently, advances in molecular biology and bioinformatics have allowed a more thorough understanding of tumorigenesis in aggressive PitNETs (pituitary neuroendocrine tumors) through the identification of specific essential genes, crucial molecular pathways, regulators, and effects of the tumoral microenvironment. Target therapies have been developed to cure oncology patients refractory to traditional treatments, introducing the concept of precision medicine. Preliminary data on PitNETs are derived from preclinical studies conducted on cell cultures, animal models, and a few case reports or small case series. This study comprehensively reviews the principal pathways involved in aggressive PitNETs, describing the potential target therapies. A search was conducted on Pubmed, Scopus, and Web of Science for English papers published between 1 January 2004, and 15 June 2023. 254 were selected, and the topics related to aggressive PitNETs were recorded and discussed in detail: epigenetic aspects, membrane proteins and receptors, metalloprotease, molecular pathways, PPRK, and the immune microenvironment. A comprehensive comprehension of the molecular mechanisms linked to PitNETs' aggressiveness and invasiveness is crucial. Despite promising preliminary findings, additional research and clinical trials are necessary to confirm the indications and effectiveness of target therapies for PitNETs.
    Mesh-Begriff(e) Animals ; Humans ; Pituitary Neoplasms/pathology ; Pituitary Gland/metabolism ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/therapy ; Neuroendocrine Tumors/metabolism ; Aggression ; Tumor Microenvironment/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-10-29
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115719
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch: La repubblica immaginaria

    Agostini, Ludovico / Firpo, Luigi

    (Pubblicazioni dell'Istituto di Scienze Politiche dell'Università di Torino ; 4)

    1957  

    Verfasserangabe di Ludovico Agostini. Testo critico, con la bibliografia dell'autore. A cura di Luigi Firpo
    Serientitel Pubblicazioni dell'Istituto di Scienze Politiche dell'Università di Torino ; 4
    Sprache Italienisch
    Umfang 187 S, 1 Taf
    Verlag Ed. Ramella
    Erscheinungsort Torino
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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