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  1. Article ; Online: Reply to "Lower urinary tract (LUT) symptoms like over- (OAB) or underactive bladder (UAB) often are caused by pelvic organ prolapse (POP) in women and can often be cured by ligamentous POP-repair".

    Agrò, Enrico Finazzi / Serati, Maurizio / Mancini, Vito

    Neurourology and urodynamics

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Letter
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25431
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    Zs.A 1828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Can we predict and manage persistent storage and voiding LUTS following bladder outflow resistance reduction surgery in men? ICI-RS 2023.

    Tarcan, Tufan / Hashim, Hashim / Malde, Sachin / Sinha, Sanjay / Sahai, Arun / Acar, Omer / Selai, Caroline / Agro, Enrico Finazzi / Abrams, Paul / Wein, Alan

    Neurourology and urodynamics

    2024  

    Abstract: Aims: Lower urinary tract symptoms (LUTS) persist in up to 50% of patients after bladder outflow resistance reduction surgery (BORRS) in men. Our think tank aims to address the predictive factors for persistent LUTS after BORRS and to propose the ... ...

    Abstract Aims: Lower urinary tract symptoms (LUTS) persist in up to 50% of patients after bladder outflow resistance reduction surgery (BORRS) in men. Our think tank aims to address the predictive factors for persistent LUTS after BORRS and to propose the recommendations for future research to enable improved better patient counseling and selection by more accurate prediction of treatment outcome.
    Methods: A think tank of ICI-RS gathered in 2023, Bristol, UK, to discuss the pre and postsurgical clinical and urodynamic evaluation of men undergoing BORRS and whether it is possible to predict which men will have persistent LUTS after BORRS.
    Results: Our think tank agrees that due to the multifactorial, and still not fully understood, etiology of male LUTS it is not possible to precisely predict in many men who will have persistent LUTS after BORRS. However, severe storage symptoms (overactive bladder, OAB) in association with low volume and high amplitude detrusor overactivity and low bladder capacity in preoperative urodynamics, increase the likelihood of persistent OAB/storage symptoms after BORRS. Furthermore, patients who are clearly obstructed and have good bladder contractility on preoperative pressure flow studies do better postoperatively compared to their counterparts. However, the benefit of pressure flow studies is decreased in patients who do not acceptably void during the study. Poor voiding after BORRS may occur due to persistent obstruction or detrusor underactivity.
    Conclusion: Future research is needed to increase our understanding of why male LUTS persist after surgery, and to enable better patient selection and more precise patient counseling before BORRS.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25435
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    Zs.A 1828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Can we predict whether a man with acute or chronic urinary retention will void after bladder outflow resistance reduction surgery? ICI-RS 2023.

    Tarcan, Tufan / Acar, Ömer / Malde, Sachin / Sinha, Sanjay / Sahai, Arun / Perrouin-Verbe, Marie-Aimee / Hashim, Hashim / Agro, Enrico Finazzi / Wein, Alan / Abrams, Paul

    Neurourology and urodynamics

    2024  

    Abstract: Aims: To address the predictive factors of a successful voiding after bladder outflow resistance reduction surgery (BORRS) in men presenting with acute or chronic urinary retention (UR).: Methods: A think tank (TT) of ICI-RS was gathered in 2023, ... ...

    Abstract Aims: To address the predictive factors of a successful voiding after bladder outflow resistance reduction surgery (BORRS) in men presenting with acute or chronic urinary retention (UR).
    Methods: A think tank (TT) of ICI-RS was gathered in 2023, Bristol, UK, to discuss several aspects of the problem, such as the pathophysiology of UR, the clinical and urodynamic evaluation of men with UR and whether it is possible to predict which men will be able to successfully void after treatment with contemporary surgical options.
    Results: The TT agreed that successful voiding after BORRS depends on several factors but that a strong recommendation cannot be made regarding preoperative evaluation and whether there are predictive factors of success because of the heterogeneity of patients and methodology in published trials. The diagnosis of obstruction in men with UR may be challenging when there is apparent reduced detrusor contraction during urodynamic studies. Even in the absence of bladder contractility there is documentation of such cases that have voided adequately after BORRS. Still, detrusor underactivity and inadequate relief of prostatic obstruction are the main causes of an unsuccessful voiding after BORRS. Conventional resection and enucleation methods remain the most successful surgeries in relieving UR in men, whereas the efficacy of minimally invasive surgical treatments needs to be assessed further.
    Conclusion: Research is needed to understand the pathophysiology of UR and the predictors of successful voiding after different types of BORRS in men with UR.
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25404
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    Zs.A 1828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Urodynamics Before Surgery for Stress Urinary Incontinence: The Urodynamic Examination Is Still One of the Best Friends of the Surgeon and of Patients with Stress Urinary Incontinence.

    Serati, Maurizio / Agrò, Enrico Finazzi

    European urology focus

    2016  Volume 2, Issue 3, Page(s) 272–273

    Abstract: In the large majority of patients with stress urinary incontinence, urodynamics could provide new information, in comparison to simple clinical examination, and change subsequent management in a relevant percentage of cases. ...

    Abstract In the large majority of patients with stress urinary incontinence, urodynamics could provide new information, in comparison to simple clinical examination, and change subsequent management in a relevant percentage of cases.
    Language English
    Publishing date 2016-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2015.10.006
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  5. Article: Preoperative abdominal straining in uncomplicated stress urinary incontinence: is there a correlation with voiding dysfunction and

    Iacovelli, Valerio / Serati, Maurizio / Bianchi, Daniele / Braga, Andrea / Turbanti, Andrea / Agrò, Enrico Finazzi

    Therapeutic advances in urology

    2021  Volume 13, Page(s) 17562872211058243

    Abstract: Objectives: To evaluate the role of preoperative abdominal straining in predicting : Methods: Data from patients who underwent TVT-O surgery for SUI were retrospectively analyzed. Inclusion criteria included: history of pure SUI. Exclusion criteria ... ...

    Abstract Objectives: To evaluate the role of preoperative abdominal straining in predicting
    Methods: Data from patients who underwent TVT-O surgery for SUI were retrospectively analyzed. Inclusion criteria included: history of pure SUI. Exclusion criteria included previous surgery for urinary incontinence, pelvic radiation, pelvic surgery within the last 3 months, and anterior or apical pelvic organ prolapse (POP) ⩾ +1 cm. Voiding dysfunction has been defined through symptoms and or urodynamics (UDS) signs. Accordingly, patients were divided into group A and group B according to the presence of abdominal straining during UDS. Patients were observed clinically and with UDS at a 3-year follow-up.
    Results: A total of 192 patients underwent TVT-O surgery for uncomplicated SUI. Preoperative abdominal straining was identified in 60/192 patients (Group A: 31.2%
    Conclusion: Preoperative abdominal straining was found to be related to a significant incidence of
    Language English
    Publishing date 2021-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2492591-3
    ISSN 1756-2880 ; 1756-2872
    ISSN (online) 1756-2880
    ISSN 1756-2872
    DOI 10.1177/17562872211058243
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  6. Article ; Online: Double-J stent placement during laparoscopic ureterolithotomy: the "seagull" technique.

    Asimakopoulos, Anastasios D / Colalillo, Gaia / Miano, Roberto / Agrò, Enrico Finazzi / Farullo, Giuseppe / Fuschi, Andrea / Pastore, Antonio Luigi / Germani, Stefano

    BJU international

    2022  Volume 130, Issue 6, Page(s) 839–843

    Abstract: Objective: To present a new technique of double-j stent (DJ) placement during laparoscopic transperitoneal ureterolithotomy (LUL).: Patients and methods: Following the extraction of the stone, a 6 French DJ open-end stent is prepared: two straight- ... ...

    Abstract Objective: To present a new technique of double-j stent (DJ) placement during laparoscopic transperitoneal ureterolithotomy (LUL).
    Patients and methods: Following the extraction of the stone, a 6 French DJ open-end stent is prepared: two straight-tip hydrophilic guidewires are inserted into the appropriate lateral holes of the stent, as identified by the preoperative evaluation of the CT scan. Approximately 5 centimeters of each wire protrude from the proximal and distal ends of the stent to straighten its terminal curl, thus resembling the wings of a flying seagull. The remaining proximal portions of both guide wires are left within each guidewire dispenser. The two ends of the stent are grasped together in a U-fashion and inserted into the abdomen through a 10mm port. Once in the abdomen, the longer segment of the stent is inserted and pushed into the ureterotomy until it reaches the target site. The guide wire is then removed. The same procedure is repeated for the other end of the stent. A brief literature review on the currents techniques of laparoscopic DJ placement is also presented.
    Results: Analyzing the outcomes of 21 LUL, the "seagull" technique is time-saving and safe. No perioperative complications were encountered. There is no risk of enlarging or tearing the ureterotomy and no need for patient replacement, extra cystoscopic or ureteroscopic procedures as well as of using modified guidewires and closed-tip stents.
    Conclusion: We described our step-by-step technique for DJ placement during LUL.
    MeSH term(s) Humans ; Ureter/surgery ; Stents ; Urologic Surgical Procedures/methods ; Laparoscopy/methods
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15866
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    Ui VI Zs.107: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 13: Show issues

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  7. Article ; Online: Evaluation of the effect of 100U of Onabotulinum toxin A on detrusor contractility in women with idiopathic OAB: A multicentre prospective study.

    De Rienzo, Gaetano / Minafra, Paolo / Iliano, Ester / Agrò, Enrico Finazzi / Serati, Maurizio / Giammò, Alessandro / Bianchi, Francesco Paolo / Costantini, Elisabetta / Ditonno, Pasquale

    Neurourology and urodynamics

    2021  Volume 41, Issue 1, Page(s) 306–312

    Abstract: Aims: Intradetrusor injection of Onabotulinum Toxin A (BTX-A) is a third-line treatment for overactive bladder (OAB). Voiding dysfunction and the need for intermittent catheterization are potential complications, consequent to bladder contractility (BC) ...

    Abstract Aims: Intradetrusor injection of Onabotulinum Toxin A (BTX-A) is a third-line treatment for overactive bladder (OAB). Voiding dysfunction and the need for intermittent catheterization are potential complications, consequent to bladder contractility (BC) decrement. Primary aim: to evaluate BC variation after BTX-A detrusor injection in women with idiopathic OAB.
    Methods: A prospective multi-institutional observational study was conducted. Medical history, bladder diary, 24-h pad test, and invasive urodynamic parameters were recorded before and 4-6 weeks after BTX-A 100U administration. BC was measured as Modified Projected Isovolumetric Pressure (PIP1), that is, maximum flow rate (Qmax) + detrusor pressure at Qmax (PdetQmax). Continuous variables were expressed as median and interquartile range. We compared continuous variables using Wilcoxon test and proportions between two times with Fisher exact test.
    Results: No changes in PIP1 were observed (p > 0.05) in 45 women enrolled between January 2018 and September 2019. Median age was 54.6 years. At baseline, 91.1% had urge urinary incontinence, with 4.9 ± 2.6 daily pads used and a 24-h pad test of 205.4 ± 70.8 g. Baseline detrusor contractility was normal in all the patients. Postoperatively, an improvement in the 24-h pad test (p < 0.01), daily voids (p < 0.01), and nocturia (p < 0.01) occurred. Urodynamics pointed out a significant reduction of detrusor overactivity rate (p < 0.01) and an increase of median maximum cystometric capacity (p < 0.01). No difference was observed in median Qmax (p > 0.05), PdetQmax (p > 0.05), and PVR (p > 0.05). No patient needed postoperative catheterization.
    Conclusions: The current series provides evidence that detrusor injection of botulinum toxin is an effective option for treating OAB, without causing voiding dysfunction and BC impairment.
    MeSH term(s) Botulinum Toxins, Type A ; Female ; Humans ; Middle Aged ; Neuromuscular Agents ; Prospective Studies ; Treatment Outcome ; Urinary Bladder, Overactive/complications ; Urinary Bladder, Overactive/etiology ; Urodynamics
    Chemical Substances Neuromuscular Agents ; Botulinum Toxins, Type A (EC 3.4.24.69) ; onabotulinum toxin A (EC 3.4.24.69)
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.24820
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    Zs.A 1828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Extensive impact of COVID-19 pandemic on pelvic floor dysfunctions care: A nationwide interdisciplinary survey.

    Sacco, Emilio / Gandi, Carlo / Li Marzi, Vincenzo / Lamberti, Gianfranco / Serati, Maurizio / Agro', Enrico Finazzi / Soligo, Marco

    Neurourology and urodynamics

    2021  Volume 40, Issue 2, Page(s) 695–704

    Abstract: Aims: To investigate the impact of COVID-19 pandemic on health-care provision to patients suffering from pelvic floor dysfunctions in Italy.: Methods: A retrospective web-based interdisciplinary survey was mailed by the Italian Society of Urodynamics  ...

    Abstract Aims: To investigate the impact of COVID-19 pandemic on health-care provision to patients suffering from pelvic floor dysfunctions in Italy.
    Methods: A retrospective web-based interdisciplinary survey was mailed by the Italian Society of Urodynamics to members involved in pelvic floor dysfunctions management from June 22, 2020 to July 17, 2020. The 84-item questionnaire investigated the period March-June 2020 (first epidemic wave) and showed high content validity. The primary outcome was the mean rate of cancellation for health-care services. Secondary outcomes included estimation of the accumulated surgeries backload until return to baseline activity and of the recovery pattern, using linear regression and scenario-based forecasting.
    Results: A total of 85 participants provided complete responses. Respondents were mostly urologists (47%), followed by gynecologists (29.5%) and physiatrists (17.6%). On average, 78.4% of outpatient services and 82.7% of functional surgeries were canceled, without significant differences by geographical distribution. An impact on patients' quality of life was anticipated by most of the respondents (87%) and 48.2% also reported potentially serious health risks for patients. Thirty-three percent of the respondents reported the use of telemedicine. If the nation-wide surgical activity increases by 20% postpandemic, it would take 37 months to clear the backlog of functional surgeries. We acknowledge the inherent limitations of the survey methodology and retrospective design.
    Conclusions: Access to care for patients suffering from pelvic floor dysfunctions has been dramatically affected by the COVID-19 outbreak. The indirect effects of this unprecedented disruption on pelvic floor dysfunctions care may last for several months.
    MeSH term(s) Adult ; Ambulatory Care ; COVID-19 ; Delivery of Health Care ; Elective Surgical Procedures ; Female ; Gynecologic Surgical Procedures ; Gynecology ; Humans ; Italy ; Male ; Middle Aged ; Pandemics ; Pelvic Floor ; Pelvic Floor Disorders/therapy ; Pelvic Organ Prolapse/surgery ; Physiatrists ; Prostatic Hyperplasia/surgery ; Quality of Life ; Rectal Diseases/surgery ; Retrospective Studies ; SARS-CoV-2 ; Surveys and Questionnaires ; Telemedicine ; Time-to-Treatment ; Urinary Incontinence, Stress/surgery ; Urologic Surgical Procedures ; Urologists ; Workload
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.24610
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    Zs.A 1828: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: The ETS Homologous Factor (EHF) Represents a Useful Immunohistochemical Marker for Predicting Prostate Cancer Metastasis.

    Scimeca, Manuel / Montanaro, Manuela / Bonfiglio, Rita / Anemona, Lucia / Agrò, Enrico Finazzi / Asimakopoulos, Anastasios D / Bei, Roberto / Manzari, Vittorio / Urbano, Nicoletta / Giacobbi, Erica / Servadei, Francesca / Bonanno, Elena / Schillaci, Orazio / Mauriello, Alessandro

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 4

    Abstract: The main aim of this study was to investigate the risk of prostate cancer metastasis formation associated with the expression of ETS homologous factor (EHF) in a cohort of bioptic samples. To this end, the expression of EHF was evaluated in a cohort of ... ...

    Abstract The main aim of this study was to investigate the risk of prostate cancer metastasis formation associated with the expression of ETS homologous factor (EHF) in a cohort of bioptic samples. To this end, the expression of EHF was evaluated in a cohort of 152 prostate biopsies including primary prostate cancers that developed metastatic lesions, primary prostate cancers that did not develop metastasis, and benign lesions. Data here reported EHF as a candidate immunohistochemical prognostic biomarker for prostate cancer metastasis formation regardless of the Gleason scoring system. Indeed, our data clearly show that primary lesions with EHF positive cells ≥40% had a great risk of developing metastasis within five years from the first diagnosis. Patients with these lesions had about a 40-fold increased risk of developing metastasis as compared with patients with prostate lesions characterized by a percentage of EHF positive cells ≤30%. In conclusion, the immunohistochemical evaluation of EHF could significantly improve the management of prostate cancer patients by optimizing the diagnostic and therapeutic health procedures and, more important, ameliorating the patient's quality of life.
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12040800
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  10. Article: Conservative treatment of monolateral giant renal angiomyolipoma in a patient with Tuberous Sclerosis Complex (TSC): A case report.

    Ambrosi Grappelli, Virgilio Michael / Pastore, Serena / Spicchiale, Claudia Fede / Alteri, Lorenzo / Turbanti, Andrea / Agrò, Enrico Finazzi

    Urology case reports

    2020  Volume 33, Page(s) 101413

    Abstract: Tuberous sclerosis complex has several renal manifestations like angiomyolipomas. We report a case of a giant AML and discuss its diagnosis and treatment. A 42-year-old woman was admitted to emergency department due to flank pain and hematuria. The ... ...

    Abstract Tuberous sclerosis complex has several renal manifestations like angiomyolipomas. We report a case of a giant AML and discuss its diagnosis and treatment. A 42-year-old woman was admitted to emergency department due to flank pain and hematuria. The patient had history of mental retardation and epilepsy. Abdominal CT without contrast medium revealed a large mass with a fat/blood content inside. On those findings, we diagnosed the patient a bleeding giant AML. We performed selective embolization of the bleeding source with subsequent conservative management. TSC-associated AMLs occur more frequently as multiple lesions and grow to larger size than idiopathic AML.
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2020.101413
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