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  1. AU="Agrawal, Sonali"
  2. AU="Martinez, Luis R"
  3. AU="Passoni, Lorena"
  4. AU="Slimani, Wafa"
  5. AU="Jin, J"
  6. AU="Xia, Hongmin"
  7. AU="Akdemir, İrem"
  8. AU=Ciccone Giovannino

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  1. Artikel ; Online: Host-directed therapies for malaria and tuberculosis: common infection strategies and repurposed drugs.

    Baindara, Piyush / Agrawal, Sonali / Franco, O L

    Expert review of anti-infective therapy

    2022  Band 20, Heft 6, Seite(n) 849–869

    Abstract: Introduction: Malaria and tuberculosis are highly infectious diseases declared a global health emergency by the World Health Organization, and together they account for more than 1.5 million deaths worldwide each year. In the case of both malaria and ... ...

    Abstract Introduction: Malaria and tuberculosis are highly infectious diseases declared a global health emergency by the World Health Organization, and together they account for more than 1.5 million deaths worldwide each year. In the case of both malaria and tuberculosis, emergence of multidrug resistance towards frontline drugs has been reported in the recent past. Therefore, an urgent need exists for the discovery and development of novel drugs or therapies to fight these diseases.
    Areas covered: We provide a detailed overview of major infection strategies, commonly used by both the parasite
    Expert opinion: Investigation of common infection strategies used by both
    Mesh-Begriff(e) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Coinfection/drug therapy ; Humans ; Malaria/drug therapy ; Mycobacterium tuberculosis ; Plasmodium ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
    Chemische Substanzen Antitubercular Agents
    Sprache Englisch
    Erscheinungsdatum 2022-03-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2044794
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Host-directed therapies: a potential solution to combat COVID-19.

    Baindara, Piyush / Agrawal, Sonali / Mandal, Santi M

    Expert opinion on biological therapy

    2020  Band 20, Heft 10, Seite(n) 1117–1120

    Abstract: Coronavirus disease 2019 (COVID-19) characterized by immuno-pathological host responses including pneumonia, lymphopenia, and cytokine storm that leads to severe lung inflammation, developed in acute respiratory distress syndrome (ARDS). In the absence ... ...

    Abstract Coronavirus disease 2019 (COVID-19) characterized by immuno-pathological host responses including pneumonia, lymphopenia, and cytokine storm that leads to severe lung inflammation, developed in acute respiratory distress syndrome (ARDS). In the absence of an effective vaccine or any definitive cure, the use of host-directed therapies is an effective alternative and demanding treatment option in the current pandemic outbreak of COVID-19.
    Mesh-Begriff(e) Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Immunotherapy ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-12
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1807001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Host-directed therapies: a potential solution to combat COVID-19

    Baindara, Piyush / Agrawal, Sonali / Mandal, Santi M

    Expert Opin Biol Ther

    Abstract: Coronavirus disease 2019 (COVID-19) characterized by immuno-pathological host responses including pneumonia, lymphopenia, and cytokine storm that leads to severe lung inflammation, developed in acute respiratory distress syndrome (ARDS). In the absence ... ...

    Abstract Coronavirus disease 2019 (COVID-19) characterized by immuno-pathological host responses including pneumonia, lymphopenia, and cytokine storm that leads to severe lung inflammation, developed in acute respiratory distress syndrome (ARDS). In the absence of an effective vaccine or any definitive cure, the use of host-directed therapies is an effective alternative and demanding treatment option in the current pandemic outbreak of COVID-19.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #712939
    Datenquelle COVID19

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  4. Artikel ; Online: Host-directed therapies

    Baindara, Piyush / Agrawal, Sonali / Mandal, Santi M.

    Expert Opinion on Biological Therapy

    a potential solution to combat COVID-19

    2020  Band 20, Heft 10, Seite(n) 1117–1120

    Schlagwörter Clinical Biochemistry ; Pharmacology ; Drug Discovery ; covid19
    Sprache Englisch
    Verlag Informa UK Limited
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    ZDB-ID 2052501-1
    ISSN 1471-2598
    ISSN 1471-2598
    DOI 10.1080/14712598.2020.1807001
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Comparative Outcomes of Second-line Topoisomerase-I Inhibitor Therapies on Neuroendocrine Carcinoma.

    Yeung, Ho-Man / Sreekrishnanilayam, Krishnalatha / Meeker, Caitlin / Deng, Mengying / Agrawal, Sonali / Abdullah, Haaris / Vijayvergia, Namrata

    Journal of gastrointestinal cancer

    2022  Band 54, Heft 1, Seite(n) 73–79

    Abstract: Introduction: This investigation aims to assess the outcomes for second-line therapies to treat extrapulmonary neuroendocrine carcinoma (EP-NEC) after first-line platinum-based chemotherapy.: Methods: With IRB approval, we conducted a retrospective ... ...

    Abstract Introduction: This investigation aims to assess the outcomes for second-line therapies to treat extrapulmonary neuroendocrine carcinoma (EP-NEC) after first-line platinum-based chemotherapy.
    Methods: With IRB approval, we conducted a retrospective study of EP-NEC patients that progressed on first-line platinum chemotherapy from 2008 to 2018. Demographic data and treatment-related characteristics were collected and represented as descriptive statistics. The primary endpoints include overall survival (OS) and progression-free survival (PFS). OS and PFS were estimated and stratified by site of primary (gastroenteropancreatic [GEP] versus non-GEP) and type of second-line therapy (irino/topotecan versus others). Log-rank test and Kaplan-Meier curves were used to compare survival distributions between groups.
    Results: Forty-seven patients met eligibility, with median age 65 (range 31-82), 62% male, and 83% White; 22 were GEP and 25 were non-GEP primary. Thirty patients (63.8%) received second-line therapy where 11 received irinotecan/topotecan (ir/to), while 19 received other agents (temozolomide, other platinum agents, gemcitabine, paclitaxel, pembrolizumab, and sunitinib). The median OS was 10.3 months in the ir/to group versus 13.4 months for other therapies, p = 0.10. The median PFS for ir/to therapy compared to other therapies was 2.0 months versus 1.8 months, respectively, p = 0.72. The OS and PFS with and without ir/to were not significantly different by the primary site (p = 0.61 and p = 0.21).
    Discussion/conclusion: Many EP-NEC patients undergo second-line therapies. Interestingly, outcomes for ir/to-containing second-line therapies were not statistically different from other agents, regardless of the site of primary. With approval of new second-line therapies for small cell lung cancer, further research in therapeutic options is needed for this aggressive disease.
    Mesh-Begriff(e) Humans ; Male ; Aged ; Female ; Topoisomerase I Inhibitors/therapeutic use ; Topotecan/therapeutic use ; Retrospective Studies ; Treatment Outcome ; Carcinoma, Neuroendocrine/drug therapy ; Irinotecan/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemische Substanzen Topoisomerase I Inhibitors ; Topotecan (7M7YKX2N15) ; Irinotecan (7673326042)
    Sprache Englisch
    Erscheinungsdatum 2022-01-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-021-00800-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2184: Hefte anzeigen Standort:
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  6. Artikel ; Online: T regulatory cells: Achilles' heel of Mycobacterium tuberculosis infection?

    Parkash, Om / Agrawal, Sonali / Madhan Kumar, M

    Immunologic research

    2015  Band 62, Heft 3, Seite(n) 386–398

    Abstract: T regulatory cells (Treg) constitute a specialized subset of T cells that play a pivotal role in preventing the occurrence of autoimmune diseases by suppressing deleterious activities of immune cells. Contrarily, they can have adverse effect on immune ... ...

    Abstract T regulatory cells (Treg) constitute a specialized subset of T cells that play a pivotal role in preventing the occurrence of autoimmune diseases by suppressing deleterious activities of immune cells. Contrarily, they can have adverse effect on immune response against infectious diseases where Treg weaken the host immunity leading to enhanced microbial load and thereby increase in severity of the disease. Here, we have attempted to review plethora of information documenting prevalence of Treg in tuberculosis (TB) and their involvement in progression and immunopathogenesis of the disease. Further, we have laid emphasis on the possible use of Treg as a biomarker for determining the TB treatment efficacy. Also, we have discussed the probable contribution of Treg in dampening the efficacy of BCG, the anti-TB vaccine. Finally, we have speculated some of the possible strategies which might be explored by exploiting Treg for enhancing the efficacy of TB management.
    Mesh-Begriff(e) Animals ; Disease Models, Animal ; Humans ; Interferon-gamma/immunology ; Mice ; Mycobacterium bovis/immunology ; Mycobacterium tuberculosis/immunology ; T-Lymphocytes, Regulatory/immunology ; Tuberculosis Vaccines/immunology ; Tuberculosis, Pulmonary/immunology ; Tuberculosis, Pulmonary/microbiology
    Chemische Substanzen Tuberculosis Vaccines ; Interferon-gamma (82115-62-6)
    Sprache Englisch
    Erscheinungsdatum 2015-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-015-8654-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Physicochemical properties of the modeled structure of astacin metalloprotease moulting enzyme NAS-36 and mapping the druggable allosteric space of Heamonchus contortus, Brugia malayi and Ceanorhabditis elegans via molecular dynamics simulation.

    Sharma, Om Prakash / Agrawal, Sonali / Kumar, M Suresh

    Interdisciplinary sciences, computational life sciences

    2013  Band 5, Heft 4, Seite(n) 312–323

    Abstract: Nematodes represent the second largest phylum in the animal kingdom. It is the most abundant species (500,000) in the planet. It causes chronic, debilitating infections worldwide such as ascariasis, trichuriasis, hookworm, enterobiasis, strongyloidiasis, ...

    Abstract Nematodes represent the second largest phylum in the animal kingdom. It is the most abundant species (500,000) in the planet. It causes chronic, debilitating infections worldwide such as ascariasis, trichuriasis, hookworm, enterobiasis, strongyloidiasis, filariasis and trichinosis, among others. Molecular modeling tools can play an important role in the identification and structural investigation of molecular targets that can act as a vital candidate against filariasis. In this study, sequence analysis of NAS-36 from H. contortus (Heamonchus contortus), B. malayi (Brugia malayi) and C. elegans (Ceanorhabditis elegans) has been performed, in order to identify the conserved residues. Tertiary structure was developed for an insight into the molecular structure of the enzyme. Molecular Dynamics Simulation (MDS) studies have been carried out to analyze the stability and the physical properties of the proposed enzyme models in the H. contortus, B. malayi and C. elegans. Moreover, the drug binding sites have been mapped for inhibiting the function of NAS-36 enzyme. The molecular identity of this protease could eventually demonstrate how ex-sheathment is regulated, as well as provide a potential target of anthelmintics for the prevention of nematode infections.
    Mesh-Begriff(e) Animals ; Brugia malayi/enzymology ; Caenorhabditis elegans/enzymology ; Metalloendopeptidases/chemistry ; Models, Molecular ; Molecular Dynamics Simulation
    Chemische Substanzen Metalloendopeptidases (EC 3.4.24.-) ; astacin (EC 3.4.24.21)
    Sprache Englisch
    Erscheinungsdatum 2013-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2493085-4
    ISSN 1867-1462 ; 1913-2751
    ISSN (online) 1867-1462
    ISSN 1913-2751
    DOI 10.1007/s12539-013-0182-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Efficacy of T Regulatory Cells, Th17 Cells and the Associated Markers in Monitoring Tuberculosis Treatment Response.

    Agrawal, Sonali / Parkash, Om / Palaniappan, Alangudi Natarajan / Bhatia, Ashok Kumar / Kumar, Santosh / Chauhan, Devendra Singh / Madhan Kumar, M

    Frontiers in immunology

    2018  Band 9, Seite(n) 157

    Abstract: Treatment monitoring is an essential aspect for tuberculosis (TB) disease management. Sputum smear microscopy is the only available tool for monitoring, but it suffers from demerits. Therefore, we sought to evaluate markers and cellular subsets of T ... ...

    Abstract Treatment monitoring is an essential aspect for tuberculosis (TB) disease management. Sputum smear microscopy is the only available tool for monitoring, but it suffers from demerits. Therefore, we sought to evaluate markers and cellular subsets of T regulatory (Treg) cells and T helper (Th) 17 cells in pulmonary TB patients (PTB) for TB treatment monitoring. Peripheral blood mononuclear cells (PBMCs) were stimulated
    Mesh-Begriff(e) Adult ; Antitubercular Agents/therapeutic use ; Biomarkers/analysis ; Cells, Cultured ; Drug Monitoring/methods ; Female ; Flow Cytometry ; Humans ; Interleukin-2 Receptor alpha Subunit/genetics ; Leukocytes, Mononuclear/drug effects ; Male ; Middle Aged ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology ; Treatment Outcome ; Tuberculin/pharmacology ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/immunology ; Young Adult
    Chemische Substanzen Antitubercular Agents ; Biomarkers ; IL2RA protein, human ; Interleukin-2 Receptor alpha Subunit ; Tuberculin
    Sprache Englisch
    Erscheinungsdatum 2018-02-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00157
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: The role of T regulatory cell-associated markers in monitoring tuberculosis treatment completion and failure.

    Agrawal, Sonali / Parkash, Om / Palaniappan, Alangudi Natarajan / Bhatia, Ashok K / Kumar, Santosh / Chauhan, Devendra S / Madhan Kumar, M

    Immunologic research

    2018  Band 66, Heft 5, Seite(n) 620–631

    Abstract: Monitoring tuberculosis (TB) treatment success is crucial for clinical decision-making. The only available tool in this regard is sputum microscopy, but it has demerits. Moreover, in case of smear negatives and extrapulmonary TB, an efficient tool is ... ...

    Abstract Monitoring tuberculosis (TB) treatment success is crucial for clinical decision-making. The only available tool in this regard is sputum microscopy, but it has demerits. Moreover, in case of smear negatives and extrapulmonary TB, an efficient tool is still sought for. Therefore, we evaluated T regulatory cell (Treg)-associated markers (CD25, CD39, and FoxP3) and cellular subsets in monitoring treatment success in treatment-completed groups. Expression profile of various markers and subsets were compared real time among treatment-naive pulmonary TB patients (TN-PTB), followed-up treatment-completed (TC-fu) cohort, and a not followed-up (TC-nfu) cohort. Peripheral blood mononuclear cells from various groups were incubated overnight and were stained with antibodies for specific markers and studied by flow cytometry. In both the treatment-completed groups, a decline in frequencies of CD25
    Mesh-Begriff(e) Adolescent ; Adult ; Antigens, CD/metabolism ; Antitubercular Agents/therapeutic use ; Apyrase/metabolism ; Biomarkers/metabolism ; Cell Separation ; Cohort Studies ; Female ; Flow Cytometry ; Forkhead Transcription Factors/metabolism ; Humans ; Interleukin-2 Receptor alpha Subunit/metabolism ; Male ; Middle Aged ; Mycobacterium tuberculosis/physiology ; T-Lymphocytes, Regulatory/immunology ; Treatment Failure ; Treatment Outcome ; Tuberculosis, Pulmonary/diagnosis ; Young Adult
    Chemische Substanzen Antigens, CD ; Antitubercular Agents ; Biomarkers ; FOXP3 protein, human ; Forkhead Transcription Factors ; Interleukin-2 Receptor alpha Subunit ; Apyrase (EC 3.6.1.5) ; CD39 antigen (EC 3.6.1.5)
    Sprache Englisch
    Erscheinungsdatum 2018-07-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-018-9022-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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