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  1. Article ; Online: Myostatin inhibitory peptides in sports drug testing.

    Walpurgis, Katja / Agricola, Johannes / Thomas, Andreas / Thevis, Mario

    Drug testing and analysis

    2023  Volume 15, Issue 11-12, Page(s) 1477–1487

    Abstract: Across species, skeletal muscle mass is negatively regulated by the TGF-β cytokine myostatin (MSTN). Inhibitors of this growth factor and its signaling pathways are therefore not only promising therapeutics for muscular diseases but also potential ... ...

    Abstract Across species, skeletal muscle mass is negatively regulated by the TGF-β cytokine myostatin (MSTN). Inhibitors of this growth factor and its signaling pathways are therefore not only promising therapeutics for muscular diseases but also potential performance-enhancing agents in sports. Within this study, protein precipitation and liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS) were employed to develop a detection method for six novel MSTN inhibitory peptides derived from the regulatory MSTN propeptide and the natural MSTN inhibitor follistatin (FST) from doping control serum samples. The approach was comprehensively characterized and found to allow for a specific detection down to concentrations of 3-9 ng/mL. Moreover, several potential metabolites of the drug candidates referred to as DF-3, DF-25, and Peptide 7 were identified as valuable complementary analytical targets for doping control analytical assays. Overall, the acquired data pave the way for an implementation of MSTN inhibitory peptides into routine sports drug testing. Even though no drug candidate has obtained clinical approval yet, a proactive development of detection assays is of utmost importance to deter athletes from misusing such compounds, which are readily available for research purposes and on the black market.
    MeSH term(s) Humans ; Myostatin ; Peptides/pharmacology ; Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Substance Abuse Detection/methods ; Doping in Sports
    Chemical Substances Myostatin ; Peptides
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of systemic inflammatory factors in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with peptide receptor radionuclide therapy (PRRT): From biology to theragnosis.

    Abou-Jokh Casas, E / Martínez-Lago, N / Mallón Araujo, M C / Cabezas Agrícola, J M / Nogareda Seoane, Z / Cousillas Castiñeira, A / Ruibal Morell, A / Pubul Núñez, V

    Revista espanola de medicina nuclear e imagen molecular

    2023  Volume 42, Issue 3, Page(s) 156–162

    Abstract: Aim: Systemic inflammatory factors have been validated as indicators of ongoing systemic inflammation that could be predictive markers of poor prognosis for oncological outcomes. However, the prognostic impact of systemic inflammation markers is unknown ...

    Abstract Aim: Systemic inflammatory factors have been validated as indicators of ongoing systemic inflammation that could be predictive markers of poor prognosis for oncological outcomes. However, the prognostic impact of systemic inflammation markers is unknown in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with peptide receptor radionuclide therapy (PRRT).
    Methods: We conducted an observational, retrospective, multicentric study of 40 patients with GEP or unknown origin NETs treated with PRRT between 2016 and 2020. The systemic inflammatory markers were calculated as follows: neutrophil to lymphocyte ratio (NLR)=neutrophil count/lymphocyte count, monocyte to lymphocyte ratio (MLR)=monocyte count/lymphocyte count, platelet to lymphocyte ratio (PLR)=platelet count/lymphocyte count, albumin to lymphocyte ratio (ALR)=albumin levels/lymphocyte count and derived Neutrophil to Lymphocyte ratio (dNLR)=neutrophil count/(leucocytes count - neutrophils count). Baseline analysis and after the second dose were used for the calculation of different ratios.
    Results: The median age was 63 years (range 41-85), 55% were male. The baseline cut-off values for NLR were 2.61, for MLR 0.31, for PLR 110.14, for ALR 2.39 and for dNLR 1.71. The cut-off values after the 2° dose were, for NLR 2.3, for MLR 0.3, for PLR 131.61, ALR 4.16, and dNLR 1.48. Median progression-free survival (PFS) was 21.7 months (95% CI 10.7-32.8 months) and overall survival (OS) was 32.1 months (95% CI 19.6-44.7 months), PFS was shorter in patients with elevated NLR (p=0.001), ALR (0.03), and dNLR (p=0.001) in baseline analysis. DCR was 81% and ORR 18%.
    Conclusions: In GEP or unknown origin NETs treated with PRRT, we have identified the predictive and prognostic impact of baseline systemic inflammatory factors.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Neuroendocrine Tumors/radiotherapy ; Retrospective Studies ; Inflammation ; Radioisotopes ; Albumins ; Receptors, Peptide ; Biology
    Chemical Substances Radioisotopes ; Albumins ; Receptors, Peptide
    Language English
    Publishing date 2023-04-04
    Publishing country Spain
    Document type Observational Study ; Journal Article
    ISSN 2253-8089
    ISSN (online) 2253-8089
    DOI 10.1016/j.remnie.2023.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Chymische Medicin

    Agricola, Johann / Humberg, Oliver

    ein Kompendium der Bereitung und Anwendung alchemistischer Heilmittel

    2000  

    Title translation Commentaria, notae, observationes et animadversiones in Johannis Poppii Chymische Medicin
    Author's details Johann Agricola
    Keywords Alchemie ; Medizin ; Geschichte 1638
    Subject Humanmedizin ; Heilkunst ; Medicine ; Alchimie ; Alchymie
    Language German
    Size 1408 S. : Ill.
    Edition Nach der Erstausg. Leipzig 1638/39
    Publisher Humberg
    Publishing place Elberfeld
    Publishing country Germany
    Document type Book
    HBZ-ID HT011264190
    ISBN 3-9802788-5-9 ; 978-3-9802788-5-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 A 1523 order for loan Magazin

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  4. Article ; Online: Pulse-resolved multi-photon X-ray detection at 31 MHz based on a quadrant avalanche photodiode.

    Reusch, Tobias / Osterhoff, Markus / Agricola, Johannes / Salditt, Tim

    Journal of synchrotron radiation

    2014  Volume 21, Issue Pt 4, Page(s) 708–715

    Abstract: The technical realisation and the commissioning experiments of a high-speed X-ray detector based on a quadrant avalanche silicon photodiode and high-speed digitizers are described. The development is driven by the need for X-ray detectors dedicated to ... ...

    Abstract The technical realisation and the commissioning experiments of a high-speed X-ray detector based on a quadrant avalanche silicon photodiode and high-speed digitizers are described. The development is driven by the need for X-ray detectors dedicated to time-resolved diffraction and imaging experiments, ideally requiring pulse-resolved data processing at the synchrotron bunch repetition rate. By a novel multi-photon detection scheme, the exact number of X-ray photons within each X-ray pulse can be recorded. Commissioning experiments at beamlines P08 and P10 of the storage ring PETRA III, at DESY, Hamburg, Germany, have been used to validate the pulse-wise multi-photon counting scheme at bunch frequencies ≥ 31 MHz, enabling pulse-by-pulse readout during the PETRA III 240-bunch mode with single-photon detection capability. An X-ray flux of ≥ 3.7 × 10(9) photons s(-1) can be detected while still resolving individual photons at low count rates.
    Language English
    Publishing date 2014-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2021413-3
    ISSN 1600-5775 ; 0909-0495
    ISSN (online) 1600-5775
    ISSN 0909-0495
    DOI 10.1107/S1600577514006730
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  5. Article ; Online: Pediatric HIV care and treatment services in Tanzania: implications for survival.

    Somi, G / Majigo, M / Manyahi, J / Nondi, J / Agricola, J / Sambu, V / Todd, J / Rwebembera, A / Makyao, N / Ramadhani, A / Matee, Min

    BMC health services research

    2017  Volume 17, Issue 1, Page(s) 540

    Abstract: Background: Improving child survival for HIV-infected children remains an important health agenda. We present progress regarding care and treatment services to HIV infected children in Tanzania.: Methods: The National AIDS Control Programme Care and ... ...

    Abstract Background: Improving child survival for HIV-infected children remains an important health agenda. We present progress regarding care and treatment services to HIV infected children in Tanzania.
    Methods: The National AIDS Control Programme Care and Treatment (CTC 2) database was used to obtain information of all children aged 0-14yearsenrolled in the HIV Care and Treatment Program between January 2011 and December 2014. We assessed eligibility for ART, time from enrolment to ART initiation, nutritional status, and mortality using Kaplan-Meier methods.
    Results: A total of 29,531 (14,304 boys and 15,227 girls) ART-naive children aged 0-14 years were enrolled during the period, approximately 6700 to 8000 children per year. The male to female ratio was 48:50. At enrolment 72% were eligible for ART, 2-3% of children were positive for TB, and 2-4% were severely malnourished. Between 2011 and 2014, 2368 (8%) died, 9243 (31%) were Lost to Follow-up and 17,920 (61%) were on care or ART. The probability of death was 31% (95% CI 26-35), 43% (40-47), 52% (49-55) and 61% (58-64) by 1,2, 5 and 10 years of age, respectively. The hazard of death was greatest at very young ages (<2 years old), and decreased sharply by 4 years old. Children who were on ART had around 10-15% higher survival over time.
    Conclusions: Significant progress has been made regarding provision of paediatric HIV care and treatment in Tanzania. On average 7000 children are enrolled annually, and that approximately two thirds of children diagnosed under the age of 2 years were initiated on ART within a month. Provision of ART as soon as the child is diagnosed is the biggest factor in improving survival. However we noted that i) most children had advanced disease at the time of enrolment ii) approximately two-thirds of children were missing a baseline CD4 measurement and only 35% of children had either a CD4 count or percentage recorded, indicating limited access to CD4 testing services, and iii) 31% were lost to follow-up (LTFU). These challenges need to be addressed to improve early detection, enrolment and retention of HIV-infected children into care and improve documentation of services offered.
    MeSH term(s) Adolescent ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Databases, Factual ; Female ; HIV Infections/drug therapy ; Health Services ; Humans ; Infant ; Kaplan-Meier Estimate ; Lost to Follow-Up ; Male ; Survival Analysis ; Tanzania
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2017-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-017-2492-9
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  6. Book: Chymische Medicin

    Agricola, Johannes

    ein Kompendium der Bereitung und Anwendung alchemistischer Heilmittel

    2000  

    Author's details Johann Agricola
    MeSH term(s) Alchemy ; History of Medicine ; History, 17th Century
    Language German
    Dates of publication 2000-1638
    Size 1408 p. :, ill., ports., facsims.
    Publisher Buchverlag Oliver Humberg
    Publishing place Wuppertal
    Document type Book
    Note "Nach der Erstausgabe Leipzig 1638/39; herausgegeben, eingeleitet und mit einer biographischen Skizze versehen von Oliver Humberg." ; Originally published: Leipzig : Gregorio Ritzchen, 1638. ; Includes facsim. of original engraved title page.
    ISBN 9783980278850 ; 3980278859
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Chymische Medicin

    Agricola, Johann / Humberg, Oliver

    ein Kompendium der Bereitung und Anwendung alchemistischer Heilmittel

    2000  

    Title translation Commentaria, notae, observationes et animadversiones in Johannis Poppii Chymische Medicin <dt.>
    Author's details Johann Agricola
    Keywords Medizin ; Alchemie
    Language German
    Dates of publication 2000-1638
    Size 1408 S, Ill, 23 cm
    Publisher Humberg
    Publishing place Elberfeld
    Document type Book
    ISBN 3980278859 ; 9783980278850
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Pegvisomant and cabergoline combination therapy in acromegaly.

    Bernabeu, I / Alvarez-Escolá, C / Paniagua, A E / Lucas, T / Pavón, I / Cabezas-Agrícola, J M / Casanueva, F F / Marazuela, M

    Pituitary

    2012  Volume 16, Issue 1, Page(s) 101–108

    Abstract: Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response. An observational, retrospective, ...

    Abstract Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response. An observational, retrospective, cross-sectional study. Fourteen acromegalic patients (9 females), who were partially resistant to somatostatin analogs and on pegvisomant monotherapy. Cabergoline was added because of the presence of persistent mildly increased IGF-I. The mean follow-up time was 18.3 ± 10.4 months. The efficacy and safety profile was assessed. The influence of clinical and biochemical characteristics on treatment efficacy was studied. IGF-I levels returned to normal in 4 patients (28%) at the end of the study. In addition, some decline in IGF-I levels was observed in a further 5 patients. The % IGF-I decreased from 158 ± 64% to 124 ± 44% (p = 0.001). The average change in IGF-I was -18 ± 27% (range -67 to +24%). Lower baseline IGF-I (p = 0.007), female gender (p = 0.013), lower body weight (p = 0.031), and higher prolactin (PRL) levels (p = 0.007) were associated with a better response to combination therapy. There were no significant severe adverse events. Significant tumour shrinkage was observed in 1 patient. Combination therapy with pegvisomant and cabergoline could provide better control of IGF-I in some patients with acromegaly. Baseline IGF-I levels, female gender, body weight, and PRL levels affect the response to this combination therapy.
    MeSH term(s) Acromegaly/drug therapy ; Adult ; Cabergoline ; Drug Therapy, Combination ; Ergolines/therapeutic use ; Female ; Human Growth Hormone/analogs & derivatives ; Human Growth Hormone/therapeutic use ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances Ergolines ; Human Growth Hormone (12629-01-5) ; Cabergoline (LL60K9J05T) ; pegvisomant (N824AOU5XV)
    Language English
    Publishing date 2012-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-012-0382-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6139: Show issues Location:
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  9. Book: Ausgewählte Texte

    Agricola, Johann

    (Bibliotheca anastatica Germanica)

    1986  

    Title variant Sammlung
    Author's details Johann Agricola
    Series title Bibliotheca anastatica Germanica
    Language German
    Size [160] S, Ill, 23 cm
    Publisher Lang
    Publishing place Bern u.a.
    Document type Book
    ISBN 3261036192 ; 9783261036193
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Die Historia des Leidens und Sterbens Jhesu Christi

    Agricola, Johann

    (Bibliotheca anastatica Germanica)

    1986  

    Title translation Die Historia des Leidens und Sterbens unsers lieben Herrn und Heilands Jhesu Christi
    Author's details Johann Agricola
    Series title Bibliotheca anastatica Germanica
    Language German
    Size CXXXVII Bl. [zweiseitig bedr.], Ill., 25 cm
    Publisher Lang
    Publishing place Bern u.a.
    Document type Book
    ISBN 3261035323 ; 9783261035325
    Database Former special subject collection: coastal and deep sea fishing

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