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  1. Book ; Online ; E-Book: Infectious complications in biologic and targeted therapies

    Cervera, Carlos / Aguado, Jose Maria

    2022  

    Abstract: This text approaches the epidemiology, diagnosis and management of infectious complications related to the use of biologic and targeted therapies. The first part is a general overview on the epidemiology and prevention of infections with the use of these ...

    Author's details editors : Carlos Cervera, Jose Maria Aguado
    Abstract This text approaches the epidemiology, diagnosis and management of infectious complications related to the use of biologic and targeted therapies. The first part is a general overview on the epidemiology and prevention of infections with the use of these agents. Timelines, pre-treatment evaluation, use of vaccines and travel counseling. In the second part, we will analyze the specific risk of infections associated with the use of the most important agents. The third part approach the problem on a syndromic point of view. For example, how to evaluate pulmonary infiltrates in a patient receiving biologic agents. This part III includes the most difficult and conflicting syndromes that clinicians may face when evaluating these patients. This book is intended not only for infectious diseases specialists, but also for different medical specialties prescribing biologic and targeted therapies.
    Keywords Drug targeting.<U+0009> ; Infection/Prevention.<U+0009> ; Infection/Treatment ; Pathology ; Medical
    Subject code 615.7
    Language English
    Size 1 online resource (466 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-11363-2 ; 9783031113628 ; 978-3-031-11363-5 ; 3031113624
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Current state of antimicrobial stewardship and organ transplantation in Spain.

    Silva, Jose Tiago / Aguado, José María

    Transplant infectious disease : an official journal of the Transplantation Society

    2022  Volume 24, Issue 5, Page(s) e13851

    Abstract: Introduction: Solid-organ transplantation (SOT) remains the best therapeutic option for end-stage organ disease. Regrettably, SOT recipients are disproportionately affected by nosocomial infections produced by multidrug-resistant (MDR) microorganisms ... ...

    Abstract Introduction: Solid-organ transplantation (SOT) remains the best therapeutic option for end-stage organ disease. Regrettably, SOT recipients are disproportionately affected by nosocomial infections produced by multidrug-resistant (MDR) microorganisms and antimicrobial adverse events. Both have a negative impact on the patient´s outcome.
    Methods: Description of data concerning the antimicrobial stewardship program (ASP) in SOT recipients of the University Hospital "12 de Octubre", and review of other Spanish ASPs.
    Results: From May 2017 to December 2021, the ASP issued 2.785 recommendations. Approximately, 4.9% were aimed at improving the antimicrobial treatment administered to SOT recipients. Treatment discontinuation or change to a better therapeutic regimen was recommended in 51.8% and 26.3% of cases, respectively. The acceptance rate of the recommendations was close to 92%. Between June 2015 and March 2016, a quasi-experimental study consisting of a joint ASP and hospital-acquired infection control (HAIC) initiative, which included kidney transplant recipients, reported a significant reduction in the consumption of meropenem, vancomycin and ciprofloxacin, and a reduction in the incidence of global bacterial infections, upper urinary tract infections, and cystitis. Although Spain has several robust regional ASPs (e.g., VINCat and PIRASOA), data specifically concerning SOT patients is lacking.
    Conclusion: ASP coupled with HAIC programs have proven to be effective in SOT, and should be implemented in centers that perform transplantation. Since data is scarce, Spanish centers which have ASP should report their experience in SOT. Understanding the efficacy and safety of the Spanish ASP´s intervention in the SOT population is essential and deserves further study.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Antimicrobial Stewardship ; Ciprofloxacin ; Humans ; Meropenem ; Organ Transplantation/adverse effects ; Spain/epidemiology ; Vancomycin
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Ciprofloxacin (5E8K9I0O4U) ; Vancomycin (6Q205EH1VU) ; Meropenem (FV9J3JU8B1)
    Language English
    Publishing date 2022-05-17
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5100: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Duration of antibiotic therapy in central venous catheter-related bloodstream infection due to Gram-negative bacilli.

    Ruiz-Ruigómez, María / Aguado, Jose María

    Current opinion in infectious diseases

    2023  Volume 34, Issue 6, Page(s) 681–685

    Abstract: Purpose of review: The aim of this study was to review recent data evaluating the duration of antibiotic therapy in central venous catheter-related bloodstream infection (CRBSI) due to Gram-negative bacilli (GNB).: Recent findings: CRBSI is the most ... ...

    Abstract Purpose of review: The aim of this study was to review recent data evaluating the duration of antibiotic therapy in central venous catheter-related bloodstream infection (CRBSI) due to Gram-negative bacilli (GNB).
    Recent findings: CRBSI is the most common complication associated with the use of intravascular catheters. CRBSI directly contributes to increase additional days of hospitalization, morbidity and therefore economic costs.The incidence of GNB CRBSI has been increasing considerably in the last years; this has raised a concern due to the high reported rate of multi drug resistant bacteria in these infections what poses a considerable challenge for effective treatment. However, there are no specific guidelines for management of GNB-CRBSI and optimal treatment duration has not been clearly defined.Recent studies evaluating the impact of the duration of antibiotic therapy of GNB-CRBSI have shown that short-course antibiotic therapy might be as effective as long-course therapy once the central venous catheter (CVC) has been removed.
    Summary: CRBSI due to GNB has shown a rapid increase in the last years. Current guidelines recommend antibiotic treatment for at least 7-14 days, although no randomized clinical trials have evaluated the optimal duration of antibiotic therapy for GNB-CRBSI. Recent data suggest that administration of appropriate antibiotic therapy for 7 days or less may be as well tolerated and effective as longer courses in episodes of GNB-CRBSI, once the CVC has been removed.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Catheter-Related Infections/drug therapy ; Central Venous Catheters/adverse effects ; Gram-Negative Bacteria ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Which trial do we need? Elective early surgical treatment of left-sided infective endocarditis.

    Fernández-Ruiz, Mario / Aguado, José María

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 9, Page(s) 1103–1106

    MeSH term(s) Humans ; Endocarditis/surgery ; Endocarditis/microbiology ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/surgery ; Endocarditis, Bacterial/microbiology
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  5. Article ; Online: Mortality due to carbapenemase-producing GNB in transplantation: Are risk scores useful?

    San-Juan, Rafael / Aguado, José María

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 2, Page(s) e14035

    MeSH term(s) Humans ; beta-Lactamases ; Bacterial Proteins ; Risk Factors ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances carbapenemase (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-01
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5100: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Isavuconazole for Treating Invasive Mould Disease in Solid Organ Transplant Recipients.

    Silva, Jose Tiago / Husain, Shahid / Aguado, José María

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11845

    Abstract: Solid organ transplant (SOT) recipients have a higher risk of developing invasive mould diseases (IMD). Isavuconazole is a novel broad-spectrum azole active ... ...

    Abstract Solid organ transplant (SOT) recipients have a higher risk of developing invasive mould diseases (IMD). Isavuconazole is a novel broad-spectrum azole active against
    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Antifungal Agents/pharmacology ; Aspergillosis/drug therapy ; Aspergillosis/chemically induced ; Nitriles/therapeutic use ; Nitriles/pharmacology ; Organ Transplantation/adverse effects ; Transplant Recipients ; Voriconazole/therapeutic use
    Chemical Substances isavuconazole (60UTO373KE) ; Antifungal Agents ; Nitriles ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2358: Show issues Location:
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  7. Book ; Online: Score EQUAL de Scedosporiosis/Lomentosporiosis 2021

    Stemler, Jannik / Lackner, Michaela / Chen, Shuang / Hoenigl, Martin / Cornely, Oliver Andreas / Aguado, Jose Maria

    un Score de ECMM Derivado de las Guías Actuales Para Medir el nivel de QUALity para el Manejo Clinico de Scedosporiosis/Lomentosporiosis

    (EQUAL Scedosporiosis/Lomentosporiosis Scorecard)

    2021  

    Abstract: El score EQUAL de Scedosporiosis/Lomentosporiosis puntúa y suma factores que ayudan al manejo ideal de los pacientes con scedosporiosis y la lomentosporiosis. Las puntuaciones reflejan las recomendaciones de las guías más reconocidas. Las tarjetas del ... ...

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Jannik Stemler, Michaela Lackner, Sharon Chen, Martin Hoenigl, Oliver A. Cornely, José M. Aguado ; Uniklinik Köln, Medical University of Graz, The University of Sydney, Medizinische Universität Innsbruck
    Series title EQUAL Scedosporiosis/Lomentosporiosis Scorecard
    Abstract El score EQUAL de Scedosporiosis/Lomentosporiosis puntúa y suma factores que ayudan al manejo ideal de los pacientes con scedosporiosis y la lomentosporiosis. Las puntuaciones reflejan las recomendaciones de las guías más reconocidas. Las tarjetas del score EQUAL son una referencia rápida para cuantificar el cumplimiento de las pautas y para respaldar la administración adecuada (stewardship) de antimicóticos.
    Subject code 610
    Language Spanish
    Size 1 Online-Ressource (2 Blätter)
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    Note Der Volltext wurde vom Herausgebenden zurückgezogen, die neue Version finden Sie hier: 10.4126/FRL01-006399388
    HBZ-ID HT021134990
    DOI 10.4126/FRL01-006430115
    Database Repository for Life Sciences

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  8. Book ; Online: Score EQUAL de Scedosporiosis/Lomentosporiosis 2021

    Stemler, Jannik / Lackner, Michaela / Chen, Shuang / Hoenigl, Martin / Cornely, Oliver Andreas / Aguado, Jose Maria

    un Score de ECMM Derivado de las Guías Actuales Para Medir el nivel de QUALity para el Manejo Clinico de Scedosporiosis/Lomentosporiosis

    (EQUAL Scedosporiosis/Lomentosporiosis Scorecard)

    2021  

    Abstract: El score EQUAL de Scedosporiosis/Lomentosporiosis puntúa y suma factores que ayudan al manejo ideal de los pacientes con scedosporiosis y la lomentosporiosis. Las puntuaciones reflejan las recomendaciones de las guías más reconocidas. Las tarjetas del ... ...

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Jannik Stemler, Michaela Lackner, Sharon Chen, Martin Hoenigl, Oliver A. Cornely, José M. Aguado ; Uniklinik Köln, Medical University of Graz, The University of Sydney, Medizinische Universität Innsbruck
    Series title EQUAL Scedosporiosis/Lomentosporiosis Scorecard
    Abstract El score EQUAL de Scedosporiosis/Lomentosporiosis puntúa y suma factores que ayudan al manejo ideal de los pacientes con scedosporiosis y la lomentosporiosis. Las puntuaciones reflejan las recomendaciones de las guías más reconocidas. Las tarjetas del score EQUAL son una referencia rápida para cuantificar el cumplimiento de las pautas y para respaldar la administración adecuada (stewardship) de antimicóticos.
    Subject code 610
    Language Spanish
    Size 1 Online-Ressource (2 Blätter)
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT021448751
    Database Repository for Life Sciences

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  9. Article ; Online: Is there a real risk of bacterial infection in patients receiving targeted and biological therapies?

    Noreña, Ivan / Fernández-Ruiz, Mario / Aguado, José María

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 5, Page(s) 266–272

    Abstract: Over the past decades, the advent of targeted and biological therapies has revolutionized the management of cancer and autoimmune, hematological and inflammatory conditions. Although a large amount of information is now available on the risk of ... ...

    Abstract Over the past decades, the advent of targeted and biological therapies has revolutionized the management of cancer and autoimmune, hematological and inflammatory conditions. Although a large amount of information is now available on the risk of opportunistic infections associated with some of these agents, the evidence regarding the susceptibility to bacterial infections is more limited. Biological agents have been shown to entail a variable risk of bacterial infections in pivotal randomized clinical trials and post-marketing studies. Recommendations on risk minimization strategies and therapeutic interventions are therefore scarce and often based on expert opinion, with only a few clear statements for some particular agents (i.e. meningococcal vaccination for patients receiving eculizumab). In the present review the available information regarding the incidence of and risk factors for bacterial infection associated with the use of different groups of biological agents is summarized according to their mechanisms of action, and recommendations based on this evidence are provided. Additional information coming from clinical research and real-world studies is required to address unmet questions in this emerging field.
    MeSH term(s) Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Bacterial Infections/etiology ; Biological Factors ; Biological Therapy/adverse effects ; Humans ; Incidence ; Opportunistic Infections/epidemiology ; Opportunistic Infections/etiology
    Chemical Substances Biological Factors
    Language English
    Publishing date 2022-05-14
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2020.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: EQUAL Candida Score 2018

    Mellinghoff, Sibylle Christiane / Köhler, Philipp / Cornely, Oliver Andreas / Aguado, José Maria

    un score de ECMM derivado de las guías actuales que permite medir la calidad del manejo clínico de la candidemia mediante el parámetro QUALity

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details Mellinghoff, S.C., Köhler, P., Cornely, O.A., Aguado, J.M. ; Uniklinik Köln
    Subject code 610
    Language Spanish
    Size 1 Online-Ressource (2 Seiten)
    Edition Noviembre 2018
    Publisher Uniklinik Köln
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019865457
    DOI 10.4126/FRL01-006410984
    Database Repository for Life Sciences

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