Article ; Online: Engineering a nanoantibiotic system displaying dual mechanism of action.
Proceedings of the National Academy of Sciences of the United States of America
2024 Volume 121, Issue 16, Page(s) e2321498121
Abstract: In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report a dual-therapeutic system constituted by an antimicrobial PA and a ... ...
Abstract | In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report a dual-therapeutic system constituted by an antimicrobial PA and a cylindrical protease inhibitor (LJC) to achieve broad antimicrobial spectrum and to enhance therapeutic efficacy. We studied two strategies: PA-LJC nanostructures ( |
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MeSH term(s) | Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Nanostructures/chemistry ; Anti-Infective Agents |
Chemical Substances | Anti-Bacterial Agents ; Anti-Infective Agents |
Language | English |
Publishing date | 2024-04-09 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 209104-5 |
ISSN | 1091-6490 ; 0027-8424 |
ISSN (online) | 1091-6490 |
ISSN | 0027-8424 |
DOI | 10.1073/pnas.2321498121 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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