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Article ; Online: Digital imaging, virtual and augmented reality.

Cirugia espanola

2024

Abstract: The sensorial perception of what is captured is what we know as "image" and consists of a static component and a dynamic process. This continuous process of images capture is essential in surgery. The image is crucial for the surgeon, who requires it for ...

Abstract	The sensorial perception of what is captured is what we know as "image" and consists of a static component and a dynamic process. This continuous process of images capture is essential in surgery. The image is crucial for the surgeon, who requires it for the diagnosis, for the therapeutic process and for postoperative follow-up. In minimally invasive surgery the sequence of images is essential and promotes the appearance of digital video. Digital video is the representation of moving images in the form of encoded digital data, unlike classic analog video, with continuous analog signals. Beyond what we can consider the "real image" (what we see as part of the existing reality) other realities appear in these decades; the Virtual Reality and Augmented Reality. With these realities we refer in the medical ambitus to the creation or superposition, respectively, of a three-dimensional virtual environment to support healthcare and teaching or research processes. Today, these technologies have already begun to be integrated into various surgical specialties, with predictive surgical planning and intraoperative navigation us their main applications. When using these digital environments, it is difficult to completely separate virtual reality from augmented reality, often being Mixed Reality. The current developments offer an environment that mixes the best aspects of both, unifying the simulation and requiring a single helmet or glasses to enjoy the sensorial experience. In this fusion of realities it will be possible to simultaneously create a virtual world from scratch to which we can add virtual elements from our real environment.
Language	English
Publishing date	2024-03-01
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2024.01.013
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Article: Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage.

Jamet, Marguerite / Dupuis, Luc / Gonzalez De Aguilar, Jose-Luis

Frontiers in molecular neuroscience

2024 Volume 17, Page(s) 1375330

Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells. The implication of oligodendrocytes has been the subject of a number of studies conducted on patients and related animal models. In this review we summarize our current knowledge on the alterations specific to myelin and the oligodendrocyte lineage occurring in ALS and FTD. We also consider different ways by which specific oligodendroglial alterations influence neurodegeneration and highlight the important role of oligodendrocytes in these two intrinsically associated neurodegenerative diseases.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2024.1375330
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Article ; Online: Molecular dynamics simulations suggest the potential toxicity of fluorinated graphene to HP35 protein via unfolding the α-helix structure.

Zou, Fangrong / Gu, Zonglin / Perez-Aguilar, Jose Manuel / Luo, Yuqi

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9168

Abstract: Fluorinated graphene, a two-dimensional nanomaterial composed of three atomic layers, a central carbon layer sandwiched between two layers of fluorine atoms, has attracted considerable attention across various fields, particularly for its potential use ... ...

Abstract	Fluorinated graphene, a two-dimensional nanomaterial composed of three atomic layers, a central carbon layer sandwiched between two layers of fluorine atoms, has attracted considerable attention across various fields, particularly for its potential use in biomedical applications. Nonetheless, scant effort has been devoted to assessing the potential toxicological implications of this nanomaterial. In this study, we scrutinize the potential impact of fluorinated graphene on a protein model, HP35 by utilizing extensive molecular dynamics (MD) simulation methods. Our MD results elucidate that upon adsorption to the nanomaterial, HP35 undergoes a denaturation process initiated by the unraveling of the second helix of the protein and the loss of the proteins hydrophobic core. In detail, substantial alterations in various structural features of HP35 ensue, including alterations in hydrogen bonding, Q value, and RMSD. Subsequent analyses underscore that hydrophobic and van der Waals interactions (predominant), alongside electrostatic energy (subordinate), exert influence over the adsorption of HP35 on the fluorinated graphene surface. Mechanistic scrutiny attests that the unrestrained lateral mobility of HP35 on the fluorinated graphene nanomaterial primarily causes the exposure of HP35's hydrophobic core, resulting in the eventual structural denaturation of HP35. A trend in the features of 2D nanostructures is proposed that may facilitate the denaturation process. Our findings not only substantiate the potential toxicity of fluorinated graphene but also unveil the underlying molecular mechanism, which thereby holds significance for the prospective utilization of such nanomaterials in the field of biomedicine.
MeSH term(s)	Graphite/chemistry ; Graphite/toxicity ; Molecular Dynamics Simulation ; Protein Conformation, alpha-Helical ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Protein Unfolding/drug effects ; Halogenation ; Adsorption ; Nanostructures/chemistry ; Nanostructures/toxicity ; Peptide Fragments ; Neurofilament Proteins
Chemical Substances	Graphite (7782-42-5) ; villin headpiece subdomain peptide ; Peptide Fragments ; Neurofilament Proteins
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59780-3
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Article ; Online: Case studies of clinical decision-making through prescriptive models based on machine learning.

Hoyos, William / Aguilar, Jose / Raciny, Mayra / Toro, Mauricio

Computer methods and programs in biomedicine

2023 Volume 242, Page(s) 107829

Abstract: Background: The development of computational methodologies to support clinical decision-making is of vital importance to reduce morbidity and mortality rates. Specifically, prescriptive analytic is a promising area to support decision-making in the ... ...

Abstract	Background: The development of computational methodologies to support clinical decision-making is of vital importance to reduce morbidity and mortality rates. Specifically, prescriptive analytic is a promising area to support decision-making in the monitoring, treatment and prevention of diseases. These aspects remain a challenge for medical professionals and health authorities. Materials and methods: In this study, we propose a methodology for the development of prescriptive models to support decision-making in clinical settings. The prescriptive model requires a predictive model to build the prescriptions. The predictive model is developed using fuzzy cognitive maps and the particle swarm optimization algorithm, while the prescriptive model is developed with an extension of fuzzy cognitive maps that combines them with genetic algorithms. We evaluated the proposed approach in three case studies related to monitoring (warfarin dose estimation), treatment (severe dengue) and prevention (geohelminthiasis) of diseases. Results: The performance of the developed prescriptive models demonstrated the ability to estimate warfarin doses in coagulated patients, prescribe treatment for severe dengue and generate actions aimed at the prevention of geohelminthiasis. Additionally, the predictive models can predict coagulation indices, severe dengue mortality and soil-transmitted helminth infections. Conclusions: The developed models performed well to prescribe actions aimed to monitor, treat and prevent diseases. This type of strategy allows supporting decision-making in clinical settings. However, validations in health institutions are required for their implementation.
MeSH term(s)	Humans ; Severe Dengue ; Warfarin/therapeutic use ; Algorithms ; Machine Learning ; Clinical Decision-Making
Chemical Substances	Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2023-10-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107829
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Article ; Online: Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning.

Rodríguez-Martín, Manuel / Aguilar, José Manuel / Castro-Criado, Daniel / Romero, Alberto

Biomimetics (Basel, Switzerland)

2024 Volume 9, Issue 2

Abstract: New advances in materials science and medicine have enabled the development of new and increasingly sophisticated biomaterials. One of the most widely used biopolymers is polycaprolactone (PCL) because it has properties suitable for biomedical ... ...

Abstract	New advances in materials science and medicine have enabled the development of new and increasingly sophisticated biomaterials. One of the most widely used biopolymers is polycaprolactone (PCL) because it has properties suitable for biomedical applications, tissue engineering scaffolds, or drug delivery systems. However, PCL scaffolds do not have adequate bioactivity, and therefore, alternatives have been studied, such as mixing PCL with bioactive polymers such as gelatin, to promote cell growth. Thus, this work will deal with the fabrication of nanofiber membranes by means of the electrospinning technique using PCL-based solutions (12 wt.% and 20 wt.%) and PCL with gelatin (12 wt.% and 8 wt.%, respectively). Formic acid and acetic acid, as well as mixtures of both in different proportions, have been used to prepare the preliminary solutions, thus supporting the electrospinning process by controlling the viscosity of the solutions and, therefore, the size and uniformity of the fibers. The physical properties of the solutions and the morphological, mechanical, and thermal properties of the membranes were evaluated. Results demonstrate that it is possible to achieve the determined properties of the samples with an appropriate selection of polymer concentrations as well as solvents.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics9020070
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Article ; Online: Research Note: Bovine lactoferrin in chickens: an investigation into its viability as an antibiotic alternative.

Wong, Theresa W / Rai, Vikrant / Dong, Fanglong / Tkalcic, Suzana / Aguilar, Jose Santiago / Dawes, Maisie E

Poultry science

2024 Volume 103, Issue 6, Page(s) 103658

Abstract: Finding effective antibiotic alternatives is crucial to managing the re-emerging health risk of Clostridium perfringens (CP) type A/G-induced avian necrotic enteritis (NE), a disease that has regained prominence in the wake of governmental restrictions ... ...

Abstract	Finding effective antibiotic alternatives is crucial to managing the re-emerging health risk of Clostridium perfringens (CP) type A/G-induced avian necrotic enteritis (NE), a disease that has regained prominence in the wake of governmental restrictions on antibiotic use in poultry. Known for its antimicrobial and immunomodulatory effects, the use of bovine lactoferrin (bLF) in chickens is yet to be fully explored. In this study, we hypothesized that bLF can accumulate in the small intestines of healthy chickens through gavage and intramuscular supplementation and serves as a potential antibiotic alternative. Immunohistochemistry located bLF in various layers of the small intestines and ELISA testing confirmed its accumulation. Surprisingly, sham-treated chickens also showed the presence of bLF, prompting a western blotting analysis that dismissed the notion of cross-reactivity between bLF and the avian protein ovotransferrin. Although the significance of the route of administration remains inconclusive, this study supports the hypothesis that bLF is a promising and safe antibiotic alternative with demonstrated resistance to the degradative environment of the chicken intestines. Further studies are needed to determine its beneficial pharmacological effects in CP-infected chickens.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2024.103658
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Article: Psychological wellbeing in teachers. Study in teachers of early childhood and primary education.

Salavera, Carlos / Urbón, Eva / Usán, Pablo / Franco, Vitor / Paterna, Adrián / Aguilar, José M

Heliyon

2024 Volume 10, Issue 7, Page(s) e28868

Abstract: Recently, there has been a growing interest in emotional wellbeing, even from the early stages of education. In order to work wellbeing among the students it is essential to analyze the wellbeing of the teachers who are teaching and working with the ... ...

Abstract	Recently, there has been a growing interest in emotional wellbeing, even from the early stages of education. In order to work wellbeing among the students it is essential to analyze the wellbeing of the teachers who are teaching and working with the children. This study examines psychological wellbeing in early childhood (0-6 years) and primary school teachers (6-12 years). The study comprised 236 early childhood and primary school teachers - 76 men (32.2%) and 160 women (67.8%) - with ages ranging from 25 to 61 years (average 37.69 years -
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28868
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Article ; Online: Reply to "Propofol and survival: an updated meta‑analysis of randomized clinical trials".

Gutierrez, Manuel Alberto Guerrero / Meade-Aguilar, José A / Martinez, Diego Escarraman

Critical care (London, England)

2023 Volume 27, Issue 1, Page(s) 192

MeSH term(s)	Humans ; Propofol/pharmacology ; Propofol/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Propofol (YI7VU623SF)
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-023-04484-9
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Article: An autonomous cycle of data analysis tasks for the clinical management of dengue.

Hoyos, William / Aguilar, Jose / Toro, Mauricio

Heliyon

2022 Volume 8, Issue 10, Page(s) e10846

Abstract: Dengue is the most widespread vector-borne disease worldwide. Timely diagnosis and treatment of dengue is the main objective of medical professionals to decrease mortality rates. In this paper, we propose an autonomous cycle that integrates data analysis ...

Abstract	Dengue is the most widespread vector-borne disease worldwide. Timely diagnosis and treatment of dengue is the main objective of medical professionals to decrease mortality rates. In this paper, we propose an autonomous cycle that integrates data analysis tasks to support decision-making in the clinical management of dengue. Particularly, the autonomous cycle supports dengue diagnosis and treatment. The proposed system was built using machine learning techniques for classification tasks (artificial neural networks and support vector machines) and evolutionary techniques (a genetic algorithm) for prescription tasks (treatment). The system was quantitatively evaluated using dengue-patient datasets reported by healthcare institutions. Our system was compared with previous works using qualitative criteria. The proposed system has the ability to classify a patient's clinical picture and recommend the best treatment option. In particular, the classification of dengue was done with 98% accuracy and a genetic algorithm recommends treatment options for particular patients. Finally, our system is flexible and easily adaptable, which will allow the addition of new tasks for dengue analysis.
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10846
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Article ; Online: Fluorinated graphene nanomaterial causes potential mechanical perturbations to a biomembrane.

Gu, Zonglin / Xie, Guanhua / Perez-Aguilar, Jose Manuel

Journal of molecular modeling

2022 Volume 28, Issue 2, Page(s) 49

Abstract: Fluorinated graphene (F-GRA) has attracted great interest in biomedical applications. In this context, the direct interaction between F-GRA and various biomolecules is a vital process guiding the bio-function of this nanomaterial. Nevertheless, ... ...

Abstract	Fluorinated graphene (F-GRA) has attracted great interest in biomedical applications. In this context, the direct interaction between F-GRA and various biomolecules is a vital process guiding the bio-function of this nanomaterial. Nevertheless, information regarding the interaction of F-GRA with biomolecules is scarce, particularly at the molecular level. In this study, using an in silico approach, we investigate the adsorption of F-GRA to a phospholipid bilayer to evaluate the potential effect of the nanomaterial to a biomembrane and its mechanism. Our results indicate that F-GRA can either slightly insert into the membrane or parallelly adhere on the membrane surface, different from the complete insertion of graphene. Detailed analysis confirms that the electrostatic forces dominantly mediate the adsorption process. F-GRA in its parallel binding pattern causes a partial enlargement in the membrane thickness via the disruption of the lipids' order parameters, indicating a mild mechanical influence to the membrane structure. Although the potential mechanical perturbation of F-GRA to membrane is detected, this impact is much weaker than graphene. These findings suggest the potentially weak physical perturbations of F-GRA to the cellular membrane, which may establish the basis for the future biomedical applications of this material after proper surface coating.
MeSH term(s)	Biocompatible Materials/chemistry ; Cell Membrane/chemistry ; Chemical Phenomena ; Graphite/chemistry ; Halogenation ; Lipid Bilayers/chemistry ; Mechanical Phenomena ; Models, Molecular ; Nanostructures/chemistry
Chemical Substances	Biocompatible Materials ; Lipid Bilayers ; Graphite (7782-42-5)
Language	English
Publishing date	2022-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1284729-X
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-022-05040-y
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